TY - JOUR AU - Sipos, Dávid AU - Varga, Adorján AU - Kappéter, Ágnes AU - Halda-Kiss, Bernadett AU - Kása, Péter AU - Pál, Szilárd AU - Kocsis, Béla AU - Péterfi, Zoltán TI - Encapsulation protocol for fecal microbiota transplantation JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 14 PY - 2024 PG - 9 SN - 2235-2988 DO - 10.3389/fcimb.2024.1424376 UR - https://m2.mtmt.hu/api/publication/35070806 ID - 35070806 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - CONF AU - Gyula, Farkas AU - Sándor, Nagy AU - Dévay, Attila AU - Széchenyi, Aleksandar AU - Pál, Szilárd TI - Dynamic Real-Time Analysis of Pharmaceutical Powder Flow Properties T2 - Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024 PB - Magyar Gyógyszerésztudományi Társaság (MGYT) C1 - Budapest PY - 2024 SP - 260 EP - 260 PG - 1 UR - https://m2.mtmt.hu/api/publication/34915527 ID - 34915527 N1 - (Poster Presentations) LA - English DB - MTMT ER - TY - CONF AU - Ferenczi, Krisztina AU - Széchenyi, Aleksandar AU - Nagy, Sándor AU - Kovács, B. AU - Rácz-Németh, K. AU - Pál, Szilárd TI - Production of an Emulsion-Type Rectal Suppository Using Conventional and 3D Printing Techniques for the Treatment of Congenital Hypothyroidism T2 - Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024 PB - Magyar Gyógyszerésztudományi Társaság (MGYT) C1 - Budapest PY - 2024 SP - 262 EP - 263 PG - 2 UR - https://m2.mtmt.hu/api/publication/34915505 ID - 34915505 N1 - (Poster Presentations) LA - English DB - MTMT ER - TY - JOUR AU - Farkas, Gyula AU - Nagy, Sándor AU - Dévay, Attila AU - Széchenyi, Aleksandar AU - Pál, Szilárd TI - Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 16 PY - 2024 IS - 3 PG - 18 SN - 1999-4923 DO - 10.3390/pharmaceutics16030405 UR - https://m2.mtmt.hu/api/publication/34763930 ID - 34763930 N1 - Export Date: 12 April 2024 Correspondence Address: Pál, S.; Institute of Pharmaceutical Technology and Biopharmacy, Rókus Str. 2, Hungary; email: szilard.pal@aok.pte.hu AB - The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes. LA - English DB - MTMT ER - TY - JOUR AU - Helyes, Zsuzsanna AU - Horvath, Adam Horvath AU - Szentes, Nikolett AU - Tekus, Valeria AU - Pál, Szilárd AU - Kálai, Tamás AU - Matyus, Peter TI - Preclinical and Phase I Clinical Development of a Novel Multi-target Drug Candidate for Neuropathic Pain JF - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J2 - J PHARMACOL EXP THER VL - 385 PY - 2023 PG - 1 SN - 0022-3565 DO - 10.1124/jpet.122.161660 UR - https://m2.mtmt.hu/api/publication/35345135 ID - 35345135 LA - English DB - MTMT ER - TY - JOUR AU - Helyes, Zsuzsanna AU - Horvath, Adam Istvan AU - Szentes, Nikolett AU - Tekus, Valeria AU - Kálai, Tamás AU - Pál, Szilárd AU - Szoke, Eva AU - Matyus, Peter TI - Development of a novel multi-target drug candidate for neuropathic pain: preclinical and phase I clinical studies JF - BRITISH JOURNAL OF PHARMACOLOGY J2 - BR J PHARMACOL VL - 180 PY - 2023 SP - 433 EP - 434 PG - 2 SN - 0007-1188 UR - https://m2.mtmt.hu/api/publication/34212245 ID - 34212245 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Makszin, Lilla AU - Bufa, Anita AU - Sipos, Dávid AU - Kása, Péter AU - Pál, Szilárd AU - Rosenstiel, Philip AU - Sommer, Felix AU - Kocsis, Béla AU - Péterfi, Zoltán TI - Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 13 PY - 2023 PG - 15 SN - 2235-2988 DO - 10.3389/fcimb.2023.1041384 UR - https://m2.mtmt.hu/api/publication/33588242 ID - 33588242 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Vörös-Horváth, Barbara AU - Zivkovic, Pavo AU - Bánfai, Krisztina AU - Bovári-Biri, Judit AU - Pongrácz, Judit AU - Bálint, Gábor AU - Pál, Szilárd AU - Széchenyi, Aleksandar TI - Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection JF - ACS OMEGA J2 - ACS OMEGA VL - 7 PY - 2022 IS - 4 SP - 3240 EP - 3253 PG - 14 SN - 2470-1343 DO - 10.1021/acsomega.1c05149 UR - https://m2.mtmt.hu/api/publication/32623813 ID - 32623813 AB - The COVID-19 virus is spread by pulmonary droplets. Its high infectivity is caused by the high-affinity binding of the viral spike protein to the ACE2 receptors on the surface of respiratory epithelial cell membranes. The proper hydration of nasal mucosa plays an essential role in defense of bacterial and viral infections. Therefore, a nasal formulation, which can moisture the nasal mucosa and contains the ACE2 receptor inhibitor, can reduce the risk of COVID-19 infection. This article presents a systematic study of the preparation of chitosan hydrogels with dicarboxylic acids (malic and glutaric acid) and their detailed characterization (Fourier transform infrared spectroscopy, deter-mination of cross-linking efficiency, rheological studies, thermal analysis, and swelling kinetics). The results confirm that chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The adsorption capacity of hydrogels for three different ACE2 inhibitors, as APIs, has also been investigated. The API content of hydrogels and their mucoadhesive property can provide an excellent basis to use the hydrogels for the development of a nasal formulation in order to reduce the risk of SARS-CoV 2 infection. LA - English DB - MTMT ER - TY - CHAP AU - Bakó, Csongor AU - Balázs, Viktória Lilla AU - Takács, Gyöngyi AU - Pallos, József Péter AU - Pál, Szilárd AU - Kocsis, Béla AU - Pethő, Dóra AU - Horváth, Györgyi TI - Muskotályzsálya (Salvia sclarea L.) szuperkritikus fluid extraktumok biológiai aktivitásának optimalizálása válaszfelület modellezés segítségével T2 - METT25 a Magyar Elválasztástudományi Társaság jubileumi konferenciája PB - Magyar Elválasztástudományi Társaság CY - Pécs SN - 9786155270666 PY - 2021 UR - https://m2.mtmt.hu/api/publication/32474355 ID - 32474355 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bakó, Csongor AU - Balázs, Viktória Lilla AU - Takács, Gyöngyi AU - Pallos, József Péter AU - Pál, Szilárd AU - Kocsis, Béla AU - Pethő, Dóra AU - Horváth, Györgyi TI - Combination of Analytical and Statistical Methods in Order to Optimize Antibacterial Activity of Clary Sage Supercritical Fluid Extracts JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 21 PG - 15 SN - 1420-3049 DO - 10.3390/molecules26216449 UR - https://m2.mtmt.hu/api/publication/32471114 ID - 32471114 LA - English DB - MTMT ER -