@article{MTMT:34822369,
	title = {Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?},
	url = {https://m2.mtmt.hu/api/publication/34822369},
	author = {Nádorvári, Maja Lilla and Lotz, Gábor and Kulka, Janina and Kiss, András and Tímár, József},
	doi = {10.3389/pore.2024.1611719},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {30},
	unique-id = {34822369},
	issn = {1219-4956},
	abstract = {Current clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR protein IHC as the gold standard test to identify cancers with MMR deficiency and recommend molecular MSI tests only in special circumstances or to screen for Lynch syndrome. However, there are data in the literature which suggest that the two test types may not be equal. For example, molecular epidemiology studies reported different rates of deficient MMR (dMMR) and MSI in various cancer types. Additionally, direct comparisons of the two tests revealed relatively frequent discrepancies between MMR IHC and MSI tests, especially in non-colorectal and non-endometrial cancers and in cases with unusual dMMR phenotypes. There are also scattered clinical data showing that the efficacy of immune checkpoint inhibitors is different if the patient selection was based on dMMR versus MSI status of the cancers. All these observations question the current dogma that dMMR phenotype and genetic MSI status are equal predictive markers of the immunotherapies.},
	year = {2024},
	eissn = {1532-2807},
	orcid-numbers = {Lotz, Gábor/0000-0002-6921-8978; Kulka, Janina/0000-0001-6498-5943; Kiss, András/0000-0002-7453-3163; Tímár, József/0000-0001-9183-0859}
}

@article{MTMT:34763500,
	title = {Research autopsy programmes in oncology. shared experience from 14 centres across the world},
	url = {https://m2.mtmt.hu/api/publication/34763500},
	author = {Geukens, Tatjana and Maetens, Marion and Hooper, Jody E and Oesterreich, Steffi and Lee, Adrian V and Miller, Lori and Atkinson, Jenny M and Rosenzweig, Margaret and Puhalla, Shannon and Thorne, Heather and Devereux, Lisa and Bowtell, David and Loi, Sherene and Bacon, Eliza R and Ihle, Kena and Song, Mihae and Rodriguez-Rodriguez, Lorna and Welm, Alana L and Gauchay, Lisa and Murali, Rajmohan and Chanda, Pharto and Karacay, Ali and Naceur-Lombardelli, Cristina and Bridger, Hayley and Swanton, Charles and Jamal-Hanjani, Mariam and Kollath, Lori and True, Lawrence and Morrissey, Colm and Chambers, Meagan and Chinnaiyan, Arul M and Wilson, Allecia and Mehra, Rohit and Reichert, Zachery and Carey, Lisa A and Perou, Charles M and Kelly, Erin and Maeda, Daichi and Goto, Akiteru and Kulka, Janina and Székely, Borbála and Szász, Attila Marcell and Tőkés, Anna-Mária and Van Den Bogaert, Wouter and Floris, Giuseppe and Desmedt, Christine},
	doi = {10.1002/path.6271},
	journal-iso = {J PATHOL},
	journal = {JOURNAL OF PATHOLOGY},
	volume = {Mar 29},
	unique-id = {34763500},
	issn = {0022-3417},
	abstract = {While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field through synchronous, extensive, and high-volume sample collection. However, it remains an underused strategy in translational research. Via an extensive questionnaire, we collected information on the study design, enrolment strategy, study conduct, sample and data management, and challenges and opportunities of research autopsy programmes in oncology worldwide. Fourteen programmes participated in this study. Eight programmes operated 24 h/7 days, resulting in a lower median postmortem interval (time between death and start of the autopsy, 4 h) compared with those operating during working hours (9 h). Most programmes (n = 10) succeeded in collecting all samples within a median of 12 h after death. A large number of tumour sites were sampled during each autopsy (median 15.5 per patient). The median number of samples collected per patient was 58, including different processing methods for tumour samples but also non-tumour tissues and liquid biopsies. Unique biological insights derived from these samples included metastatic progression, treatment resistance, disease heterogeneity, tumour dormancy, interactions with the tumour micro-environment, and tumour representation in liquid biopsies. Tumour patient-derived xenograft (PDX) or organoid (PDO) models were additionally established, allowing for drug discovery and treatment sensitivity assays. Apart from the opportunities and achievements, we also present the challenges related with postmortem sample collections and strategies to overcome them, based on the shared experience of these 14 programmes. Through this work, we hope to increase the transparency of postmortem tissue donation, to encourage and aid the creation of new programmes, and to foster collaborations on these unique sample collections. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.},
	keywords = {liquid biopsy; metastatic cancer; tissue donation; research autopsy; tumour model},
	year = {2024},
	eissn = {1096-9896},
	orcid-numbers = {Kulka, Janina/0000-0001-6498-5943; Szász, Attila Marcell/0000-0003-2739-4196; Tőkés, Anna-Mária/0000-0002-9581-7536}
}

