TY - BOOK AU - Bakó, Pál AU - Domonkos, Norbert AU - Dovalovszkiné, Tóth Tünde AU - Andó, Bálint AU - Dobi, Ágnes AU - Ducza, Eszter AU - Elmer, Magdolna AU - Erdősi, Erika AU - Buzás, Norbert AU - Benkő, Sándor AU - Bitó, Tamás AU - Helembai, Kornélia AU - Joó, Gabriella AU - Kádár, Bettina Kata AU - Kapus, Katalin AU - Kiss, Éva AU - Kovách, Kornél AU - Lázár, Bence András AU - Budai, Éva AU - Márki, Árpád AU - Marton, Imelda AU - Miszlai, Péter AU - Mohos, András AU - Nagy-Grócz, Gábor AU - Németh, Anikó AU - Szakács, Júlia ED - Szatmári, Angelika AU - Tandori, Júlia AU - Tari, Gergely Róbert AU - Tobak, Orsolya AU - Vida, Anikó AU - Vincze, Anikó AU - Erdélyiné Oláh, Mónika AU - Festő, Blanka AU - Flach, István AU - Glózik, Ágnes AU - Godáné, Reisinger Karolina AU - Halmos, Helga AU - Horváth, Ádám AU - Kovácsné, Bilejov Brigitta AU - Meleg, Sándor Zsolt AU - Mező, Judit AU - Nagy, Erika AU - Oltványi, Beáta AU - Orosz, Annamária AU - Poszert, Anikó AU - Paulik, Edit AU - Tóth, Erika AU - Tóth, Renáta AU - Vajnai, Mária TI - Záróvizsga tesztgyűjtemény. Ápolás és betegellátás alapszak, ápoló szakirány TS - Ápolás és betegellátás alapszak, ápoló szakirány PB - Szegedi Tudományegyetem, Egészségtudományi és Szociális Képzési Kar CY - Szeged PY - 2023 SP - 715 SN - 9789633069707 UR - https://m2.mtmt.hu/api/publication/34496784 ID - 34496784 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ivić, Vedrana AU - Zjalić, Milorad AU - Blažetić, Senka AU - Fenrich, Matija AU - Labak, Irena AU - Scitovski, Rudolf AU - Szűcs, Kálmán Ferenc AU - Ducza, Eszter AU - Tábi, Tamás AU - Bagaméry, Fruzsina AU - Szökő, Éva AU - Vuković, Rosemary AU - Rončević, Alen AU - Mandić, Dario AU - Debeljak, Željko AU - Berecki, Monika AU - Balog, Marta AU - Seres, Adrienn AU - Sztojkov-Ivanov, Anita AU - Hajagos-Tóth, Judit AU - Gajović, Srećko AU - Imširović, Alen AU - Bakula, Marina AU - Mahiiovych, Solomiia AU - Gáspár, Róbert AU - G. Vari, Sandor AU - Heffer, Marija TI - Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 14 PY - 2023 PG - 22 SN - 1664-2392 DO - 10.3389/fendo.2023.1181064 UR - https://m2.mtmt.hu/api/publication/34207754 ID - 34207754 N1 - Funding Agency and Grant Number: This study was supported by the RECOOP-CSMC Fusion Research Grant No. 029 2015-2021 "Obesity and Diabetes", and by the Ministry of Human Capacities [Hungary grant 20391-3/2018/FEKUSTRAT]. This study was supported in part with the following grants: Croatian [029 2015-2021]; Ministry of Human Capacities [Hungary] [20391-3/2018/FEKUSTRAT]; Croatian Science Foundation [IP-2014-09-2324, IP-2016-06-6545, IP-06-2016-1892]; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine institutional grant [IP9-2019]; Josip Juraj Strossmayer University of Osijek [INGI-2015-35, UNIOS-ZUP 2018-44]; European Union through the European Regional Development Fund [KK.01.1.1.01.0007, KK.01.1.1.02.0015]; diagnostics of malignant, infectious and rare metabolic diseases based on MALDI TOF technology" Funding text: We would like to extend our sincere gratitude to the reviewers for their invaluable contributions in reviewing this manuscript. Their thoughtful comments and suggestions significantly improved the quality of our work.r This study was supported by the RECOOP-CSMC Fusion Research Grant No. 029 2015-2021 "Obesity and Diabetes", and by the Ministry of Human Capacities [Hungary grant 20391-3/2018/FEKUSTRAT]. This study was supported in part with the following grants: Croatian Science Foundation grants to MH (Raft tuning, IP-2014-09-2324), RS (IP-2016-06-6545), and