@article{MTMT:32546342,
	title = {A promising combination: Pacap and parp inhibitor have therapeutic potential in models of diabetic and hypertensive retinopathies},
	url = {https://m2.mtmt.hu/api/publication/32546342},
	author = {Pöstyéni, Etelka and Szabadfi, Krisztina and Sétáló, György (ifj.) and Gábriel, Róbert},
	doi = {10.3390/cells10123470},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {10},
	unique-id = {32546342},
	year = {2021},
	eissn = {2073-4409},
	orcid-numbers = {Gábriel, Róbert/0000-0001-9323-8795}
}

@article{MTMT:31788019,
	title = {Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats},
	url = {https://m2.mtmt.hu/api/publication/31788019},
	author = {Tékus, Valéria and Horváth, Ádám István and Csekő, Kata and Szabadfi, Krisztina and Kovács-Valasek, Andrea and Dányádi, Bese and Deres, László and Halmosi, Róbert and Sághy, Éva and Varga, Zoltán and Adeghate, Ernest Akingunola and Kőszegi, Tamás and Mátyus, Péter and Gábriel, Róbert and Ferdinandy, Péter and Pintér, Erika and Helyes, Zsuzsanna},
	doi = {10.1016/j.biopha.2020.111105},
	journal-iso = {BIOMED PHARMACOTHER},
	journal = {BIOMEDICINE & PHARMACOTHERAPY},
	volume = {134},
	unique-id = {31788019},
	issn = {0753-3322},
	year = {2021},
	eissn = {1950-6007},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Varga, Zoltán/0000-0002-2758-0784; Mátyus, Péter/0000-0003-3963-9445; Gábriel, Róbert/0000-0001-9323-8795; Ferdinandy, Péter/0000-0002-6424-6806; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:31356167,
	title = {Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy},
	url = {https://m2.mtmt.hu/api/publication/31356167},
	author = {Sükösd, Andrea Krisztina and Szabadfi, Krisztina and Szabó-Meleg, Edina and Gáspár, B. and Stodulka, P. and Sétáló, György (ifj.) and Gábriel, Róbert and Nyitrai, Miklós and Biró, Zsolt and Ábrahám, Hajnalka},
	doi = {10.18240/ijo.2020.06.11},
	journal-iso = {INT J OPHTHALMOL (ENGLISH EDITION)},
	journal = {INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (ENGLISH EDITION)},
	volume = {13},
	unique-id = {31356167},
	issn = {2222-3959},
	year = {2020},
	eissn = {2227-4898},
	pages = {927-934},
	orcid-numbers = {Gábriel, Róbert/0000-0001-9323-8795; Nyitrai, Miklós/0000-0002-6229-4337}
}

