@article{MTMT:34779723,
	title = {Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine},
	url = {https://m2.mtmt.hu/api/publication/34779723},
	author = {Eszlári, Nóra and Hullám, Gábor István and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, Andras and Baksa, Dániel and Gonda, Xénia and Antal, Peter and Bagdy, György and Juhász, Gabriella},
	doi = {10.1038/s41398-024-02867-2},
	journal-iso = {TRANSL PSYCHIAT},
	journal = {TRANSLATIONAL PSYCHIATRY},
	volume = {14},
	unique-id = {34779723},
	issn = {2158-3188},
	abstract = {Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n  = 149,879) and females ( n  = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression.},
	year = {2024},
	eissn = {2158-3188},
	orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@misc{MTMT:34631480,
	title = {Negative correlation between plasma kynurenine concentration and periaqueductal gray matter functional connectivity in migraine},
	url = {https://m2.mtmt.hu/api/publication/34631480},
	author = {Gecse, Kinga and A., Németh and G. G., Fedor and C. S., Aranyi and M., Emri and Kökönyei, Gyöngyi and Bagdy, György and Juhász, Gabriella},
	unique-id = {34631480},
	year = {2024},
	orcid-numbers = {Gecse, Kinga/0000-0002-3512-2572; Kökönyei, Gyöngyi/0000-0001-6750-2644; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34496842,
	title = {Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk},
	url = {https://m2.mtmt.hu/api/publication/34496842},
	author = {Kristóf, Zsüliet and Gál, Zsófia and Török, Dóra and Eszlári, Nóra and Sutori, Sara and Sperlágh, Beáta and Anderson, Ian M. and Deakin, Bill and Bagdy, György and Juhász, Gabriella and Gonda, Xénia},
	doi = {10.3390/ijms25020865},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34496842},
	issn = {1661-6596},
	abstract = {Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors on lifetime suicide attempts and current suicide risk markers. Overall, 1644 participants completed questionnaires assessing childhood adversities, recent negative life events, and provided information about previous suicide attempts and current suicide risk-related markers, including thoughts of ending their life, death, and hopelessness. Subjects were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into logistic and linear regression models, followed by a clumping procedure to identify clumps of SNPs with a significant main and interaction effect. We identified two significant clumps with a main effect on current suicidal ideation with top SNPs rs641940 and rs1653613. In interaction with childhood trauma, we identified a clump with top SNP psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP. Our results suggest that P2RX7 variation may mediate the effect of early childhood adversities and traumas on later emergence of suicide risk.},
	keywords = {STRESS; neuroinflammation; suicide; P2rx7; GxE interaction; childhood adversities; recent life events},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Kristóf, Zsüliet/0000-0001-5041-0444; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Eszlári, Nóra/0000-0003-4913-028X; Sutori, Sara/0000-0003-3468-0780; Deakin, Bill/0000-0002-2750-962X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Gonda, Xénia/0000-0001-9015-4203}
}

@article{MTMT:34631933,
	title = {Inverse relationship between trait-anxiety and periaqueductal grey connectivity in migraineurs compared to tension-type headache patients},
	url = {https://m2.mtmt.hu/api/publication/34631933},
	author = {Gecse, Kinga and Norbert, Károlyi and Angela, Hammer and Csaba, Sándor Aranyi and Miklos, Emri and Bagdy, György and Juhász, Gabriella},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {43},
	unique-id = {34631933},
	issn = {0333-1024},
	year = {2023},
	eissn = {1468-2982},
	pages = {198-199},
	orcid-numbers = {Gecse, Kinga/0000-0002-3512-2572; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34631855,
	title = {Machine-learning based drug-drug interaction prediction identifies acetylsalicylic acid as risk for cardiovascular events during migraine treatment},
	url = {https://m2.mtmt.hu/api/publication/34631855},
	author = {Gecse, Kinga and Duc, Anh Nguyen and Juhász, Gabriella and Hiroshi, Mamitsuka and Petschner, Péter},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {43},
	unique-id = {34631855},
	issn = {0333-1024},
	year = {2023},
	eissn = {1468-2982},
	pages = {76},
	orcid-numbers = {Gecse, Kinga/0000-0002-3512-2572; Juhász, Gabriella/0000-0002-5975-4267; Petschner, Péter/0000-0002-3198-858X}
}

@article{MTMT:34631775,
	title = {Uncovering Potential Interictal Suppression of ERK Cascade and miR-21 in Migraine Patients: Insights from RNA-Seq Analysis},
	url = {https://m2.mtmt.hu/api/publication/34631775},
	author = {Kumar, Sahel and Gecse, Kinga and Baksa, Dániel and Bagdy, György and Juhász, Gabriella and Petschner, Péter},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {43},
	unique-id = {34631775},
	issn = {0333-1024},
	year = {2023},
	eissn = {1468-2982},
	pages = {76-77},
	orcid-numbers = {Kumar, Sahel/0000-0003-2108-2992; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Petschner, Péter/0000-0002-3198-858X}
}

