TY - JOUR AU - Nádorvári, Maja Lilla AU - Lotz, Gábor AU - Kulka, Janina AU - Kiss, András AU - Tímár, József TI - Microsatellite instability and mismatch repair protein deficiency: equal predictive markers? JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 30 PY - 2024 PG - 12 SN - 1219-4956 DO - 10.3389/pore.2024.1611719 UR - https://m2.mtmt.hu/api/publication/34822369 ID - 34822369 AB - Current clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecular epidemiology studies reported different rates of deficient MMR (dMMR) and MSI in various cancer types. Additionally, direct comparisons of the two tests revealed relatively frequent discrepancies between MMR IHC and MSI tests, especially in non-colorectal and non-endometrial cancers and in cases with unusual dMMR phenotypes. There are also scattered clinical data showing that the efficacy of immune checkpoint inhibitors is different if the patient selection was based on dMMR versus MSI status of the cancers. All these observations question the current dogma that dMMR phenotype and genetic MSI status are equal predictive markers of the immunotherapies. LA - English DB - MTMT ER - TY - JOUR AU - Geukens, Tatjana AU - Maetens, Marion AU - Hooper, Jody E AU - Oesterreich, Steffi AU - Lee, Adrian V AU - Miller, Lori AU - Atkinson, Jenny M AU - Rosenzweig, Margaret AU - Puhalla, Shannon AU - Thorne, Heather AU - Devereux, Lisa AU - Bowtell, David AU - Loi, Sherene AU - Bacon, Eliza R AU - Ihle, Kena AU - Song, Mihae AU - Rodriguez-Rodriguez, Lorna AU - Welm, Alana L AU - Gauchay, Lisa AU - Murali, Rajmohan AU - Chanda, Pharto AU - Karacay, Ali AU - Naceur-Lombardelli, Cristina AU - Bridger, Hayley AU - Swanton, Charles AU - Jamal-Hanjani, Mariam AU - Kollath, Lori AU - True, Lawrence AU - Morrissey, Colm AU - Chambers, Meagan AU - Chinnaiyan, Arul M AU - Wilson, Allecia AU - Mehra, Rohit AU - Reichert, Zachery AU - Carey, Lisa A AU - Perou, Charles M AU - Kelly, Erin AU - Maeda, Daichi AU - Goto, Akiteru AU - Kulka, Janina AU - Székely, Borbála AU - Szász, Attila Marcell AU - Tőkés, Anna-Mária AU - Van Den Bogaert, Wouter AU - Floris, Giuseppe AU - Desmedt, Christine TI - Research autopsy programmes in oncology. shared experience from 14 centres across the world TS - shared experience from 14 centres across the world JF - JOURNAL OF PATHOLOGY J2 - J PATHOL VL - Mar 29 PY - 2024 SN - 0022-3417 DO - 10.1002/path.6271 UR - https://m2.mtmt.hu/api/publication/34763500 ID - 34763500 AB - While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field through synchronous, extensive, and high-volume sample collection. However, it remains an underused strategy in translational research. Via an extensive questionnaire, we collected information on the study design, enrolment strategy, study conduct, sample and data management, and challenges and opportunities of research autopsy programmes in oncology worldwide. Fourteen programmes participated in this study. Eight programmes operated 24 h/7 days, resulting in a lower median postmortem interval (time between death and start of the autopsy, 4 h) compared with those operating during working hours (9 h). Most programmes (n = 10) succeeded in collecting all samples within a median of 12 h after death. A large number of tumour sites were sampled during each autopsy (median 15.5 per patient). The median number of samples collected per patient was 58, including different processing methods for tumour samples but also non-tumour tissues and liquid biopsies. Unique biological insights derived from these samples included metastatic progression, treatment resistance, disease heterogeneity, tumour dormancy, interactions with the tumour micro-environment, and tumour representation in liquid biopsies. Tumour patient-derived xenograft (PDX) or organoid (PDO) models were additionally established, allowing for drug discovery and treatment sensitivity assays. Apart from the opportunities and achievements, we also present the challenges related with postmortem sample collections and strategies to overcome them, based on the shared experience of these 14 programmes. Through this work, we hope to increase the transparency of postmortem tissue donation, to encourage and aid the creation of new programmes, and to foster collaborations on these unique sample collections. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. LA - English DB - MTMT ER - TY - JOUR AU - Bossuyt, V. AU - Provenzano, E. AU - Symmans, W.F. AU - Webster, F. AU - Allison, K.H. AU - Dang, C. AU - Helenice, G. AU - Kulka, Janina AU - Lakhani, S.R. AU - Moriya, T. AU - Quinn, C.M. AU - Sapino, A. AU - Schnitt, S. AU - Sibbering, D.M. AU - Slodkowska, E. AU - Yang, W. AU - Tan, P.H. AU - Ellis, I. TI - A dedicated structured data set for reporting of invasive carcinoma of the breast in the setting of neoadjuvant therapy: recommendations from the International Collaboration on Cancer Reporting (ICCR) JF - HISTOPATHOLOGY J2 - HISTOPATHOLOGY PY - 2024 SN - 0309-0167 DO - 10.1111/his.15165 UR - https://m2.mtmt.hu/api/publication/34744786 ID - 34744786 LA - English DB - MTMT ER - TY - JOUR AU - Nádorvári, Maja Lilla AU - Kenessey, István AU - Kiss, András AU - Barbai, Tamás AU - Kulka, Janina AU - Rásó, Erzsébet AU - Tímár, József TI - Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series JF - JOURNAL OF TRANSLATIONAL MEDICINE J2 - J TRANSL MED VL - 22 PY - 2024 IS - 1 PG - 9 SN - 1479-5876 DO - 10.1186/s12967-024-04960-y UR - https://m2.mtmt.hu/api/publication/34581410 ID - 34581410 LA - English DB - MTMT ER - TY - JOUR AU - Borbély, Katalin AU - Györke, Tamás AU - Gődény, Mária AU - Battyáni, István AU - Kovács, Péter AU - Kiss, András AU - Besenyi, Zsuzsanna AU - Sinkó, Mária AU - Garai, Ildikó AU - Ambrózay, Éva AU - Tasnádi, Tünde AU - Cserni, Gábor AU - Kulka, Janina AU - Esperger, Zsófia AU - Maráz, Róbert TI - A Belügyminisztérium egészségügyi szakmai irányelve az emlődaganatos betegek diagnosztikai és onko-pszichológiai ellátásáról JF - EGÉSZSÉGÜGYI KÖZLÖNY J2 - EGÉSZSÉGÜGYI KÖZLÖNY VL - 74 PY - 2024 IS - 1 SP - 194 EP - 250 PG - 57 SN - 2063-1146 UR - https://m2.mtmt.hu/api/publication/34547857 ID - 34547857 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Leduc, S. AU - De, Schepper M. AU - Richard, F. AU - Maetens, M. AU - Pabba, A. AU - Borremans, K. AU - Jaekers, J. AU - Latacz, E. AU - Zels, G. AU - Bohlok, A. AU - Van, Baelen K. AU - Nguyen, H.L. AU - Geukens, T. AU - Dirix, L. AU - Larsimont, D. AU - Vankerckhove, S. AU - Santos, E. AU - Oliveira, R.C. AU - Dede, K. AU - Kulka, Janina AU - Székely, Borbála AU - Salamon, F. AU - Madaras, Lilla AU - Szász, Attila Marcell AU - Lucidi, V. AU - Meyer, Y. AU - Topal, B. AU - Verhoef, C. AU - Engstrand, J. AU - Moro, C.F. AU - Gerling, M. AU - Bachir, I. AU - Biganzoli, E. AU - Donckier, V. AU - Floris, G. AU - Vermeulen, P. AU - Desmedt, C. TI - Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases JF - NPJ BREAST CANCER J2 - NPJ BREAST CANCER VL - 9 PY - 2023 IS - 1 PG - 11 SN - 2374-4677 DO - 10.1038/s41523-023-00602-6 UR - https://m2.mtmt.hu/api/publication/34452856 ID - 34452856 LA - English DB - MTMT ER - TY - JOUR AU - Cserni, Gábor AU - Kálmán, Endre AU - Udvarhelyi, Nóra AU - Papp, Eszter AU - Grote, Isabel AU - Bartels, Stephan AU - Christgen, Matthias AU - Kreipe, Hans AU - Kulka, Janina TI - Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas : results of a randomized diagnostic study JF - HISTOPATHOLOGY J2 - HISTOPATHOLOGY VL - 83 PY - 2023 IS - 5 SP - 810 EP - 821 PG - 12 SN - 0309-0167 DO - 10.1111/his.15026 UR - https://m2.mtmt.hu/api/publication/34113096 ID - 34113096 N1 - Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary Institute of Pathology, University of Pécs, Pécs, Hungary Department of Surgical and Molecular Pathology, Centre of Tumour Pathology, National Institute of Oncology, Budapest, Hungary Institute of Pathology, Hannover Medical School, Hannover, Germany Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary Export Date: 20 March 2024 CODEN: HISTD Correspondence Address: Cserni, G.; Department of