@article{MTMT:34495912,
	title = {In Vivo Evaluation of Brain [18F]F-FDG Uptake Pattern Under Different Anaesthesia Protocols},
	url = {https://m2.mtmt.hu/api/publication/34495912},
	author = {Képes, Zita and Arató, Viktória Zsófia and Csaba, Csikos and Eva, Hegedus and Regina, Esze and Nagy, Tamás and Jószai, István and Emri, Miklós and Kertész, István and Trencsényi, György},
	journal-iso = {IN VIVO},
	journal = {IN VIVO},
	unique-id = {34495912},
	issn = {0258-851X},
	year = {2024},
	eissn = {1791-7549},
	orcid-numbers = {Képes, Zita/0000-0003-2889-8521; Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:34484514,
	title = {Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection},
	url = {https://m2.mtmt.hu/api/publication/34484514},
	author = {Linkner, Tamás Richárd and Ambrus, Viktor Attila and Kunkli, Balázs Tibor and Szojka, Zsófia Ilona and Kalló, Gergő and Csősz, Éva and Kumar, Ajneesh and Emri, Miklós and Tőzsér, József and Mahdi, Mohamed},
	doi = {10.3390/ijms25010380},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34484514},
	issn = {1661-6596},
	abstract = {In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction with host–cell proteins during the early phase of infection. We utilized proteo-transcriptomic analyses to determine differential genome expression and proteomic changes induced by transduction with HIV-1/2 pseudovirions during 8, 12 and 26 h time-points in HEK-293T cells. We show that alteration in the cellular milieu was indeed different between the two pseudovirions. The significantly higher number of genes altered by HIV-2 in the first two time-points suggests a more diverse yet subtle effect on the host cell, preparing the infected cell for integration and latency. On the other hand, GO analysis showed that, while HIV-1 induced cellular oxidative stress and had a greater effect on cellular metabolism, HIV-2 mostly affected genes involved in cell adhesion, extracellular matrix organization or cellular differentiation. Proteomics analysis revealed that HIV-2 significantly downregulated the expression of proteins involved in mRNA processing and translation. Meanwhile, HIV-1 influenced the cellular level of translation initiation factors and chaperones. Our study provides insight into the understudied replication cycle of HIV-2 and enriches our knowledge about the use of HIV-based lentiviral vectors in general.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Kunkli, Balázs Tibor/0000-0003-1266-2792; Kumar, Ajneesh/0000-0001-5513-4135; Mahdi, Mohamed/0000-0002-7959-5996}
}

@book{MTMT:34407280,
	title = {Bevezetés a proteomikába : a fehérjék korszerű vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/34407280},
	isbn = {9789633316009},
	author = {Csősz, Éva and Darula, Zsuzsanna and Drahos, László and Emri, Miklós and Hunyadi-Gulyás, Éva and Janáky, Tamás and Juhász, Gábor and Kalló, Gergő and Kékesi, Adrienna Katalin and Klement, Éva and Márk, László and Medzihradszky, F. Katalin and Pettkó-Szandtner, Aladár and Rokobné Révész, Ágnes and Schlosser, Gitta (Vácziné) and Szabó, Zoltán and Tóth, Gábor and Turiák, Lilla},
	publisher = {Semmelweis Egyetem},
	unique-id = {34407280},
	year = {2023},
	orcid-numbers = {Rokobné Révész, Ágnes/0000-0002-6221-1239; Schlosser, Gitta (Vácziné)/0000-0002-7637-7133; Szabó, Zoltán/0000-0001-8278-8038}
}

