TY - JOUR AU - Obeid, Rima AU - Andrès, Emmanuel AU - Češka, Richard AU - Hooshmand, Babak AU - Guéant-Rodriguez, Rosa-Maria AU - Prada, Gabriel Ioan AU - Sławek, Jarosław AU - Traykov, Latchezar AU - Ta Van, Binh AU - Várkonyi, Tamás AU - Reiners, Karlheinz ED - Agata, Sobczynska-Malefora / Collaborator ED - Aleksandra, Araszkiewicz / Collaborator ED - Andrew, McCaddon / Collaborator ED - Anne, M Molloy / Collaborator ED - Bruce, H.R. Wolffenbuttel / Collaborator ED - Bruno, Annibale / Collaborator ED - Christine, A.F. von Arnim / Collaborator ED - Christy, C Tangney / Collaborator ED - David, Smith / Collaborator ED - Dongming, Zheng / Collaborator ED - Edith, Lahner / Collaborator ED - Gabriela, Spulber / Collaborator ED - Georgeta, Daniela Georgescu / Collaborator ED - Francesca, Mangialasche / Collaborator ED - Hendrika, (H.J.M.) Smelt / Collaborator ED - Janet, B McGill / Collaborator ED - J., David Spence / Collaborator ED - John, Killen / Collaborator ED - P, Julian Owen / Collaborator ED - Lisette, CPGM de Groot / Collaborator ED - Michelle, Murphy / Collaborator ED - G, Bhanuprakash Reddy / Collaborator ED - Pradeepa, Rajendra / Collaborator ED - Ralph, Green / Collaborator ED - Sadanand, Naik / Collaborator ED - Tsvetalina, Tankova / Collaborator ED - William, Huynh / Collaborator ED - Wolfgang, N. Löscher / Collaborator ED - Zyta, Beata Wojszel / Collaborator TI - Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 8 PG - 18 SN - 2077-0383 DO - 10.3390/jcm13082176 UR - https://m2.mtmt.hu/api/publication/34788761 ID - 34788761 AB - Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy. LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Orosz, Andrea AU - Ambrus, Nóra AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND PY - 2024 PG - 8 SN - 0091-2751 DO - 10.1002/jcu.23672 UR - https://m2.mtmt.hu/api/publication/34778284 ID - 34778284 N1 - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Export Date: 23 April 2024 CODEN: JCULD Correspondence Address: Nemes, A.; Department of Medicine, H-6725 Szeged, emmelweis street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu AB - Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation. LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Orosz, Andrea AU - Ambrus, Nóra AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND VL - 52 PY - 2024 IS - 2 SP - 178 EP - 185 PG - 8 SN - 0091-2751 DO - 10.1002/jcu.23603 UR - https://m2.mtmt.hu/api/publication/34400260 ID - 34400260 N1 - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 23 April 2024 CODEN: JCULD Correspondence Address: Nemes, A.; Department of Medicine, Semmelweis Street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu AB - The functioning of the left atrium (LA) is partly controlled by the neural system. It was purposed to evaluate correlations between the result of Ewing's 5 standard cardiovascular reflex tests (SCRTs) characterizing autonomic function and LA volumetric and functional features as assessed by three-dimensional speckle-tracking echocardiography (3DSTE) in healthy individuals.The current study comprised 18 healthy volunteers being in sinus rhythm (mean age: 35 ± 12 years, 10 men). Measurement of blood pressure, ECG, 5 SCRTs, two-dimensional Doppler echocardiography and 3DSTE were performed. These parameters were in normal ranges in all cases.From LA volumetric parameters, only systolic total atrial emptying fraction (r = 0.559, p = 0.037) and early diastolic passive atrial emptying fraction (r = 0.539, p = 0.047) correlated with systolic blood pressure response to standing representing sympathetic autonomic function. From LA strains, peak mean segmental LA radial strain (RS) (r = -0.532, p = 0.050), global and mean segmental LA circumferential strain (CS) (r = 0.662, p = 0.010 and r = 0.635, p = 0.015, respectively) representing systolic LA function correlated with Valsalva ratio representing parasympathetic autonomic function. Global LA-RS (r = -0.713, p = 0.040) and LA-CS (r = 0.657, p = 0.011) and mean segmental LA-CS (r = 0.723, p = 0.003) at atrial contraction representing end-diastolic atrial contraction showed correlations with Valsalva ratio, as well. Peak global and mean segmental LA-CS (r = 0.532, p = 0.050 and r = 0.530, p = 0.050) and the same strains at atrial contraction (r = 0.704, p = 0.005 and r = 0.690, p = 0.006) representing systolic function and end-diastolic atrial contraction correlated with