TY - JOUR AU - Molnár, Tihamér AU - Lehoczki, Andrea Marianna AU - Fekete, Mónika AU - Várnai, Réka AU - Zavori, Laszlo AU - Erdő-Bonyár, Szabina AU - Simon, Diána AU - Berki, Tímea AU - Csécsei, Péter AU - Ezer, Erzsébet TI - Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - In press PY - 2024 SN - 2509-2715 DO - 10.1007/s11357-024-01165-5 UR - https://m2.mtmt.hu/api/publication/34824081 ID - 34824081 N1 - * Megosztott szerzőség AB - The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition. LA - English DB - MTMT ER - TY - CHAP AU - Molnár, Tihamér ED - Mühl, Diána ED - Csontos, Csaba TI - Ischaemiás és vérzéses stroke T2 - Az intenzív terápia gyakorlata PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269153 PY - 2024 SP - 24 UR - https://m2.mtmt.hu/api/publication/34823776 ID - 34823776 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Tihamér ED - Vámos, Zoltán TI - Súlyos koponya- és agysérült felnőtt aneszteziológiája T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 139 EP - 144 PG - 6 UR - https://m2.mtmt.hu/api/publication/34818206 ID - 34818206 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Molnár, Tihamér TI - Subarachnoidalis vérzés intenzív osztályos kezelése: úton a személyre szabott medicina felé JF - FOCUS MEDICINAE J2 - FOCUS MEDICINAE VL - 25 PY - 2024 IS - 3 SP - 15 EP - 18 PG - 4 SN - 1419-0478 UR - https://m2.mtmt.hu/api/publication/34569393 ID - 34569393 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ezer, Erzsébet AU - Schrick, Diana Zsuzsanna AU - Tőkés-Füzesi, Margit AU - Papp, István AU - Réger, Barbara AU - Molnár, Abigél AU - Ábrahám, Hajnalka AU - Koller, Ákos AU - Hársfalvi, Jolán AU - Kellermayer, Miklós AU - Molnár, Tihamér TI - Gravity sedimentation reveals functionally and morphologically different platelets in human blood JF - PLATELETS J2 - PLATELETS VL - 35 PY - 2024 IS - 1 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2023.2298341 UR - https://m2.mtmt.hu/api/publication/34493390 ID - 34493390 LA - English DB - MTMT ER - TY - JOUR AU - Závori, László AU - Várnai, Réka AU - Molnár, Tihamér AU - Szirmay, Balázs AU - Borbásné Farkas, Kornélia AU - Schwarcz, Attila AU - Csécsei, Péter TI - Acute Phase Protein Orosomucoid (Alpha-1-Acid Glycoprotein) Predicts Delayed Cerebral Ischemia and 3-Month Unfavorable Outcome after Aneurysmal Subarachnoid Hemorrhage JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 20 PG - 10 SN - 1661-6596 DO - 10.3390/ijms242015267 UR - https://m2.mtmt.hu/api/publication/34202983 ID - 34202983 N1 - Export Date: 13 November 2023 Correspondence Address: Szirmay, B.; Department of Laboratory Medicine, Hungary; email: szirmay.balazs@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Csécsei, Péter AU - Oláh, Csaba Zsolt AU - Várnai, Réka AU - Simon, Diána AU - Erdő-Bonyár, Szabina AU - Berki, Tímea AU - Czabajszki, Mate AU - Závori, László AU - Schwarcz, Attila AU - Molnár, Tihamér TI - Different Kinetics of Serum ADAMTS13, GDF-15, and Neutrophil Gelatinase-Associated Lipocalin in the Early Phase of Aneurysmal Subarachnoid Hemorrhage JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 13 PG - 16 SN - 1661-6596 DO - 10.3390/ijms241311005 UR - https://m2.mtmt.hu/api/publication/34043095 ID - 34043095 AB - Growth differentiation factor 15 (GDF-15), neutrophil gelatinase-associated lipocalin (NGAL), and ADAMTS13 have previously been implicated in the pathophysiological processes of SAH. In the present study, we aim to examine their role in the early period of SAH and their relationship to primary and secondary outcomes. Serum samples were collected at five time periods after SAH (at 24 h (D1), at 72 h (D3), at 120 h (D5), at 168 h (D7) and at 216 h (D9), post-admission) and) were measured by using MILLIPLEX Map Human Cardiovascular Disease (CVD) Magnetic Bead Panel 2. We included 150 patients with SAH and 30 healthy controls. GDF-15 levels at