TY  - JOUR
AU  - Toldi, János
AU  - Kelava, Leonardo
AU  - Márton, Sándor
AU  - Mühl, Diána
AU  - Kustán, Péter
AU  - Feher, Zsolt
AU  - Maár, Klaudia
AU  - Garai, János
AU  - Pákai, Eszter
AU  - Garami, András
TI  - Distinct patterns of serum and urine macrophage migration inhibitory factor kinetics predict death in sepsis : a prospective, observational clinical study
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 13
PY  - 2023
IS  - 1
PG  - 15
SN  - 2045-2322
DO  - 10.1038/s41598-023-27506-6
UR  - https://m2.mtmt.hu/api/publication/33564254
ID  - 33564254
AB  - Macrophage migration inhibitory factor (MIF) has been considered as a biomarker in sepsis, however the predictive value of the pattern of its kinetics in the serum and in the urine has remained unclarified. It is also unclear whether the kinetics of MIF are different between males and females. We conducted a single-center prospective, observational study with repeated measurements of MIF in serum and urine on days 0, 2, and 4 from admission to the intensive care unit (ICU) in 50 adult septic patients. We found that in patients who died within 90 days, there was an increase in serum MIF level from day 0 to 4, whereas in the survivors there was rather a decrease (p = 0.018). The kinetics were sex-dependent as the same difference in the pattern was present in males (p = 0.014), but not in females (p = 0.418). We also found that urine MIF was markedly lower in patients who died than in survivors of sepsis (p < 0.050). Urine MIF levels did not show temporal changes: there was no meaningful difference between day 0 and 4. These results suggest that kinetics of serum MIF during the initial days from ICU admission can predict death, especially in male patients. Additionally, lower urine MIF levels can also indicate death without showing meaningful temporal kinetics.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Garai, János
AU  - Radnai, Balázs
AU  - Vámos, Eszter
AU  - Kovács, Dominika
AU  - Bagóné Vántus, Viola
AU  - Rumbus, Zoltán
AU  - Pákai, Eszter
AU  - Garami, András
AU  - Gulyás, Gergely
AU  - Agócs, Attila
AU  - Krekó, Marcell
AU  - Zaman, K.
AU  - Prókai, L.
AU  - Őrfi, László
AU  - Jakus, Péter
AU  - Lóránd, Tamás
TI  - Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice
JF  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
J2  - EUR J MED CHEM
VL  - 247
PY  - 2023
PG  - 11
SN  - 0223-5234
DO  - 10.1016/j.ejmech.2022.115050
UR  - https://m2.mtmt.hu/api/publication/33546311
ID  - 33546311
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Rumbus, Zoltán
AU  - Garai, János
AU  - Kéringer, Patrik
AU  - Radnai, Balázs
AU  - Lóránd, Tamás
AU  - Garami, András
ED  - Csiszár, Beáta
ED  - Hankó, Csilla
ED  - Kajos, Luca Fanni
ED  - Mező, Emerencia
TI  - The role of the macrophage migration inhibitory factor in lipopolysaccharide-induced hypothermia in mice
T2  - Medical Conference for PhD Students and Experts of Clinical Sciences 2021
PB  - University of Pécs, Doctoral Student Association
CY  - Pécs
SN  - 9789634296539
PY  - 2021
SP  - 115
EP  - 115
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/32131103
ID  - 32131103
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Garai, János
AU  - Krekó, Marcell
AU  - Őrfi, László
AU  - Jakus, Péter
AU  - Rumbus, Zoltán
AU  - Kéringer, Patrik
AU  - Garami, András
AU  - Vámos, Eszter
AU  - Kovács, Dominika
AU  - Bagóné Vántus, Viola
AU  - Radnai, Balázs
AU  - Lóránd, Tamás
TI  - Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice
JF  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
J2  - J ENZYM INHIB MED CH
VL  - 36
PY  - 2021
IS  - 1
SP  - 1357
EP  - 1369
PG  - 13
SN  - 1475-6366
DO  - 10.1080/14756366.2021.1916010
UR  - https://m2.mtmt.hu/api/publication/32095838
ID  - 32095838
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Circulatory disorders of specific organs
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 74
EP  - 90
PG  - 17
UR  - https://m2.mtmt.hu/api/publication/34183582
ID  - 34183582
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Alterations of cardiovascular functions in the elderly
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 90
EP  - 91
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/34183578
ID  - 34183578
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Pathophysiology of lipoprotein metabolism
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 346
EP  - 353
PG  - 8
UR  - https://m2.mtmt.hu/api/publication/34183563
ID  - 34183563
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Pathophysiology of endocrine systems
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 355
EP  - 395
PG  - 41
UR  - https://m2.mtmt.hu/api/publication/34183561
ID  - 34183561
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Inflammation
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 497
EP  - 503
PG  - 7
UR  - https://m2.mtmt.hu/api/publication/34183547
ID  - 34183547
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Garai, János
ED  - Székely, Miklós
TI  - Ischemia - reperfusion
T2  - Basic concepts in pathophysiology
PB  - Medicina Könyvkiadó Zrt.
CY  - Budapest
SN  - 9789632267395
PY  - 2020
SP  - 505
EP  - 506
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/34183545
ID  - 34183545
LA  - English
DB  - MTMT
ER  -