@article{MTMT:33704619,
	title = {Maximum likelihood-based estimation of diffusion coefficient is quick and reliable method for analyzing estradiol actions on surface receptor movements},
	url = {https://m2.mtmt.hu/api/publication/33704619},
	author = {Makkai, Géza and Ábrahám, István and Barabás, Klaudia and Godó, Soma and Ernszt, Dávid and Kovács, Tamás and Kovács, Gergely and Szőcs, Szilárd and Jánosi, Tibor Zoltán},
	doi = {10.3389/fninf.2023.1005936},
	journal-iso = {FRONT NEUROINFORM},
	journal = {FRONTIERS IN NEUROINFORMATICS},
	volume = {17},
	unique-id = {33704619},
	abstract = {The rapid effects of estradiol on membrane receptors are in the focus of the estradiol research field, however, the molecular mechanisms of these non-classical estradiol actions are poorly understood. Since the lateral diffusion of membrane receptors is an important indicator of their function, a deeper understanding of the underlying mechanisms of non-classical estradiol actions can be achieved by investigating receptor dynamics. Diffusion coefficient is a crucial and widely used parameter to characterize the movement of receptors in the cell membrane. The aim of this study was to investigate the differences between maximum likelihood-based estimation (MLE) and mean square displacement (MSD) based calculation of diffusion coefficients. In this work we applied both MSD and MLE to calculate diffusion coefficients. Single particle trajectories were extracted from simulation as well as from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor tracking in live estradiol-treated differentiated PC12 (dPC12) cells. The comparison of the obtained diffusion coefficients revealed the superiority of MLE over the generally used MSD analysis. Our results suggest the use of the MLE of diffusion coefficients because as it has a better performance, especially for large localization errors or slow receptor movements.},
	year = {2023},
	eissn = {1662-5196}
}

@article{MTMT:32235080,
	title = {Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons},
	url = {https://m2.mtmt.hu/api/publication/32235080},
	author = {Godó, Soma and Barabás, Klaudia and Lengyel, Ferenc and Ernszt, Dávid and Kovács, Tamás and Kecskés, Miklós and Varga, Csaba and Jánosi, Tibor Zoltán and Makkai, Géza and Kovács, Gergely and Orsolits, Barbara and Fujiwara, Takahiro and Kusumi, Akihiro and Ábrahám, István},
	doi = {10.3389/fcell.2021.708715},
	journal-iso = {FRONT CELL DEV BIOL},
	journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
	volume = {9},
	unique-id = {32235080},
	issn = {2296-634X},
	abstract = {Gonadal steroid 17β-estradiol (E2) exerts rapid, non-genomic effects on neurons and strictly regulates learning and memory through altering glutamatergic neurotransmission and synaptic plasticity. However, its non-genomic effects on AMPARs are not well understood. Here, we analyzed the rapid effect of E2 on AMPARs using single-molecule tracking and super-resolution imaging techniques. We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner. The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR. E2 also decreased the surface movement of AMPAR both in synaptic and extrasynaptic regions on neurites and increased the synaptic dwell time of AMPARs. Our results provide evidence for understanding E2 action on neuronal plasticity and glutamatergic neurotransmission at the molecular level.},
	year = {2021},
	eissn = {2296-634X}
}

@article{MTMT:31848850,
	title = {Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation},
	url = {https://m2.mtmt.hu/api/publication/31848850},
	author = {Horváth, Ádám and Payrits, Maja and Steib, Anita and Kántás, Boglárka and Biró-Sütő, Tünde and Erostyák, János and Makkai, Géza and Sághy, Éva and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3389/fphar.2020.593319},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {11},
	unique-id = {31848850},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461}
}