Pathology, Nyíri út 38, Hungary; email: cserni@freemail.hu Chemicals/CAS: uvomorulin, 112956-45-3 AB - Invasive lobular carcinoma (ILC) has distinct morphology and association with loss of E-cadherin function. It has special clinical and imaging features, and its proper recognition is important. Following a recent proposal, we tested the value of the routine use of E-cadherin immunohistochemistry (IHC) in recognizing ILC.Five pathologists with experience in breast pathology from four Hungarian institutions histotyped 1001 breast cancers from diagnostic core biopsies or excision specimens randomly assigned to haematoxylin and eosin (HE) diagnosis first, followed by E-cadherin IHC; or to immediate HE and E-cadherin-based diagnosis. Of 524 cases with HE diagnosis, 73(14%) were deemed uncertain. E-cadherin made the initial histological type change in 14/524 cases (2.7%), including three with confident HE-based type allocation. Use of E-cadherin immunostaining was considered useful in 88/477 cases (18%) with immediate dual assessment, and typing uncertainty went down to 5% (25/477 cases), but was not zero. Collective assessment of 171 uncertain, difficult, nonclassical cases resulted in consensus diagnosis in most cases, but 15 cases were still doubtful as concerns their proper histological type. CDH1 gene sequencing was attempted and successful in 13; pathogenic genetic alterations were identified in seven cases.The routine use of E-cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E-cadherin-positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic. LA - English DB - MTMT ER - TY - JOUR AU - Dank, Magdolna AU - Mühl, Dorottya AU - Pölhös, Annamária AU - Csanda, Renata AU - Herold, Magdolna AU - Kovács, Attila AU - Madaras, Lilla AU - Kulka, Janina AU - Pálházy, Tímea AU - Tőkés, Anna-Mária AU - Tóth, Mónika Anna AU - Újhelyi, Mihály AU - Szász, Attila Marcell AU - Herold, Zoltán TI - The Prediction Analysis of Microarray 50 (PAM50) Gene Expression Classifier Utilized in Indeterminate-Risk Breast Cancer Patients in Hungary: A Consecutive 5-Year Experience JF - GENES J2 - GENES-BASEL VL - 14 PY - 2023 IS - 9 PG - 14 SN - 2073-4425 DO - 10.3390/genes14091708 UR - https://m2.mtmt.hu/api/publication/34112970 ID - 34112970 N1 - Export Date: 15 December 2023 LA - English DB - MTMT ER - TY - JOUR AU - Elfgen, C. AU - Leo, C. AU - Kubik-Huch, R.A. AU - Muenst, S. AU - Schmidt, N. AU - Quinn, C. AU - McNally, S. AU - van, Diest P.J. AU - Mann, R.M. AU - Bago-Horvath, Z. AU - Bernathova, M. AU - Regitnig, P. AU - Fuchsjäger, M. AU - Schwegler-Guggemos, D. AU - Maranta, M. AU - Zehbe, S. AU - Tausch, C. AU - Güth, U. AU - Fallenberg, E.M. AU - Schrading, S. AU - Kothari, A. AU - Sonnenschein, M. AU - Kampmann, G. AU - Kulka, Janina AU - Tille, J.-C. AU - Körner, M. AU - Decker, T. AU - Lax, S.F. AU - Daniaux, M. AU - Bjelic-Radisic, V. AU - Kacerovsky-Strobl, S. AU - Condorelli, R. AU - Gnant, M. AU - Varga, Z. TI - Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) JF - VIRCHOWS ARCHIV J2 - VIRCHOWS ARCH VL - 483 PY - 2023 IS - 1 SP - 5 EP - 20 PG - 16 SN - 0945-6317 DO - 10.1007/s00428-023-03566-x UR - https://m2.mtmt.hu/api/publication/34046934 ID - 34046934 N1 - Export Date: 05 July 2023; Cited By: 0; Correspondence Address: C. Elfgen; University of Witten-Herdecke, Witten, Germany; email: c.elfgen@brust-zentrum.ch; CODEN: VARCE LA - English DB - MTMT ER - TY - JOUR AU - Nádorvári, Maja Lilla AU - Kiss, András AU - Barbai, Tamás AU - Kulka, Janina AU - Rásó, Erzsébet AU - Tímár, József TI - A mikroszatellita-instabilitás/mismatch repair deficiencia genetikai hibák molekuláris epidemiológiája intézetünkben: módszertani megfontolások JF - MAGYAR ONKOLÓGIA J2 - MAGYAR ONKOLÓGIA VL - 67 PY - 2023 IS - 2 SP - 147 EP - 153 PG - 7 SN - 0025-0244 UR - https://m2.mtmt.hu/api/publication/34034658 ID - 34034658 N1 - Export Date: 4 December 2023 CODEN: MGONA Correspondence Address: József, T.; Semmelweis Egyetem, Hungary; email: timar.jozsef@med.semmelweis-univ.hu LA - Hungarian DB - MTMT ER -