@article{MTMT:34631071,
	title = {Microparticles and multi-unit systems for advanced drug delivery},
	url = {https://m2.mtmt.hu/api/publication/34631071},
	author = {Kállai-Szabó, Nikolett and Farkas, Dóra and Lengyel, Miléna and Basa, Bálint and Fleck, C. and Antal, István},
	doi = {10.1016/j.ejps.2024.106704},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {194},
	unique-id = {34631071},
	issn = {0928-0987},
	year = {2024},
	eissn = {1879-0720},
	orcid-numbers = {Kállai-Szabó, Nikolett/0000-0002-8164-3993; Farkas, Dóra/0000-0003-4737-2108; Lengyel, Miléna/0000-0001-8865-054X; Basa, Bálint/0000-0003-4546-1727; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34405975,
	title = {Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements},
	url = {https://m2.mtmt.hu/api/publication/34405975},
	author = {MAGRAMANE, Sabrina and Vlahovic, Kristina and Gordon, Péter and Kállai-Szabó, Nikolett and Zelkó, Romána and Antal, István and Farkas, Dóra},
	doi = {10.3390/ph16121658},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {16},
	unique-id = {34405975},
	abstract = {In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms.},
	year = {2023},
	eissn = {1424-8247},
	orcid-numbers = {MAGRAMANE, Sabrina/0000-0001-6818-8300; Vlahovic, Kristina/0009-0002-0045-7425; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X; Farkas, Dóra/0000-0003-4737-2108}
}

@misc{MTMT:34128875,
	title = {Drug delivery system for the improvement of patient centricity, compliance, and adherence},
	url = {https://m2.mtmt.hu/api/publication/34128875},
	author = {Antal, István},
	unique-id = {34128875},
	year = {2023},
	orcid-numbers = {Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34096036,
	title = {Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies},
	url = {https://m2.mtmt.hu/api/publication/34096036},
	author = {Tóth, Gergő D. and Kállai-Szabó, Nikolett and Lengyel, Miléna and Süvegh, Károly and Ender, Ferenc and Katona, Gábor and Nochta-Kazsoki, Adrienn Katalin and Zelkó, Romána and Antal, István and Balogh, György Tibor and Balogh Weiser, Diána},
	doi = {10.1016/j.molliq.2023.122819},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {389},
	unique-id = {34096036},
	issn = {0167-7322},
	year = {2023},
	eissn = {1873-3166},
	orcid-numbers = {Kállai-Szabó, Nikolett/0000-0002-8164-3993; Lengyel, Miléna/0000-0001-8865-054X; Süvegh, Károly/0000-0001-8147-0546; Katona, Gábor/0000-0003-1564-4813; Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X; Balogh, György Tibor/0000-0003-3347-1880; Balogh Weiser, Diána/0000-0002-9957-1203}
}

@article{MTMT:34096011,
	title = {Viscoelasticity of Liposomal Dispersions},
	url = {https://m2.mtmt.hu/api/publication/34096011},
	author = {Budai, Lívia and Budai, Marianna and Pápay, Zsófia Edit and Szalkai, Petra and Niczinger, Noémi and Kijima, S. and Sugibayashi, K. and Antal, István and Kállai-Szabó, Nikolett},
	doi = {10.3390/nano13162340},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {13},
	unique-id = {34096011},
	year = {2023},
	eissn = {2079-4991},
	orcid-numbers = {Budai, Lívia/0000-0002-6720-5989; Budai, Marianna/0000-0003-4947-9924; Pápay, Zsófia Edit/0000-0002-7653-1065; Niczinger, Noémi/0000-0002-2076-0643; Antal, István/0000-0002-5434-201X; Kállai-Szabó, Nikolett/0000-0002-8164-3993}
}