@article{MTMT:34744786,
	title = {A dedicated structured data set for reporting of invasive carcinoma of the breast in the setting of neoadjuvant therapy: recommendations from the International Collaboration on Cancer Reporting (ICCR)},
	url = {https://m2.mtmt.hu/api/publication/34744786},
	author = {Bossuyt, V. and Provenzano, E. and Symmans, W.F. and Webster, F. and Allison, K.H. and Dang, C. and Helenice, G. and Kulka, Janina and Lakhani, S.R. and Moriya, T. and Quinn, C.M. and Sapino, A. and Schnitt, S. and Sibbering, D.M. and Slodkowska, E. and Yang, W. and Tan, P.H. and Ellis, I.},
	doi = {10.1111/his.15165},
	journal-iso = {HISTOPATHOLOGY},
	journal = {HISTOPATHOLOGY},
	unique-id = {34744786},
	issn = {0309-0167},
	year = {2024},
	eissn = {1365-2559},
	orcid-numbers = {Kulka, Janina/0000-0001-6498-5943}
}

@article{MTMT:34581410,
	title = {Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series},
	url = {https://m2.mtmt.hu/api/publication/34581410},
	author = {Nádorvári, Maja Lilla and Kenessey, István and Kiss, András and Barbai, Tamás and Kulka, Janina and Rásó, Erzsébet and Tímár, József},
	doi = {10.1186/s12967-024-04960-y},
	journal-iso = {J TRANSL MED},
	journal = {JOURNAL OF TRANSLATIONAL MEDICINE},
	volume = {22},
	unique-id = {34581410},
	issn = {1479-5876},
	year = {2024},
	eissn = {1479-5876},
	orcid-numbers = {Kenessey, István/0000-0002-6963-8489; Kiss, András/0000-0002-7453-3163; Barbai, Tamás/0000-0002-2374-6097; Kulka, Janina/0000-0001-6498-5943; Rásó, Erzsébet/0000-0002-4589-5771; Tímár, József/0000-0001-9183-0859}
}

@article{MTMT:34547857,
	title = {A Belügyminisztérium egészségügyi szakmai irányelve az emlődaganatos betegek diagnosztikai és onko-pszichológiai ellátásáról},
	url = {https://m2.mtmt.hu/api/publication/34547857},
	author = {Borbély, Katalin and Györke, Tamás and Gődény, Mária and Battyáni, István and Kovács, Péter and Kiss, András and Besenyi, Zsuzsanna and Sinkó, Mária and Garai, Ildikó and Ambrózay, Éva and Tasnádi, Tünde and Cserni, Gábor and Kulka, Janina and Esperger, Zsófia and Maráz, Róbert},
	journal-iso = {EGÉSZSÉGÜGYI KÖZLÖNY},
	journal = {EGÉSZSÉGÜGYI KÖZLÖNY},
	volume = {74},
	unique-id = {34547857},
	issn = {2063-1146},
	year = {2024},
	pages = {194-250},
	orcid-numbers = {Borbély, Katalin/0000-0002-1675-4128; Györke, Tamás/0000-0002-8772-9931; Gődény, Mária/0000-0003-0020-3476; Kovács, Péter/0009-0003-6352-2113; Besenyi, Zsuzsanna/0000-0001-9115-9620; Kulka, Janina/0000-0001-6498-5943; Maráz, Róbert/0000-0003-0146-6024}
}