@inproceedings{MTMT:31887429,
	title = {Magnéziummal adalékolt sztöchiometrikus lítium- niobát hőméréskletfüggő dielektromos paraméterei a terahertzes tartományon},
	url = {https://m2.mtmt.hu/api/publication/31887429},
	author = {Buzády, Andrea and Gálos, Réka and Makkai, Géza and Xiaojun, Wu and Tóth, György and Kovács, László and Almási, Gábor and Hebling, János and Pálfalvi, László},
	booktitle = {Kvantumelektronika 2021},
	doi = {10.14232/kvantumelektronika.9.5},
	unique-id = {31887429},
	year = {2020},
	pages = {25-30},
	orcid-numbers = {Makkai, Géza/0000-0001-5579-167X; Tóth, György/0000-0002-9255-7281; Kovács, László/0000-0001-6388-0496; Hebling, János/0000-0001-9669-2977; Pálfalvi, László/0000-0003-0955-6569}
}

@article{MTMT:31625361,
	title = {In vitro and in vivo evidence for the role of lipid rafts in Ca2+-gating of the Transient Receptor Potential channels in sensory neurons},
	url = {https://m2.mtmt.hu/api/publication/31625361},
	author = {Szőke, Éva and Horvath, Adam and Biró-Sütő, Tünde and Sághy, Éva and Payrits, Maja and Erostyák, János and Makkai, Géza and Szolcsányi, János and Helyes, Zsuzsanna},
	doi = {10.1096/fasebj.2020.34.s1.05167},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {34},
	unique-id = {31625361},
	issn = {0892-6638},
	keywords = {Biology; Biochemistry & Molecular Biology},
	year = {2020},
	eissn = {1530-6860},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461}
}

@article{MTMT:31387590,
	title = {Resolvin D1 and D2 inhibit transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation on sensory neurons via lipid raft modification},
	url = {https://m2.mtmt.hu/api/publication/31387590},
	author = {Payrits, Maja and Horváth, Ádám and Biró-Sütő, Tünde and Erostyák, János and Makkai, Géza and Sághy, Éva and Pohóczky, Krisztina and Kecskés, Angéla and Kecskés, Miklós and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3390/ijms21145019},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31387590},
	issn = {1661-6596},
	abstract = {Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolvin D1 (RvD1) is described as a selective inhibitor of TRPA1-related postoperative and inflammatory pain in mice acting on the G protein-coupled receptor DRV1/GPR32. Resolvin D2 (RvD2) is a very potent TRPV1 and TRPA1 inhibitor in DRG neurons, and decreases inflammatory pain in mice acting on the GPR18 receptor, via TRPV1/TRPA1-independent mechanisms. We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively. We showed that RvD1 and RvD2 in nanomolar concentrations significantly decreased TRPV1 and TRPA1 activation on sensory neurons by fluorescent calcium imaging and inhibited the CAPS-and AITC-evoked45Ca-uptake on TRPV1-and TRPA1-expressing CHO cells. Since CHO cells are unlikely to express resolvin receptors, resolvins are suggested to inhibit channel opening through surrounding lipid raft disruption. Here, we proved the ability of resolvins to alter the membrane polarity related to cholesterol composition by fluorescence spectroscopy. It is concluded that targeting lipid raft integrity can open novel peripheral analgesic opportunities by decreasing the activation of nociceptors. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.},
	keywords = {LIPID RAFTS; transient receptor potential channel; sensory neuron; resolvin D1; nerve terminal; Resolvin D2},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Pohóczky, Krisztina/0000-0003-0385-5162}
}

@article{MTMT:31278977,
	title = {Temperature-dependent terahertz time-domain spectroscopy study of Mg-doped stoichiometric lithium niobate},
	url = {https://m2.mtmt.hu/api/publication/31278977},
	author = {Buzády, Andrea and Gálos, R. and Makkai, Géza and Wu, X. and Tóth, György and Kovács, László and Almási, Gábor and Hebling, János and Pálfalvi, László},
	doi = {10.1364/OME.384997},
	journal-iso = {OPT MATER EXPRESS},
	journal = {OPTICAL MATERIALS EXPRESS},
	volume = {10},
	unique-id = {31278977},
	issn = {2159-3930},
	year = {2020},
	pages = {998-1006},
	orcid-numbers = {Tóth, György/0000-0003-3179-0319; Kovács, László/0000-0001-6388-0496}
}

