TY - CONF AU - Hegedüs, Imre AU - Pázmány, Rita AU - Voniatis, Constantinos AU - Kellermayer, Miklós AU - Máthé, Domokos AU - Jedlovszky-Hajdú, Angéla TI - Elektrospininggel készült nanoszálak mechanikai tulajdonságainak atomerő mikroszkópos vizsgálata T2 - 53. Membrán-Transzport Konferencia - Programfüzet PY - 2024 SP - 82 PG - 1 UR - https://m2.mtmt.hu/api/publication/35444267 ID - 35444267 LA - Hungarian DB - MTMT ER - TY - CONF AU - Halmóczki, Sarolta AU - RIZMAJER, VIVIEN AU - OSÁN, KITTI AU - Jedlovszky-Hajdú, Angéla TI - Application of metal nanoparticles in order to develop electrospun wound healing matrices T2 - 22nd International Summer School on Bioanalysis Book of Abstracts PY - 2024 SP - 29 EP - 29 PG - 1 UR - https://m2.mtmt.hu/api/publication/35256293 ID - 35256293 LA - English DB - MTMT ER - TY - CONF AU - Pálos, Veronika Teréz AU - S. Nagy, Krisztina AU - Pázmány, Rita AU - Juriga-Tóth, Krisztina AU - Budavári, Bálint Péter AU - Domokos, Judit AU - Szabó, Dóra AU - Zsembery, Ákos AU - Jedlovszky-Hajdú, Angéla TI - Inorganic salt-polysuccinimide composite scaffold for potential wound dressing application T2 - BOOK OF ABSTRACTS PY - 2024 SP - 163 EP - 163 PG - 1 UR - https://m2.mtmt.hu/api/publication/35255905 ID - 35255905 LA - English DB - MTMT ER - TY - CONF AU - Pálos, Veronika Teréz AU - S. Nagy, Krisztina AU - Pázmány, Rita AU - Juriga-Tóth, Krisztina AU - Budavári, Bálint Péter AU - Domokos, Judit AU - Szabó, Dóra AU - Zsembery, Ákos AU - Jedlovszky-Hajdú, Angéla TI - Polysuccinimide-salt electrospun composite scaffold as a potential wound dressing material T2 - 22nd International Summer School on Bioanalysis Book of Abstracts PY - 2024 SP - 67 EP - 68 PG - 2 UR - https://m2.mtmt.hu/api/publication/35171843 ID - 35171843 LA - English DB - MTMT ER - TY - CONF AU - Halmóczki, Sarolta AU - Rizmajer, Vivien AU - Osán, Kitti AU - Jedlovszky-Hajdú, Angéla TI - Fabrication of Electrospun Polymer Matrices Embedded with Metal Nanoparticles for Antibacterial Wound Dressings T2 - BOOK OF ABSTRACTS PY - 2024 SP - 158 EP - 158 PG - 1 UR - https://m2.mtmt.hu/api/publication/35171834 ID - 35171834 LA - English DB - MTMT ER - TY - CONF AU - Pálos, Veronika Teréz AU - Krisztina, S. Nagy AU - Rita, Pázmány AU - Krisztina, Juriga-Tóth AU - Budavári, Bálint Péter AU - Judit, Domokos AU - Dóra, Szabó AU - Ákos, Zsembery AU - Jedlovszky-Hajdú, Angéla TI - Inorganic salt-polysuccinimide composite scaffold for potential wound dressing application T2 - PhD Scientific Days 2024 PY - 2024 SP - 163 UR - https://m2.mtmt.hu/api/publication/35171827 ID - 35171827 LA - English DB - MTMT ER - TY - JOUR AU - Pálos, Veronika Teréz AU - S. Nagy, Krisztina AU - Pázmány, Rita AU - Juriga-Tóth, Krisztina AU - Budavári, Bálint Péter AU - Domokos, Judit AU - Szabó, Dóra AU - Zsembery, Ákos AU - Jedlovszky-Hajdú, Angéla TI - Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material JF - BEILSTEIN JOURNAL OF NANOTECHNOLOGY J2 - BEILSTEIN J NANOTECH VL - 15 PY - 2024 SP - 781 EP - 796 PG - 16 SN - 2190-4286 DO - 10.3762/bjnano.15.65 UR - https://m2.mtmt.hu/api/publication/35082149 ID - 35082149 N1 - Laboratory of Nanochemistry, Institute of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Department of Oral Biology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Export Date: 9 October 2024 Correspondence Address: Jedlovszky-Hajdu, A.; Laboratory of Nanochemistry, Nagyvárad tér 4, Hungary; email: hajdu.angela@semmelweis.hu AB - In this research, we applied electrospinning to create a two-component biodegradable polymeric scaffold containing polysuccinimide (PSI) and antibacterial salts. Antibacterial agents for therapeutical purposes mostly contain silver ions which are associated with high environmental impact and, in some cases, may cause undesired immune reactions. In our work, we prepared nanofibrous systems containing antibacterial and tissue-regenerating salts of zinc acetate or strontium nitrate in different concentrations, whose structures may be suitable for developing biomedical wound dressing systems in the future. Several experiments have been conducted to optimize the physicochemical, mechanical, and biological properties of the scaffolds developed for application as wound dressings. The scaffold systems obtained by PSI synthesis, salt addition, and fiber formation were first investigated by scanning electron microscopy. In almost all cases, different salts caused a decrease in the fiber diameter of PSI polymer-based systems (<500 nm). Fourier-transform infrared spectroscopy was applied to verify the presence of salts in the scaffolds and to determine the interaction between the salt and the polymer. Another analysis, energy-dispersive X-ray spectroscopy, was carried out to determine strontium and zinc atoms in the scaffolds. Our result showed that the salts influence the mechanical properties of the polymer