TY - JOUR AU - Eitmann, Szimonetta AU - Mátrai, Péter AU - Hegyi, Péter AU - Balaskó, Márta AU - Erőss, Bálint Mihály AU - Dorogi, Kira AU - Pétervári, Erika TI - Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis JF - AGEING RESEARCH REVIEWS J2 - AGEING RES REV VL - 93 PY - 2024 PG - 20 SN - 1568-1637 DO - 10.1016/j.arr.2023.102164 UR - https://m2.mtmt.hu/api/publication/34453597 ID - 34453597 AB - The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dóra Krisztina AU - Eitmann, Szimonetta AU - Berta, Gergely AU - Kormos, Viktória AU - Gaszner, Balázs AU - Pétervári, Erika AU - Balaskó, Márta TI - Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 10 PG - 15 SN - 1661-6596 DO - 10.3390/ijms24108992 UR - https://m2.mtmt.hu/api/publication/33937641 ID - 33937641 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pecs, 7624, Hungary Department of Medical Biology, Medical School, University of Pécs, Szigeti út 12, Pecs, 7624, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pecs, 7624, Hungary Department of Anatomy, Medical School, University of Pécs, Szigeti út 12, Pecs, 7624, Hungary Export Date: 6 September 2023 Correspondence Address: Balaskó, M.; Institute for Translational Medicine, Szigeti út 12, Hungary; email: marta.balasko@aok.pte.hu AB - Middle-aged obesity and aging cachexia present healthcare challenges. Central responsiveness to body-weight-reducing mediators, e.g., to leptin, changes during aging in a way, which may promote middle-aged obesity and aging cachexia. Leptin is connected to urocortin 2 (Ucn2), an anorexigenic and hypermetabolic member of the corticotropin family. We aimed to study the role of Ucn2 in middle-aged obesity and aging cachexia. The food intake, body weight and hypermetabolic responses (oxygen consumption, core temperature) of male Wistar rats (3, 6, 12 and 18 months) were tested following intracerebroventricular injections of Ucn2. Following one central injection, Ucn2-induced anorexia lasted for 9 days in the 3-month, 14 days in the 6-month and 2 days in the 18-month group. Middle-aged 12-month rats failed to show anorexia or weight loss. Weight loss was transient (4 days) in the 3-month, 14 days in the 6-month and slight but long-lasting in the 18-month rats. Ucn2-induced hypermetabolism and hyperthermia increased with aging. The age-dependent changes in the mRNA expression of Ucn2 detected by RNAscope in the paraventricular nucleus correlated with the anorexigenic responsiveness. Our results show that age-dependent changes in Ucn2 may contribute to middle-aged obesity and aging cachexia. Ucn2 shows potential in the prevention of middle-aged obesity. LA - English DB - MTMT ER - TY - JOUR AU - Kőrösi, Eszter AU - Biró, Botond AU - Kovács, Dóra Krisztina AU - Pétervári, Erika AU - Balaskó, Márta TI - 12 hetes treadmill tréning hatása a centrális hyperthermiás corticotropin-hatások korfüggő eltéréseire középkorú patkányokban JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - 20 PY - 2022 IS - Suppl. 1 SP - S20 EP - S20 SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/33331690 ID - 33331690 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Marcell AU - Eitmann, Szimonetta AU - Baksa, Franciska AU - Szigeti, Lilla AU - Jessica, Seetge AU - Balaskó, Márta AU - Pétervári, Erika TI - Intranazális étvágycsökkentő kezelés új célpontjai: a galanin peptidcsalád vizsgálata patkányban JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - 20 PY - 2022 IS - Suppl. 1 SP - S22 EP - S22 SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/33331563 ID - 33331563 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta AU - Balaskó, Márta AU - Pétervári, Erika TI - Az anyai túltáplálás fokozza-e az utód inzulinrezisztenciára való hajlamát? JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - 20 PY - 2022 IS - Suppl. 1 SP - S21 EP - S22 SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/33330408 ID - 33330408 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Baksa, Franciska AU - Eitmann, Szimonetta AU - Szigeti, Lilla AU - Kovács, Marcell AU - Jeesica, Seetge AU - Balaskó, Márta AU - Pétervári, Erika TI - Az anyai túltáplálás az utódban valóban korai elhízáshoz és felgyorsult öregedéshez vezet? JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - 20 PY - 2022 IS - Suppl. 1 SP - S21 SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/33329223 ID - 33329223 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pétervári, Erika AU - Molnár, Andrea TI - Sarcopenia és esendőség ― Felmérés és kezelés a gyakorlatban JF - MEDICAL TRIBUNE J2 - MEDICAL TRIBUNE VL - 20 PY - 2022 IS - 11 SP - 16 EP - 17 PG - 2 SN - 1589-1283 UR - https://m2.mtmt.hu/api/publication/33313766 ID - 33313766 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Molnár, Andrea AU - Pétervári, Erika AU - Székács, Béla TI - Összefoglaló dietetikusok számár a a multimorbid, geriátriai betegek ellátásáról és kezeléséről szóló szakmai irányelvből JF - ÚJ DIÉTA: A MAGYAR DIETETIKUSOK LAPJA (2001-) J2 - ÚJ DIÉTA (GYŐR) (2001) VL - 2022 PY - 2022 IS - 3 SP - 24 EP - 26 PG - 3 SN - 1587-169X UR - https://m2.mtmt.hu/api/publication/33313546 ID - 33313546 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pétervári, Erika TI - Szakmai irányelv a multimorbid geriátriai betegek ellátásáról és kezeléséről. Irányelv-bemutató TS - Irányelv-bemutató JF - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE J2 - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE VL - 27 PY - 2022 IS - 5 SP - 319 EP - 322 PG - 4 SN - 1219-8641 UR - https://m2.mtmt.hu/api/publication/32889613 ID - 32889613 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ruzsics, István AU - Mátrai, Péter AU - Hegyi, Péter AU - Németh, Dávid AU - Tenk, Judit AU - Csenkey, Alexandra AU - Erőss, Bálint Mihály AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika AU - Veres, Gábor AU - Sepp, Róbert AU - Rakonczay, Zoltán AU - Vincze, Áron AU - Garami, András AU - Rumbus, Zoltán TI - Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis JF - JOURNAL OF INFECTION AND PUBLIC HEALTH J2 - J INFECT PUBLIC HEALTH VL - 15 PY - 2022 IS - 3 SP - 349 EP - 359 PG - 11 SN - 1876-0341 DO - 10.1016/j.jiph.2022.02.004 UR - https://m2.mtmt.hu/api/publication/32692193 ID - 32692193 AB - Background Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults. Methods We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis. Results With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13–1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07–0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08–0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09–0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03–0.46; P = 0.002). Conclusion NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis. Availability of data and materials All data and materials generated during the current study are available from the corresponding author on reasonable request. LA - English DB - MTMT ER -