@article{MTMT:30306941,
	title = {Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse},
	url = {https://m2.mtmt.hu/api/publication/30306941},
	author = {Borbély, Éva and Kiss, Tamás and Szabadfi, Krisztina and Pintér, Erika and Szolcsányi, János and Helyes, Zsuzsanna and Botz, Bálint},
	doi = {10.1038/s41598-018-34005-6},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {8},
	unique-id = {30306941},
	issn = {2045-2322},
	abstract = {Capsaicin-sensitive afferents have complex regulatory functions in the joints orchestrated via neuropeptides. This study aimed to determine their role in the collagen-antibody induced rheumatoid arthritis model. Capsaicin-sensitive nerves were defunctionalized by the capsaicin receptor agonist resiniferatoxin in C57Bl/6 mice. Arthritis was induced by the ArithroMab antibody cocktail and adjuvant. Arthritis was monitored by measuring body weight, joint edema by plethysmometry, arthritis severity by clinical scoring, mechanonociceptive threshold by plantar esthesiometry, thermonociceptive threshold by hot plate, cold tolerance by paw withdrawal latency from 0 °C water. Grasping ability was determined by the wire-grid grip test. Bone structure was evaluated by in vivo micro-CT and histology. Arthritic animals developed a modest joint edema, mechanical and cold hyperalgesia, weight loss, and a diminished grasping function, while thermal hyperalgesia is absent in the model. Desensitised mice displayed reduced arthritis severity, edema, and mechanical hyperalgesia, however, cold hyperalgesia was significantly greater in this group. Arthritic controls displayed a transient decrease of bone volume and an increased porosity, while bone density and trabecularity increased in desensitised mice. The activation of capsaicin-sensitive afferents increases joint inflammation and mechanical hyperalgesia, but decreases cold allodynia. It also affects inflammatory bone structural changes by promoting bone resorption.},
	keywords = {SERUM; RESINIFERATOXIN; SUBSTANCE-P; PAIN; RHEUMATOID-ARTHRITIS; ANIMAL-MODELS; INDUCED INFLAMMATION; KNEE-JOINT; rat},
	year = {2018},
	eissn = {2045-2322},
	orcid-numbers = {Borbély, Éva/0000-0002-1234-4391; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:3192281,
	title = {Accelerated retinal aging in PACAP knock-out mice.},
	url = {https://m2.mtmt.hu/api/publication/3192281},
	author = {Kovács-Valasek, Andrea and Szabadfi, Krisztina and Dénes, Viktória and Szalontai, Bálint and Tamás, Andrea and Kiss, Péter and Szabó, Aliz and Sétáló, György (ifj.) and Reglődi, Dóra and Gábriel, Róbert},
	doi = {10.1016/j.neuroscience.2017.02.003},
	journal-iso = {NEUROSCIENCE},
	journal = {NEUROSCIENCE},
	volume = {348},
	unique-id = {3192281},
	issn = {0306-4522},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophic and neuroprotective peptide. PACAP and its receptors are widely distributed in the retina. A number of reports provided evidence that PACAP is neuroprotective in retinal degenerations. The current study compared retina cell type-specific differences in young (3-4months) and aged adults (14-16months), of wild-type (WT) mice and knock-out (KO) mice lacking endogenous PACAP production during the course of aging. Histological, immunocytochemical and Western blot examinations were performed. The staining for standard neurochemical markers (tyrosine hydroxylase for dopaminergic cells, calbindin 28 kDa for horizontal cells, protein kinase Calpha for rod bipolar cells) of young adult PACAP KO retinas showed no substantial alterations compared to young adult WT retinas, except for the specific PACAP receptor (PAC1-R) staining. We could not detect PAC1-R immunoreactivity in bipolar and horizontal cells in young adult PACAP KO animals. Some other age-related changes were observed only in the PACAP KO mice only. These alterations included horizontal and rod bipolar cell dendritic sprouting into the photoreceptor layer and decreased ganglion cell number. Also, Muller glial cells showed elevated GFAP expression compared to the aging WT retinas. Furthermore, Western blot analyses revealed significant differences between the phosphorylation state of ERK1/2 and JNK in KO mice, indicating alterations in the MAPK signaling pathway. These results support the conclusion that endogenous PACAP contributes to protection against aging of the nervous system.},
	year = {2017},
	eissn = {1873-7544},
	pages = {1-10},
	orcid-numbers = {Gábriel, Róbert/0000-0001-9323-8795}
}

@article{MTMT:2994283,
	title = {Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway},
	url = {https://m2.mtmt.hu/api/publication/2994283},
	author = {Szabadfi, Krisztina and Reglődi, Dóra and Szabó, Aliz and Szalontai, Bálint and Kovács-Valasek, Andrea and Sétáló, György (ifj.) and Kiss, Péter and Tamás, Andrea and Wilhelm, Márta and Gábriel, Róbert},
	doi = {10.1007/s12640-015-9593-1},
	journal-iso = {NEUROTOX RES},
	journal = {NEUROTOXICITY RESEARCH},
	volume = {29},
	unique-id = {2994283},
	issn = {1029-8428},
	keywords = {PHOTORECEPTORS; Retinal Pigment Epithelium; BIPOLAR CELLS; ribbon synapses; Ganglion cells},
	year = {2016},
	eissn = {1476-3524},
	pages = {432-446},
	orcid-numbers = {Gábriel, Róbert/0000-0001-9323-8795}
}

