TY  - JOUR
ED  - Cs., Nagy Gábor / Arranged for publication by
AU  - Szabó, Zoltán
AU  - Forgács, József
AU  - Kertész, Éva
AU  - Bagoly, Gabriella
AU  - Kálmánczhelyiné, Sipos Anikó
AU  - Leskovicsné, Meszesán Katalin
AU  - Cs., Nagy Gábor
AU  - Kiss, Tamás
TI  - Egy 70 éves intézmény
JF  - MAGYAR KÉMIKUSOK LAPJA
J2  - MAGY KEM LAP
VL  - 76
PY  - 2021
IS  - 12
SP  - 367
EP  - 379
PG  - 13
SN  - 0025-0163
UR  - https://m2.mtmt.hu/api/publication/32598373
ID  - 32598373
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Balázs, Csaba
AU  - Kupihár, Zoltán
AU  - Kele, Zoltán
AU  - Szabó, Zoltán
AU  - Ferenc, Györgyi
AU  - Kovács, Lajos
TI  - Quadruplex forming of oligonucleotides containing 2'-deoxy-5-hydroxyuridine
ET  - 0
PY  - 2018
UR  - https://m2.mtmt.hu/api/publication/30427692
ID  - 30427692
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Ferenc, Györgyi
AU  - Balázs, Csaba
AU  - Paragi, Gábor
AU  - Kupihár, Zoltán
AU  - Kele, Zoltán
AU  - Szabó, Zoltán
AU  - Kovács, Lajos
TI  - Study of the quadruplex-forming properties of 2’-deoxy-5-hydroxyuridine-containing oligonucleotides
T2  - Straub-Napok
PY  - 2018
SP  - 22
UR  - https://m2.mtmt.hu/api/publication/30426990
ID  - 30426990
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, Zoltán
AU  - Guttman, András
AU  - Bones, Jonathan
AU  - Karger, Barry L
TI  - Rapid High-Resolution Characterization of Functionally Important Monoclonal Antibody N-Glycans by Capillary Electrophoresis
JF  - ANALYTICAL CHEMISTRY
J2  - ANAL CHEM
VL  - 83
PY  - 2011
IS  - 13
SP  - 5329
EP  - 5336
PG  - 8
SN  - 0003-2700
DO  - 10.1021/ac2007587
UR  - https://m2.mtmt.hu/api/publication/1615481
ID  - 1615481
AB  - Characterization of the N-glycosylation present in the Fc region of therapeutic monoclonal antibodies requires rapid, high-resolution separation methods to guarantee product safety and efficacy during all stages of process development. Determination of fucosylated oligosaccharides is particularly important during clone selection, product characterization, and lot release as fucose has been shown to adversely affect the ability of mAbs to induce antibody dependent cellular cytotoxicity (ADCC). Here, we apply a general capillary electrophoresis optimization strategy to separate functionally relevant fucosylated and afucosylated glycans on mononclonal antibody products in the presence of several high mannose oligosaccharides. The N-glycans chosen represent those most commonly reported on CHO cell derived therapeutic antibodies. A rapid (<7 min) high-resolution separation of 12 commonly reported and functionally important IgG glycans was developed by systematically evaluating the effects of selectivity (boric acid) and efficiency (linear polyacrylamide) enhancing additives. The approach can be used to rapidly optimize capillary electrophoresis separation of other glycan mixtures. Following optimization, the method was applied to overnight sample processing for automated 96 well plate-based glycosylation analyses of two nonproprietary therapeutic monoclonal antibodies, demonstrating ruggedness and suitability for high-throughput process and product monitoring applications.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kilár, Anikó
AU  - Dörnyei, Ágnes
AU  - Bui, Annamária
AU  - Szabó, Zoltán
AU  - Kocsis, Béla
AU  - Kilár, Ferenc
TI  - Structural variability of endotoxins from R-type isogenic mutants of Shigella sonnei
JF  - JOURNAL OF MASS SPECTROMETRY
J2  - J MASS SPECTROM
VL  - 46
PY  - 2011
