TY  - JOUR
AU  - Péterfi, Zoltán
TI  - A mikrobiom és a kardiovaszkuláris egészség
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 54
PY  - 2024
IS  - 1
SP  - 32
EP  - 38
PG  - 7
SN  - 0133-5596
DO  - 10.26430/CHUNGARICA.2024.54.1.32
UR  - https://m2.mtmt.hu/api/publication/34728591
ID  - 34728591
AB  - A bél mikrobiom fontos szerepet játszik számos betegség kialakulásában vagy annak progressziójában. Egy kevésbé ismert terület a kardiovaszkuláris rendszer betegségei és a mikrobiom közötti kapcsolat, a bél–szív tengely és ateroszklerózis kapcsolata. A bél mikrobiom hatását különböző közvetítő molekulákon, mint a lipopoliszacharid, trimetilamin, fenilactetil-glutamin, rövid szénláncú zsírsavak, másodlagos epesavak, keresztül fejti ki. A legtöbb hatás, nem közvetlen, hanem az anyagcsere-folyamatok megváltoztatásán keresztül érvényesül és tartós folyamat eredménye, ezért vizsgálata és az összefüggések bizonyítása is nehézségekbe ütközik. A bél mikrobiom egyensúlyának helyreállítása segíthet a kóros folyamatok megállításában vagy azok visszafordításában. Jelen közleményben összefoglaljuk az eddigi ismereteinket a mikrobiom anyagcseretermékeinek kardiovaszkuláris rendszerre való hatásáról, valamint a rendelkezésünkre álló lehetőségeket a kóros hatások kivédése érdekében.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - El-Sayed, Mohamed Mahmoud
AU  - Mohak, Sidhesh
AU  - Gala, Dhir
AU  - Fabian, Reka
AU  - Péterfi, Zoltán
AU  - Fabian, Zsolt
TI  - The Role of the Intestinal Microbiome in Multiple Sclerosis—Lessons to Be Learned from Hippocrates
JF  - BIOLOGY-BASEL
J2  - BIOLOGY-BASEL
VL  - 12
PY  - 2023
IS  - 12
PG  - 26
SN  - 2079-7737
DO  - 10.3390/biology12121463
UR  - https://m2.mtmt.hu/api/publication/34398321
ID  - 34398321
N1  - * Megosztott szerzőség
AB  - Based on recent advances in research of chronic inflammatory conditions, there is a growing body of evidence that suggests a close correlation between the microbiota of the gastrointestinal tract and the physiologic activity of the immune system. This raises the idea that disturbances of the GI ecosystem contribute to the unfolding of chronic diseases including neurodegenerative pathologies. Here, we overview our current understanding on the putative interaction between the gut microbiota and the immune system from the aspect of multiple sclerosis, one of the autoimmune conditions accompanied by severe chronic neuroinflammation that affects millions of people worldwide.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rábai, Miklós
AU  - Sándor, Barbara
AU  - Magyar, Klára
AU  - Kenyeres, Péter
AU  - Várady, Edit
AU  - Tóth, Levente
AU  - Márton, Zsolt
AU  - Péterfi, Zoltán
AU  - Szabados, Eszter
AU  - Huszár, Judit
AU  - Tóth, Kálmán
AU  - Habon, Tamás
AU  - Halmosi, Róbert
TI  - Löffler endokarditisz talaján kialakult infektív endokarditisz esete
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 53
PY  - 2023
IS  - Suppl. A
SP  - A339
EP  - A339
SN  - 0133-5596
UR  - https://m2.mtmt.hu/api/publication/34306768
ID  - 34306768
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Czakó, László
AU  - Dubravcsik, Zsolt
AU  - Gyökeres, Tibor
AU  - Hritz, István
AU  - Illés, Dóra
AU  - Madácsy, László
AU  - Nagy, András
AU  - Péterfi, Zoltán
AU  - Szepes, Zoltán
AU  - Szücs, Ákos
AU  - Vincze, Áron