@article{MTMT:2977092,
	title = {Modeling long-term diabetes and related complications in rats},
	url = {https://m2.mtmt.hu/api/publication/2977092},
	author = {Hajna, Zsófia Réka and Szabadfi, Krisztina and Balla, Z and Biró, Zsolt and Degrell, P and Molnár, Gergő Attila and Kőszegi, Tamás and Tékus, Valéria and Helyes, Zsuzsanna and Dobos, András and Farkas, S and Szűcs, Gyula and Gábriel, Róbert and Pintér, Erika},
	doi = {10.1016/j.vascn.2015.11.003},
	journal-iso = {J PHARMACOL TOXICOL METH},
	journal = {JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS},
	volume = {78},
	unique-id = {2977092},
	issn = {1056-8719},
	abstract = {INTRODUCTION: Accurate preclinical modeling of diabetic complications such as retinopathy, nephropathy and neuropathy is crucial to enable the development of novel preventative therapies. The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia. METHODS: Streptozotocin-induced diabetic CFY rats were subjected to four different insulin substitution protocols to achieve different levels of glycemic control (Diabetic 1-4 groups). Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, and neuropathy by functional tests. Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electronmicroscopy. RESULTS: Rats of the Diabetic 3 group showed massive hyperglycemia-dependent anterior segment neovascularization, enhanced total retinal score and retinal apoptotic cell number, degeneration of dopaminergic amacrine cells, increased glomerular PAS-positivity, altered excreted total protein/creatinine ratio and cold allodynia, beside medium scale hyperglycemia (blood glucose level between 22 and 25mmol/L) and acceptable health status of the animals parallelly. DISCUSSION: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period. Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials. Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research in this field.},
	year = {2016},
	eissn = {1873-488X},
	pages = {1-12},
	orcid-numbers = {Molnár, Gergő Attila/0000-0001-6052-5907; Gábriel, Róbert/0000-0001-9323-8795; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:2914853,
	title = {Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema},
	url = {https://m2.mtmt.hu/api/publication/2914853},
	author = {Helyes, Zsuzsanna and Kun, József and Dobrosi, Nóra and Sándor, Katalin and Németh, J and Perkecz, A and Pintér, Erika and Szabadfi, Krisztina and Gaszner, Balázs and Tékus, Valéria and Szolcsányi, János and Steinhoff, M and Hashimoto, H and Reglődi, Dóra and Bíró, Tamás},
	doi = {10.1038/jid.2015.156},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	volume = {135},
	unique-id = {2914853},
	issn = {0022-202X},
	year = {2015},
	eissn = {1523-1747},
	pages = {2209-2218},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X; Gaszner, Balázs/0000-0003-2830-2732}
}

@article{MTMT:2867789,
	title = {Retinal aging in the diurnal Chilean rodent (Octodon degus): histological, ultrastructural and neurochemical alterations of the vertical information processing pathway},
	url = {https://m2.mtmt.hu/api/publication/2867789},
	author = {Szabadfi, Krisztina and Estrada, C and Fernandez-Villalba, E and Tarragon, E and Sétáló, György (ifj.) and Izura, V and Reglődi, Dóra and Tamás, Andrea and Gábriel, Róbert and Herrero, MT},
	doi = {10.3389/fncel.2015.00126},
	journal-iso = {FRONT CELL NEUROSCI},
	journal = {FRONTIERS IN CELLULAR NEUROSCIENCE},
	volume = {9},
	unique-id = {2867789},
	issn = {1662-5102},
	abstract = {BACKGROUND: The retina is sensitive to age-dependent degeneration. To find suitable animal models to understand and map this process has particular importance. The degu (Octodon degus) is a diurnal rodent with dichromatic color vision. Its retinal structure is similar to that in humans in many respects, therefore, it is well suited to study retinal aging. Histological, cell type-specific and ultrastructural alterations were examined in 6, 12 and 36 months old degus. The characteristic layers of the retina were present at all ages, but slightly loosened tissue structure could be observed in 36-month-old animals both at light and electron microscopic levels. Elevated glial fibrillary acidic protein expression was observed in Müller glial cells in aging retinas. The number of rod bipolar cells and the ganglion cells was reduced in the aging specimens, while that of cone bipolar cells remained unchanged. Other age-related differences were detected at ultrastructural level: alteration of the retinal pigment epithelium and degenerated photoreceptor cells were evident. Ribbon synapses were sparse and often differed in morphology from those in the young animals. These results support our hypothesis that (i) the rod pathway seems to be more sensitive than the cone pathway to age-related cell loss; (ii) structural changes in the basement membrane of pigment epithelial cells can be one of the early signs of degenerative processes; (iii) the loss of synaptic proteins especially from those of the ribbon synapses are characteristic and (iv) the degu retina may be a suitable model for studying retinal aging.},
	keywords = {ultrastructure; Aging; Retina; Octodon degus; rod bipolar cells; Synaptic proteins; vertical pathway},
	year = {2015},
	eissn = {1662-5102},
	orcid-numbers = {Gábriel, Róbert/0000-0001-9323-8795}
}

@CONFERENCE{MTMT:2781369,
	title = {A Chilean rodent, Octodon degus is a promising model for studying retinal aging [poster]},
	url = {https://m2.mtmt.hu/api/publication/2781369},
	author = {Szabadfi, Krisztina and Gábriel, Róbert and Ifj., Sétáló György and Tarragon, E. and Estrada, C. and Lopez, D. and Ros, C.M. and Reglődi, Dóra and Tamás, Andrea and Herrero, M.T.},
	booktitle = {9th FENS Forum of Neuroscience},
	unique-id = {2781369},
	year = {2014},
	pages = {x}
}