@article{MTMT:34745300, title = {Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model}, url = {https://m2.mtmt.hu/api/publication/34745300}, author = {Marosvölgyi, Tamás and Mintál, Kitti and Borbásné Farkas, Kornélia and Sipos, Zoltán and Makszin, Lilla and Szabó, Éva and Tóth, Attila and Kocsis, Béla and Kovács, Krisztina and Hormay, Edina and Lénárd, László and Karádi, Zoltán György and Bufa, Anita}, doi = {10.1038/s41598-024-57046-6}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34745300}, issn = {2045-2322}, abstract = {Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Mintál, Kitti/0009-0003-4739-2902; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Makszin, Lilla/0000-0002-9764-4763; Hormay, Edina/0009-0004-0598-5061} } @CONFERENCE{MTMT:34735416, title = {Different aspects of the taste reactivity test to interpret gustatory responses elicited organismic changes.}, url = {https://m2.mtmt.hu/api/publication/34735416}, author = {Hormay, Edina and Mintál, Kitti and László, Bettina Réka and Szabó, István and Tóth, Attila and László, Kristóf and Győrfi, Nina Rubina and Lénárd, László and Karádi, Zoltán György}, booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet}, unique-id = {34735416}, year = {2024}, pages = {48}, orcid-numbers = {Hormay, Edina/0009-0004-0598-5061; Mintál, Kitti/0009-0003-4739-2902} } @CONFERENCE{MTMT:34735333, title = {Long term saccharose consumption associated activity of limbic forebrain glucose-monitoring neurons: A pilot study in the rat.}, url = {https://m2.mtmt.hu/api/publication/34735333}, author = {Hormay, Edina and Mintál, Kitti and László, Bettina Réka and Szabó, István and Tóth, Attila and László, Kristóf and Győrfi, Nina Rubina and Lénárd, László and Karádi, Zoltán György}, booktitle = {International Neuroscience Conference, Pécs 2024}, unique-id = {34735333}, year = {2024}, pages = {129}, orcid-numbers = {Hormay, Edina/0009-0004-0598-5061; Mintál, Kitti/0009-0003-4739-2902} } @article{MTMT:34448557, title = {Continuous Electrode Models and Application of Exact Schemes in Modeling of Electrical Impedance Measurements}, url = {https://m2.mtmt.hu/api/publication/34448557}, author = {Vizvári, Zoltán Ákos and Klincsik, Mihály and Odry, Péter and Tadity, Vladimir and Győrfi, Nina Rubina and Tóth, Attila and Sári, Zoltán}, doi = {10.3390/electronics13010066}, journal = {ELECTRONICS (SWITZ)}, volume = {13}, unique-id = {34448557}, abstract = {The crucial issue in electrical impedance (EI) measurements lies in the galvanic interaction between the electrodes and the investigated material. This paper brings together the basic and applied research experience and combines their results with excellent properties. Consequently, innovative precise methodologies have emerged, enabling the direct modeling of EI measurements, free from the inaccuracies often associated with numerical approaches. As an outcome of the efficiency and robustness of the applied method, the conductivity of the material and the electrodes are represented by a common piecewise function, which is used to solve the differential equation modeling of the EI measurement. Moreover, this allows the possibility for modeling the conductivity of electrodes with continuous functions, providing an important generalization of the Complete Electrode Model (CEM), which has been widely used so far. The effectiveness of the novel approach was showcased through two distinct case studies. In the first case study, potential functions within both the material and the electrodes were computed using the CEM. In the second case study, calculations were performed utilizing the newly introduced continuous electrode model. The simulation results suggest that the new method is a powerful tool for biological research, from in vitro experiments to animal studies and human applications.}, year = {2024}, eissn = {2079-9292} } @article{MTMT:34124226, title = {Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases}, url = {https://m2.mtmt.hu/api/publication/34124226}, author = {Győrfi, Nina Rubina and Gál, Adrián Róbert and Fincsur, András and Kalmar-Nagy, Karoly and Mintál, Kitti and Hormay, Edina and Miseta, Attila János and Tornóczky, Tamás and Nemeth, Anita K. and Bogner, Péter and Kiss, Tamas and Helyes, Zsuzsanna and Sári, Zoltán and Klincsik, Mihály and Tadity, Vladimir and Lénárd, László and Vereczkei, András and Karádi, Zoltán György and Vizvári, Zoltán Ákos and Tóth, Attila}, doi = {10.3390/biomedicines11092449}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {11}, unique-id = {34124226}, abstract = {Based on a prior university patent, the authors developed a novel type of bioimpedance-based test method to noninvasively detect nonalcoholic fatty liver disease (NAFLD). The development of a new potential NAFLD diagnostic procedure may help to understand the underlying mechanisms between NAFLD and severe liver diseases with a painless and easy-to-use paraclinical examination method, including the additional function to detect even the earlier stages of liver disease. The aim of this study is to present new results and the experiences gathered in relation to NAFLD progress during animal model and human clinical trials.