@article{MTMT:34453597, title = {Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34453597}, author = {Eitmann, Szimonetta and Mátrai, Péter and Hegyi, Péter and Balaskó, Márta and Erőss, Bálint Mihály and Dorogi, Kira and Pétervári, Erika}, doi = {10.1016/j.arr.2023.102164}, journal-iso = {AGEING RES REV}, journal = {AGEING RESEARCH REVIEWS}, volume = {93}, unique-id = {34453597}, issn = {1568-1637}, abstract = {The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO.}, keywords = {Body Mass Index; Sarcopenia; fat mass; Sarcopenic obesity; Biological aging; [Meta-analysis]}, year = {2024}, eissn = {1872-9649}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33937641, title = {Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats}, url = {https://m2.mtmt.hu/api/publication/33937641}, author = {Kovács, Dóra Krisztina and Eitmann, Szimonetta and Berta, Gergely and Kormos, Viktória and Gaszner, Balázs and Pétervári, Erika and Balaskó, Márta}, doi = {10.3390/ijms24108992}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33937641}, issn = {1661-6596}, abstract = {Middle-aged obesity and aging cachexia present healthcare challenges. Central responsiveness to body-weight-reducing mediators, e.g., to leptin, changes during aging in a way, which may promote middle-aged obesity and aging cachexia. Leptin is connected to urocortin 2 (Ucn2), an anorexigenic and hypermetabolic member of the corticotropin family. We aimed to study the role of Ucn2 in middle-aged obesity and aging cachexia. The food intake, body weight and hypermetabolic responses (oxygen consumption, core temperature) of male Wistar rats (3, 6, 12 and 18 months) were tested following intracerebroventricular injections of Ucn2. Following one central injection, Ucn2-induced anorexia lasted for 9 days in the 3-month, 14 days in the 6-month and 2 days in the 18-month group. Middle-aged 12-month rats failed to show anorexia or weight loss. Weight loss was transient (4 days) in the 3-month, 14 days in the 6-month and slight but long-lasting in the 18-month rats. Ucn2-induced hypermetabolism and hyperthermia increased with aging. The age-dependent changes in the mRNA expression of Ucn2 detected by RNAscope in the paraventricular nucleus correlated with the anorexigenic responsiveness. Our results show that age-dependent changes in Ucn2 may contribute to middle-aged obesity and aging cachexia. Ucn2 shows potential in the prevention of middle-aged obesity.}, keywords = {OBESITY; Aging; Weight Loss; Metabolic rate; Urocortin 2}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Kovács, Dóra Krisztina/0000-0001-5152-2069; Gaszner, Balázs/0000-0003-2830-2732; Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33331690, title = {12 hetes treadmill tréning hatása a centrális hyperthermiás corticotropin-hatások korfüggő eltéréseire középkorú patkányokban}, url = {https://m2.mtmt.hu/api/publication/33331690}, author = {Kőrösi, Eszter and Biró, Botond and Kovács, Dóra Krisztina and Pétervári, Erika and Balaskó, Márta}, journal-iso = {OBESIT HUNG}, journal = {OBESITOLOGIA HUNGARICA}, volume = {20}, unique-id = {33331690}, issn = {1586-7935}, year = {2022}, pages = {S20-S20}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33331563, title = {Intranazális étvágycsökkentő kezelés új célpontjai: a galanin peptidcsalád vizsgálata patkányban}, url = {https://m2.mtmt.hu/api/publication/33331563}, author = {Kovács, Marcell and Eitmann, Szimonetta and Baksa, Franciska and Szigeti, Lilla and Jessica, Seetge and Balaskó, Márta and Pétervári, Erika}, journal-iso = {OBESIT HUNG}, journal = {OBESITOLOGIA HUNGARICA}, volume = {20}, unique-id = {33331563}, issn = {1586-7935}, year = {2022}, pages = {S22-S22}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33330408, title = {Az anyai túltáplálás fokozza-e az utód inzulinrezisztenciára való hajlamát?