@article{MTMT:34452856,
	title = {Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases},
	url = {https://m2.mtmt.hu/api/publication/34452856},
	author = {Leduc, S. and De, Schepper M. and Richard, F. and Maetens, M. and Pabba, A. and Borremans, K. and Jaekers, J. and Latacz, E. and Zels, G. and Bohlok, A. and Van, Baelen K. and Nguyen, H.L. and Geukens, T. and Dirix, L. and Larsimont, D. and Vankerckhove, S. and Santos, E. and Oliveira, R.C. and Dede, K. and Kulka, Janina and Székely, Borbála and Salamon, F. and Madaras, Lilla and Szász, Attila Marcell and Lucidi, V. and Meyer, Y. and Topal, B. and Verhoef, C. and Engstrand, J. and Moro, C.F. and Gerling, M. and Bachir, I. and Biganzoli, E. and Donckier, V. and Floris, G. and Vermeulen, P. and Desmedt, C.},
	doi = {10.1038/s41523-023-00602-6},
	journal-iso = {NPJ BREAST CANCER},
	journal = {NPJ BREAST CANCER},
	volume = {9},
	unique-id = {34452856},
	year = {2023},
	eissn = {2374-4677},
	orcid-numbers = {Kulka, Janina/0000-0001-6498-5943; Madaras, Lilla/0000-0002-4137-4696; Szász, Attila Marcell/0000-0003-2739-4196}
}

@article{MTMT:34113096,
	title = {Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas : results of a randomized diagnostic study},
	url = {https://m2.mtmt.hu/api/publication/34113096},
	author = {Cserni, Gábor and Kálmán, Endre and Udvarhelyi, Nóra and Papp, Eszter and Grote, Isabel and Bartels, Stephan and Christgen, Matthias and Kreipe, Hans and Kulka, Janina},
	doi = {10.1111/his.15026},
	journal-iso = {HISTOPATHOLOGY},
	journal = {HISTOPATHOLOGY},
	volume = {83},
	unique-id = {34113096},
	issn = {0309-0167},
	abstract = {Invasive lobular carcinoma (ILC) has distinct morphology and association with loss of E-cadherin function. It has special clinical and imaging features, and its proper recognition is important. Following a recent proposal, we tested the value of the routine use of E-cadherin immunohistochemistry (IHC) in recognizing ILC.Five pathologists with experience in breast pathology from four Hungarian institutions histotyped 1001 breast cancers from diagnostic core biopsies or excision specimens randomly assigned to haematoxylin and eosin (HE) diagnosis first, followed by E-cadherin IHC; or to immediate HE and E-cadherin-based diagnosis. Of 524 cases with HE diagnosis, 73(14%) were deemed uncertain. E-cadherin made the initial histological type change in 14/524 cases (2.7%), including three with confident HE-based type allocation. Use of E-cadherin immunostaining was considered useful in 88/477 cases (18%) with immediate dual assessment, and typing uncertainty went down to 5% (25/477 cases), but was not zero. Collective assessment of 171 uncertain, difficult, nonclassical cases resulted in consensus diagnosis in most cases, but 15 cases were still doubtful as concerns their proper histological type. CDH1 gene sequencing was attempted and successful in 13; pathogenic genetic alterations were identified in seven cases.The routine use of E-cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E-cadherin-positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic.},
	keywords = {immunohistochemistry; breast cancer; E-CADHERIN; INVASIVE LOBULAR CARCINOMA; CDH1 mutation},
	year = {2023},
	eissn = {1365-2559},
	pages = {810-821},
	orcid-numbers = {Cserni, Gábor/0000-0003-1344-7744; Kulka, Janina/0000-0001-6498-5943}
}