@article{MTMT:34089339,
	title = {Laboratóriumi paraméterek kódolása a LOINC-rendszer szerint a Debreceni Egyetem Klinikai Központjában},
	url = {https://m2.mtmt.hu/api/publication/34089339},
	author = {Rácz, Szilvia and Emri, Miklós and Opposits, Gábor and Berényi, Ervin László and Benczik, Lajos and Ludman, István Attila and Kappelmayer, János and Bhattoa Harjit, Pál},
	doi = {10.1556/650.2023.32814},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {164},
	unique-id = {34089339},
	issn = {0030-6002},
	abstract = {Bevezetés: A Debreceni Egyetem adatvagyonának jelentős részét alkotja a Klinikai Központban zajló betegellátás során keletkezett orvosi, biokémiai és képi adat, rendszerezetlen változatban. Ezek kutatási célú alkalmazhatósága jelentősen korlátozott. Az egyetemi „Tématerületi Kiválósági Programon” belül, a „Big Data tématerület” keretében elindított K+F projekt legfontosabb célja az anonimizált adatvagyon elérhetővé tétele a felhasználók számára megfelelő transzformációs eljárások kidolgozásával. Az elemzésre kiválóan használható adatokat az in vitro rutindiagnosztikai laboratórium által szolgáltatott adatok jelentik. A rutindiagnosztikai gyakorlatban használatos adatmezőket rövidített, magyar nyelvű, nem standardizált kulcsszavak jelölik, és e kulcsszavak kódolására a nemzetközi Logikai Megfigyelési Azonosítók, Nevek és Kódok (Logical Observation Identifiers Names and Codes – LOINC) szabvány alkalmazását határoztuk el. Referencialaboratóriumok, egészségügyi szolgáltatók, kormányhivatalok, egészségügyi biztosítók, orvosi szoftverek és műszerek gyártói, kutatók, valamint az egészségügyi rendszert igénybe vevők világszerte használják a LOINC-rendszert az adatok azonosítására, valamint azok rendszerek közötti zökkenőmentes átadására. Célkitűzés: Célunk a Debreceni Egyetem Klinikai Központjának Laboratóriumi Medicina Intézete által meghatározott rutindiagnosztikai paraméterek (n = 448) megfeleltetése a LOINC kódolási rendszernek, figyelembe véve az azonos adatok hátterében az időbeli és módszertani eltéréseket. Módszerek: A laboratóriumi adatokhoz rendelt kulcsszavakat a kórházi informatikai rendszer üzemeltetőjétől kapott adatbázis alapján elemeztük. A rutindiagnosztikában használatos kulcsszavakat, megnevezéseket használtuk a LOINC-szabvány szerinti kódolásra azután, hogy a kódolás módszertanát áttanulmányoztuk, és megfelelő jártasságra tettünk szert az alkalmazásában. Eredmények: Magyarországon egyedülálló módon megfeleltettük az elvégzett rutindiagnosztikai laboratóriumi adatok és vizsgálatok elnevezéseit a LOINC-rendszer követelményeinek, és nyilvánosan hozzáférhetővé tettük őket a Debreceni Egyetem https://labmed.unideb.hu/hu/loinc-tablazatok világhálójának elérhetőségén. Következtetés: Az egységes nemzetközi LOINC-rendszer szerint kódolt adatok hatékonyabban elősegítik a Debreceni Egyetem nemzetközi integrációs törekvéseit, többek között a laboratóriumok közötti kommunikációt, valamint a nemzetközi, határokon átívelő információáramlást és a valamennyi érdekelttel való kapcsolattartást. Orv Hetil. 2023; 164(27): 1043–1051.},
	year = {2023},
	eissn = {1788-6120},
	pages = {1043-1051},
	orcid-numbers = {Bhattoa Harjit, Pál/0000-0002-4909-0065}
}

@misc{MTMT:34055604,
	title = {Nyugalmi agyi hálózatok eltéréseinek vizsgálata 2-es típusú diabetes mellitusban és obezitásban},
	url = {https://m2.mtmt.hu/api/publication/34055604},
	author = {Aranyi, Sándor Csaba and Képes, Zita and Nagy, Marianna and Opposits, Gábor and Garai, Ildikó and Káplár, Miklós and Emri, Miklós},
	unique-id = {34055604},
	year = {2023},
	orcid-numbers = {Aranyi, Sándor Csaba/0000-0001-9569-5404; Képes, Zita/0000-0003-2889-8521}
}

@article{MTMT:33578502,
	title = {Epileptic diathesis: An EEG-LORETA study},
	url = {https://m2.mtmt.hu/api/publication/33578502},
	author = {Clemens, Béla and Emri, Miklós and Fekete, István and Fekete, Klára},
	doi = {10.1016/j.clinph.2022.11.004},
	journal-iso = {CLIN NEUROPHYSIOL},
	journal = {CLINICAL NEUROPHYSIOLOGY},
	volume = {145},
	unique-id = {33578502},
	issn = {1388-2457},
	year = {2023},
	eissn = {1872-8952},
	pages = {54-61}
}

