@article{MTMT:33420086, title = {Effects of anterior thalamic nucleus DBS on interictal heart rate variability in patients with refractory epilepsy}, url = {https://m2.mtmt.hu/api/publication/33420086}, author = {Lőrincz, Katalin and Bóné, Beáta and Karádi, Kázmér and Kis-Jakab, Gréta and Tóth, Natália and Halász, László and Erőss, Loránd and Balás, István and Faludi, Béla and Jordán, Zsófia and Zoltan, Chadaide and Trischlerné Gyimesi, Csilla and Fabó, Dániel and Janszky, József Vladimír}, doi = {10.1016/j.clinph.2022.11.020}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {147}, unique-id = {33420086}, issn = {1388-2457}, year = {2023}, eissn = {1872-8952}, pages = {17-30}, orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32893951, title = {Epilepsziasebészet a pécsi epilepsziacentrumban}, url = {https://m2.mtmt.hu/api/publication/32893951}, author = {Trischlerné Gyimesi, Csilla and Barsi, Péter and Bóné, Beáta and Dóczi, Tamás Péter and Horváth, Réka and Horváth, Zsolt and Komoly, Sámuel and Lőrincz, Katalin Nóra and Tóth, Márton and Janszky, József Vladimír}, journal-iso = {IDEGGYÓGY SZEMLE PROC}, journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS}, volume = {7}, unique-id = {32893951}, issn = {2498-6240}, year = {2022}, pages = {17-17}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32893852, title = {Fehérállományi neuronok és szerepük a temporalislebeny-epilepsziában}, url = {https://m2.mtmt.hu/api/publication/32893852}, author = {Ábrahám, Hajnalka and Sóki, Noémi and Richter, Zsófia and Karádi, Kázmér and Lőrincz, Katalin and Horváth, Réka and Trischlerné Gyimesi, Csilla and Szekeres-Paraczky, Cecília and Sétáló, György (ifj.) and Horváth, Zsolt and Janszky, József Vladimír and Dóczi, Tamás Péter and Seress, László}, journal-iso = {IDEGGYÓGY SZEMLE PROC}, journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS}, volume = {7}, unique-id = {32893852}, issn = {2498-6240}, year = {2022}, pages = {8-8}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32598077, title = {Investigation of synapses in the cortical white matter in human temporal lobe epilepsy}, url = {https://m2.mtmt.hu/api/publication/32598077}, author = {Sóki, Noémi and Richter, Zsófia and Karádi, Kázmér and Lőrincz, Katalin and Horváth, Réka and Trischlerné Gyimesi, Csilla and Szekeres-Paraczky, Cecília Kata and Horváth, Zsolt and Janszky, József Vladimír and Dóczi, Tamás Péter and Seress, László and Ábrahám, Hajnalka}, doi = {10.1016/j.brainres.2022.147787}, journal-iso = {BRAIN RES}, journal = {BRAIN RESEARCH}, volume = {1779}, unique-id = {32598077}, issn = {0006-8993}, year = {2022}, eissn = {1872-6240}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32560906, title = {Adjuváns brivaracetam fokális epilepsziában}, url = {https://m2.mtmt.hu/api/publication/32560906}, author = {Trischlerné Gyimesi, Csilla}, journal-iso = {NEUROL PRAX}, journal = {NEUROLÓGIAI PRAXIS}, volume = {4}, unique-id = {32560906}, issn = {2560-2667}, year = {2021}, pages = {16-17} } @article{MTMT:32219141, title = {The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy}, url = {https://m2.mtmt.hu/api/publication/32219141}, author = {Tóth, Márton and Barsi, Péter and Tóth, Zoltán and Borbély, Katalin and Lückl, János and Emri, Miklós and Repa, Imre and Janszky, József Vladimír and Dóczi, Tamás Péter and Horváth, Zsolt and Halász, Péter and Juhos, Vera and Trischlerné Gyimesi, Csilla and Bóné, Beáta and Kuperczkó, Diána and Horváth, Réka and Nagy, Ferenc and Kelemen, Anna and Jordán, Zsófia and Újvári, Ákos and Hagiwara, Koichi and Isnard, Jean and Pál, Endre and Fekésházy, Attila and Fabó, Dániel and Vajda, Zsolt}, doi = {10.1186/s12883-021-02352-z}, journal-iso = {BMC NEUROL}, journal = {BMC NEUROLOGY}, volume = {21}, unique-id = {32219141}, issn = {1471-2377}, abstract = {When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary.008899/2016/OTIG . Date of registration: 08 February 2016.