SG (RepairStroke, IP-06-2016-1892); Josip Juraj Strossmayer University of Osijek, Faculty of Medicine institutional grant to MH (Lipid profile of metabolic stress, IP9-2019); Josip Juraj Strossmayer University of Osijek grant to MH (INGI-2015-35) and VI (UNIOS-ZUP 2018-44); and European Union through the European Regional Development Fund, Operational Programme "Competitiveness and Cohesion 2014-2020", grant agreement No. KK.01.1.1.01.0007, CoRE - Neuro, and grant agreement No. KK.01.1.1.02.0015, "Research and diagnostics of malignant, infectious and rare metabolic diseases based on MALDI TOF technology". LA - English DB - MTMT ER - TY - JOUR AU - Kékesi, Gabriella AU - Ducza, Eszter AU - Gálity, Hristifor AU - Büki, Alexandra AU - Tóth, Kálmán AU - Tuboly, Gábor AU - Horváth, Gyöngyi TI - Neurobehavioral impairments in ciprofloxacin-treated osteoarthritic adult rats JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 76 PY - 2023 IS - 9-10 SP - 327 EP - 337 PG - 11 SN - 0019-1442 DO - 10.18071/isz.76.0327 UR - https://m2.mtmt.hu/api/publication/34178429 ID - 34178429 N1 - Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Department of Orthopaedics, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary Department of Neurology, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary Export Date: 19 January 2024 CODEN: IDSZA Correspondence Address: Kékesi, G.; Department of Physiology, Dóm tér 10, Hungary; email: kekesi.gabriella@med.u-szeged.hu Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0 Funding text 1: The skilled technical assistance of Ágnes Tandari is gratefully acknowledged. AB - Background and purpose – Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinoloneinduced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition. Methods – Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex. Results – CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex. Conclusion – This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity. LA - English DB - MTMT ER - TY - CONF AU - Kemény, Kata Kira AU - Seres, Adrienn AU - Gáspár, Róbert AU - Barna, Tamara AU - Mirdamadi, Seyedmohsen AU - Surányi, Andrea AU - Németh, Gábor László AU - Altorjay, Ábel Tamás AU - Molnár, András AU - Ducza, Eszter TI - Role of aquaporin 5 in the regulation of pregnant uterus contraction T2 - 4th European Spontaneous Preterm Birth Congress Abstract Book PY - 2023 SP - 1 UR - https://m2.mtmt.hu/api/publication/34170498 ID - 34170498 LA - English DB - MTMT ER - TY - JOUR AU - Szatmári, Péter AU - Ducza, Eszter TI - Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 17 PG - 15 SN - 1661-6596 DO - 10.3390/ijms241713089 UR - https://m2.mtmt.hu/api/publication/34109597 ID - 34109597 AB - ABC transporters are ubiquitous in the human body and are responsible for the efflux of drugs. They are present in the placenta, intestine, liver and kidney, which are the major organs that can affect the pharmacokinetic and pharmacologic properties of drugs. P-gp and BCRP transporters are the best-characterized transporters in the ABC superfamily, and they have a pivotal role in the barrier tissues due to their efflux mechanism. Moreover, during pregnancy, drug efflux is even more important because of the developing fetus. Recent studies have shown that placental and intestinal ABC transporters have great importance in drug absorption and distribution. Placental and intestinal P-gp and BCRP show gestational-age-dependent expression changes, which determine the drug concentration both in the mother and the fetus during pregnancy. They