TY - JOUR AU - Kovács, Márton AU - Uzsaly, János Gáspár AU - Bodzai, G AU - Pap, István AU - Lippai, Bálint AU - Dergez, Tímea AU - Németh, Adrienn AU - Gerlinger, Imre AU - Szanyi, István AU - Bakó, Péter TI - Efficacy of high dose systemic versus combined (systemic and intratympanic) corticosteroid therapy in idiopathic sudden sensorineural hearing loss : A prospective randomized trial and risk factor analysis JF - AMERICAN JOURNAL OF OTOLARYNGOLOGY J2 - AM J OTOLARYNG VL - 45 PY - 2024 IS - 1 PG - 8 SN - 0196-0709 DO - 10.1016/j.amjoto.2023.104099 UR - https://m2.mtmt.hu/api/publication/34335469 ID - 34335469 N1 - University of Pécs, Medical School, Department of Otorhinolaryngology, Munkácsy M St 2, Pécs, H-7621, Hungary University of Pecs, Szentagothai Research Centre, Ifjusag Str 20, Pécs, H-7624, Hungary University of Pécs, Medical School, Institute of Bioanalysis, Honved St 1, Pécs, H-7624, Hungary Export Date: 20 November 2023 CODEN: AJOTD Correspondence Address: Szanyi, I.; University of Pécs, Munkácsy M St 2, Hungary; email: szanyi.istvan@pte.hu AB - The pathophysiology and the proper treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are an ongoing subject of debate. Locally or systemic administered corticosteroids are the most accepted drugs of treatment in reference to ISSNHL (idiopathic sudden sensorineural hearing loss), however, no strong evidence nor guidelines regarding their effectiveness yet exists. In our prospective, randomized, controlled trial 78 participants were enrolled. Patients were randomly assigned based on the day of admission to two groups according to treatment: group SS (n = 43) received intravenous systemic methylprednisolone alone, and group CT (n = 35) received intratympanic dexamethasone + systemic methylprednisolone. The primary outcome was to compare the hearing outcomes between the treatment groups based on different, widely accepted categories (Siegel, Kanzaki, modified Siegel and PTA4 gain). In consideration of the secondary outcome, we examined the effect of the various risk factors on the hearing improvement. No differences were detected regarding hearing improvement between the two groups, based on any criteria [Siegel's criteria (p = 0.604); Kanzaki's criteria (p = 0.720); modified Siegel's criteria (p = 0.524) and PTA 4 gain (p = 0.569)]. However, several clinical factors such as vertigo (p = 0.039), or cardiovascular comorbidity (p = 0.02) and the severity of initial hearing loss (p = 0.033) were found to bear a significant impact upon the hearing outcome. To the best of our knowledge, this is the first randomized controlled trial comparing high dose systemic and combination corticosteroid therapy in ISSNHL patients. Our findings suggest coexisting cardiovascular comorbidity, vertigo and severity of the initial hearing loss may bear a significantly higher impact upon hearing improvement, than the additional intratympanic steroid administration. The presented trial was registered in the European Union Drug Regulating Authorities Clinical Trials Database (name: Combinated systemic and intratympanic steroid therapy in idiopathic sudden sensorineural hearing loss, No.: 2017-000658-20) and with the ethical approval of The National Institute of Pharmacy and Nutrition (OGYÉI) (protocol No.: 7621, on 2017.02.16.). LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Tamás Ferenc AU - Németh, Adrienn AU - Bakó, Péter AU - Révész, Péter AU - Gerlinger, Imre AU - Szanyi, István TI - Matching the pitch perception of the cochlear implanted ear with the contralateral ear in patients with single-sided deafness: a novel approach JF - EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY J2 - EUR ARCH OTO-RHINO-L VL - 280 PY - 2023 IS - 11 SP - 4851 EP - 4859 PG - 9 SN - 0937-4477 DO - 10.1007/s00405-023-08002-z UR - https://m2.mtmt.hu/api/publication/33806009 ID - 33806009 LA - English DB - MTMT ER - TY - JOUR AU - Pál, Margit AU - Nagy, Dóra AU - Neller, Alexandra AU - Farkas, Katalin AU - Török, Dóra AU - Nagy, Nikoletta AU - Füstös, Dalma AU - Nagy, Roland AU - Németh, Adrienn AU - Szilvássy, Judit AU - Rovó, László AU - Kiss, József Géza AU - Széll, Márta TI - Genetic Etiology of Nonsyndromic Hearing Loss in Hungarian Patients JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 8 PG - 14 SN - 1661-6596 DO - 10.3390/ijms24087401 UR - https://m2.mtmt.hu/api/publication/33764466 ID - 33764466 N1 - * Megosztott szerzőség AB - Hearing loss is the most prevalent sensory disorder worldwide. The majority of congenital nonsyndromic hearing loss (NSHL) cases are caused by hereditary factors. Previously, the majority of NSHL studies focused on the GJB2 gene; however, with the availability of next-generation sequencing (NGS) methods, the number of novel variants associated with NSHL has increased. The