@article{MTMT:33542619,
	title = {Central Nervous System Involvement in Primary Sjögren’s Syndrome: Narrative Review of MRI Findings},
	url = {https://m2.mtmt.hu/api/publication/33542619},
	author = {Módis, László and Aradi, Zsófia and Horváth, Ildikó Fanny and Bencze, János and Papp, Tamás and Emri, Miklós and Berényi, Ervin László and Bugán, Antal and Szántó, Antónia},
	doi = {10.3390/diagnostics13010014},
	journal-iso = {DIAGNOSTICS},
	journal = {DIAGNOSTICS},
	volume = {13},
	unique-id = {33542619},
	issn = {2075-4418},
	abstract = {Central nervous system (CNS) involvement is one of the numerous extraglandular manifestations of primary Sjögren’s syndrome (pSS). Moreover, neurological complaints precede the sicca symptoms in 25–60% of the cases. We review the magnetic resonance imaging (MRI) lesions typical for pSS, involving the conventional examination, volumetric and morphometric studies, diffusion tensor imaging (DTI) and resting-state fMRI. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, DTI and resting-state fMRI alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these MRI alterations are expectedly related to them. This relationship is not clearly delineated in conventional MRI studies, but DTI and resting-state fMRI examinations show more convincing correlations. In conclusion, the CNS manifestations of pSS do not follow a certain pattern. As the link between the MRI lesions and clinical manifestations is not well established, more studies involving larger populations should be performed to elucidate the correlations.},
	year = {2023},
	eissn = {2075-4418},
	pages = {14},
	orcid-numbers = {Módis, László/0000-0002-3813-5264}
}

@article{MTMT:33286181,
	title = {Oxyhemoglobin and cerebral blood flow transients detect infarction in rat focal brain ischemia},
	url = {https://m2.mtmt.hu/api/publication/33286181},
	author = {Lückl, János and Baker, Wesley and Boda, Krisztina and Emri, Miklós and YodhArjun G Yodh, Arjun G and Greenberg, Joel H},
	doi = {10.1016/j.neuroscience.2022.11.028},
	journal-iso = {NEUROSCIENCE},
	journal = {NEUROSCIENCE},
	volume = {509},
	unique-id = {33286181},
	issn = {0306-4522},
	abstract = {depolarizations (SD) refer to the near-complete depolarization of neurons that is associated with brain injuries such as ischemic stroke. The present gold standard for SD monitoring in humans is invasive electrocorticography (ECoG). A promising non-invasive alternative to ECoG is diffuse optical monitoring of SD -related flow and hemoglobin transients. To investigate the clinical utility of flow and hemoglobin transients, we analyzed their association with infarction in rat focal brain ischemia. Optical images of flow, oxy-hemoglobin, and deoxy-hemoglobin were continuously acquired with Laser Speckle and Optical Intrinsic Signal imaging for 2 h after photochemically induced distal middle cerebral artery occlusion in Sprague-Dawley rats (n = 10). Imag-ing was performed through a 6 x 6 mm window centered 3 mm posterior and 4 mm lateral to Bregma. Rats were sacrificed after 24 h, and the brain slices were stained for assessment of infarction. We mapped the infarcted area onto the imaging data and used nine circular regions of interest (ROI) to distinguish infarcted from non-infarcted tissue. Transients propagating through each ROI were characterized with six parameters (negative, positive, and total amplitude; negative and positive slope; duration). Transients were also classified into three morphology types (positive monophasic, biphasic, negative monophasic). Flow transient morphology, positive amplitude, positive slope, and total amplitude were all strongly associated with infarction (p < 0.001). Associations with infarction were also observed for oxy-hemoglobin morphology, oxy-hemoglobin positive amplitude and slope, and deoxy-hemoglobin positive slope and duration (all p < 0.01). These results suggest that flow and hemoglobin transients accompanying SD have value for detecting infarction.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.},
	year = {2023},
	eissn = {1873-7544},
	pages = {132-144},
	orcid-numbers = {Lückl, János/0000-0001-8094-771X; Boda, Krisztina/0000-0002-9937-0460}
}