}, url = {https://m2.mtmt.hu/api/publication/33330408}, author = {Eitmann, Szimonetta and Balaskó, Márta and Pétervári, Erika}, journal-iso = {OBESIT HUNG}, journal = {OBESITOLOGIA HUNGARICA}, volume = {20}, unique-id = {33330408}, issn = {1586-7935}, year = {2022}, pages = {S21-S22}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33329223, title = {Az anyai túltáplálás az utódban valóban korai elhízáshoz és felgyorsult öregedéshez vezet?}, url = {https://m2.mtmt.hu/api/publication/33329223}, author = {Baksa, Franciska and Eitmann, Szimonetta and Szigeti, Lilla and Kovács, Marcell and Jeesica, Seetge and Balaskó, Márta and Pétervári, Erika}, journal-iso = {OBESIT HUNG}, journal = {OBESITOLOGIA HUNGARICA}, volume = {20}, unique-id = {33329223}, issn = {1586-7935}, year = {2022}, pages = {S21}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33313766, title = {Sarcopenia és esendőség ― Felmérés és kezelés a gyakorlatban}, url = {https://m2.mtmt.hu/api/publication/33313766}, author = {Pétervári, Erika and Molnár, Andrea}, journal-iso = {MEDICAL TRIBUNE}, journal = {MEDICAL TRIBUNE}, volume = {20}, unique-id = {33313766}, issn = {1589-1283}, year = {2022}, pages = {16-17}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:33313546, title = {Összefoglaló dietetikusok számár a a multimorbid, geriátriai betegek ellátásáról és kezeléséről szóló szakmai irányelvből}, url = {https://m2.mtmt.hu/api/publication/33313546}, author = {Molnár, Andrea and Pétervári, Erika and Székács, Béla}, journal-iso = {ÚJ DIÉTA (GYŐR) (2001)}, journal = {ÚJ DIÉTA: A MAGYAR DIETETIKUSOK LAPJA (2001-)}, volume = {2022}, unique-id = {33313546}, issn = {1587-169X}, year = {2022}, pages = {24-26}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:32889613, title = {Szakmai irányelv a multimorbid geriátriai betegek ellátásáról és kezeléséről. Irányelv-bemutató}, url = {https://m2.mtmt.hu/api/publication/32889613}, author = {Pétervári, Erika}, journal-iso = {HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE}, journal = {HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE}, volume = {27}, unique-id = {32889613}, issn = {1219-8641}, year = {2022}, pages = {319-322}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:32692193, title = {Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/32692193}, author = {Ruzsics, István and Mátrai, Péter and Hegyi, Péter and Németh, Dávid and Tenk, Judit and Csenkey, Alexandra and Erőss, Bálint Mihály and Varga, Gábor and Balaskó, Márta and Pétervári, Erika and Veres, Gábor and Sepp, Róbert and Rakonczay, Zoltán and Vincze, Áron and Garami, András and Rumbus, Zoltán}, doi = {10.1016/j.jiph.2022.02.004}, journal-iso = {J INFECT PUBLIC HEALTH}, journal = {JOURNAL OF INFECTION AND PUBLIC HEALTH}, volume = {15}, unique-id = {32692193}, issn = {1876-0341}, abstract = {Background Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults. Methods We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis. Results With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13–1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07–0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08–0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09–0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03–0.46; P = 0.002). Conclusion NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis. Availability of data and materials All data and materials generated during the current study are available from the corresponding author on reasonable request.}, keywords = {MORTALITY; Meta-analysis; pneumonia; Noninvasive ventilation; INVASIVE VENTILATION; [Meta-analysis]}, year = {2022}, eissn = {1876-035X}, pages = {349-359}, orcid-numbers = {Ruzsics, István/0000-0002-6381-8884; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Varga, Gábor/0000-0002-5506-8198; Pétervári, Erika/0000-0002-3673-8491; Veres, Gábor/0000-0002-0911-1941; Sepp, Róbert/0000-0003-4964-1661; Rakonczay, Zoltán/0000-0002-1499-3416; Vincze, Áron/0000-0003-2217-7686; Garami, András/0000-0003-2493-0571} }