TY - CHAP AU - Csulak, Timea AU - Hajnal, András Sándor AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Varjú-Solymár, Margit AU - Sipos, Zoltán AU - Kovács, Márton Áron AU - Herold, Márton AU - Varga, Eszter AU - Hegyi, Péter AU - Tényi, Tamás AU - Herold, Róbert ED - Bosia, Marta ED - Parola, Alberto ED - Soto, Guillermo ED - Garcia, Ricardo R TI - Implicit mentalizing in patients with schizophrenia : a systematic review and meta-analysis T2 - Psychotic experiences, social cognition and pragmatic communication in the psychosis continuum PB - Frontiers Media S.A. CY - Lausanne SN - 9782832517383 T3 - Frontiers Research Topics, ISSN 1664-8714 PY - 2023 SP - - UR - https://m2.mtmt.hu/api/publication/34066695 ID - 34066695 LA - English DB - MTMT ER - TY - JOUR AU - Pál, Sándor AU - Réger, Barbara AU - Alizadeh, Hussain AU - Szomor, Árpád AU - Vereczkei, András AU - Kiss, Tamás AU - Miseta, Attila János AU - Varjú-Solymár, Margit AU - Faust, Zsuzsanna TI - Use of blood products during the first months of COVID-19 pandemic period : A single center report JF - HELIYON J2 - HELIYON VL - 9 PY - 2023 IS - 3 PG - 8 SN - 2405-8440 DO - 10.1016/j.heliyon.2023.e14391 UR - https://m2.mtmt.hu/api/publication/33706187 ID - 33706187 AB - The novel coronavirus (SARS-CoV-2) outbreak exerted a serious effect on healthcare. Between 1st of January and May 31, 2020 due to the special regulations in Hungary, the number of reported COVID-19 infections were relatively low (3876 cases). The inpatient and outpatient care and the blood supply were significantly affected by the implemented regulations. The aim of this study was to evaluate the use of blood products amid the first five months of the pandemic situation. This investigation has observed a significant reduction of hospitalizations (37.35%). Analyzing individually the included units, pre-transfusion hemoglobin concentrations of transfused patients presented slight modifications, which were not statistically significant. The special regulations resulted major changes in the frequency of diagnoses at admissions in case of the Department of Surgery, while in case of the other specialities (Division of Hematology and Department of Anesthesiology and Intensive Therapy), there were no major changes compared to pre-pandemic period. Considering each department separately, transfused red blood cell concentrates (RBC) per patient, and the proportion of transfused patients did not change significantly. However, the combination of these modifications resulted in the significant decrease in RBC transfusions (p < 0.0001) compared to the pre-pandemic baseline. With regard to platelet and fresh frozen plasma (FFP), their usage was significantly reduced (44.40% platelet concentrates and 34.27% FFP). Our results indicate that the pandemic had an important effect on the blood product usage at the included departments by introducing different patient care policies and the temporary deferral of the elective surgical interventions. Despite the challenging circumstances of blood collection and blood product supply, the hospitalized patients received adequate care. LA - English DB - MTMT ER - TY - JOUR AU - Bálint, Alexandra AU - Hanák, Lilla AU - Hegyi, Péter AU - Szakács, Zsolt AU - Eitmann, Szimonetta AU - Garami, András AU - Varjú-Solymár, Margit AU - Márta, Katalin AU - Rumbus, Zoltán AU - Komócsi, András TI - Increased risk of adverse events in patients with low-on clopidogrel platelet reactivity after percutaneous coronary intervention : A systematic review and meta-analysis JF - CARDIOLOGY JOURNAL J2 - CARDIOL J VL - 30 PY - 2023 IS - 3 SP - 391 EP - 400 PG - 10 SN - 1897-5593 DO - 10.5603/CJ.a2021.0084 UR - https://m2.mtmt.hu/api/publication/32127261 ID - 32127261 N1 - Heart Institute, Medical School, University of Pécs, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Hungary Szentágothai Research Center, University of Pécs, Hungary Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Hungary Export Date: 12 October 2023 Correspondence Address: Bálint, A.; Heart Institute, Ifjúság útja 13, Hungary; email: balint.alexandra@pte.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8, 120202-65-5, 120202-67-7, 894353-16-3, 744256-69-7; ticagrelor, 274693-27-5; Clopidogrel; Platelet Aggregation Inhibitors Manufacturers: R Foundation AB - Clinical evidence has been controversial regarding the influence of low platelet reactivity (LPR), ischemic and bleeding outcomes among patients receiving coronary stent implantation. Hence, the present study performed a meta-analysis to systematically evaluate the significance of LPR on adverse cardiovascular events.MEDLINE, EMBASE and CENTRAL databases were searched up to November 2020 for relevant studies including patients with acute coronary syndrome undergoing percutaneous coronary intervention. LPR was the exposed arm while the non-LPR group represented the control. The primary outcome of interest