}, keywords = {clinical decision-making; epilepsy surgery; Drug-resistant epilepsy; Hybrid FDG-PET/MRI; Preoperative workflow}, year = {2021}, eissn = {1471-2377}, orcid-numbers = {Barsi, Péter/0000-0002-3574-9973; Tóth, Zoltán/0000-0002-8096-3813; Borbély, Katalin/0000-0002-1675-4128; Lückl, János/0000-0001-8094-771X; Janszky, József Vladimír/0000-0001-6100-832X; Kelemen, Anna/0000-0003-3942-3409; Fabó, Dániel/0000-0001-5141-5351} } @article{MTMT:31602482, title = {Etiology-related degree of sprouting of parvalbumin-immunoreactive axons in the human dentate gyrus in temporal lobe epilepsy}, url = {https://m2.mtmt.hu/api/publication/31602482}, author = {Ábrahám, Hajnalka and Molnár, Judit E. and Sóki, Noémi and Trischlerné Gyimesi, Csilla and Horváth, Zsolt and Janszky, József Vladimír and Dóczi, Tamás Péter and Seress, László}, doi = {10.1016/j.neuroscience.2020.09.018}, journal-iso = {NEUROSCIENCE}, journal = {NEUROSCIENCE}, volume = {448}, unique-id = {31602482}, issn = {0306-4522}, year = {2020}, eissn = {1873-7544}, pages = {55-70}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:30938838, title = {Hungarian Experiences In Ant DBS Therapy At University Of Pecs}, url = {https://m2.mtmt.hu/api/publication/30938838}, author = {Bóné, Beáta and Horváth, Réka and Trischlerné Gyimesi, Csilla and Kovács, Norbert and Balás, István and Janszky, József Vladimír}, journal-iso = {EPILEPSIA}, journal = {EPILEPSIA}, volume = {60}, unique-id = {30938838}, issn = {0013-9580}, year = {2019}, eissn = {1528-1167}, pages = {102-102}, orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:30721762, title = {Surgical outcomes related to invasive EEG monitoring with subdural grids or depth electrodes in adults : A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/30721762}, author = {Tóth, Márton and Papp, Kata Szilvia and Gede, Noémi and Borbásné Farkas, Kornélia and Kovács, Sándor and Isnard, Jean and Hagiwara, Koichi and Trischlerné Gyimesi, Csilla and Kuperczkó, Diána and Dóczi, Tamás Péter and Janszky, József Vladimír}, doi = {10.1016/j.seizure.2019.06.022}, journal-iso = {SEIZURE-EUR J EPILEP}, journal = {SEIZURE-EUROPEAN JOURNAL OF EPILEPSY}, volume = {70}, unique-id = {30721762}, issn = {1059-1311}, abstract = {Resective epilepsy surgery based on an invasive EEG-monitors performed with subdural grids (SDG) or depth electrodes (stereo-electroencephalography, SEEG) is considered to be the best option towards achieving seizure-free state in drug-resistant epilepsy. The authors present a meta-analysis, due to the lack of such a study focusing on surgical outcomes originating from SDG- or SEEG-monitors.English-language studies published until May 2018, highlighting surgical outcomes were reviewed. Outcome measures including total number of SDG- or SEEG-monitors and resective surgeries; consecutively followed surgical cases; surgical outcomes classified by Engel in overall, temporal/extratemporal and lesional/nonlesional subgroups were analyzed.19 articles containing 1025 SDG-interventions and 16 publications comprising 974 SEEG-monitors were researched. The rate of resective surgery deriving from SDG-monitoring hovered at 88.8% (95%CI:83.3-92.6%) (I2 = 77.0%;p < 0.001); in SEEG-group, 79.0% (95%CI:70.4-85.7%) (I2 = 72.5%;p < 0.001) was measured. After SDG-interventions, percentage of post-resective follow-up escalated