TI  - A Belügyminisztérium egészségügyi szakmai irányelve az epeút- és epehólyag-gyulladás diagnosztikus kritériumairól és terápiájáról. Klinikai egészségügyi szakmai irányelv
TS  - Klinikai egészségügyi szakmai irányelv
JF  - EGÉSZSÉGÜGYI KÖZLÖNY
J2  - EGÉSZSÉGÜGYI KÖZLÖNY
VL  - 73
PY  - 2023
IS  - 8
SP  - 898
EP  - 936
PG  - 39
SN  - 2063-1146
UR  - https://m2.mtmt.hu/api/publication/34276104
ID  - 34276104
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kappéter, Ágnes
AU  - Sipos, Dávid
AU  - Varga, Adorján
AU  - Vigvári, Szabolcs József
AU  - Halda-Kiss, Bernadett
AU  - Péterfi, Zoltán
TI  - Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation
JF  - MICROORGANISMS
J2  - MICROORGANISMS
VL  - 11
PY  - 2023
IS  - 8
PG  - 14
SN  - 2076-2607
DO  - 10.3390/microorganisms11082083
UR  - https://m2.mtmt.hu/api/publication/34095174
ID  - 34095174
N1  - ISSN:2076-2607
AB  - Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut–brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Péterfi, Zoltán
AU  - Varga, Adorján
AU  - Vigvári, Szabolcs József
AU  - Sipos, Dávid
TI  - A széklettranszplantáció aktuális hazai helyzete
JF  - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE
J2  - CENT EUR J GASTRO HEPATOL
VL  - 9
PY  - 2023
IS  - 2
SP  - 59
EP  - 62
PG  - 4
SN  - 2415-9107
DO  - 10.33570/CEUJGH.9.2.59
UR  - https://m2.mtmt.hu/api/publication/34025825
ID  - 34025825
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Czakó, László
AU  - Gyökeres, Tibor Zoltán
AU  - Hritz, István
AU  - Madácsy, László
AU  - Illés, Dóra
AU  - Szepes, Zoltán
AU  - Dubravcsik, Zsolt
AU  - Péterfi, Zoltán
AU  - Nagy, András
AU  - Szűcs, Ákos
AU  - Vincze, Áron
TI  - Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia [Cholangitis and cholecystitis: diagnostic criteria and management]
JF  - ORVOSI HETILAP
J2  - ORV HETIL
VL  - 164
PY  - 2023
IS  - 20
SP  - 770
EP  - 787
PG  - 18
SN  - 0030-6002
DO  - 10.1556/650.2023.32770
UR  - https://m2.mtmt.hu/api/publication/33842885
ID  - 33842885
N1  - Belgyógyászati Klinika, Gasztroenterológiai Osztály, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary            
            Gasztroenterológiai Osztály, ÉSzak-Pesti Centrumkórház - Honvédkórház, Budapest, Hungary            
            Sebészeti, Transzplantációs és Gasztroenterológiai Klinika, Általános Orvostudományi Kar, Semmelweis Egyetem, Budapest, Hungary            
            Endo-Kapszula Magánorvosi Centrum, Székesfehérvár, Hungary            
            Gasztroenterológiai Osztály, Bács-Kiskun Megyei Oktatókórház, Kecskemét, Hungary            
            I. Belgyógyászati Klinika, Általános Orvostudományi Kar, Pécsi Tudományegyetem, Pécs, Hungary            
            Radiológiai Klinika, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary            
            Export Date: 7 September 2023            
            CODEN: ORHEA            
            Correspondence Address: László, C.Pf. 469, Hungary; email: czako.laszlo@med.u-szeged.hu