@article{MTMT:34631657,
	title = {Headache-Related Quality of Life Associates Differently with Emotional Processing in Migraine and Tension-Type Headache Patients – an fMRI Study},
	url = {https://m2.mtmt.hu/api/publication/34631657},
	author = {Dobos, Dóra and Gecse, Kinga and Szabó, Edina and Baksa, Dániel and Kocsel, Natália and Galambos, Attila and Kökönyei, Gyöngyi and Juhász, Gabriella},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {43},
	unique-id = {34631657},
	issn = {0333-1024},
	year = {2023},
	eissn = {1468-2982},
	pages = {196-197},
	orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Gecse, Kinga/0000-0002-3512-2572; Szabó, Edina/0000-0003-4087-5373; Baksa, Dániel/0000-0002-7826-9179; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Kökönyei, Gyöngyi/0000-0001-6750-2644; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34478390,
	title = {A sound mind in a sound body a novel concept unravelling heterogeneity of depression.},
	url = {https://m2.mtmt.hu/api/publication/34478390},
	author = {Hullám, Gábor István and Gál, Zsófia and Gonda, Xénia and Nagy, Tamás and Gézsi, András and Cano, Isaac and Van der Auwera, Sandra and Koukkanen, Mikko and Antal, Péter and Juhász, Gabriella},
	journal-iso = {NEUROPSYCHOPHARM HUNG},
	journal = {NEUROPSYCHOPHARMACOLOGIA HUNGARICA},
	volume = {25},
	unique-id = {34478390},
	issn = {1419-8711},
	abstract = {Depression is a highly prevalent and debilitating condition, yet we still lack both in-depth knowledge concerning its etiopathology and sufficiently efficacious treatment options. With approximately one third of patients resistant to currently available antidepressants there is a pressing need for a better understanding of depression, identifying subgroups within the highly heterogeneous illness category and to understand the divergent underlying biology of such subtypes, to help develop and personalise treatments. The TRAJECTOME project aims to address such challenges by (1) identifying depression-related multimorbidity subgroups and shared molecular pathways based on temporal disease profiles from healthcare systems and biobank data using machine learning approaches, and by (2) characterising these subgroups from multiple aspects including genetic variants, metabolic processes, lifestyle and environmental factors. Following the identification of multimorbidity trajectories, a disease burden score related to depression and adjusted for multimorbidity was established summarising the current state of the patient to weigh the molecular mechanisms associated with depression. In addition, the role of genetic and environmental factors, and also their interactions were identified for all subgroups. The project also attempted to identify potential metabolomic markers for the early diagnostics of these multimorbidity conditions. Finally, we prioritized molecular drug candidates matching the multimorbidity pathways indicated for the individual subgroups which would potentially offer personalised treatment simultaneously for the observable multimorbid conditions yet minimising polypharmacy and related side effects. The present paper overviews the TRAJECTOME project including its aims, tasks, procedures and accomplishments. (Neuropsychopharmacol Hung 2023; 25(4): 183-193)},
	keywords = {GENETICS; DEPRESSION; metabolomics; Multimorbidity; machine learning.},
	year = {2023},
	pages = {183-193},
	orcid-numbers = {Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Gonda, Xénia/0000-0001-9015-4203; Nagy, Tamás/0000-0002-0137-4341; Gézsi, András/0000-0003-1022-6356; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34474549,
	title = {Microstructural differences in migraine: A diffusion-tensor imaging study},
	url = {https://m2.mtmt.hu/api/publication/34474549},
	author = {Dobos, Dóra and Kökönyei, Gyöngyi and Gyebnár, Gyula and Szabó, Edina and Kocsel, Natália and Galambos, Attila and Gecse, Kinga and Baksa, Dániel and Kozák, Lajos Rudolf and Juhász, Gabriella},
	doi = {10.1177/03331024231216456},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {43},
	unique-id = {34474549},
	issn = {0333-1024},
	year = {2023},
	eissn = {1468-2982},
	orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Kökönyei, Gyöngyi/0000-0001-6750-2644; Szabó, Edina/0000-0003-4087-5373; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179; Kozák, Lajos Rudolf/0000-0003-0368-3663; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34186094,
	title = {A migrén és a táplálkozás kapcsolata},
	url = {https://m2.mtmt.hu/api/publication/34186094},
	author = {Rimek, Adrienn Dóra and Gecse, Kinga and Juhász, Gabriella},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {67},
	unique-id = {34186094},
	issn = {0017-6036},
	year = {2023},
	pages = {420-426},
	orcid-numbers = {Gecse, Kinga/0000-0002-3512-2572; Juhász, Gabriella/0000-0002-5975-4267}
}