@article{MTMT:34788761, title = {Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus}, url = {https://m2.mtmt.hu/api/publication/34788761}, author = {Obeid, Rima and Andrès, Emmanuel and Češka, Richard and Hooshmand, Babak and Guéant-Rodriguez, Rosa-Maria and Prada, Gabriel Ioan and Sławek, Jarosław and Traykov, Latchezar and Ta Van, Binh and Várkonyi, Tamás and Reiners, Karlheinz}, doi = {10.3390/jcm13082176}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {13}, unique-id = {34788761}, abstract = {Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy.}, year = {2024}, eissn = {2077-0383}, orcid-numbers = {Obeid, Rima/0000-0002-0064-7029; Andrès, Emmanuel/0000-0002-7914-7616; Prada, Gabriel Ioan/0000-0002-4762-9581; Sławek, Jarosław/0000-0001-6816-0877; Várkonyi, Tamás/0000-0001-6833-3563; Reiners, Karlheinz/0000-0002-1093-1867} } @article{MTMT:34778284, title = {Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study}, url = {https://m2.mtmt.hu/api/publication/34778284}, author = {Nemes, Attila and Kormányos, Árpád and Orosz, Andrea and Ambrus, Nóra and Várkonyi, Tamás and Lengyel, Csaba Attila}, doi = {10.1002/jcu.23672}, journal-iso = {J CLIN ULTRASOUND}, journal = {JOURNAL OF CLINICAL ULTRASOUND}, unique-id = {34778284}, issn = {0091-2751}, abstract = {Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation.}, keywords = {Echocardiography; Correlation; three-dimensional; Autonomic; Speckle-tracking; Right atrial}, year = {2024}, eissn = {1097-0096}, orcid-numbers = {Nemes, Attila/0000-0002-7570-6214; Kormányos, Árpád/0000-0002-7052-2184; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067} } @article{MTMT:34400260, title = {Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study}, url = {https://m2.mtmt.hu/api/publication/34400260}, author = {Nemes, Attila and Kormányos, Árpád and Orosz, Andrea and Ambrus, Nóra and Várkonyi, Tamás and Lengyel, Csaba Attila}, doi = {10.1002/jcu.23603}, journal-iso = {J CLIN ULTRASOUND}, journal = {JOURNAL OF CLINICAL ULTRASOUND}, volume = {52}, unique-id = {34400260}, issn = {0091-2751}, abstract = {The functioning of the left atrium (LA) is partly controlled by the neural system. It was purposed to evaluate correlations between the result of Ewing's 5 standard cardiovascular reflex tests (SCRTs) characterizing autonomic function and LA volumetric and functional features as assessed by three-dimensional speckle-tracking echocardiography (3DSTE) in healthy individuals.The current study comprised 18 healthy volunteers being in sinus rhythm (mean age: 35 ± 12 years, 10 men). Measurement of blood pressure, ECG, 5 SCRTs, two-dimensional Doppler echocardiography and 3DSTE were performed. These parameters were in normal ranges in all cases.From LA volumetric parameters, only systolic total atrial emptying fraction (r = 0.559, p = 0.037) and early diastolic passive atrial emptying fraction (r = 0.539, p = 0.047) correlated with systolic blood pressure response to standing representing sympathetic autonomic function. From LA strains, peak mean segmental LA radial strain (RS) (r = -0.532, p = 0.050), global and mean segmental LA circumferential strain (CS) (r = 0.662, p = 0.010 and r = 0.635, p = 0.015, respectively) representing systolic LA function correlated with Valsalva ratio representing parasympathetic autonomic function. Global LA-RS (r = -0.713, p = 