@article{MTMT:34198121, title = {Circulating microRNAs correlate with structural and functional MRI parameters in patients with multiple sclerosis}, url = {https://m2.mtmt.hu/api/publication/34198121}, author = {Geiger, Lili and Orsi, Gergely and Cseh, Tamás and Gombos, Katalin and Illés, Zsolt László and Czéh, Boldizsár}, doi = {10.3389/fnmol.2023.1173212}, journal-iso = {FRONT MOL NEUROSCI}, journal = {FRONTIERS IN MOLECULAR NEUROSCIENCE}, volume = {16}, unique-id = {34198121}, issn = {1662-5099}, year = {2023}, eissn = {1662-5099}, orcid-numbers = {Illés, Zsolt László/0000-0001-9655-0450} } @article{MTMT:33665711, title = {NGS-based pipeline for routine non-invasive preimplantation genetic assessment in IVF}, url = {https://m2.mtmt.hu/api/publication/33665711}, author = {Gombos, Katalin and Gálik, Bence and Godony, K. and Varnagy, A. and Bódis, József and Gyenessei, A. and Kovács, L. Gábor}, doi = {10.1016/j.cca.2022.04.431}, journal-iso = {CLIN CHIM ACTA}, journal = {CLINICA CHIMICA ACTA}, volume = {530}, unique-id = {33665711}, issn = {0009-8981}, year = {2022}, eissn = {1873-3492}, pages = {S407-S408}, orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401} } @article{MTMT:33061357, title = {Diagnostic accuracy of SARS-CoV-2 Panbio™ rapid antigen diagnostic tests in a 4,440-case clinical follow-up.}, url = {https://m2.mtmt.hu/api/publication/33061357}, author = {Hamar, Ágoston László and Filipánits, Kristóf and Váradi, Alex and Váradi-Rácz, Rita and Gellén, Henrietta Orsolya and Futács, Krisztina and Urbán, Péter and Kovács, L. Gábor and Gombos, Katalin}, doi = {10.3389/fmed.2022.908127}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {9}, unique-id = {33061357}, abstract = {Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Rapid Antigen Detection Testing (RADT) has been subjected to several evaluations in reference to diagnostic accuracy, ranging from small scale up to large population studies including nation-wide community-based studies. All confirmed the diagnostic accuracy of the tests which were strongly dependent upon the infection's population prevalence. In our retrospective study, parallel SARS-CoV-2 Panbio™ RADT assay, including real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) tests, were aimed to evaluate diagnostic performance regarding the rapid antigen diagnostic testing. Out of 4,440 paired tests, 609 samples tested positive using RT-qPCR, resulting in a prevalence of 13.7%. Panbio detected 251 (5.7%) positive tested samples. Overall sensitivity was 41.2% (95% CI 37.4-45.2%) and overall specificity was 99.7% (95% CI 99.4-99.8%). Positive predictive value (PPV) was 95.1% (95% CI 91.8-97.1%) and the negative predictive value (NPV) was 91.4% (95% CI 90.5-92.2%). RADT sensitivity increased with stratification in reference to the results according to PCR Cycle threshold (Ct) and presence of the symptoms considerably influenced PPV and NPV. Sensitivity in the group of Ct values ≤ 20 was 91.2%, 68.6% within the Ct range of 20-25, 47.9% in the group of Ct values between 25 and 30, and 12.6% in the group of Ct values between 30 and 35. A follow-up of the positive cases aligned with RT-qPCR testing and comparison of the general population enrolled in the testing in which the fatal cases occurred enabled us to estimate real clinical diagnostic performance regarding the SARS-CoV-2 Panbio RADT. Based upon our results, we recommend the SARS-CoV-2 Panbio RADT tests be carried out as the primary test, without parallel PCR testing, only among high population prevalence rates of the infection and to be used for symptomatic individuals with average or low severe disease developmental risk. In the case of high risk regarding the development of severe infection complications, a parallel SARS-CoV-2 RT-qPCR is needed to be carried out to attain proper diagnostic accuracy and avoid delaying appropriate medical care.