systolic blood pressure response to standing representing both parasympathetic and sympathetic autonomic functions.Significant correlations between features of vegetative autonomic function represented by Ewing's 5 SCRTs and specific LA functions represented by 3DSTE-derived LA volume-based functional properties and strains could be demonstrated in healthy adults. LA - English DB - MTMT ER - TY - CONF AU - Várkonyi, Ákos AU - Kupai, Krisztina AU - Várkonyi, Tamás AU - Tokodi, Margaréta ED - Fritz, P TI - A fel nem ismert hypoglykaemia gyakoriságának vizsgálata a sport szerepének tükrében T2 - IV. Leisure Tudományos Konferencia PB - Közép-Kelet-Európai Rekreációs Társaság C1 - Budapest SN - 9786156637185 PY - 2024 SP - 18 EP - 19 PG - 2 UR - https://m2.mtmt.hu/api/publication/34395722 ID - 34395722 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fejes, Imola AU - Bajcsi, Dóra AU - Czakó, László AU - Turkevi-Nagy, Sándor AU - Iványi, Béla AU - Ábrahám, György AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila AU - Légrády, Péter TI - SGLT2-GÁTLÓ DAPAGLIFLOZIN EREDMÉNYES ALKALMAZÁSA NEPHROSIS SZINDRÓMÁVAL JÁRÓ, SZÖVETTANILAG IGAZOLT DIABETESES VESEBETEGSÉGBEN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 306 EP - 306 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34560639 ID - 34560639 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vágvölgyi, Anna AU - Nyiraty, Szabolcs AU - Máthéné, Köteless É AU - Korom, A AU - Ábrahám, Erzsébet Judit AU - Barnai, Mária AU - Szűcs, Mónika AU - Orosz, Andrea AU - Nemes, Attila AU - Baczkó, István AU - Kempler, Péter AU - Várkonyi, Tamás AU - Kósa, István AU - Lengyel, Csaba Attila TI - Három hónapos edzésprogram javítja a kardiovaszkuláris autonóm funkciót a metabolikus szindrómás páciensekben JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 338 EP - 339 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34519512 ID - 34519512 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Szálka, Brigitta AU - Vassányi, István AU - Máthéné Köteles, Éva AU - Kiszely, Ildikó AU - Szabó, Lili Adrienn AU - Lada, Szilvia AU - Bolgár, Tímea AU - Korom, Andrea AU - Staberecz, Dóra Terézia AU - Ábrahám, Erzsébet Judit AU - Szűcs, Mónika AU - Seffer, Péter AU - Biliczki, Vilmos AU - Rafael, Beatrix AU - Barnai, Mária AU - Várkonyi, Tamás AU - Nemes, Attila AU - Lengyel, Csaba Attila AU - Kósa, István ED - Vassányi, István ED - Fogarassyné Vathy, Ágnes TI - Metabólikus szindrómás páciensek dietetikai vezetése telemedicinális támogatással T2 - Orvosi informatika. A XXXVI. Neumann Kollokvium konferencia-kiadványa PB - Neumann János Számítógép-tudományi Társaság CY - Veszprém SN - 9789633962725 PY - 2023 SP - 73 EP - 77 PG - 5 UR - https://m2.mtmt.hu/api/publication/34478552 ID - 34478552 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Várkonyi, Tamás AU - Vágvölgyi, Anna AU - Ábrahám, Erzsébet Judit AU - Máthéné Köteles, Éva AU - Korom, Andrea AU - Barnai, Mária AU - Szűcs, Mónika AU - Orosz, Andrea AU - Nyiraty, Szabolcs AU - Kempler, Péter AU - Baczkó, István AU - Kósa, István AU - Nemes, Attila AU - Lengyel, Csaba Attila TI - Improvement of cardiovascular autonomic function in patients with metabolic syndrome with and without diabetes after a physical training program JF - Hellenic Journal of Medicine J2 - Hellenic J Med VL - 138 PY - 2023 SP - 74 SN - 2241-7109 UR - https://m2.mtmt.hu/api/publication/34433988 ID - 34433988 LA - English DB - MTMT ER - TY - JOUR AU - Fejes, Imola AU - Bajcsi, Dóra AU - Czakó, László AU - Turkevi-Nagy, Sándor AU - Iványi, Béla AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila AU - Ábrahám, György AU - Légrády, Péter TI - SGLT2-gátló dapagliflozin eredményes alkalmazása nefrózis szindrómával járó, szövettanilag igazolt diabéteszes vesebetegségben JF - HYPERTONIA ÉS NEPHROLOGIA J2 - HYPERTONIA NEPHROLOGIA VL - 27 PY - 2023 IS - Suppl. 2 SP - 27 EP - 28 PG - 2 SN - 1418-477X UR - https://m2.mtmt.hu/api/publication/34224658 ID - 34224658 LA - English DB - MTMT ER - TY - JOUR AU - Várkonyi, Tamás AU - Balogh, Zoltán AU - Brasnyó, Pál AU - Mazzag, Bálint TI - A 2-es típusú diabétesz kezelésének hazai szemlélete és gyakorlata a Delphi-konszenzus tükrében JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 31 PY - 2023 IS - 2 SP - 123 EP - 138 PG - 16 SN - 1217-372X DO - 10.24121/dh.2023.11 UR - https://m2.mtmt.hu/api/publication/34104575 ID - 34104575 LA - Hungarian DB - MTMT ER -