AB  - In developed countries, diseases of the gallbladder and the biliary tract count as some of the most frequent gastrointestinal disorders. The inflammation of the gallbladder/biliary tree is a potentially severe, even lethal condition that requires rapid diagnosis and early multidisciplinary approach to be treated. Although the frequency of these diseases is high, the treatment is not unified in Hungary yet. The aim of the evidence-based recommendation is to clarify the diagnostic criteria and severity grading of these diseases and to highlight the indications and rules of proper application of the numerous available therapeutic interventions. The recent guideline is based on the consensus of the Board members of the Endoscopic Section of the Hungarian Gastroenterology Society in contribution with renown experts of surgery, infectology as well as interventional radiology and it counts as a clear and easy applicable guide during the all-day healthcare practice. Our guidelines are based on Tokyo guidelines established on the basis of the consensus reached in the International Consensus Meeting held in Tokyo which were revised in 2013 (TG13) and in 2018 (TG18). Orv Hetil. 2023; 164(20): 770-787.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Varga, Adorján
AU  - Makszin, Lilla
AU  - Bufa, Anita
AU  - Sipos, Dávid
AU  - Kása, Péter
AU  - Pál, Szilárd
AU  - Rosenstiel, Philip
AU  - Sommer, Felix
AU  - Kocsis, Béla
AU  - Péterfi, Zoltán
TI  - Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer
JF  - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
J2  - FRONT CELL INFECT MI
VL  - 13
PY  - 2023
PG  - 15
SN  - 2235-2988
DO  - 10.3389/fcimb.2023.1041384
UR  - https://m2.mtmt.hu/api/publication/33588242
ID  - 33588242
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kanizsai, Andrea
AU  - Zavori, Laszlo
AU  - Molnár, Tihamér
AU  - Tőkés-Füzesi, Margit
AU  - Szalai, Zoltan
AU  - Berecz, Janos
AU  - Várnai, Réka
AU  - Péterfi, Zoltán
AU  - Schwarcz, Attila
AU  - Csécsei, Péter
TI  - Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme
JF  - VACCINES (BASEL)
J2  - VACCINES-BASEL
VL  - 11
PY  - 2023
IS  - 1
PG  - 10
SN  - 2076-393X
DO  - 10.3390/vaccines11010182
UR  - https://m2.mtmt.hu/api/publication/33567482
ID  - 33567482
AB  - Background: It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it is not clear how the adverse reactions following the booster vaccination are related to the antibody levels that can be measured after a 3rd dose. The primary goal of this study was to investigate whether the adverse reactions following the booster vaccination show a correlation with subsequent antibody levels. Methods: Adverse reactions occurring within 7 days after the 3rd vaccination were recorded and the anti-SARS-CoV-2 spike protein immunoglobulin (Ig) level in the venous blood was measured on post-vaccination 14th, 60th and 120th days. Results: A total of 218 volunteers were included in the study. Main findings: (i) The adverse reactions that appeared after the booster dose did not show a positive correlation with the subsequent antibody level, except a correlation in the case of fever; (ii) there were more symptomatic patients in the group receiving heterologous booster vaccine, (iii) fever after the 2nd dose was independently associated with a reduction in the likelihood of COVID-19 positivity after the booster dose. Conclusion: No adverse reactions, but fever showed a correlation with the antibody level after the booster SARS-CoV-2 vaccine.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Trøseid, Marius
AU  - Arribas, José R
AU  - Assoumou, Lambert
AU  - Holten, Aleksander Rygh
AU  - Poissy, Julien
AU  - Terzić, Vida
AU  - Mazzaferri, Fulvia