@article{MTMT:30545067,
	title = {Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways},
	url = {https://m2.mtmt.hu/api/publication/30545067},
	author = {Chisholm, David R. and Tomlinson, Charles W. E. and Zhou, Garr-Layy and Holden, Claire and Affleck, Valerie and Lamb, Rebecca and Newling, Katherine and Ashton, Peter and Valentine, Roy and Redfern, Christopher and Erostyák, János and Makkai, Géza and Ambler, Carrie A. and Whiting, Andrew and Pohl, Ehmke},
	doi = {10.1021/acschembio.8b00916},
	journal-iso = {ACS CHEM BIOL},
	journal = {ACS CHEMICAL BIOLOGY},
	volume = {14},
	unique-id = {30545067},
	issn = {1554-8929},
	year = {2019},
	eissn = {1554-8937},
	pages = {369-377}
}

@article{MTMT:3402940,
	title = {Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by lipid raft modulation.},
	url = {https://m2.mtmt.hu/api/publication/3402940},
	author = {Sághy, Éva and Payrits, Maja and Biro-Suto, T and Skodáné Földes, Rita and Szánti-Pintér, Eszter and Erostyák, János and Makkai, Géza and Sétáló, György (ifj.) and Kollár, László and Kőszegi, Tamás and Jakabfi-Csepregi, Rita and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.1194/jlr.M084723},
	journal-iso = {J LIPID RES},
	journal = {JOURNAL OF LIPID RESEARCH},
	volume = {59},
	unique-id = {3402940},
	issn = {0022-2275},
	abstract = {Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 and TRP Ankyrin 1 (TRPV1 and TRPA1) are expressed on primary sensory neurons. These thermosensor channels play role in pain processing. We provided evidence that lipid raft disruption influenced the TRP channel activation and a carboxamido-steroid compound (C1) inhibited TRPV1 activation. Therefore, our aim was to investigate whether this compound exerts its effect through lipid raft disruption and the steroid backbone (C3) or altered position of the carboxamido group (C2) influence the inhibitory action by measuring Ca2+-transients on isolated neurons and calcium-uptake on receptor-expressing CHO cells. Membrane cholesterol content was measured by filipin staining and membrane polarisation by fluorescence spectroscopy. Both the percentage of responsive cells and the magnitude of the intracellular Ca2+-enhancement evoked by the TRPV1 agonist capsaicin were significantly inhibited after C1 and C2 incubation, but not after C3 administration. C1 was able to reduce other TRP channel activation as well. The compounds induced cholesterol depletion in CHO cells, but only C1 induced changes in membrane polarisation. The inhibitory action of the compounds on TRP channel activation develops by lipid raft disruption, and the presence and the position of the carboxamido group is essential.},
	keywords = {CELL-LINE; ACTIVATION; NICOTINIC ACETYLCHOLINE-RECEPTOR; ROOT GANGLION NEURONS; LIPID RAFTS; steroid; transient receptor potential channel; TRPV1 receptor; sensory neuron; Cation channels; nerve terminal; TRIGEMINAL SENSORY NEURONS; ALPHA-SPINASTEROL; SCREEN REVEALS},
	year = {2018},
	eissn = {1539-7262},
	pages = {1851-1863},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Skodáné Földes, Rita/0000-0002-9810-1509; Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:3000846,
	title = {Light-Enhanced Fluorescence of Multi-Level Cavitands Possessing Pyridazine Upper rim},
	url = {https://m2.mtmt.hu/api/publication/3000846},
	author = {Jánosi, Tibor Zoltán and Makkai, Géza and Kégl, Tímea and Mátyus, Péter and Kollár, László and Erostyák, János},
	doi = {10.1007/s10895-015-1754-3},
	journal-iso = {J FLUORESC},
	journal = {JOURNAL OF FLUORESCENCE},
	volume = {26},
	unique-id = {3000846},
	issn = {1053-0509},
	year = {2016},
	eissn = {1573-4994},
	pages = {679-688},
	orcid-numbers = {Mátyus, Péter/0000-0003-3963-9445}
}