scaffold, both in terms of specific load capacity and relative elongation values. According to the dissolution experiments, the whole amount of strontium nitrate was dissolved from the scaffold in 8 h; however, only 50% of the zinc acetate was dissolved. In addition, antibacterial activity tests were performed with four different bacterial strains relevant to skin surface injuries, leading to the appearance of inhibition zones around the scaffold discs in most cases. We also investigated the potential cytotoxicity of the scaffolds on human tumorous and healthy cells. Except for the ones containing zinc acetate salt, the scaffolds are not cytotoxic to either tumor or healthy cells. LA - English DB - MTMT ER - TY - CONF AU - Hegedüs, Imre AU - Pázmány, Rita AU - Voniatis, Constantinos AU - Juriga-Tóth, Krisztina AU - Máthé, Domokos AU - Kellermayer, Miklós AU - Jedlovszky-Hajdú, Angéla TI - AFM investigations of nanomechanical properties of electrospun nanofibers T2 - Advances in Single-Molecule Research PY - 2024 SP - Poster 38 UR - https://m2.mtmt.hu/api/publication/34912266 ID - 34912266 LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Ákos György AU - Nanys, M. AU - Pinke, B. AU - Fadel, A. AU - Godzierz, M. AU - Juriga-Tóth, Krisztina AU - Molnár, Kolos AU - Juriga, Dávid AU - Jedlovszky-Hajdú, Angéla TI - Formation of Three-Dimensional Polysuccinimide Electrospun Fiber Meshes Induced by the Combination of CaCl2 and Humidity JF - MACROMOLECULAR RAPID COMMUNICATIONS J2 - MACROMOL RAPID COMM VL - 45 PY - 2024 IS - 7 PG - 12 SN - 1022-1336 DO - 10.1002/marc.202300625 UR - https://m2.mtmt.hu/api/publication/34533656 ID - 34533656 N1 - Funding Agency and Grant Number: NKFIH FK [137749]; TKP2021-EGA-23; NKFIH [FK138501, UNKP-21-3-II-SE-56, EFOP-3.6.3-VEKOP-16-2017-00009] Funding text: D.J. and A.J.-H. contributed equally to this work therefore both are considered as last authors. This research was supported by NKFIH FK 137749, TKP2021-EGA-23, NKFIH FK138501, UNKP-21-3-II-SE-56, and EFOP-3.6.3-VEKOP-16-2017-00009 research grants. AB - Even though electrospinning is getting more and more attention, the preparation of 3D nanofibrous meshes is still a big challenge that limits the application of electrospun materials, especially in tissue engineering. To overcome this problem, several solutions are introduced but most of them focus on the postprocessing of the electrospun meshes. This paper presents a straightforward novel method that utilizes the joint effect of the addition of CaCl2 and the relative environmental humidity (RH), which can induce the random 3D formation of polysuccinimide (PSI) electrospun fibers with different such as wrinkled or ribbon-like structures. Although the effect of humidity and inorganic salt additives on the micro and macrostructure of electrospun fibers is known, the connection between the two in this manner has never been presented. To investigate the effect, fibers with different PSI and CaCl2 concentrations at different humidity RH levels are prepared, and their microstructure is visualized with high-resolution scanning electron microscopy (SEM). To reveal the nature of the interaction between the polymer and the CaCl2, Fourier-transformed infrared (FTIR), X-ray diffraction (XRD), and thermogravimetry (TGA) measurements are carried out and 3D nanofibrous structures are obtained. © 2024 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH. LA - English DB - MTMT ER - TY - JOUR AU - Budavári, Bálint Péter AU - Karancsi, Áron AU - Pinke, Balázs Gábor AU - Pállinger, Éva AU - Juriga-Tóth, Krisztina AU - Király, Márton AU - Szász, Adrienn Zsófia AU - Voszka, István AU - Molnár, Kolos AU - Kőhidai, László AU - Jedlovszky-Hajdú, Angéla AU - S. Nagy, Krisztina TI - Long-term shelf-life liposomes for delivery of prednisolone and budesonide JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 394 PY - 2024 PG - 13 SN - 0167-7322 DO - 10.1016/j.molliq.2023.123756 UR - https://m2.mtmt.hu/api/publication/34506340 ID - 34506340 N1 - Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad tér 4., Budapest, H-1089, Hungary Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3-9., Budapest, H-1111, Hungary Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4., Budapest, H-1089, Hungary Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, Hőgyes Endre u. 7., Budapest, H-1092, Hungary Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Tűzoltó u. 37-47., Budapest, H-1094, Hungary ELKH–BME Research Group for Composite Science and Technology, Műegyetem rkp. 3., Budapest, H-1111, Hungary MTA-BME Lendület Sustainable Polymers Research Group, Műegyetem rkp. 3, Budapest, H-1111, Hungary Export Date: 14 March 2024 CODEN: JMLID Correspondence Address: Jedlovszky-Hajdu, A.; Laboratory of Nanochemistry, Nagyvárad tér 4., Hungary; email: hajdu.angela@med.semmelweis-univ.hu LA - English DB - MTMT ER -