may have an impact on the efficacy of antibiotic, antiviral, antihistamine, antiemetic and oral antidiabetic therapies. In this review, we would like to provide an overview of the pharmacokinetically relevant expression alterations of placental and intestinal ABC transporters during pregnancy. LA - English DB - MTMT ER - TY - JOUR AU - Kemény, Kata Kira AU - Seres, Adrienn AU - Gáspár, Róbert AU - Barna, Tamara AU - Mirdamadi, Seyedmohsen AU - Surányi, Andrea AU - Németh, Gábor László AU - Altorjay, Ábel Tamás AU - Molnár, András AU - Ducza, Eszter TI - Water channel AQP5 is a new factor in the regulation of pregnant uterus contraction JF - BRITISH JOURNAL OF PHARMACOLOGY J2 - BR J PHARMACOL VL - 180 PY - 2023 IS - Suppl. 1 SP - 1236 EP - 1237 PG - 2 SN - 0007-1188 UR - https://m2.mtmt.hu/api/publication/34066543 ID - 34066543 LA - English DB - MTMT ER - TY - CHAP AU - Szatmári, Péter AU - Seres, Adrienn AU - Sztojkov-Ivanov, Anita AU - Kékesi, Gabriella AU - Horváth, Gyöngyi AU - Ducza, Eszter ED - Hajdú, Péter TI - Skizofrénia hatása a placentáris P-glikoprotein expresszióra és a magzati gyógyszer expozícióra patkány modellben T2 - XXVI. Tavaszi Szél Konferencia 2023 : Absztrakt kötet PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786156457233 PY - 2023 SP - 334 EP - 335 PG - 2 UR - https://m2.mtmt.hu/api/publication/33835567 ID - 33835567 LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Bence AU - Bella, Zsolt AU - Gróf, Ilona AU - Veszelka, Szilvia AU - Deli, Mária Anna AU - Szűcs, Kálmán Ferenc AU - Sztojkov-Ivanov, Anita AU - Ducza, Eszter AU - Gáspár, Róbert AU - Kecskeméti, Gábor AU - Janáky, Tamás AU - Volk, Balázs AU - Budai-Szűcs, Mária AU - Ambrus, Rita AU - Révész, Piroska AU - Pannonhalminé Csóka, Ildikó AU - Katona, Gábor TI - Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 632 PY - 2023 PG - 11 SN - 0378-5173 DO - 10.1016/j.ijpharm.2023.122594 UR - https://m2.mtmt.hu/api/publication/33547706 ID - 33547706 LA - English DB - MTMT ER - TY - CHAP AU - Kata, Kira Kemény AU - Seres, Adrienn AU - Tamara, Barna AU - Gáspár, Róbert AU - Ducza, Eszter ED - Muszynska, Bozena TI - REGULATORY ROLE OF AQUAPORIN 5 IN THE FUNCTION OF LATE PREGNANT RAT UTERUS T2 - Natural vs. Artificial Networks: The Usefulness of the Concept in Health, Life, and Technical Sciences PB - Zakład Optymalizacji Zawodowej Ośrodek Umea Shinoda-Kuracejo CY - Martin CY - Krakow CY - Szeged SN - 9788395955457 PY - 2022 SP - 52 EP - 53 PG - 2 UR - https://m2.mtmt.hu/api/publication/33643248 ID - 33643248 AB - The aquaporin (AQP) water channels are small hydrophobic integral membrane proteins. Most of them are expressed in the female reproductive tissues and they play an important role during pregnancy. AQP5 expression was found predominant during pregnancy in the uterus of rats, although it was significantly down-regulated at the last gestational day. Moreover, our results lead us to suppose that the AQP5 expression is regulated by oxytocin and female hormones. We hypothesized an “osmotic pathway” - through AQP5 - might have an influence on the changes in transient receptor potential vanilloid 4 (TRPV4) function and uterus contraction. We aimed to determine the possible role of AQP5 in this osmotic regulation of TRPV4, thus in pregnant uterine contraction. Moreover, we investigated the “receptor pathway” in the AQP5 expression through the tocolytic agents in the late pregnant rat uterus. The pharmacological influence on AQP5 expression was investigated by terbutaline, doxazosin, and citral treatment, in vivo; and mercuric