AU  - Baño, Jesús Rodríguez
AU  - Eustace, Joe
AU  - Hites, Maya
AU  - Joannidis, Michael
AU  - Paiva, José-Artur
AU  - Reuter, Jean
AU  - Püntmann, Isabel
AU  - Patrick-Brown, Thale D J H
AU  - Westerheim, Elin
AU  - Nezvalova-Henriksen, Katerina
AU  - Beniguel, Lydie
AU  - Dahl, Tuva Børresdatter
AU  - Bouscambert, Maude
AU  - Halanova, Monika
AU  - Péterfi, Zoltán
AU  - Tsiodras, Sotirios
AU  - Rezek, Michael
AU  - Briel, Matthias
AU  - Ünal, Serhat
AU  - Schlegel, Martin
AU  - Ader, Florence
AU  - Lacombe, Karine
AU  - Amdal, Cecilie Delphin
AU  - Rodrigues, Serge
AU  - Tonby, Kristian
AU  - Gaudet, Alexandre
AU  - Heggelund, Lars
AU  - Mootien, Joy
AU  - Johannessen, Asgeir
AU  - Møller, Jannicke Horjen
AU  - Pollan, Beatriz Diaz
AU  - Tveita, Anders Aune
AU  - Kildal, Anders Benjamin
AU  - Richard, Jean-Christophe
AU  - Dalgard, Olav
AU  - Simensen, Victoria Charlotte
AU  - Baldé, Aliou
AU  - de Gastines, Lucie
AU  - Del Álamo, Marta
AU  - Aydin, Burç
AU  - Lund-Johansen, Fridtjof
AU  - Trabaud, Mary-Anne
AU  - Diallo, Alpha
AU  - Halvorsen, Bente
AU  - Røttingen, John-Arne
AU  - Tacconelli, Evelina
AU  - Yazdanpanah, Yazdan
AU  - Olsen, Inge C
AU  - Costagliola, Dominique
ED  - Dyrhol-Riise, Anne Ma / Collaborator
ED  - Stiksrud, Birgitte / Collaborator
ED  - Jenum, Synne / Collaborator
ED  - MacPherson, Magnhild Eide / Collaborator
ED  - Aarskog, Nikolai Ravn / Collaborator
ED  - Røstad, Kjerstin / Collaborator
ED  - Skeie, Linda Gail / Collaborator
ED  - Dahl, Åsne / Collaborator
ED  - Steen, Jeanette Konstance / Collaborator
ED  - Nur, Sarah / Collaborator
ED  - Segers, Filip / Collaborator
ED  - Korsan, Katrine Andersen / Collaborator
ED  - Sethupathy, Ashwini / Collaborator
ED  - Sandstå, Ann Jorunn / Collaborator
ED  - Paulsen, Gunn-Janne / Collaborator
ED  - Ueland, Thor / Collaborator
ED  - Michelsen, Annika / Collaborator
ED  - Aukrust, Pål / Collaborator
ED  - Berdal, Jan Erik / Collaborator
ED  - Melkeraaen, Ingunn / Collaborator
ED  - Tollefsen, Merete Moen / Collaborator
ED  - Andreassen, Jessica / Collaborator
ED  - Dokken, Jannicke / Collaborator
ED  - Müller, Karl Erik / Collaborator
ED  - Woll, Bjørn Martin / Collaborator
ED  - Opsand, Hanne / Collaborator
ED  - Bogen, Mette / Collaborator
ED  - Rød, Linn-Therese / Collaborator
ED  - Steinsvik, Trude / Collaborator
ED  - Åsheim-Hansen, Bjørn / Collaborator
ED  - Bjerkreim, Randi Haukaas / Collaborator
ED  - Berg, Åse / Collaborator
ED  - Moen, Solfrid / Collaborator
ED  - Kvalheim, Stina / Collaborator
ED  - Strand, Kristian / Collaborator
ED  - Gravrok, Berit / Collaborator
ED  - Skogen, Vegard / Collaborator
ED  - Lorentzen, Elias Myrvoll / Collaborator
ED  - Schive, Simen Walberg / Collaborator
ED  - Rossvoll, Lasse / Collaborator
ED  - Hoel, Hedda / Collaborator
ED  - Engebråten, Simon / Collaborator
ED  - Martinsson, Mia Schie / Collaborator
ED  - Thallinger, Monica / Collaborator
ED  - Ådnanes, Elise / Collaborator
ED  - Hannula, Raisa / Collaborator
ED  - Bremnes, Nina / Collaborator
ED  - Liyanarachi, Kristin / Collaborator
ED  - Ehrnström, Birgitta / Collaborator
ED  - Kvalshaug, Martin / Collaborator
ED  - Berge, Kari / Collaborator
ED  - Bygdås, Marte / Collaborator
ED  - Gustafsson, Linda / Collaborator
ED  - AballiB, Saad / Collaborator
ED  - Strand, Marianne / Collaborator
ED  - Andersen, Britt / Collaborator