IS  - 1
SP  - 61
EP  - 70
PG  - 10
SN  - 1076-5174
DO  - 10.1002/jms.1863
UR  - https://m2.mtmt.hu/api/publication/1401397
ID  - 1401397
N1  - Export Date: 27 January 2024; CODEN: JMSPF
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Jámbor, Éva
AU  - Böddi, Katalin
AU  - Németh, V
AU  - Tóth, G
AU  - Tóth, Cs
AU  - Szabó, Zoltán
AU  - Márk, László
TI  - MALDI TOF Analysis of an Ancient Bone Cancer
PY  - 2010
UR  - https://m2.mtmt.hu/api/publication/2450564
ID  - 2450564
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Böddi, Katalin
AU  - Brochmann, AS
AU  - Szalma, József
AU  - Lempel, Edina
AU  - Szabó, Zoltán
AU  - Takátsy, Anikó
TI  - Protein Identification from Submandibular Salivary Stones w ith MALDI TOF Mass Spectrometry
PY  - 2010
UR  - https://m2.mtmt.hu/api/publication/2450557
ID  - 2450557
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, Zoltán
AU  - Guttman, András
AU  - Karger, Barry L
TI  - Rapid Release of N-Linked Glycans from Glycoproteins by Pressure-Cycling Technology
JF  - ANALYTICAL CHEMISTRY
J2  - ANAL CHEM
VL  - 82
PY  - 2010
IS  - 6
SP  - 2588
EP  - 2593
PG  - 6
SN  - 0003-2700
DO  - 10.1021/ac100098e
UR  - https://m2.mtmt.hu/api/publication/1615480
ID  - 1615480
N1  - Export Date: 27 January 2024; CODEN: ANCHA
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, Zoltán
AU  - Guttman, András
AU  - Rejtar, Tomas
AU  - Karger, Barry L
TI  - Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MS
JF  - ELECTROPHORESIS
J2  - ELECTROPHORESIS
VL  - 31
PY  - 2010
IS  - 8
SP  - 1389
EP  - 1395
PG  - 7
SN  - 0173-0835
DO  - 10.1002/elps.201000037
UR  - https://m2.mtmt.hu/api/publication/1615479
ID  - 1615479
N1  - Export Date: 27 January 2024; CODEN: ELCTD
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, Zoltán
AU  - Vallant, RM
AU  - Takátsy, Anikó
AU  - Bakry, R
AU  - Najam-ul-Haq, M
AU  - Rainer, M
AU  - Huck, CW
AU  - Bonn, GK
TI  - Laser desorption/ionization mass spectrometric analysis of small molecules using fullerene-derivatized silica as energy-absorbing material
JF  - JOURNAL OF MASS SPECTROMETRY
J2  - J MASS SPECTROM
VL  - 45
PY  - 2010
IS  - 5
SP  - 545
EP  - 552
PG  - 8
SN  - 1076-5174
DO  - 10.1002/jms.1740
UR  - https://m2.mtmt.hu/api/publication/1425162
ID  - 1425162
N1  - Export Date: 27 January 2024; CODEN: JMSPF
AB  - In spite of the growing acceptance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the analysis of a wide variety of compounds, including polymers and proteins, its use in analyzing low-molecular-weight molecules (<1000 m/z) is still limited. This is mainly due to the interference of matrix molecules in the low-mass range. Here the derivatized fullerenes covalently bound to silica particles with different pore sizes are applied as thin layer for laser desorption/ionization (LDI) mass spectrometric analysis. Thus, an interference of intrinsic matrix ions can be eliminated or minimized in comparison with the state-of-the-art weak organic acid matrices. The desorption/ionization ability of the developed fullerene-silica materials depends on the applied laser power, sample preparation and pore size of the silica particles. Thus, fullerene-silica serves as an LDI support for mass spectrometric analysis of molecules (<1500 Da). The performance of the fullerene-silica is demonstrated by the mass analysis of variety of small molecules such as carbohydrates, amino acids, peptides, phospholipids and drugs. Copyright (C) 2010 John Wiley & Sons, Ltd.
LA  - English
DB  - MTMT
ER  -