0.040) and LA-CS (r = 0.657, p = 0.011) and mean segmental LA-CS (r = 0.723, p = 0.003) at atrial contraction representing end-diastolic atrial contraction showed correlations with Valsalva ratio, as well. Peak global and mean segmental LA-CS (r = 0.532, p = 0.050 and r = 0.530, p = 0.050) and the same strains at atrial contraction (r = 0.704, p = 0.005 and r = 0.690, p = 0.006) representing systolic function and end-diastolic atrial contraction correlated with systolic blood pressure response to standing representing both parasympathetic and sympathetic autonomic functions.Significant correlations between features of vegetative autonomic function represented by Ewing's 5 SCRTs and specific LA functions represented by 3DSTE-derived LA volume-based functional properties and strains could be demonstrated in healthy adults.}, keywords = {Echocardiography; Correlation; three-dimensional; Autonomic; Speckle-tracking; LEFT ATRIAL}, year = {2024}, eissn = {1097-0096}, pages = {178-185}, orcid-numbers = {Nemes, Attila/0000-0002-7570-6214; Kormányos, Árpád/0000-0002-7052-2184; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067} } @CONFERENCE{MTMT:34395722, title = {A fel nem ismert hypoglykaemia gyakoriságának vizsgálata a sport szerepének tükrében}, url = {https://m2.mtmt.hu/api/publication/34395722}, author = {Várkonyi, Ákos and Kupai, Krisztina and Várkonyi, Tamás and Tokodi, Margaréta}, booktitle = {IV. Leisure Tudományos Konferencia}, unique-id = {34395722}, year = {2024}, pages = {18-19}, orcid-numbers = {Kupai, Krisztina/0000-0002-0644-1718; Várkonyi, Tamás/0000-0001-6833-3563; Tokodi, Margaréta/0000-0002-0685-2904} } @article{MTMT:34560639, title = {SGLT2-GÁTLÓ DAPAGLIFLOZIN EREDMÉNYES ALKALMAZÁSA NEPHROSIS SZINDRÓMÁVAL JÁRÓ, SZÖVETTANILAG IGAZOLT DIABETESES VESEBETEGSÉGBEN}, url = {https://m2.mtmt.hu/api/publication/34560639}, author = {Fejes, Imola and Bajcsi, Dóra and Czakó, László and Turkevi-Nagy, Sándor and Iványi, Béla and Ábrahám, György and Várkonyi, Tamás and Lengyel, Csaba Attila and Légrády, Péter}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34560639}, issn = {0133-5464}, year = {2023}, pages = {306-306}, orcid-numbers = {Czakó, László/0000-0002-6331-0802; Ábrahám, György/0000-0002-2272-2317; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067} } @article{MTMT:34519512, title = {Három hónapos edzésprogram javítja a kardiovaszkuláris autonóm funkciót a metabolikus szindrómás páciensekben}, url = {https://m2.mtmt.hu/api/publication/34519512}, author = {Vágvölgyi, Anna and Nyiraty, Szabolcs and Máthéné, Köteless É and Korom, A and Ábrahám, Erzsébet Judit and Barnai, Mária and Szűcs, Mónika and Orosz, Andrea and Nemes, Attila and Baczkó, István and Kempler, Péter and Várkonyi, Tamás and Kósa, István and Lengyel, Csaba Attila}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34519512}, issn = {0133-5464}, year = {2023}, pages = {338-339}, orcid-numbers = {Vágvölgyi, Anna/0000-0002-8810-700X; Barnai, Mária/0000-0003-2184-2701; Szűcs, Mónika/0000-0002-8791-9452; Nemes, Attila/0000-0002-7570-6214; Baczkó, István/0000-0002-9588-0797; Kempler, Péter/0000-0002-6072-8832; Várkonyi, Tamás/0000-0001-6833-3563; Kósa, István/0000-0002-8805-4307; Lengyel, Csaba Attila/0000-0002-0434-0067} } @inproceedings{MTMT:34478552, title = {Metabólikus szindrómás páciensek dietetikai vezetése telemedicinális