TY - GEN AU - Rendes, Réka AU - Orsi, Gergely AU - Perlaki, Gábor AU - Bereczkei, Tamás AU - Deák, Anita TI - Neural correlates of valence and arousal ratings responding to socio-emotional stimuli. PY - 2024 UR - https://m2.mtmt.hu/api/publication/34794821 ID - 34794821 N1 - Z3-Poster 3-9002 LA - English DB - MTMT ER - TY - JOUR AU - He, Mingchen AU - Kis-Jakab, Gréta AU - Komáromy, Hedvig AU - Perlaki, Gábor AU - Orsi, Gergely AU - Bosnyák, Edit AU - Rozgonyi, Renáta AU - John, Flóra AU - Trauninger, Anita AU - Eklicsné Lepenye, Katalin AU - Pfund, Zoltán TI - Volumetric alteration of brainstem in female migraineurs with and without aura JF - CLINICAL NEUROLOGY AND NEUROSURGERY J2 - CLIN NEUROL NEUROSUR VL - 236 PY - 2024 PG - 6 SN - 0303-8467 DO - 10.1016/j.clineuro.2023.108089 UR - https://m2.mtmt.hu/api/publication/34477406 ID - 34477406 N1 - Pécs Diagnostic Center, Pécs, Hungary HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Department of Neurology, Medical School, University of Pécs, Pécs, Hungary Department of Languages for Biomedical Purposes and Communication, University of Pécs, Pécs, Hungary Export Date: 29 January 2024 CODEN: CNNSB Correspondence Address: Pfund, Z.; Department of Neurology, Rét u. 2, Hungary; email: pfund.zoltan@pte.hu AB - Brainstem descending modulatory circuits have been postulated to be involved in migraine. Differences in brainstem volume between migraineurs and healthy controls have been demonstrated in previous research, nevertheless, the effect of migraine aura on brainstem volume is still uncertain. The aim of this study was to investigate the brainstem volume in migraineurs and examine the effect of migraine aura on brainstem volume.Our study included 90 female migraine patients without white matter lesions. (29 migraine patients with aura (MwA) and 61 migraine patients without aura (MwoA) and 32 age-matched female healthy controls (HC). Using the FreeSurfer image analysis suite, the volumes of the entire brainstem and its subfields (medulla, pons, and midbrain) were measured and compared between migraine subgroups (MwA vs. MwoA) and the healthy control group. The possible effects of migraine characteristics (i.e., disease duration and migraine attack frequency) on brainstem volume were also investigated.Migraineurs had greater medulla volume (MwoA 3552 ± 459 mm3, MwA 3424 ± 448 mm3) than healthy controls (3236 ± 411 mm3). Statistically, MwA vs. HC p = 0.040, MwoA vs. HC p = 0.002, MwA vs. MwoA p = 0.555. A significant positive correlation was found between disease duration and the volume of medulla in the whole migraine group (r = 0.334, p = 0.001). Neither the whole brainstem nor its subfields were significantly different in volume between migraine subgroups.Brainstem volume changes in migraine are mainly localized to the medulla and not specific to the presence of aura. LA - English DB - MTMT ER - TY - JOUR AU - Áfra, Eszter AU - Janszky, József Vladimír AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Arató, Ákos AU - Szente, Anna Tímea AU - Alhour, Husamalddin Ali Mohammad AU - Kis-Jakab, Gréta AU - Darnai, Gergely TI - Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study JF - BRAIN IMAGING AND BEHAVIOR J2 - BRAIN IMAGING BEHAV PY - 2024 PG - 10 SN - 1931-7557 DO - 10.1007/s11682-023-00825-y UR - https://m2.mtmt.hu/api/publication/34420912 ID - 34420912 N1 - Funding Agency and Grant Number: University of Pecs from the National Research, Development and Innovation Fund of Hungary under the TKP2021-EGA funding scheme [TKP2021-EGA-16]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Laboratory of Translational Neuroscience (NLTN) [RRF-2.3.1-21-2022-00011] Funding text: Open access funding provided by University of Pecs. Project no. TKP2021-EGA-16 has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the TKP2021-EGA funding scheme. SAN was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Project no. RRF-2.3.1-21-2022-00011 were supported from the National Laboratory of Translational Neuroscience (NLTN). AB - Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning . LA - English DB - MTMT ER - TY - JOUR AU - Perlaki, Gábor AU - Darnai, Gergely AU - Arató, Ákos AU - Alhour, Husamalddin Ali Mohammad AU - Szente, Anna Tímea AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Horváth, Réka AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Orsi, Gergely AU - Janszky, József Vladimír TI - Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM PY - 2024 SN - 1053-1807 DO - 10.1002/jmri.28970 UR - https://m2.mtmt.hu/api/publication/34113102 ID - 34113102 AB - Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3. LA - English DB - MTMT ER - TY - GEN AU - Perlaki, Gábor AU - Hernádi, Gabriella AU - Pintér, Dávid AU - Rohonczi, Mirtill AU - Harmat, Márk AU - Aschermann, Zsuzsanna AU - Orsi, Gergely AU - Komoly, Sámuel AU - Janszky, József AU - Kovács, Norbert TI - Ironsleep PY - 2023 UR - https://m2.mtmt.hu/api/publication/34772738 ID - 34772738 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Deák, Anita AU - Rendes, Réka AU - Várkonyi, Gergely AU - Orsi, Gergely AU - Perlaki, Gábor AU - Bereczkei, Tamás TI - High neuroticism scorers show increased brain activation in response to negative social stimuli PY - 2023 UR - https://m2.mtmt.hu/api/publication/34314191 ID - 34314191 LA - English DB - MTMT ER - TY - JOUR AU - He, Mingchen AU - Kis-Jakab, Gréta AU - Komáromy, Hedvig AU - Perlaki, Gábor AU - Orsi, Gergely AU - Bosnyák, Edit AU - Rozgonyi, Renáta AU - John, Flóra AU - Trauninger, Anita AU - Eklicsné Lepenye, Katalin AU - Pfund, Zoltán TI - The volume of the thalamus and hippocampus in a right-handed female episodic migraine group JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 PG - 10 SN - 1664-2295 DO - 10.3389/fneur.2023.1254628 UR - https://m2.mtmt.hu/api/publication/34207248 ID - 34207248 LA - English DB - MTMT ER - TY - JOUR AU - Hernádi, Gabriella AU - Perlaki, Gábor AU - Kovács, Márton AU - Pintér, Dávid AU - Orsi, Gergely AU - Janszky, József Vladimír AU - Kovács, Norbert TI - White matter hyperintensities associated with impulse control disorders in Parkinson's Disease JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-023-37054-8 UR - https://m2.mtmt.hu/api/publication/34050785 ID - 34050785 N1 - * Megosztott szerzőség AB - Impulse control disorders (ICDs) in Parkinson's disease (PD) are increasingly recognized as clinically significant non-motor features that potentially impair the quality of life. White matter hyperintensities (WMHs), detected by magnetic resonance imaging, are frequently observed in PD and can be associated with both motor- and certain non-motor symptoms. Given the limited number of non-motor features studied in this context, our aim was to reveal the potential association between the severity of WMHs and ICDs in PD. Fluid-attenuated inversion recovery magnetic resonance images were retrospectively evaluated in 70 patients with PD (48 males; 59.3 ± 10.1 years). The severity of WMHs was assessed by Fazekas scores and by the volume and number of supratentorial WMHs. ICDs were evaluated using the modified Minnesota Impulsive Disorders Interview. Significant interaction between age and the severity of WMHs was present for ICDs. In our younger patients (< 60.5 years), severity of WMHs was positively associated with ICDs (p = 0.004, p = 0.021, p < 0.001 and p < 0.001, respectively for periventricular white matter and total Fazekas scores and the volume and number of WMHs). Our study supports the hypothesis that WMHs of presumed vascular origin may contribute to ICDs in PD. Future prospective studies are needed to assess the prognostic relevance of this finding. LA - English DB - MTMT ER - TY - GEN AU - Kovács, Márton AU - Hernádi, Gabriella AU - Perlaki, Gábor AU - Pintér, Dávid AU - Orsi, Gergely AU - Janszky, József Vladimír AU - Kovács, Norbert TI - Fehérállományi hiperintenzitások és impulzus kontroll zavarok kapcsolata Parkinson-kórban PY - 2023 UR - https://m2.mtmt.hu/api/publication/34012058 ID - 34012058 LA - Hungarian DB - MTMT ER - TY - GEN AU - Rohonczi, Mirtill AU - Perlaki, Gábor AU - Hernádi, Gabriella AU - Kovács, Norbert AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Harmat, Márk AU - Pintér, Dávid AU - Aschermann, Zsuzsanna TI - A fecskefarok jel aszimmetria és a klinikai lateralitás kapcsolata Parkinson-kórban PY - 2023 UR - https://m2.mtmt.hu/api/publication/34012040 ID - 34012040 LA - Hungarian DB - MTMT ER -