ED  - Aukrust, Pål / Collaborator
ED  - Barratt-Due, Andreas / Collaborator
ED  - Henriksen, Katerina Nezvalova / Collaborator
ED  - Kåsine, Trine / Collaborator
ED  - Dyrhol-Riise, Anne Ma / Collaborator
ED  - Berdal, Jan Erik / Collaborator
ED  - Favory, Raphaël / Collaborator
ED  - Nseir, Saad / Collaborator
ED  - Preau, Sebastien / Collaborator
ED  - Jourdain, Mercé / Collaborator
ED  - Ledoux, Geoffrey / Collaborator
ED  - Durand, Arthur / Collaborator
ED  - Houard, Marion / Collaborator
ED  - Moreau, Anne-Sophie / Collaborator
ED  - Rouzé, Anahita / Collaborator
ED  - Tortuyaux, Romain / Collaborator
ED  - Degouy, Guillaume / Collaborator
ED  - Levy, Clémentin / Collaborator
ED  - Liu, Vincent / Collaborator
ED  - Dognon, Nicolas / Collaborator
ED  - Mariller, Laure / Collaborator
ED  - Delcourte, Claire / Collaborator
ED  - Reguig, Zineb / Collaborator
ED  - Cerf, Amélie / Collaborator
ED  - Cuvelliez, Marie / Collaborator
ED  - Kipnis, Eric / Collaborator
ED  - Boyer-Beysserre, Marielle / Collaborator
ED  - Bignon, Anne / Collaborator
ED  - Parmentier, Laurie / Collaborator
ED  - Meddour, Damia / Collaborator
ED  - Frade, Sarah / Collaborator
ED  - Timsit, Jean-François / Collaborator
ED  - Peiffer-Smadja, Nathan / Collaborator
ED  - Wicky, Paul-Henri / Collaborator
ED  - De Montmollin, Etienne / Collaborator
ED  - Bouadma, Lila / Collaborator
ED  - Dessajan, Julien / Collaborator
ED  - Sonneville, Romain / Collaborator
ED  - Patrier, Juliette / Collaborator
ED  - Presente, Simona / Collaborator
ED  - Sylia, Zmihi / Collaborator
ED  - Rioux, Christophe / Collaborator
ED  - Thy, Michaël / Collaborator
ED  - Collias, Lio / Collaborator
ED  - Bouaraba, Yasmine / Collaborator
ED  - Dobremel, Nikita / Collaborator
ED  - Dureau, Anne-Florence / Collaborator
ED  - Oudeville, Pierre / Collaborator
ED  - Pointurier, Valentin / Collaborator
ED  - Rabouel, Yannick / Collaborator
ED  - Stiel, Laure / Collaborator
ED  - Alzina, Camille / Collaborator
ED  - Ramstein, Camille / Collaborator
ED  - Ait-Oufella, Hafid / Collaborator
ED  - Hamoudi, Fatima / Collaborator
ED  - Urbina, Thomas / Collaborator
ED  - Zerbib, Yoann / Collaborator
ED  - Maizel, Julien / Collaborator
ED  - Wilpotte, Celine / Collaborator
ED  - Piroth, Lionel / Collaborator
ED  - Blot, Mathieu / Collaborator
ED  - Sixt, Thibault / Collaborator
ED  - Moretto, Florian / Collaborator
ED  - Charles, Carole / Collaborator
ED  - Gohier, Sandrine / Collaborator
ED  - Roux, Damien / Collaborator
ED  - Le Breton, Camille / Collaborator
ED  - Gernez, Coralie / Collaborator
ED  - Thiry, Ingrid / Collaborator
ED  - Baboi, Loredana / Collaborator
ED  - Malvy, Denis / Collaborator
ED  - Boyer, Alexandre / Collaborator
ED  - Perreau, Pauline / Collaborator
ED  - Armellini, Maddalena / Collaborator
ED  - De Luca, Giulia / Collaborator
ED  - Di Pietro, Ospedale S M Massimo / Collaborator
ED  - Romanin, Benedetta / Collaborator
ED  - Brogi, Michela / Collaborator
ED  - Castelli, Francesco / Collaborator
ED  - Amadasi, Silvia / Collaborator
ED  - Barchiesi, Francesco / Collaborator
ED  - Canovari, Benedetta / Collaborator
ED  - Coppola, Nicola / Collaborator
ED  - Pisaturo, Mariantonietta / Collaborator
ED  - Russo, Antonio / Collaborator
ED  - Occhiello, Laura / Collaborator
ED  - Cataldo, Francesco / Collaborator
ED  - Rillo, Marta Mora / Collaborator