purpose of this study was to design effective genetic screening for a Hungarian population based on a pilot study with 139 NSHL patients. A stepwise, comprehensive genetic approach was developed, including bidirectional capillary sequencing, multiplex ligation-dependent probe amplification (MLPA), and an NGS panel of 108 hearing loss genes. With our results, a genetic diagnosis was possible for 92 patients. Sanger sequencing and MLPA identified the genetic background of 50% of these diagnosed cases, and the NGS panel identified another 16%. The vast majority (92%) of the diagnosed cases showed autosomal recessive inheritance and 76% were attributed to GJB2. The implementation of this stepwise analysis markedly increased our diagnostic yield and proved to be cost-effective as well. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Éva AU - Molnár, Krisztián AU - Kovács, Márton AU - Németh, Adrienn AU - Beke, Zsolt AU - Gerlinger, Imre AU - Szanyi, István AU - Bakó, Péter TI - Tág aquaeductus vestibuli okozta harmadikablak-szindróma komplex sebészeti ellátása JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 68 PY - 2022 IS - 4 SP - 153 EP - 155 PG - 3 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/33255083 ID - 33255083 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gerlinger, Imre AU - Bakó, Péter AU - Németh, Adrienn AU - Szanyi, István AU - Perényi, Ádám AU - Horváth, Bence AU - Rovó, László TI - III. típusú inkomplett partíció - a cochlea ritka fejlődési rendellenessége, amely komoly kihívás a cochlearis implantációt végzőknek JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 68 PY - 2022 IS - 4 SP - 147 EP - 152 PG - 6 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/33255050 ID - 33255050 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bakó, Péter AU - Kovács, Márton AU - Uzsaly, János Gáspár AU - Burián, András AU - Bodzai, Greta AU - Németh, Adrienn AU - Tóth, Arnold AU - Szanyi, István AU - Gerlinger, Imre TI - Subtotal Petrosectomy and Cochlear Implantation in Children With Chronic Suppurative Otitis Media: A Single Institutional Experience JF - Journal of Audiology and Otology J2 - Journal of Audiology and Otology VL - 26 PY - 2022 IS - 4 SP - 214 EP - 222 PG - 9 SN - 2384-1621 DO - 10.7874/jao.2022.00220 UR - https://m2.mtmt.hu/api/publication/33202705 ID - 33202705 AB - Chronic suppurative otitis media (CSOM) with or without cholesteatoma is a frequent chronic inflammatory condition in children, which may lead to severe hearing loss that affects speech development. Treatment of recurrent CSOM associated with unserviceable hearing requires a specialized approach with regard to disease eradication and hearing rehabilitation. In this study, we investigated the advantages of subtotal petrosectomy (SP) combined with cochlear implantation (CI) in children with CSOM associated with unserviceable hearing and describe our experience with regard to the efficacy of this method, together with a literature review.SP with sequential or simultaneous CI was performed in three children (four ears), and postoperative audiometric data were recorded.The study included two male and one female patient. Mean age at the time of SP was 10.75 years (7-13 years). Sequential implantation was performed in three ears. Facial nerve palsy occurred after SP in one patient. The latest word recognition scores of Cases 1, 2, and 3 were 80% (at 60 dB), 75% (at 60 dB), and 70% (at 50 dB) and 90% (at 50 dB), respectively.SP with CI may be safe and reliable in children with CSOM associated with unserviceable hearing. LA - English DB - MTMT ER - TY - JOUR AU - Maász, Anita AU - Hadzsiev, Kinga AU - Ripszám, Réka AU - Zsigmond, Anna AU - Maka, Erika AU - Knézy, Krisztina AU - Lesch, Balázs AU - Németh, Adrienn AU - Bene, Judit AU - Gálik, Bence AU - Gyenesei, Attila AU - Melegh, Béla TI - TUBB4B gene mutation in Leber phenotype of congenital amaurosis syndrome associated with early-onset deafness JF - EUROPEAN JOURNAL OF MEDICAL GENETICS J2 - EUR J MED GENET VL - 65 PY - 2022 IS - 4 PG - 5 SN - 1769-7212 DO - 10.1016/j.ejmg.2022.104471 UR - https://m2.mtmt.hu/api/publication/32711829 ID - 32711829 LA - English DB - MTMT ER - TY - JOUR AU - Pap, István AU - Tóth, István AU - Szakács, Zsolt AU - Gede, Noémi AU - Koukkoullis, Alexandros AU - Révész, Péter AU - Harmat, Kinga AU - Németh, Adrienn AU - Lujber, László AU - Bocskai, Tímea AU - Hegyi, Péter AU - Varga, Gábor AU - Gerlinger, Imre AU - Szanyi, István TI - Az endoszkópos I-es típusú tympanoplastica ugyanolyan hatékony, mint a mikroszkópos I-es típusú tympanoplastica, de kevésbé invazív - Metaanalízis JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 67 PY - 2021 IS - 4 SP - 139 EP - 146 PG - 8 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/32508864 ID - 32508864 