chloride, in vitro. The effect of AQP5 on the lengths of the gestational period was investigated by AQP5-siRNA-treated rats. The changes in AQP5 and TRPV4 mRNA and protein expressions were measured using RT-PCR and western blot, respectively. The TRPV4 antagonist citral increased the AQP5 level in the uterus which was prevented by the TRPV4 agonist RN1747. In addition, citral treatment significantly prolonged the normal gestation period and delayed preterm delivery. The gestational period was significantly shorter after AQP5 siRNA treatment compared to the control. Terbutaline treatment significantly increased the AQP5 mRNA and protein expression, in vivo. We created an AQP5 down-regulated animal model with AQP5 siRNA which proved the crucial role of AQP5 in the process of birth. We proved that the AQP5 expression can regulate by pharmacology (e.g. citral and terbutaline), therefore we hope this will open a new possibility for the therapy and prevention of preterm birth. LA - English DB - MTMT ER - TY - CHAP AU - Alaa, A.M. Osman AU - Laczkó, Dávid AU - Vágvölgyi, Máté AU - Hunyadi, Attila AU - Ducza, Eszter ED - Muszynska, Bozena TI - Effects of calonysterone and 20-hydroxyecdysone in the obese rat model T2 - Natural vs. Artificial Networks: The Usefulness of the Concept in Health, Life, and Technical Sciences PB - Zakład Optymalizacji Zawodowej Ośrodek Umea Shinoda-Kuracejo CY - Martin CY - Krakow CY - Szeged SN - 9788395955457 PY - 2022 SP - 83 PG - 1 UR - https://m2.mtmt.hu/api/publication/33552107 ID - 33552107 AB - Obesity is a global pandemic and a serious health problem. Phytoecdysteroids, the polyhydroxylated steroids of the C-27 cholesterol skeleton, has a wide variety of beneficial effects including anabolic, antidiabetic, and anti-obesity. Our studies aimed to investigate the effects of two phytoecdysteroids derivatives (calonysterone and 20-hydroxyecdysone) on body weight, blood glucose, antioxidant capacity, and the level of adipokines, the expression of cytokines of lowgrade inflammation, and the epigenetic modification in the obese rat model. 48 male Sprague Dawley rats, aged 5-6 weeks were divided into 8 groups (6 rats/group) and fed high fat and high sugar diet (HFHSD) or a normal diet. Rats received daily oral treatments for 12 weeks of calonysterone, 20-hydroxyecdysone, vehicle, or no treatment. Body weight, caloric intake, and plasma glucose during the glucose tolerance test were measured at baseline and during the experiment. We measured the liver levels of catalase (CAT) and superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and global DNA methylation using colorimetric assay kits. The hepatic expression of leptin, adiponectin, TNF α, IL-6, IL2, and IL10 mRNA and protein were measured using RT-PCR and western blot, respectively. CAT levels were increased by both treatments, while T-AOC increased by 20-hydroxyecdysone. Obese rats showed increased expression of leptin mRNA and protein levels that were reduced by calonysterone. 20-hydroxyecdysone further increased leptin mRNA but reduced protein levels. The levels of global DNA methylation were increased by both treatments. Calonysterone may have anti-obesity effects and both treatments may have antidiabetic and antioxidant effects. Our preliminary screening of the effects of treatments on markers of inflammation showed significant differences in the levels of IL-6 and IL10 between normal and obese rats. We suppose these phytoecdysteroids may affect epigenetic modification at specific gene levels too. LA - English DB - MTMT ER -