ED  - Queiruga, Javier / Collaborator
ED  - Seco, Enrique / Collaborator
ED  - Stewart, Stefan / Collaborator
ED  - Borobia, Alberto M / Collaborator
ED  - Moraga, Paloma / Collaborator
ED  - Prieto, Rocío / Collaborator
ED  - García, Irene / Collaborator
ED  - Rivera, Carlota / Collaborator
ED  - Narro, José Luis / Collaborator
ED  - Chacón, Natalia / Collaborator
ED  - de la Rosa, Sandra / Collaborator
ED  - Macías, María / Collaborator
ED  - Barrera, Lydia / Collaborator
ED  - Serna, Almudena / Collaborator
ED  - Palomo, Virginia / Collaborator
ED  - Sánchez, Maria Isabel García / Collaborator
ED  - Gutiérrez, David / Collaborator
ED  - Campos, Ana Silva / Collaborator
ED  - Garfia, Miguel Ángel Gómez / Collaborator
ED  - Toyos, Elvira Bonilla / Collaborator
ED  - Cabrera, Judith Sanabria / Collaborator
ED  - Lucena, María Isabel / Collaborator
ED  - Lapique, Eva Larranaga / Collaborator
ED  - Englert, Pierre / Collaborator
ED  - Khalil, Zineb / Collaborator
ED  - Jacobs, Frédérique / Collaborator
ED  - Malaise, Justine / Collaborator
ED  - Mukangenzi, Odette / Collaborator
ED  - Smissaert, Cinderella / Collaborator
ED  - Hildebrand, Marc / Collaborator
ED  - Martiny, Delphine / Collaborator
ED  - Vervacke, Audrey / Collaborator
ED  - Scarnière, Axelle / Collaborator
ED  - Yin, Nicolas / Collaborator
ED  - Michel, Charlotte / Collaborator
ED  - Seyler, Lucie / Collaborator
ED  - Allard, Sabine / Collaborator
ED  - Van Laethem, Johan / Collaborator
ED  - Verschelden, Gil / Collaborator
ED  - Meeuwissen, Annelies / Collaborator
ED  - De Waele, Alex / Collaborator
ED  - Van Buggenhout, Virgini / Collaborator
ED  - Monteyne, Dora / Collaborator
ED  - Noppe, Nils / Collaborator
ED  - Belkhir, Leila / Collaborator
ED  - Yombi, Jean Cyr / Collaborator
ED  - De Greef, Julien / Collaborator
ED  - Mesland, Jean Baptiste / Collaborator
ED  - De Ghellinck, Léopold / Collaborator
ED  - Kin, Valérie / Collaborator
ED  - D'Aoust, Céline / Collaborator
ED  - Bouvier, Anne / Collaborator
ED  - Dekeister, Anne- Charlotte / Collaborator
ED  - Hawia, Estelle / Collaborator
ED  - Gaillet, Adeline / Collaborator
ED  - Deshorme, Hélène / Collaborator
ED  - Halleux, Severine / Collaborator
ED  - Galand, Vanessa / Collaborator
ED  - Roncon-Albuquerque, Roberto / Collaborator
ED  - Santos, Luís Linhares / Collaborator
ED  - Vieira, César Burgi / Collaborator
ED  - Magalhaes, Rosana / Collaborator
ED  - Ferreira, Sónia / Collaborator
ED  - Bernardo, Mariana / Collaborator
ED  - Jackson, Arthur / Collaborator
ED  - Sadlier, Corinna / Collaborator
ED  - O'Connell, Sarah / Collaborator
ED  - Blair, Matthew / Collaborator
ED  - Manning, Edmund / Collaborator
ED  - Cusack, Fiona / Collaborator
ED  - Kelly, Niamh / Collaborator
ED  - Stephenson, Hannah / Collaborator
ED  - Keane, Ruben / Collaborator
ED  - Murphy, Aisling / Collaborator
ED  - Cunnane, Michele / Collaborator
ED  - Keane, Fionnuala / Collaborator
ED  - O'Regan, Mary-Claire / Collaborator
ED  - de Barra, Eoghan / Collaborator
ED  - Bellone, Aimee McGreal / Collaborator
ED  - O'Regan, Siobhan / Collaborator
ED  - Carey, Patrick / Collaborator
ED  - Harte, Jeffrey / Collaborator
ED  - Coakley, Peter / Collaborator
ED  - Heeney, Aoife / Collaborator
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ED  - Curley, Gerard / Collaborator
ED  - McConkey, Samuel / Collaborator
