TY - GEN AU - Tóth, Márton AU - Szőcs, Szilárd AU - Henn-Mike, Nóra AU - Agócs-Laboda, Ágnes AU - Kovács, Tamás AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Varga, Csaba TI - Altered h-current in cortical interneurons of drug-resistant epileptic patients PY - 2022 UR - https://m2.mtmt.hu/api/publication/33335271 ID - 33335271 N1 - előadás AB - Approximately 30% of the epileptic patients are drug-resistant. Most of this drugresistant group has a well-defined, focal onset region. For these focal onset, drug-resistant epilepsy patients the surgical resection might be the best therapeutic option for achieving seizure freedom. In many cases the pathological high-frequency oscillations (pHFO) are continuously present in the epileptogenic zone (EZ), however, the pHFOs do not always propagate to neighboring areas. The mechanism which blocks this continuously ongoing pHFOs from generating generalized epilepsy is not entirely known. In the present study, we compared the basic electrophysiological properties of GABAergic interneurons of surgically removed EZ and control (non-epileptic, subcortical tumor patient) cortical interneurons. Most GABAergic interneurons in the control cortical preparations showed prominent sag-potentials caused by hcurrent. In contrast, sag-potentials were less prominent or completely missing in epileptic interneurons. H-current in fast-spiker interneurons have been shown previously to be involved in the maintenance of repeated, high-frequency bursting of interneurons. We hypothesize that the epileptic interneurons are unable to maintain high-frequency bursting activity for longer period, which contributes to the propagation and generalization of pHFOs in epilepsy.Our research was funded by TKP20214. The research was performed in collaboration with the Nano-Bio-Imaging core facility at the Szentágothai Research Centre of the University of Pécs. LA - English DB - MTMT ER - TY - JOUR AU - Trischlerné Gyimesi, Csilla AU - Barsi, Péter AU - Bóné, Beáta AU - Dóczi, Tamás Péter AU - Horváth, Réka AU - Horváth, Zsolt AU - Komoly, Sámuel AU - Lőrincz, Katalin Nóra AU - Tóth, Márton AU - Janszky, József Vladimír TI - Epilepsziasebészet a pécsi epilepsziacentrumban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 17 EP - 17 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893951 ID - 32893951 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ábrahám, Hajnalka AU - Sóki, Noémi AU - Richter, Zsófia AU - Karádi, Kázmér AU - Lőrincz, Katalin AU - Horváth, Réka AU - Trischlerné Gyimesi, Csilla AU - Szekeres-Paraczky, Cecília AU - Sétáló, György (ifj.) AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Seress, László TI - Fehérállományi neuronok és szerepük a temporalislebeny-epilepsziában JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 8 EP - 8 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893852 ID - 32893852 LA - Hungarian DB - MTMT ER - TY - CONF AU - Tóth, Márton AU - Szőcs, Szilárd AU - Henn-Mike, Nóra AU - Agócs-Laboda, Ágnes AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Varga, Csaba TI - Altered H-current in cortical interneurons of drug-resistant epileptic patients T2 - International Neuroscience Meeting, Budapest 2022 PY - 2022 SP - 125 UR - https://m2.mtmt.hu/api/publication/32643404 ID - 32643404 LA - English DB - MTMT ER - TY - JOUR AU - Sóki, Noémi AU - Richter, Zsófia AU - Karádi, Kázmér AU - Lőrincz, Katalin AU - Horváth, Réka AU - Trischlerné Gyimesi, Csilla AU - Szekeres-Paraczky, Cecília Kata AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Seress, László AU - Ábrahám, Hajnalka TI - Investigation of synapses in the cortical white matter in human temporal lobe epilepsy JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1779 PY - 2022 PG - 12 SN - 0006-8993 DO - 10.1016/j.brainres.2022.147787 UR - https://m2.mtmt.hu/api/publication/32598077 ID - 32598077 N1 - Department of Medical Biology and Central Electron Microscopic Laboratory, University of Pécs Medical School, Szigeti u. 12, Pécs, 7643, Hungary Neuromorphology and Cellular Neurobiology Research Group, Center for Neuroscience, University of Pécs, Ifjúság u. 20, Pécs, 7624, Hungary Department of Behavioral Sciences, University of Pécs Medical School, Szigeti u. 12, Pécs, 7624, Hungary Department of Neurology, University of Pécs Medical School, Rét u. 2, Pécs, 7623, Hungary Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, Szigony u. 43, Budapest, 1083, Hungary Department of Neurosurgery, University of Pécs Medical School, Rét u. 2, Pécs, 7623, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Center for Neuroscience, University of Pécs, Ifjúság u 20, Pécs, 7624, Hungary Cited By :2 Export Date: 5 March 2024 CODEN: BRREA Correspondence Address: Ábrahám, H.; Department of Medical Biology and Central Electron Microscopic Laboratory, Szigeti u. 12, Hungary; email: hajnalka.abraham@aok.pte.hu Chemicals/CAS: Synaptophysin; SYP protein, human Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, -16-2016-00004, 2020-4.1.1-TKP2020, K125436, TKP2020-IKA-08 Funding details: Innovációs és Technológiai Minisztérium, GINOP-2.3.3-15-2016-00026 Funding text 1: This work was supported by the Hungarian Brain Research Program NAP 2.0 (2017-1.2.1-NKP-2017-00002), by National Research, Development and Innovation Fund of Hungary (NKFIH) K125436, by PTE EFOP-3.6.1.