@article{MTMT:34112970,
	title = {The Prediction Analysis of Microarray 50 (PAM50) Gene Expression Classifier Utilized in Indeterminate-Risk Breast Cancer Patients in Hungary: A Consecutive 5-Year Experience},
	url = {https://m2.mtmt.hu/api/publication/34112970},
	author = {Dank, Magdolna and Mühl, Dorottya and Pölhös, Annamária and Csanda, Renata and Herold, Magdolna and Kovács, Attila and Madaras, Lilla and Kulka, Janina and Pálházy, Tímea and Tőkés, Anna-Mária and Tóth, Mónika Anna and Újhelyi, Mihály and Szász, Attila Marcell and Herold, Zoltán},
	doi = {10.3390/genes14091708},
	journal-iso = {GENES-BASEL},
	journal = {GENES},
	volume = {14},
	unique-id = {34112970},
	issn = {2073-4425},
	year = {2023},
	eissn = {2073-4425},
	orcid-numbers = {Dank, Magdolna/0000-0002-4442-8733; Mühl, Dorottya/0000-0001-7565-8462; Herold, Magdolna/0000-0002-1036-6343; Madaras, Lilla/0000-0002-4137-4696; Kulka, Janina/0000-0001-6498-5943; Pálházy, Tímea/0000-0002-0542-8976; Tőkés, Anna-Mária/0000-0002-9581-7536; Újhelyi, Mihály/0000-0001-7164-563X; Szász, Attila Marcell/0000-0003-2739-4196; Herold, Zoltán/0000-0001-5990-4889}
}

@article{MTMT:34046934,
	title = {Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)},
	url = {https://m2.mtmt.hu/api/publication/34046934},
	author = {Elfgen, C. and Leo, C. and Kubik-Huch, R.A. and Muenst, S. and Schmidt, N. and Quinn, C. and McNally, S. and van, Diest P.J. and Mann, R.M. and Bago-Horvath, Z. and Bernathova, M. and Regitnig, P. and Fuchsjäger, M. and Schwegler-Guggemos, D. and Maranta, M. and Zehbe, S. and Tausch, C. and Güth, U. and Fallenberg, E.M. and Schrading, S. and Kothari, A. and Sonnenschein, M. and Kampmann, G. and Kulka, Janina and Tille, J.-C. and Körner, M. and Decker, T. and Lax, S.F. and Daniaux, M. and Bjelic-Radisic, V. and Kacerovsky-Strobl, S. and Condorelli, R. and Gnant, M. and Varga, Z.},
	doi = {10.1007/s00428-023-03566-x},
	journal-iso = {VIRCHOWS ARCH},
	journal = {VIRCHOWS ARCHIV},
	volume = {483},
	unique-id = {34046934},
	issn = {0945-6317},
	year = {2023},
	eissn = {1432-2307},
	pages = {5-20},
	orcid-numbers = {Kulka, Janina/0000-0001-6498-5943}
}

@article{MTMT:34034658,
	title = {A mikroszatellita-instabilitás/mismatch repair deficiencia genetikai hibák molekuláris epidemiológiája intézetünkben: módszertani megfontolások},
	url = {https://m2.mtmt.hu/api/publication/34034658},
	author = {Nádorvári, Maja Lilla and Kiss, András and Barbai, Tamás and Kulka, Janina and Rásó, Erzsébet and Tímár, József},
	journal-iso = {MAGYAR ONKOLÓGIA},
	journal = {MAGYAR ONKOLÓGIA},
	volume = {67},
	unique-id = {34034658},
	issn = {0025-0244},
	year = {2023},
	eissn = {2060-0399},
	pages = {147-153},
	orcid-numbers = {Kiss, András/0000-0002-7453-3163; Barbai, Tamás/0000-0002-2374-6097; Kulka, Janina/0000-0001-6498-5943; Rásó, Erzsébet/0000-0002-4589-5771; Tímár, József/0000-0001-9183-0859}
}