to 96.0% (95%CI:92.0-98.1%) (I2 = 49.1%;p = 0.010), and in SEEG-group, it reached 94.9% (95%CI:89.3-97.6%) (I2 = 80.2%;p < 0.001). In SDG-group, ratio of seizure-free outcomes reached 55.9% (95%CI:50.9-60.8%) (I2 = 54.47%;p = 0.002). Using SEEG-monitor, seizure-freedom occurred in 64.7% (95%CI:59.2-69.8%) (I2 = 11.9%;p = 0.32). Assessing lesional cases, likelihood of Engel I outcome was found in 57.3% (95%CI:48.7%-65.6%) (I2 = 69.9%;p < 0.001), using SDG; while in SEEG-group, it was 71.6% (95%CI:61.6%-79.9%) (I2 = 24.5%;p = 0.225). In temporal subgroup, ratio of seizure-freedom was found to be 56.7% (95%CI:51.5%-61.9%) (I2 = 3.2%;p = 0.412) in SDG-group; whereas, SEEG-group reached 73.9% (95%CI:64.4%-81.6%); (I2 = 0.00%;p = 0.45). Significant differences between seizure-free outcomes were found in overall (p = 0.02), lesional (p = 0.031), and also, temporal (p = 0.002) comparisons.SEEG-interventions were associated, at least, non-inferiorly, with seizure-freedom compared with SDG-monitors in temporal, lesional and overall subgroups.}, keywords = {Adult; outcome; epilepsy surgery; SEEG; Drug-resistant epilepsy; intracranial electrodes; SDG; [Meta-analysis]}, year = {2019}, eissn = {1532-2688}, pages = {12-19}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:30432269, title = {Epilepszia sebészeti beavatkozások eredményei a Pécsi Epilepszia Centrumban 2005-2016 között}, url = {https://m2.mtmt.hu/api/publication/30432269}, author = {Lőrincz, Katalin Nóra and Bóné, Beáta and Tóth, Márton and Horváth, Réka and Kovács, Norbert and Komoly, Sámuel and Karádi, Kázmér and Barsi, Péter and Ábrahám, Hajnalka and Seress, László and Horváth, Zsolt and Dóczi, Tamás Péter and Janszky, József Vladimír and Trischlerné Gyimesi, Csilla}, doi = {10.1556/650.2019.31321}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {160}, unique-id = {30432269}, issn = {0030-6002}, abstract = {Epilepsy as a chronic, severe neurologic disease significantly influences the quality of life of the epileptic patients. In candidates well selected for surgery, the seizure freedom is realistically achievable, and the quality of life can be further improved with complex individual rehabilitation.We aimed to evaluate the postoperative outcome of patients who underwent epilepsy surgery between 2005 and 2016 at the Epilepsy Center at Pécs.We evaluated seizure status at regular follow-up visits after surgery and the quality of life using questionnaires focusing on employment and social status.76% of the 72 patients who underwent surgical resection for epilepsy were free from disabling seizures , and 10% had rare disabling seizures (almost seizure-free), 7% experienced worthwhile improvement and 7% had no worthwhile improvement. Comparing the employment status of patients free from disabling seizures to patients not free from disabling seizures, we found that the employment status is significantly influenced by seizure freedom (p<0.01, Fisher's exact test). While 67% of seizure-free patients were employed, only 19% of patients not free from disabling seizures were hired.Our results resemble the international tendencies and success rate, proving epilepsy surgery as an available, valid and effective treatment in well selected patients. Orv Hetil. 2019; 160(7): 270-278.}, keywords = {Quality of Life; EMPLOYMENT STATUS; életminőség; foglalkoztatottság; epilepsy surgery; epilepsziasebészet; postoperative seizure outcome; posztoperatív rohamkimenetel}, year = {2019}, eissn = {1788-6120}, pages = {270-278}, orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Barsi, Péter/0000-0002-3574-9973; Janszky, József Vladimír/0000-0001-6100-832X} }