-16-2016-00004 and by project no. TKP2020-IKA-08 that has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the 2020-4.1.1-TKP2020 funding scheme and by the Thematic Excellence Program 2021 Health Sub-programme of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the Pécs of University. JEOL JEM-1400Flash TEM electron microscope was funded by the GINOP-2.3.3-15-2016-00026 (New generation electron microscope: 3D ultrastructure). LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Barsi, Péter AU - Tóth, Zoltán AU - Borbély, Katalin AU - Lückl, János AU - Emri, Miklós AU - Repa, Imre AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Halász, Péter AU - Juhos, Vera AU - Trischlerné Gyimesi, Csilla AU - Bóné, Beáta AU - Kuperczkó, Diána AU - Horváth, Réka AU - Nagy, Ferenc AU - Kelemen, Anna AU - Jordán, Zsófia AU - Újvári, Ákos AU - Hagiwara, Koichi AU - Isnard, Jean AU - Pál, Endre AU - Fekésházy, Attila AU - Fabó, Dániel AU - Vajda, Zsolt TI - The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy JF - BMC NEUROLOGY J2 - BMC NEUROL VL - 21 PY - 2021 IS - 1 PG - 20 SN - 1471-2377 DO - 10.1186/s12883-021-02352-z UR - https://m2.mtmt.hu/api/publication/32219141 ID - 32219141 N1 - * Megosztott szerzőség AB - When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary.008899/2016/OTIG . Date of registration: 08 February 2016. LA - English DB - MTMT ER - TY - JOUR AU - Soltani, Amina AU - Kajtár, Béla AU - Elhusseiny, Mohamed Mahmoud Abdelwahab AU - Steib, Anita AU - Horváth, Zsolt AU - Mangel, László Csaba AU - Járomi, Luca AU - Pongrácz, Judit TI - Is an Immunosuppressive Microenvironment a Characteristic of Both Intra- and Extraparenchymal Central Nervous Tumors? JF - PATHOPHYSIOLOGY J2 - PATHOPHYSIOLOGY VL - 28 PY - 2021 IS - 1 SP - 34 EP - 49 PG - 16 SN - 0928-4680 DO - 10.3390/pathophysiology28010004 UR - https://m2.mtmt.hu/api/publication/31846958 ID - 31846958 N1 - Funding Agency and Grant Number: University of Pecs KA Research Fund 2018 [TUDFO/51757-1/2019-ITM]; [EFOP-3.6.1-16-2016-00004]; [GINOP-2.3.2.-15-2016-00022] Funding text: This research was supported by grants EFOP-3.6.1-16-2016-00004; University of Pecs KA Research Fund 2018 (to J.E.P.), TUDFO/51757-1/2019-ITM; GINOP-2.3.2.-15-2016-00022. LA - English DB - MTMT ER - TY - JOUR AU - Ábrahám, Hajnalka AU - Molnár, Judit E. AU - Sóki, Noémi AU - Trischlerné Gyimesi, Csilla AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Seress, László TI - Etiology-related degree of sprouting of parvalbumin-immunoreactive axons in the human dentate gyrus in temporal lobe epilepsy JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 448 PY - 2020 IS - 10 SP - 55 EP - 70 PG - 16 SN - 0306-4522 DO - 10.1016/j.neuroscience.2020.09.018 UR - https://m2.mtmt.hu/api/publication/31602482 ID - 31602482 LA - English DB - MTMT ER - TY - CHAP AU - Mangel, László Csaba AU - Máhr, Károly AU - Horváth, Zsolt ED - Mangel, László Csaba ED - Bellyei, Szabolcs ED - Boronkai, Árpád TI - Központi idegrendszeri daganatok T2 - Onkológiai jegyzet PB - PTE ÁOK Onkoterápiás Intézet CY - Pécs PY - 2019 SP - 141 EP - 147 PG - 7 UR - https://m2.mtmt.hu/api/publication/31016142 ID - 31016142 N1 - 19. fejezet LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Katalin Nóra AU - Bóné, Beáta AU - Tóth, Márton AU - Horváth, Réka AU - Kovács, Norbert AU - Komoly, Sámuel AU - Karádi, Kázmér AU - Barsi, Péter AU - Ábrahám, Hajnalka AU - Seress, László AU - Horváth, Zsolt AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír AU - Trischlerné Gyimesi, Csilla TI - Epilepszia sebészeti beavatkozások eredményei a Pécsi Epilepszia Centrumban 2005-2016 között JF - ORVOSI HETILAP J2 - ORV HETIL VL - 160 ET - 0 PY - 2019 IS - 7 SP - 270 EP - 278 PG - 9 SN - 0030-6002 DO - 10.1556/650.2019.31321 UR - https://m2.mtmt.hu/api/publication/30432269 ID - 30432269 AB - Epilepsy as a chronic, severe neurologic disease significantly influences the quality of life of the epileptic patients. In candidates well selected for surgery, the seizure freedom is realistically achievable, and the quality of life can be further improved with complex individual rehabilitation.We aimed to evaluate the postoperative outcome of patients who underwent epilepsy surgery between 2005 and 2016 at the Epilepsy Center at Pécs.We evaluated seizure status at regular follow-up visits after surgery and the quality of life using questionnaires focusing on employment and social status.76% of the 72 patients who underwent surgical resection for epilepsy were free from disabling seizures , and 10% had rare disabling seizures (almost seizure-free), 7% experienced worthwhile improvement and 7% had no worthwhile improvement. Comparing the employment status of patients free from disabling seizures to patients not free from disabling seizures, we found that the employment status is significantly influenced by seizure freedom (p<0.01, Fisher's exact test). While 67% of seizure-free patients were employed, only 19% of patients not free from disabling seizures were hired.Our results resemble the international tendencies and success rate, proving epilepsy surgery as an available, valid and effective treatment in well selected patients. Orv Hetil. 2019; 160(7): 270-278. LA - Hungarian DB - MTMT ER -