TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, M AU - Perlaki, G AU - Karádi, Zoltán György AU - Lénárd, László TI - Examination of manganese toxicity for behavior associated memri in the rat. T2 - 5th FENS Regional Meeting 2017 PB - Federation of European Neuroscience Societies C1 - Pécs PY - 2017 UR - https://m2.mtmt.hu/api/publication/3296087 ID - 3296087 LA - English DB - MTMT ER - TY - JOUR AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, Mihály AU - Perlaki, Gábor AU - Pál, József AU - Steier, Roy AU - Lénárd, László AU - Karádi, Zoltán György TI - Identifying non-toxic doses of manganese for manganese-enhanced magnetic resonance imaging to map brain areas activated by operant behavior in trained rats. JF - MAGNETIC RESONANCE IMAGING J2 - MAGN RESON IMAGING VL - 37 PY - 2017 SP - 122 EP - 133 PG - 12 SN - 0730-725X DO - 10.1016/j.mri.2016.11.017 UR - https://m2.mtmt.hu/api/publication/3148677 ID - 3148677 N1 - Case report Funding Agency and Grant Number: PTE [AOK-KA 2013/34039/1]; [SROP-4.2.2/B-10/1-2010-0029]; [SCROP-4.2.1.B-10/2/KONV-2010-002] Funding text: Authors wish to thank Attila Schwartz for his technical support. We would like to thank Mrs. Iren Takacs, Mrs. Erzsebet Kovacs and Ildiko Fuchs for their technical assistance. This study was supported by SROP-4.2.2/B-10/1-2010-0029, SCROP-4.2.1.B-10/2/KONV-2010-002 and by PTE AOK-KA 2013/34039/1. AB - Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl2, at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels. Neurological examination was also carried out. The animals were tested in visual cue discriminated operant task. Imaging was performed using a 3T clinical MR scanner. T1 values were determined before and after MnCl2 administrations. Manganese-enhanced images of each animal were subtracted from their baseline images to calculate decrease in the T1 value (DeltaT1) voxel by voxel. The subtracted T1 maps of trained animals performing visual cue discriminated operant task, and those of naive rats were compared. The dose of 60mg/kg MnCl2 showed hepatotoxic effect, but even these animals did not exhibit neurological symptoms. The dose of 20 and 40mg/kg MnCl2 increased the number of omissions and did not affect the accuracy of performing the visual cue discriminated operant task. Using the accumulated dose of 40mg/kg, voxels with a significant enhanced DeltaT1 value were detected in the following brain areas of the visual cue discriminated operant behavior performed animals compared to those in the controls: the visual, somatosensory, motor and premotor cortices, the insula, cingulate, ectorhinal, entorhinal, perirhinal and piriform cortices, hippocampus, amygdala with amygdalohippocampal areas, dorsal striatum, nucleus accumbens core, substantia nigra, and retrorubral field. In conclusion, the MEMRI proved to be a reliable method to accomplish brain activity mapping in correlation with the operant behavior of freely moving rodents. LA - English DB - MTMT ER - TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, Mihály AU - Pál, József AU - Perlaki, Gábor AU - Karádi, Zoltán György AU - Lénárd, László TI - Application of activation induced manganese-enhanced magnetic resonance imaging (MEMRI) for mapping of brain structures involved in operant responses in rats. T2 - FAMÉ 2016 PY - 2016 UR - https://m2.mtmt.hu/api/publication/3079594 ID - 3079594 LA - English DB - MTMT ER - TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, M AU - Pál, J AU - Perlaki, G AU - Schwarcz, A AU - Lénárd, László AU - Karádi, Zoltán György TI - Mapping of brain structures involved in response dependent reinforcement: application of manganese-enhanced magnetic resonance imaging (MEMRI) in rats. T2 - 15th Annual Conference of the Hungarian Neuroscience Society PY - 2015 SP - 34 UR - https://m2.mtmt.hu/api/publication/2874912 ID - 2874912 LA - English DB - MTMT ER - TY - THES AU - Szalay, László Csaba TI - Az íz - érzékelés és a metabolizmus központi idegrendszeri szabályozásának vizsgálata emberben ill. állatkísérletes modellen PY - 2014 SP - 86 UR - https://m2.mtmt.hu/api/publication/2712921 ID - 2712921 LA - Hungarian DB - MTMT ER - TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, M AU - Pál, J AU - Perlaki, Gábor AU - Schwarcz, Attila AU - Lénárd, László AU - Karádi, Zoltán György TI - Examination of MNCL2 toxicity to develop a useful method for activity-induced memri in 3T clinical scanner. T2 - A Magyar Élettani, Farmakológiai és Mikrocirkulációs Társaságok 2013. évi közös Tudományos Kongresszusa PB - Semmelweis Egyetem Testnevelési és Sporttudományi Kar C1 - Budapest PY - 2013 SP - 190 UR - https://m2.mtmt.hu/api/publication/2347217 ID - 2347217 LA - English DB - MTMT ER - TY - CHAP AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, Mihály AU - Perlaki, Gábor AU - Pál, J AU - Schwarcz, Attila AU - Karádi, Zoltán György AU - Lénárd, László ED - Csillag, A ED - Dobolyi, Á ED - Gerber, G ED - Zacher, G TI - Mangán kontraszttal történő MRI vizsgálatok, mint új lehetőség a magatartás szabályozásában résztvevő agyi struktúrák feltérképezésére patkányban. T2 - XIV. Conference of the Hungarian Neuroscience Society [elektronikus dok.] PB - Magyar Idegtudományi Társaság CY - Budapest SN - 9789638822420 PY - 2013 UR - https://m2.mtmt.hu/api/publication/2347213 ID - 2347213 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Takács, Gábor AU - Szalay, László Csaba AU - Nagy, Bernadett AU - Szabó, István AU - Simon, Diána AU - Berki, Tímea AU - Karádi, Zoltán György TI - Insulin and leptin plasma levels after the microinjection of interleukin-1β into the nucleus accumbens of the rat JF - ACTA PHYSIOLOGICA HUNGARICA J2 - ACTA PHYSIOL HUNG VL - 99 PY - 2012 IS - 4 SP - 472 EP - 478 PG - 7 SN - 0231-424X DO - 10.1556/APhysiol.99.2012.4.11 UR - https://m2.mtmt.hu/api/publication/2103748 ID - 2103748 N1 - Export Date: 27 January 2024; CODEN: APHDU LA - English DB - MTMT ER - TY - JOUR AU - Szalay, László Csaba AU - Aradi, M AU - Schwarcz, Attila AU - Orsi, Gergely AU - Perlaki, Gábor AU - Németh, L AU - Takács, Gábor AU - Gáti, Á AU - Lénárd, László AU - Karádi, Zoltán György TI - Taste perception disturbances in anorexia nervosa. fMRI investigations TS - fMRI investigations JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 65 PY - 2012 IS - 1. klsz. SP - 63 SN - 0019-1442 UR - https://m2.mtmt.hu/api/publication/2097627 ID - 2097627 LA - English DB - MTMT ER - TY - CONF AU - Gálosi, Rita AU - Szalay, László Csaba AU - Aradi, M AU - Pál, J AU - Perlaki, Gábor AU - Karádi, Zoltán György AU - Lénárd, László TI - Application of manganese-enhanced magnetic resonance imaging for mapping of brain structures involved in thirst motivated operant responses in rats T2 - 8th FENS Forum of European Neuroscience C1 - Barcelona T3 - FENS Abstract ; 6. PY - 2012 SP - 520 UR - https://m2.mtmt.hu/api/publication/2055876 ID - 2055876 LA - English DB - MTMT ER -