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Tamás Ferenc AU - Gerlinger, Imre AU - Bölcsföldi T., Barbara AU - Kellényi, György AU - Németh, Adrienn AU - Papp, István AU - Szanyi, István TI - A Vibrant Soundbridge aktív középfül-implantátum történeti áttekintése és sebészi alkalmazásának lehetőségei = Historical overview and surgical applications of the Vibrant Soundbridge active middle ear implant JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 40 SP - 1619 EP - 1626 PG - 8 SN - 0030-6002 DO - 10.1556/650.2021.32216 UR - https://m2.mtmt.hu/api/publication/32298322 ID - 32298322 AB - Összefoglaló. A Vibrant Soundbridge aktív középfül-implantátum vezetéses, sensorineuralis és kevert típusú halláscsökkenés esetén is megoldást jelenthet a beteg hallásrehabilitációja során. Sensorineuralis halláscsökkenés esetén akkor indikálható, ha a légvezetéses hallásküszöb nem haladja meg a 80-85 dBHL-t a 3-4 kHz frekvenciákon, vezetéses, illetve kevert típusú halláscsökkenés esetén pedig akkor, ha a csontvezetéses hallásküszöb nem haladja meg a 45-65 dBHL-t a 0,5-4 kHz közti frekvenciatartományban. Az implantátum beültetését eleinte tisztán sensorineuralis halláscsökkenés esetén végezték, és csupán egyféleképpen történhetett: a rezgéskeltő rendszer oldalán lévő rögzítőcsipeszt rá kellett applikálni az incus hosszú nyújtványára. Azokra az esetekre, amikor a rezgéskeltő rögzítése nem kivitelezhető, különböző rögzítőelemeket (coupler) fejlesztettek ki. Az incusra való rögzítés hosszúnyújtvány-couplerrel, illetve rövidnyújtvány-couplerrel lehetséges. Vezetéses és kevert típusú halláscsökkenés esetén a kerek ablak membránjához is illeszthető a rendszer, előrehaladott otosclerosis esetén pedig a Soundbridge-implantáció stapedotomiával kiegészített változata ("power stapes") hozhat kielégítő halláseredményt. Ezek a technikák meglehetősen megnövelték a sebész szabadságát, így széles körben alkalmazott, megbízható megoldássá váltak. A Pécsi Tudományegyetem Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinikáján az elmúlt évtizedben számos incusvibroplastica történt, de kerekablak-vibroplasticára is több alkalommal sor került. A jelen összefoglaló tanulmányban a Vibrant Soundbridge implantátum technikai fejlődésének történeti áttekintésén felül az alkalmazható műtéti megoldásokat mutatjuk be. Orv Hetil. 2021; 162(40): 1619-1626. Summary. The Vibrant Soundbridge active middle ear implant can provide a reliable solution for hearing rehabilitation of patients with conductive, sensorineural or mixed hearing loss. For sensorineural hearing loss, the air conduction threshold of the patient should not be more increased than 80-85 dBHL at the range of 3-4 kHz, and for conductive and mixed hearing loss, the bone conduction threshold should not be more increased than 45-65 dBHL between 0.5 and 4 kHz. The standard surgical procedure was originally designed for purely sensorineural hearing loss, and the fixation clip of the vibrating transducer needed to be crimped onto the long process of the incus. In many cases, it is impossible to crimp the vibrator onto the incus. In order to solve such circumstances, fixation clips (couplers) have been developed. There are two options to crimp the device on the incus: applying a long process coupler or a short process coupler. For conductive or mixed hearing loss, a round window soft coupler has been introduced. In advanced otosclerotic cases, a special combined technique of Soundbridge implantation with simultaneous stapedotomy can result in sufficient hearing rehabilitation. These techniques significantly broadened the scale of possibilities for the implantation, therefore, it became a widely utilized, reliable procedure. At the Department of Otorhino-laryngology, Clinical Center, University of Pécs, in addition to a noteworthy amount of incus vibroplasty, several cases of round window vibroplasty have also been performed. The aim of the present study is to summarize the history of development of the Vibrant Soundbridge and to present an overview of the applicable surgical techniques. Orv Hetil. 2021; 162(40): 1619-1626. LA - Hungarian DB - MTMT ER - TY - CHAP AU - Kerémi, Beáta AU - Márta, Katalin AU - Borbásné Farkas, Kornélia AU - Czumbel, László Márk AU - Tóth, Barbara AU - Szakács, Zsolt AU - Csupor, Dezső AU - Czimmer, J AU - Rumbus, Zoltán AU - Révész, Péter AU - Németh, Adrienn AU - Gerber, Gábor AU - Hegyi, Péter AU - Varga, Gábor ED - Rakonczay, Zoltán ED - Kiss, Lóránd TI - The efficacy of chlorine dioxide containing mouthwashes in the oral hygiene – a meta-analysis T2 - Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project PB - University of Szeged CY - Szeged SN - 9789633067642 PY - 2020 SP - 35 EP - 35 PG - 1 UR - https://m2.mtmt.hu/api/publication/31638611 ID - 31638611 LA - English DB - MTMT ER -