@article{MTMT:34041182,
	title = {Determination of the Main Phase Transition Temperature of Phospholipids by Oscillatory Rheology},
	url = {https://m2.mtmt.hu/api/publication/34041182},
	author = {Budai, Lívia and Budai, Marianna and Bozó, Tamás and Agócs, Gergely and Kellermayer, Miklós and Antal, István},
	doi = {10.3390/molecules28135125},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34041182},
	issn = {1420-3049},
	abstract = {Knowledge of the physical and chemical properties of phospholipids, such as phase transition temperatures (Tc), is of great importance in order to reveal the functionalities of biological and artificial membranes. Our research group developed an oscillatory rheological method for the simple and rapid determination of phase transition temperatures (Tc). The phospholipids constructing the membranes undergo conformational changes at their Tc, which cause alterations of viscoelastic properties of the molecules. The oscillatory technique recommended by us proved to be appropriate to reveal the altered molecular properties of phospholipids as tracking the slightest changes in the viscoelasticity. Our study demonstrates the abrupt changes in rheological properties at Tc for the following phospholipids: 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine (DMPC), 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine (DPPC), and 1,2-Distearoyl-sn-glycero-3-Phosphocholine (DSPC), proving that the applied methodology is adequate for determining the Tc of phospholipids.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Budai, Lívia/0000-0002-6720-5989; Budai, Marianna/0000-0003-4947-9924; Bozó, Tamás/0000-0002-2643-0661; Agócs, Gergely/0000-0003-2489-3790; Kellermayer, Miklós/0000-0002-5553-6553; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34026885,
	title = {Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection},
	url = {https://m2.mtmt.hu/api/publication/34026885},
	author = {Szabó, Dóra and Ostorházi, Eszter and Stercz, Balázs and Makra, Nóra and Pénzes, Kinga and Kristóf, Katalin and Antal, István and Réthelyi, János and Zsigmond, Réka Ildikó and Birtalan, Ede and Merkely, Béla Péter and Tamás, László},
	doi = {10.1007/s11357-023-00850-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {34026885},
	issn = {2509-2715},
	abstract = {The SARS-CoV-2 virus is still causing a worldwide problem. The virus settles primarily on the nasal mucosa, and the infection and its course depend on individual susceptibility. Our aim was to investigate the nasopharynx composition’s role in the individual susceptibility. During the first phase of SARS-CoV-2 pandemic, nasopharyngeal microbiome samples of close contact unvaccinated patients were investigated by 16S rRNA analysis and by culturing. The whole genome of cultured Corynebacteria was sequenced. The relative expression of ACE2, TMPRSS2, and cathepsin L on Caco-2 cells and the strength of S1-ACE2 binding were determined in the presence of Corynebacteria . From 55 close contacts exposed to identical SARS-CoV-2 exposure, 26 patients became infected and 29 remained uninfected. The nasopharyngeal microbiome analysis showed significantly higher abundance of Corynebacteria in uninfected group. Corynebacterium accolens could be cultivated only from uninfected individuals and Corynebacterium propinquum from both infected and uninfected. Corynebacteria from uninfected patient significantly reduced the ACE2 and cathepsin L expression. C. accolens significantly reduced the TMPRSS2 expression compared to other Corynebacteria . Furthermore, Corynebacterium spp. weakened the binding of the S1-ACE2. Most C. accolens isolates harbored the TAG lipase LipS1 gene. Based on these results, the presence of Corynebacterium spp. in the nasopharyngeal microbiota, especially C. accolens strains, could reduce the individual susceptibility to SARS-CoV-2 infection by several mechanisms: by downregulation the ACE2, the TMPRSS2 receptors, and cathepsin L in the host; through the inhibition of S1-ACE2 binding; and lipase production. These results suggest the use of C. accolens strains as probiotics in the nasopharynx in the future.},
	year = {2023},
	eissn = {2509-2723},
	pages = {2927-2938},
	orcid-numbers = {Szabó, Dóra/0000-0002-8601-3923; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Kristóf, Katalin/0000-0002-5189-4636; Antal, István/0000-0002-5434-201X; Réthelyi, János/0000-0002-3641-012X; Zsigmond, Réka Ildikó/0000-0002-7019-6761; Birtalan, Ede/0000-0002-5699-3545; Merkely, Béla Péter/0000-0001-6514-0723; Tamás, László/0000-0003-3723-9149}
}