@article{MTMT:33130191,
	title = {Topological dissimilarities of hierarchical resting networks in type 2 diabetes mellitus and obesity},
	url = {https://m2.mtmt.hu/api/publication/33130191},
	author = {Aranyi, Sándor Csaba and Képes, Zita and Nagy, Marianna and Opposits, Gábor and Garai, Ildikó and Káplár, Miklós and Emri, Miklós},
	doi = {10.1007/s10827-022-00833-9},
	journal-iso = {J COMPUT NEUROSCI},
	journal = {JOURNAL OF COMPUTATIONAL NEUROSCIENCE},
	volume = {51},
	unique-id = {33130191},
	issn = {0929-5313},
	abstract = {Type 2 diabetes mellitus (T2DM) is reported to cause widespread changes in brain function, leading to cognitive impairments. Research using resting-state functional magnetic resonance imaging data already aims to understand functional changes in complex brain connectivity systems. However, no previous studies with dynamic causal modelling (DCM) tried to investigate large-scale effective connectivity in diabetes. We aimed to examine the differences in large-scale resting state networks in diabetic and obese patients using combined DCM and graph theory methodologies. With the participation of 70 subjects (43 diabetics, 27 obese), we used cross-spectra DCM to estimate connectivity between 36 regions, subdivided into seven resting networks (RSN) commonly recognized in the literature. We assessed group-wise connectivity of T2DM and obesity, as well as group differences, with parametric empirical Bayes and Bayesian model reduction techniques. We analyzed network connectivity globally, between RSNs, and regionally. We found that average connection strength was higher in T2DM globally and between RSNs, as well. On the network level, the salience network shows stronger total within-network connectivity in diabetes (8.07) than in the obese group (4.02). Regionally, we measured the most significant average decrease in the right middle temporal gyrus (-0.013 Hz) and the right inferior parietal lobule (-0.01 Hz) relative to the obese group. In comparison, connectivity increased most notably in the left anterior prefrontal cortex (0.01 Hz) and the medial dorsal thalamus (0.009 Hz). In conclusion, we find the usage of complex analysis of large-scale networks suitable for diabetes instead of focusing on specific changes in brain function.},
	keywords = {OBESITY; type 2 diabetes mellitus; Graph theory; Effective connectivity; Dynamic causal modelling},
	year = {2023},
	eissn = {1573-6873},
	pages = {71-86},
	orcid-numbers = {Aranyi, Sándor Csaba/0000-0001-9569-5404; Képes, Zita/0000-0003-2889-8521}
}

@article{MTMT:33851325,
	title = {Healing through faith: meeting a chaplain coupled with biblical readings could produce lymphocyte changes that correlate with brain activity (HEALING study)},
	url = {https://m2.mtmt.hu/api/publication/33851325},
	author = {Béres, András and Emri, Miklós and Aranyi, Sándor Csaba and Fajtai, Dániel and Nagy, Ferenc and Szabó, Péter and Bödecs, Pál and Hörcsik, Edit and Perpékné Papp, Éva and Tomanek, Ferenc and Kuti, Márta and Petőfalviné, Ágnes and Kisdeákné, Hajnalka and Bíró, Gergely and Kovács, Dániel and Bakos, Bettina and Vinczen, Eszter and Gál, Eszter and Sillinger, Renáta and Szalai, Zoltán and Szilágyi, Antal and Kiss-Merki, Marianna and Nagyéri, György and Fodor, Judit and Németh, Tamás and Papp, Erzsébet and Repa, Imre},
	doi = {10.12688/f1000research.74504.4},
	journal-iso = {F1000RESEARCH},
	journal = {F1000RESEARCH},
	volume = {10},
	unique-id = {33851325},
	issn = {2046-1402},
	abstract = {Introduction: Faith and systems of beliefs are known to impact not only the emotional, but also the immunological state of believers in ways that we are just starting to understand. Moreover, clinical implications of previous studies are limited.  The aim of the “HEALING” (Hospital-based Ecumenical and Linguistic Immuno-NeuroloGic) Study was to examine immunological and neurological changes in hospitalized patients after meeting a chaplain coupled with biblical readings. Methods: Hospitalized patients were pre-screened to find those who were the most in need of an intervention. A passage from the Bible was read to them during a meeting with the chaplain at the bedside (n= 20) or in the chapel (n= 18). No meeting occurred in the randomized control group (n=19). Blood samples were taken 30 minutes prior, and 60 minutes after the meeting to measure white blood cells (WBC), interferon gamma (IFN-γ), immunoglobulin M (IgM), IgA, IgG, and complement 3 (C3). A subgroup of the visited patients was subjected to functional magnetic resonance imaging (fMRI), where they were played an audiotape of readings of the same passage from the Bible (n=21). Results: Lymphocyte counts increased more often after the more successful visits, but the immunological changes were not significant. Conversely, a significant (p fwe=0.003) correlation was revealed between changes in lymphocytes and activation of the angular gyrus (left BA39) during fMRI, a brain area involved in word recognition. Conclusions: Although limited by the sample size and cohort study design, the findings suggest the depth of psycho-immunological changes could depend on the degree to which the chaplains’ main message is understood.},
	year = {2022},
	orcid-numbers = {Béres, András/0000-0002-2585-4606; Aranyi, Sándor Csaba/0000-0001-9569-5404; Fajtai, Dániel/0000-0001-7591-3101}
}