was bleeding risk including major and minor bleeding events. Secondary outcomes included all-cause mortality, repeated revascularization, nonfatal myocardial infarction, and stent thrombosis. Study-level outcomes were evaluated in random-effect models.A total of 20 studies with 19,064 patients were included. Pooled analysis showed that LPR was associated with an increased bleeding risk (relative risk [RR] 2.80, 95% confidence interval [CI] 1.95-4.02, p < 0.01). Patients with LPR had a lower risk of non-fatal myocardial infarction (RR 0.59, 95% CI 0.38-0.91, p < 0.05) and of serious vascular events (RR 0.50, 95% CI 0.30-0.84, p < 0.01).LPR is associated with an increased bleeding risk of patients who underwent coronary stent implantation. The results suggest possible benefits of this marker in risk stratification, with potential improvement in risk prediction. There are potential advantages using combinations with other factors in prediction models, however, they require further study. PROSPERO registration number: CRD42019136393). LA - English DB - MTMT ER - TY - JOUR AU - Csulak, Timea AU - Hajnal, András Sándor AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Sipos, Zoltán AU - Varjú-Solymár, Margit AU - Kovács, M AU - Herold, Márton AU - Varga, Eszter AU - Hegyi, Péter AU - Tényi, Tamás AU - Herold, Róbert TI - A systematic review and meta-analysis of implicit Theory of Mind in schizophrenia JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 65 PY - 2022 IS - Suppl. SP - S113 EP - S114 SN - 0924-9338 DO - 10.1192/j.eurpsy.2022.319 UR - https://m2.mtmt.hu/api/publication/32868375 ID - 32868375 N1 - WoS:hiba:000897965700285 2023-12-31 11:37 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Aba Tamás AU - Váradi, Alex AU - Hegyi, Péter AU - Rumbus, Zoltán AU - Tuba, Máté AU - Lamberti, Anna Gabriella AU - Varjú-Solymár, Margit AU - Párniczky, Andrea AU - Erőss, Bálint Mihály AU - Garami, András AU - Józsa, Gergő TI - Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials JF - LIFE-BASEL J2 - LIFE-BASEL VL - 12 PY - 2022 IS - 5 PG - 24 SN - 2075-1729 DO - 10.3390/life12050619 UR - https://m2.mtmt.hu/api/publication/32823871 ID - 32823871 LA - English DB - MTMT ER - TY - JOUR AU - Pál, Sándor AU - Faust, Zsuzsanna AU - Réger, Barbara AU - Miseta, Attila János AU - Varjú-Solymár, Margit AU - Nemes-Nagy, Eniko AU - Tilinca, Mariana Cornelia AU - Alizadeh, Hussain TI - Evaluation of iron replacement therapy efficiency using a complex panel of biomarkers JF - REVISTA ROMANA DE MEDICINA DE LABORATOR J2 - REV ROMANA MED LAB VL - 30 PY - 2022 IS - 1 SP - 97 EP - 105 PG - 9 SN - 1841-6624 DO - 10.2478/rrlm-2022-0005 UR - https://m2.mtmt.hu/api/publication/32716693 ID - 32716693 LA - English DB - MTMT ER - TY - JOUR AU - Müller, Katalin Eszter AU - Dohos, Dóra AU - Sipos, Zoltán AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Kovács, Norbert AU - Varjú-Solymár, Margit AU - Erőss, Bálint Mihály AU - Hegyi, Péter AU - Sarlós, Patrícia TI - Immune response to influenza and pneumococcal vaccines in adults with inflammatory bowel disease: A systematic review and meta-analysis of 1429 patients JF - VACCINE J2 - VACCINE VL - 40 PY - 2022 IS - 13 SP - 2076 EP - 2086 PG - 11 SN - 0264-410X DO - 10.1016/j.vaccine.2022.02.027 UR - https://m2.mtmt.hu/api/publication/32712083 ID - 32712083 AB - Background Patients with inflammatory bowel disease (IBD) have a high risk for infection. Pneumonia related to influenza and pneumococcal infection is one of the most common infection-related complications in IBD. Aims To evaluate the immunogenicity of pneumococcal and influenza vaccination in patients with IBD receiving different treatments. Methods We searched four databases for studies evaluating seroprotection and seroconversion rates after influenza or pneumococcal vaccination in IBD on 20th October 2020. In the meta-analysis, odds ratios (OR) were calculated with 95% confidence intervals (CI). Results We included twelve studies (1429 patients with IBD) in this meta-analysis. The seroconversion rate after pneumococcal vaccination and the seroprotection rate after influenza vaccination were not significantly lower in patients receiving conventional immunosuppressive treatment compared to the non-immunosuppressed patients. Meanwhile, the seroconversion rate following pneumococcal vaccine was significantly lower in patients with anti-TNF mono- or combination therapy (OR = 0.28, CI: 0.15–0.53, and OR = 0.27, CI: 0.15–0.49, respectively). In the analysis of patients with IBD on conventional immunosuppressive monotherapy versus anti-TNF therapy, the seroprotection rate after influenza immunization did not differ between patients receiving either anti-TNF mono-or combination therapy (OR = 1.45, CI: 0.62–3.38 and OR = 0.91, CI: 0.37–2.22, respectively). Conclusion Our data suggest that the immunization against Pneumococcus and influenza is safe and immunogenic despite immunosuppression. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dóra Krisztina AU - Gede, Noémi AU - Szabó, László AU - Hegyi, Péter AU - Szakács, Zsolt AU - Faludi, Béla AU - Sebők, Ágnes AU - Garami, András AU - Varjú-Solymár, Margit AU - Kósa, Dániel AU - Hanák, Lilla AU - Rumbus, Zoltán AU - Balaskó, Márta TI - Weight reduction added to CPAP decreases blood pressure and triglyceride level in OSA : systematic review and meta-analysis JF - CTS-CLINICAL AND TRANSLATIONAL SCIENCE J2 - CTS-CLIN TRANSL SCI VL - 15 PY - 2022 IS - 5 SP - 1238 EP - 1248 PG - 11 SN - 1752-8054 DO - 10.1111/cts.13241 UR - https://m2.mtmt.hu/api/publication/32654314 ID - 32654314 AB - Obstructive sleep apnea (OSA) is associated with treatment-resistant hypertension and high cardiovascular risk. Continuous positive airway pressure (CPAP) fails to reduce cardiovascular risks consistently. Obesity and OSA show reciprocal association and they synergistically increase hypertension via different pathways. Our meta-analysis aimed to assess the cardiovascular benefits of combining weight reduction (WL) with CPAP (versus WL or CPAP alone) in OSA. Outcomes included systolic and diastolic blood pressure (BP) and blood lipid parameters. We explored Medline, Embase, Cochrane and Scopus. Eight randomized controlled studies (2627 patients) were included. The combined therapy decreased systolic BP more than CPAP alone. Weighted mean difference (WMD) for CPAP+WL vs. CPAP was -8.89 mmHg, 95%confidence interval (95%CI)[-13.67; -4.10], p<0.001 for systolic BP. For diastolic BP this decrease was not significant. In case of blood lipids, the combined treatment decreased triglyceride levels more than CPAP alone (WMD= -0.31, 95%CI [-0.58; -0.04] p =0.027). On the other hand, addition of CPAP to WL failed to suppress BP further. The certainty of evidence according to GRADE was very low to moderate. In conclusion, our results showed that the addition of WL to CPAP significantly improved BP and blood lipid values in OSA. On the other hand, the addition of CPAP to WL could not significantly improve BP or blood lipid values. Review protocol: PROSPERO CRD42019138998. LA - English DB - MTMT ER - TY - JOUR AU - Csulak, Timea AU - Hajnal, András Sándor AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Varjú-Solymár, Margit AU - Sipos, Zoltán AU - Kovács, Márton Áron AU - Herold, Márton AU - Varga, Eszter AU - Hegyi, Péter AU - Tényi, Tamás AU - Herold, Róbert TI - Implicit mentalizing in patients with schizophrenia: a systematic review and meta-analysis JF - FRONTIERS IN PSYCHOLOGY J2 - FRONT PSYCHOL VL - 13 PY - 2022 PG - 11 SN - 1664-1078 DO - 10.3389/fpsyg.2022.790494 UR - https://m2.mtmt.hu/api/publication/32583821 ID - 32583821 LA - English DB - MTMT ER - TY - JOUR AU - Kelava, Leonardo AU - Németh, Dávid AU - Hegyi, Péter AU - Kéringer, Patrik AU - Kovács, Dóra Krisztina AU - Balaskó, Márta AU - Varjú-Solymár, Margit AU - Pákai, Eszter AU - Rumbus, Zoltán AU - Garami, András TI - Dietary supplementation of transient receptor potential vanilloid-1 channel agonists reduces serum total cholesterol level : a meta-analysis of controlled human trials JF - CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION J2 - CRIT REV FOOD SCI VL - 62 PY - 2022 IS - 25 SP - 7025 EP - 7035 PG - 11 SN - 1040-8398 DO - 10.1080/10408398.2021.1910138 UR - https://m2.mtmt.hu/api/publication/31963955 ID - 31963955 AB - Abnormal cholesterol level is a major risk factor in the development of atherosclerosis, which is a fundamental derangement in cardiovascular diseases. Any efforts should be undertaken to lower blood cholesterol levels. Among dietary interventions, capsaicinoid supplementation is also considered as a novel cholesterol-lowering approach, but human studies concluded contradictory results about its effectiveness. The present meta-analysis aimed at determining the effects of capsaicinoids on serum lipid profile in humans. We searched the PubMed, EMBASE, and CENTRAL databases from inception to February 2021. We included 10 controlled studies, which involved 398 participants. We found that dietary capsaicinoid supplementation alone or in combination with other substances significantly (p = 0.004 and 0.001, respectively) reduced serum total cholesterol level compared to controls with an overall standardized mean difference of -0.52 (95% confidence interval: -0.83, -0.21). Capsaicinoids also decreased low-density lipoprotein level significantly (p = 0.035), whereas no effect was observed on serum levels of high-density lipoprotein and triglycerides. Our findings provide novel quantitative evidence for the efficacy of dietary capsaicin supplementation in lowering serum total cholesterol and low-density lipoprotein levels in humans. To validate our conclusion, further randomized controlled trials in a diverse population of adult humans receiving dietary capsaicinoid supplementation are warranted. LA - English DB - MTMT ER -