}, keywords = {VALIDATION; clinical study; hepatic steatosis; Wistar; Bioelectrical impedance spectroscopy; NAFLD; noninvasive measurement; low-frequency measurement}, year = {2023}, eissn = {2227-9059}, orcid-numbers = {Mintál, Kitti/0009-0003-4739-2902; Hormay, Edina/0009-0004-0598-5061; Miseta, Attila János/0000-0002-7984-3347} } @article{MTMT:34081444, title = {Intraamygdaloid Oxytocin Increases Time Spent on Social Interaction in Valproate-Induced Autism Animal Model}, url = {https://m2.mtmt.hu/api/publication/34081444}, author = {Vörös, Dávid and Kiss, Orsolya and Ollmann, Tamás and Mintál, Kitti and Péczely, László and Zagorácz, Olga and Kertes, Erika and Kállai, Veronika and László, Bettina Réka and Marosné Berta, Beáta and Tóth, Attila and Lénárd, László and László, Kristóf}, doi = {10.3390/biomedicines11071802}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {11}, unique-id = {34081444}, abstract = {Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that affects about 1.5% of children worldwide. One of the core symptoms is impaired social interaction. Since proper treatment has not been found yet, an investigation of the exact pathophysiology of autism is essential. The valproate (VPA)-induced rat model can be an appropriate way to study autism. Oxytocin (OT) may amend some symptoms of ASD since it plays a key role in developing social relationships. In the present study, we investigated the effect of the intraamygdaloid OT on sham and intrauterine VPA-treated rats' social interaction using Crawley's social interaction test. Bilateral guide cannulae were implanted above the central nucleus of the amygdala (CeA), and intraamygdaloid microinjections were carried out before the test. Our results show that male Wistar rats prenatally exposed to VPA spent significantly less time on social interaction. Bilateral OT microinjection increased the time spent in the social zone; it also reached the level of sham-control animals. OT receptor antagonist blocked this effect of the OT but in itself did not significantly influence the behavior of the rats. Based on our results, we can establish that intraamygdaloid OT has significantly increased time spent on social interaction in the VPA-induced autism model, and its effect is receptor-specific.}, keywords = {OXYTOCIN; autism; valproate; Social interaction; RAT MODEL; amygdala}, year = {2023}, eissn = {2227-9059}, orcid-numbers = {Ollmann, Tamás/0009-0009-6798-7704; Mintál, Kitti/0009-0003-4739-2902} } @{MTMT:34001599, title = {Development of an impedance-based cell measuring plate.}, url = {https://m2.mtmt.hu/api/publication/34001599}, author = {Győrfi, Nina Rubina and Vizvári, Z and Tóth, Attila and Karádi, Zoltán György}, booktitle = {MedPECS - Medical Conference for PhD Students and Experts of Clinical Science}, unique-id = {34001599}, year = {2023}, pages = {52} } @{MTMT:34001582, title = {The complex relationship of glucose and neural activity in the light of limbic forebrain glucose-monitoring neurons.}, url = {https://m2.mtmt.hu/api/publication/34001582}, author = {Hormay, Edina and Mintál, Kitti and László, Bettina Réka and Szabó, István and Tóth, Attila and László, Kristóf and Győrfi, Nina Rubina and Karádi, Zoltán György}, booktitle = {MedPECS - Medical Conference for PhD Students and Experts of Clinical Science}, unique-id = {34001582}, year = {2023}, pages = {51}, orcid-numbers = {Hormay, Edina/0009-0004-0598-5061; Mintál, Kitti/0009-0003-4739-2902} } @{MTMT:34001562, title = {Modifications of the gastrointestinal microbiome have crucial role in the control of social behavioural processes.}, url = {https://m2.mtmt.hu/api/publication/34001562}, author = {Mintál, Kitti and Tóth, Attila and Hormay, Edina and Kocsis, B and László, Kristóf and Vízvári, Z and Lénárd, László and Karádi, Zoltán György}, booktitle = {MedPECS - Medical Conference for PhD Students and Experts of Clinical Science}, unique-id = {34001562}, year = {2023}, pages = {46}, orcid-numbers = {Mintál, Kitti/0009-0003-4739-2902; Hormay, Edina/0009-0004-0598-5061} } @article{MTMT:33787514, title = {Lumped Element Method Based Conductivity Reconstruction Algorithm for Localization Using Symmetric Discrete Operators on Coarse Meshes}, url = {https://m2.mtmt.hu/api/publication/33787514}, author = {Sári, Zoltán and Klincsik, Mihály and Odry, Péter and Tadity, Vladimir and Tóth, Attila and Vizvári, Zoltán Ákos}, doi = {10.3390/sym15051008}, journal-iso = {SYMMETRY-BASEL}, journal = {SYMMETRY (BASEL)}, volume = {15}, unique-id = {33787514}, abstract = {The inverse conductivity problem in electrical impedance tomography involves the solving of a nonlinear and under-determined system of equations. This paper presents a new approach, which leads to a quadratic and overdetermined system of equations. The aim of the paper is to establish new research directions in handling of the inverse conductivity problem. The basis of the proposed method is that the material, which can be considered as an isotropic continuum, is modeled as a linear network with concentrated parameters. The weights of the obtained graph represent the properties of the discretized continuum. Further, the application of the developed procedure allows for the dielectric constant to be used in the multi-frequency approach, as a result of which the optimized system of equations always remains overdetermined. Through case studies, the efficacy of the reconstruction method by changing the mesh resolution applied for discretizing is presented and evaluated. The presented results show, that, due to the application of discrete, symmetric mathematical structures, the new approach even at coarse mesh resolution is capable of localizing the inhomogeneities of the material.}, year = {2023}, eissn = {2073-8994} }