támogatással}, url = {https://m2.mtmt.hu/api/publication/34478552}, author = {Szálka, Brigitta and Vassányi, István and Máthéné Köteles, Éva and Kiszely, Ildikó and Szabó, Lili Adrienn and Lada, Szilvia and Bolgár, Tímea and Korom, Andrea and Staberecz, Dóra Terézia and Ábrahám, Erzsébet Judit and Szűcs, Mónika and Seffer, Péter and Biliczki, Vilmos and Rafael, Beatrix and Barnai, Mária and Várkonyi, Tamás and Nemes, Attila and Lengyel, Csaba Attila and Kósa, István}, booktitle = {Orvosi informatika. A XXXVI. Neumann Kollokvium konferencia-kiadványa}, unique-id = {34478552}, year = {2023}, pages = {73-77}, orcid-numbers = {Máthéné Köteles, Éva/0000-0002-9728-5182; Korom, Andrea/0000-0002-4192-6243; Szűcs, Mónika/0000-0002-8791-9452; Rafael, Beatrix/0000-0002-9272-2603; Barnai, Mária/0000-0003-2184-2701; Várkonyi, Tamás/0000-0001-6833-3563; Nemes, Attila/0000-0002-7570-6214; Lengyel, Csaba Attila/0000-0002-0434-0067; Kósa, István/0000-0002-8805-4307} } @article{MTMT:34433988, title = {Improvement of cardiovascular autonomic function in patients with metabolic syndrome with and without diabetes after a physical training program}, url = {https://m2.mtmt.hu/api/publication/34433988}, author = {Várkonyi, Tamás and Vágvölgyi, Anna and Ábrahám, Erzsébet Judit and Máthéné Köteles, Éva and Korom, Andrea and Barnai, Mária and Szűcs, Mónika and Orosz, Andrea and Nyiraty, Szabolcs and Kempler, Péter and Baczkó, István and Kósa, István and Nemes, Attila and Lengyel, Csaba Attila}, journal-iso = {Hellenic J Med}, journal = {Hellenic Journal of Medicine}, volume = {138}, unique-id = {34433988}, issn = {2241-7109}, year = {2023}, pages = {74}, orcid-numbers = {Várkonyi, Tamás/0000-0001-6833-3563; Vágvölgyi, Anna/0000-0002-8810-700X; Máthéné Köteles, Éva/0000-0002-9728-5182; Korom, Andrea/0000-0002-4192-6243; Barnai, Mária/0000-0003-2184-2701; Szűcs, Mónika/0000-0002-8791-9452; Kempler, Péter/0000-0002-6072-8832; Baczkó, István/0000-0002-9588-0797; Kósa, István/0000-0002-8805-4307; Nemes, Attila/0000-0002-7570-6214; Lengyel, Csaba Attila/0000-0002-0434-0067} } @article{MTMT:34224658, title = {SGLT2-gátló dapagliflozin eredményes alkalmazása nefrózis szindrómával járó, szövettanilag igazolt diabéteszes vesebetegségben}, url = {https://m2.mtmt.hu/api/publication/34224658}, author = {Fejes, Imola and Bajcsi, Dóra and Czakó, László and Turkevi-Nagy, Sándor and Iványi, Béla and Várkonyi, Tamás and Lengyel, Csaba Attila and Ábrahám, György and Légrády, Péter}, journal-iso = {HYPERTONIA NEPHROLOGIA}, journal = {HYPERTONIA ÉS NEPHROLOGIA}, volume = {27}, unique-id = {34224658}, issn = {1418-477X}, year = {2023}, eissn = {2498-6259}, pages = {27-28}, orcid-numbers = {Czakó, László/0000-0002-6331-0802; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067; Ábrahám, György/0000-0002-2272-2317} } @article{MTMT:34104575, title = {A 2-es típusú diabétesz kezelésének hazai szemlélete és gyakorlata a Delphi-konszenzus tükrében}, url = {https://m2.mtmt.hu/api/publication/34104575}, author = {Várkonyi, Tamás and Balogh, Zoltán and Brasnyó, Pál and Mazzag, Bálint}, doi = {10.24121/dh.2023.11}, journal-iso = {DIABETOLOGIA HUNGARICA}, journal = {DIABETOLOGIA HUNGARICA}, volume = {31}, unique-id = {34104575}, issn = {1217-372X}, year = {2023}, eissn = {2560-0168}, pages = {123-138}, orcid-numbers = {Várkonyi, Tamás/0000-0001-6833-3563} }