}, keywords = {diagnostic accuracy; RT-qPCR; COVID-19; SARS-CoV-2; Panbio; rapid antigen testing}, year = {2022}, eissn = {2296-858X}, orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Kovács, L. Gábor/0000-0001-5298-5401} } @article{MTMT:32785460, title = {Novel Molecular Approaches to the Understanding of Pathophysiologal Mechanisms Acting in Human Embryos: An Editorial}, url = {https://m2.mtmt.hu/api/publication/32785460}, author = {Kovács, L. Gábor and Gombos, Katalin}, doi = {10.3390/ijms23084327}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32785460}, issn = {1661-6596}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401} } @misc{MTMT:32635269, title = {Extracellular circulating miRNAs as potential biomarkers in multiple sclerosis and epilepsy}, url = {https://m2.mtmt.hu/api/publication/32635269}, author = {Geiger, Lili and Horváth, Réka and Janszky, József Vladimír and Kecskés, Miklós and Orsi, Gergely and Tóth, Márton and Miseta, Attila János and Illés, Zsolt László and Gombos, Katalin and Czéh, Boldizsár}, unique-id = {32635269}, year = {2022}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Miseta, Attila János/0000-0002-7984-3347; Illés, Zsolt László/0000-0001-9655-0450} } @{MTMT:32643372, title = {Az extracellulárisan keringő miRNS-ek, mint potenciális biomarkerek neuropszichiátriai rendellenességekben: Előzetes tanulmány}, url = {https://m2.mtmt.hu/api/publication/32643372}, author = {Geiger, Lili and Horváth, Réka and Kecskés, Miklós and Orsi, Gergely and M., Tóth and Miseta, Attila János and Illés, Zsolt László and Gombos, Katalin and Czéh, Boldizsár}, booktitle = {10th Jubilee Interdisciplinary Doctoral Conference : Book of Abstracts = 10. Jubileumi Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet}, unique-id = {32643372}, year = {2021}, pages = {304-304}, orcid-numbers = {Miseta, Attila János/0000-0002-7984-3347; Illés, Zsolt László/0000-0001-9655-0450} } @{MTMT:32640021, title = {Covid-19 pandemic in the Southern Transdanubia region depicted using a dynamic interactive map}, url = {https://m2.mtmt.hu/api/publication/32640021}, author = {Hamar, Ágoston László and Filipánits, Kristóf and Glavatity, András and Wágner, Róbert and Gombos, Katalin}, booktitle = {10th Jubilee Interdisciplinary Doctoral Conference : Book of Abstracts = 10. Jubileumi Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet}, unique-id = {32640021}, year = {2021}, pages = {69-69} } @article{MTMT:32153531, title = {Initial Renal Function (eGFR) Is a Prognostic Marker of Severe Acute Pancreatitis: A Cohort-Analysis of 1,224 Prospectively Collected Cases}, url = {https://m2.mtmt.hu/api/publication/32153531}, author = {Tod, Pál and Borbásné Farkas, Kornélia and Németh, Dávid and Szénási, Gábor and Vincze, Áron and Hágendorn, Roland and Czakó, László and Illés, Dóra and Izbéki, Ferenc and Dunás-Varga, Veronika and Papp, Mária and Hamvas, József and Varga, Márta and Gombos, Katalin and Nagy, Tamás and Márton, Zsolt and Faluhelyi, Nándor and Török, Imola and Ince, Ali Tüzün and Galeev, Shamil and Hegyi, Péter Jenő and Szentesi, Andrea Ildikó and Párniczky, Andrea and Szakács, Zsolt and Hegyi, Péter and Hamar, Péter}, doi = {10.3389/fmed.2021.671917}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {8}, unique-id = {32153531}, year = {2021}, eissn = {2296-858X}, orcid-numbers = {Tod, Pál/0000-0001-9163-7071; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Szénási, Gábor/0000-0002-7350-6091; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Nagy, Tamás/0000-0001-5437-1411; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Hamar, Péter/0000-0002-1095-3564} } @article{MTMT:32098656, title = {Pécsi innovációs technológiák a humán reprodukció szolgálatában : Embrióvédelemmel kapcsolatos vizsgálatok, hagyományos embriószelekciós eljárások, az embrió életképességének és betegségeinek genetikai markerei}, url = {https://m2.mtmt.hu/api/publication/32098656}, author = {Bódis, József and Szekeres, Júlia and Sulyok, Endre and Gombos, Katalin and Bognár, Zoltán and Gyenesei, Attila and Gödöny, Krisztina and Mauchart, Péter and Várnagy, Ákos and Ertl, Tibor and Nagy, Bernadett and Kovács, Kálmán András and Kovács, L. Gábor}, journal-iso = {NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE}, journal = {NŐGYÓGYÁSZATI ÉS SZÜLÉSZETI TOVÁBBKÉPZŐ SZEMLE}, volume = {23}, unique-id = {32098656}, issn = {1585-8731}, year = {2021}, pages = {72-86}, orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401} } @article{MTMT:31895580, title = {NGS-Based Application for Routine Non-Invasive Pre-Implantation Genetic Assessment in IVF}, url = {https://m2.mtmt.hu/api/publication/31895580}, author = {Gombos, Katalin and Gálik, Bence and Kalács, Krisztina Ildikó and Gödöny, Krisztina and Várnagy, Ákos and Alpár, Donát and Bódis, József and Gyenesei, Attila and Kovács, L. Gábor}, doi = {10.3390/ijms22052443}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {31895580}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Alpár, Donát/0000-0002-2638-5418; Kovács, L. Gábor/0000-0001-5298-5401} }