D1 to D9 were significantly associated with a 3-month unfavorable outcome. Based on the ROC analysis, in patients with a good clinical grade at admission (WFNS I-III), the GDF-15 value measured at time point D3 predicted a 3-month unfavorable outcome (cut-off value: 3.97 ng/mL, AUC:0.833, 95%CI: 0.728–0.938, sensitivity:73.7%, specificity:82.6%, p < 0.001). Univariate binary logistic regression analysis showed that serum NGAL levels at D1-D5 and ADAMTS13 levels at D7-D9 were associated with MVS following SAH. GDF-15 is an early indicator of a poor 3-month functional outcome even in patients with mild clinical conditions at admission. LA - English DB - MTMT ER - TY - JOUR AU - Zavori, Laszlo AU - Molnár, Tihamér AU - Várnai, Réka AU - Kanizsai, Andrea AU - Nagy, Lajos AU - Vadkerti, Bence AU - Szirmay, Balázs AU - Schwarcz, Attila AU - Csécsei, Péter TI - Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome JF - JOURNAL OF PERSONALIZED MEDICINE J2 - J PERS MED VL - 13 PY - 2023 IS - 2 PG - 11 SN - 2075-4426 DO - 10.3390/jpm13020371 UR - https://m2.mtmt.hu/api/publication/33647476 ID - 33647476 N1 - Salisbury NHS Foundation Trust, Salisbury, SP2 8BJ, United Kingdom Department of Anaesthesiology and Intensive Care, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Primary Health Care, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Dentistry, Medical School, University of Pecs, Pecs, Pecs, 7624, Hungary Department of Applied Chemistry, University of Debrecen, Debrecen, 4032, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Neurosurgery, Medical School, University of Pecs, Pecs, 7624, Hungary Export Date: 13 November 2023 Correspondence Address: Szirmay, B.; Department of Laboratory Medicine, Hungary; email: szirmay.balazs@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Kanizsai, Andrea AU - Zavori, Laszlo AU - Molnár, Tihamér AU - Tőkés-Füzesi, Margit AU - Szalai, Zoltan AU - Berecz, Janos AU - Várnai, Réka AU - Péterfi, Zoltán AU - Schwarcz, Attila AU - Csécsei, Péter TI - Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme JF - VACCINES (BASEL) J2 - VACCINES-BASEL VL - 11 PY - 2023 IS - 1 PG - 10 SN - 2076-393X DO - 10.3390/vaccines11010182 UR - https://m2.mtmt.hu/api/publication/33567482 ID - 33567482 AB - Background: It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it is not clear how the adverse reactions following the booster vaccination are related to the antibody levels that can be measured after a 3rd dose. The primary goal of this study was to investigate whether the adverse reactions following the booster vaccination show a correlation with subsequent antibody levels. Methods: Adverse reactions occurring within 7 days after the 3rd vaccination were recorded and the anti-SARS-CoV-2 spike protein immunoglobulin (Ig) level in the venous blood was measured on post-vaccination 14th, 60th and 120th days. Results: A total of 218 volunteers were included in the study. Main findings: (i) The adverse reactions that appeared after the booster dose did not show a positive correlation with the subsequent antibody level, except a correlation in the case of fever; (ii) there were more symptomatic patients in the group receiving heterologous booster vaccine, (iii) fever after the 2nd dose was independently associated with a reduction in the likelihood of COVID-19 positivity after the booster dose. Conclusion: No adverse reactions, but fever showed a correlation with the antibody level after the booster SARS-CoV-2 vaccine. LA - English DB - MTMT ER - TY - BOOK AU - Bátai, István AU - Bogár, Lajos AU - Csontos, Csaba AU - Ezer, Erzsébet AU - Molnár, Tihamér AU - Mühl, Diána AU - Almási, Róbert Gyula AU - Kövesi, Tamás AU - Márton, Sándor TI - ANAESTHESIOLOGY AND INTENSIVE CARE THERAPY UNIVERSITY COURSE BOOK PB - PTE ÁOK CY - Pécs PY - 2022 UR - https://m2.mtmt.hu/api/publication/34118867 ID - 34118867 LA - German DB - MTMT ER -