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ED  - McNally, Cora / Collaborator
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ED  - Trainor, Sophie / Collaborator
ED  - Jacob, Benson / Collaborator
ED  - Vengathodi, Suchitra / Collaborator
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ED  - Bergin, Colm / Collaborator
ED  - Townsend, Liam / Collaborator
ED  - Kerr, Colm / Collaborator
ED  - Panti, Nalini / Collaborator
ED  - Sanz, Alberto Garcia / Collaborator
ED  - Benny, Binny / Collaborator
ED  - Dea, Edel O / Collaborator
ED  - Galvin, Niamh / Collaborator
ED  - Burke, Claire / Collaborator
ED  - Galvin, Aisling / Collaborator
ED  - Aisiyabi, Sara / Collaborator
ED  - Lobo, Deepanjali / Collaborator
ED  - Laffey, John / Collaborator
ED  - McNicolas, Bairbre / Collaborator
ED  - Cosgrave, David / Collaborator
ED  - Sheehan, J R / Collaborator
ED  - Nita, Ciprian / Collaborator
ED  - Hanley, Ciara / Collaborator
ED  - Kelly, Claire / Collaborator
ED  - Kernan, Maeve / Collaborator
ED  - Murray, Jonathan / Collaborator
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ED  - Henin, Thomas / Collaborator
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ED  - Bintener, Tania / Collaborator
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ED  - Ferretti, Christian / Collaborator
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ED  - Arendt, Vic / Collaborator
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ED  - Mediouni, Chouaib / Collaborator
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ED  - Breitkopf, Robert / Collaborator
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ED  - Kovácsné-Levang, Szilvia / Collaborator
ED  - Sipos, David / Collaborator
ED  - Kappéter, Agnes / Collaborator
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ED  - Madarassi-Papp, Edit / Collaborator
ED  - Hajdú, Edit / Collaborator
ED  - Bende, Balázs / Collaborator
ED  - Konstantinos, Thomas / Collaborator
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ED  - Nagy, Andrej / Collaborator
ED  - Grodová, Karolína / Collaborator
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ED  - Demlová, Regina / Collaborator
ED  - Sonderlichová, Simona / Collaborator
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ED  - Inkaya, A C / Collaborator
ED  - de Bono, Stephanie / Collaborator
ED  - Kartman, Cynthia E / Collaborator
ED  - Adams, David H / Collaborator
ED  - Crowe, Brenda / Collaborator
ED  - Yazdanapanah, Yazdan / Collaborator
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ED  - Schneider, Gerhard / Collaborator
ED  - Mühlbauer, Bernd / Collaborator
ED  - Ødegård, Tone / Collaborator
ED  - Bakkehøi, Gine / Collaborator
ED  - Autran, Brigitte / Collaborator
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ED  - Lambellerie, Xavier de- / Collaborator
ED  - Mezzarri, Fulvia / Collaborator
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ED  - Goetghebeur, Els / Collaborator
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ED  - Del Alamo, Marta / Collaborator
ED  - Chung, Florence / Collaborator
ED  - Lumbroso, Julia / Collaborator
ED  - Zeitlinger, Markus / Collaborator
ED  - Escalera, Begonya N / Collaborator
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ED  - Williams, Clare / Collaborator
ED  - Amstutz, Alain / Collaborator