@article{MTMT:34009564,
	title = {Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity},
	url = {https://m2.mtmt.hu/api/publication/34009564},
	author = {Budai, Lívia and Budai, Marianna and Pápay, Zsófia Edit and Vilimi, Zsófia and Antal, István},
	doi = {10.3390/gels9060469},
	journal-iso = {GELS-BASEL},
	journal = {GELS (BASEL)},
	volume = {9},
	unique-id = {34009564},
	abstract = {Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine.},
	year = {2023},
	eissn = {2310-2861},
	orcid-numbers = {Budai, Lívia/0000-0002-6720-5989; Budai, Marianna/0000-0003-4947-9924; Pápay, Zsófia Edit/0000-0002-7653-1065; Vilimi, Zsófia/0000-0002-9241-5267; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:33810076,
	title = {Transdermal Delivery of α-Aminophosphonates as Semisolid Formulations—An In Vitro-Ex Vivo Study},
	url = {https://m2.mtmt.hu/api/publication/33810076},
	author = {Kocsis, Dorottya and Varga, Petra Regina and Keshwan, Rusul and Nader, Mina and Lengyel, Miléna and Szabó, Pál Tamás and Antal, István and Kánai, Károly and Keglevich, György and Erdő, Franciska},
	doi = {10.3390/pharmaceutics15051464},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33810076},
	issn = {1999-4923},
	abstract = {α-Aminophosphonates are organophosphorus compounds with an obvious similarity with α-amino acids. Owing to their biological and pharmacological characteristics, they have attracted the attention of many medicinal chemists. α-Aminophosphonates are known to exhibit antiviral, antitumor, antimicrobial, antioxidant and antibacterial activities, which can all be important in pathological dermatological conditions. However, their ADMET properties are not well studied. The aim of the current study was to provide preliminary information about the skin penetration of three preselected α-aminophosphonates when applying them as topical cream formulations in static and dynamic diffusion chambers. The results indicate that aminophosphonate 1a, without any substituent in the para position, shows the best release from the formulation and the highest absorption through the excised skin. However, based on our previous study, the in vitro pharmacological potency was higher in the case of para-substituted molecules 1b and 1c. The particle size and rheological studies revealed that the 2% cream of aminophosphonate 1a was the most homogenous formulation. In conclusion, the most promising molecule was 1a, but further experiments are proposed to uncover the possible transporter interactions in the skin, optimize the topical formulations and improve PK/PD profiles in case of transdermal delivery.},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Kocsis, Dorottya/0000-0001-7908-3248; Lengyel, Miléna/0000-0001-8865-054X; Szabó, Pál Tamás/0000-0003-2260-4641; Antal, István/0000-0002-5434-201X; Keglevich, György/0000-0002-5366-472X; Erdő, Franciska/0000-0001-6265-3777}
}

@article{MTMT:33757727,
	title = {Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin},
	url = {https://m2.mtmt.hu/api/publication/33757727},
	author = {Juriga-Tóth, Krisztina and Fekete, Nóra and Simon, Vivien Klaudia and Tóth, Bence and Kovács, Árpád Ferenc and Pállinger, Éva and Antal, István and Kőhidai, László and Jedlovszky-Hajdú, Angéla and Juriga, Dávid and S. Nagy, Krisztina},
	doi = {10.1016/j.molliq.2023.121854},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {381},
	unique-id = {33757727},
	issn = {0167-7322},
	abstract = {Electrospinning is widely applied to prepare nanofibers that provide high specific surfaces, enhanced bioavailability of poorly water-soluble drugs, moreover, enable several administration routes such as implantation. In this perspective, biocompatible poly(vinyl alcohol) (PVA), polysuccinimide (PSI), and ε-polycaprolactone (PCL) based implantable scaffolds were developed by electrospinning to improve the bioavailability of incorporated or conjugated prednisone (Pred) and doxorubicin (Dox). Besides physicochemical characterization, the effect of the loaded amount of Prednisone on the mechanical properties of the fibers as well as their drug release profile were investigated. The drug release measurement revealed that the release profile highly depends on the polarity of the applied polymer as well as the environmental pH. Concerning electrospun meshes incorporating prednisone, the anti-inflammatory effect was monitored by measuring the release of a wide spectrum of cytokines by MDA-MB-231 cells. Besides the loading of doxorubicin, the chemical conjugation to polysuccinimide was successfully carried out which provided prolonged release as well as increased cellular uptake. Based on the different drug release profiles, poly(vinyl alcohol), polysuccinimide, and ε-polycaprolactone fibrous meshes can be used to prepare a potential multi-layered drug-containing implantable scaffold, which can provide both burst and prolonged release of prednisone and doxorubicin. The anti-inflammatory effect of prednisone could be beneficial to avoid rejection after implantation while incorporation or conjugation of doxorubicin into polysuccinimide fibers provides sufficient cytotoxicity and enhanced cellular uptake of MDA-MB-231 cells.},
	year = {2023},
	eissn = {1873-3166},
	orcid-numbers = {Juriga-Tóth, Krisztina/0000-0002-7939-5492; Kovács, Árpád Ferenc/0000-0002-7742-160X; Pállinger, Éva/0000-0002-5789-0951; Antal, István/0000-0002-5434-201X; Kőhidai, László/0000-0002-9002-0296; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X; Juriga, Dávid/0000-0003-2655-5584; S. Nagy, Krisztina/0000-0002-4942-2947}
}