ED  - Rüegg, Corina Silvia / Collaborator
ED  - Burdet, Charles / Collaborator
ED  - Massonnaud, Clement / Collaborator
ED  - Belhadi, Drifa / Collaborator
ED  - Mentré, France / Collaborator
ED  - Aroun, Massinissa / Collaborator
ED  - Mentré, France / Collaborator
ED  - Ehrmann, Stephan / Collaborator
ED  - Espoerou, Helene / Collaborator
ED  - Burdet, Charles / Collaborator
ED  - Falk, Ragnhild Sørum / Collaborator
ED  - Bjordal, Kristin / Collaborator
ED  - Bakkehøi, Gina / Collaborator
ED  - Ødegård, Tone / Collaborator
ED  - Barratt-Due, Andreas / Collaborator
TI  - Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct). a randomised, double-blind, placebo-controlled phase 3 trial.
TS  - a randomised, double-blind, placebo-controlled phase 3 trial.
JF  - CRITICAL CARE
J2  - CRIT CARE
VL  - 27
PY  - 2023
IS  - 1
PG  - 15
SN  - 1364-8535
DO  - 10.1186/s13054-022-04205-8
UR  - https://m2.mtmt.hu/api/publication/33560025
ID  - 33560025
N1  - * Megosztott szerzőség
AB  - Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants.Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-controlled trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients with severe/critical COVID-19 were randomised to Baricitinib 4 mg once daily or placebo, added to standard of care. The primary endpoint was all-cause mortality within 60 days. Participants were remotely followed to day 90 for safety and patient related outcome measures.Two hundred ninety-nine patients were screened, 284 randomised, and 275 received study drug or placebo and were included in the modified intent-to-treat analyses (139 receiving baricitinib and 136 placebo). Median age was 60 (IQR 49-69) years, 77% were male and 35% had received at least one dose of SARS-CoV2 vaccine. There were 21 deaths at day 60 in each group, 15.1% in the baricitinib group and 15.4% in the placebo group (adjusted absolute difference and 95% CI - 0.1% [- 8·3 to 8·0]). In sensitivity analysis censoring observations after drug discontinuation or rescue therapy (tocilizumab/increased steroid dose), proportions of death were 5.8% versus 8.8% (- 3.2% [- 9.0 to 2.7]), respectively. There were 148 serious adverse events in 46 participants (33.1%) receiving baricitinib and 155 in 51 participants (37.5%) receiving placebo. In subgroup analyses, there was a potential interaction between vaccination status and treatment allocation on 60-day mortality. In a subsequent post hoc analysis there was a significant interaction between vaccination status and treatment allocation on the occurrence of serious adverse events, with more respiratory complications and severe infections in vaccinated participants treated with baricitinib. Vaccinated participants were on average 11 years older, with more comorbidities.This clinical trial was prematurely stopped for external evidence and therefore underpowered to conclude on a potential survival benefit of baricitinib in severe/critical COVID-19. We observed a possible safety signal in vaccinated participants, who were older with more comorbidities. Although based on a post-hoc analysis, these findings warrant further investigation in other trials and real-world studies. Trial registration Bari-SolidAct is registered at NCT04891133 (registered May 18, 2021) and EUClinicalTrials.eu ( 2022-500385-99-00 ).
LA  - English
DB  - MTMT
ER  -