TY  - JOUR
AU  - Szántó, Tamás
AU  - Béres, Szabolcs
AU  - Husznai, Róbert
AU  - Kiss, Rudolf
AU  - Kellermayer, Dalma
AU  - Tornóczky, Tamás
AU  - Hejjel, László
TI  - Aortabillentyű-beültetés antifoszfolipid szindrómában
JF  - MAGYAR SEBÉSZET
J2  - MAGYAR SEBÉSZET
VL  - 76
PY  - 2023
IS  - 4
SP  - 111
EP  - 115
PG  - 5
SN  - 0025-0295
DO  - 10.1556/1046.2023.40002
UR  - https://m2.mtmt.hu/api/publication/34484706
ID  - 34484706
AB  - Egy 44 éves férfi betegnél endokarditisz talaján kialakult súlyos aortabillentyű-elégtelenség tett szükségessé szívsebészeti beavatkozást. A kevesebb mint egy év alatt bekövetkezett többszöri trombotikus esemény felvetette antifoszfolipid szindróma lehetőségét. A lupus antikoaguláns pozitivitás és az említett klinikai kép ezt igazolta.Betegünk fiatal életkora és a biológiai műbillentyű korlátozott élettartama ellenére biológiai műbillentyű beültetése mellett döntöttünk. Választásunkat azzal indokoljuk, hogy tanulmányok bizonyítják antifoszfolipid szindrómás betegeknél a mechanikus műbillentyűvel összefüggésbe hozható thromboembolia viszonylag gyakori előfordulását. A műtétet szövődménymentesen elvégeztük, aktivált parciális thromboplastin idővel kontrollált Na-heparin korai adása mellett állítottuk be az orális antikoaguláns terápiát 3,0 INR célértékkel a műtét utáni ötödik napra. A műtét során eltávolított billentyűből korokozó nem tenyészett ki. A kórszövettani vizsgálat abakteriális endokarditiszt véleményezett, nem kizárva a korábbi fertőzést. Biológiai műbillentyű implantáció után három hónapig ajánlott aszpirin vagy K-vitamin antagonista adása, betegünk esetében viszont élethosszig tartó antikoaguláns kezelés szükséges, tekintettel rendszerbetegségére.Halmozódó tromboembóliás események kapcsán gondolni kell antifoszfolipid szindrómára, mely igazolása adott esetben meghatározhatja a választható műbillentyű fajtáját. Az ajánlások legtöbbször csak általánosságban fedik le a ritka társbetegségeket, ezért a kapcsolódó szakirodalom áttekintése is szükséges az optimális, betegre szabott döntéshez.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hajdu, Máté
AU  - Garmpis, Konstandia
AU  - Vértes, Vivien
AU  - Varga, Noémi
AU  - Molnár, Gergő Attila
AU  - Hejjel, László
AU  - Wittmann, István
AU  - Faludi, Réka
TI  - Determinants of the heart rate variability in type 1 diabetes mellitus
JF  - FRONTIERS IN ENDOCRINOLOGY
J2  - FRONT ENDOCRINOL
VL  - 14
PY  - 2023
PG  - 11
SN  - 1664-2392
DO  - 10.3389/fendo.2023.1247054
UR  - https://m2.mtmt.hu/api/publication/34180182
ID  - 34180182
AB  - <sec>BackgroundEvaluation of heart rate variability (HRV) detects the early subclinical alterations of the autonomic nervous system. Thus, impaired HRV is the earliest subclinical marker of cardiac autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM).</sec><sec>ObjectivesWe aimed to explore the HRV parameters in asymptomatic T1DM patients and compare them with the results obtained in healthy subjects. Potential associations between HRV parameters and the established risk factors for CAN and cardiovascular diseases were also investigated.</sec><sec>MethodsSeventy T1DM patients (38 ± 12 years, 46 females) and 30 healthy subjects were enrolled into the study. For HRV analysis, beat-to-beat heart rate was recorded for 30 min. The less noisy 5-min segment of the recording was analyzed by Bittium Cardiac Navigator HRV analysis software. Time domain, frequency domain, and nonlinear indices were calculated.</sec><sec>ResultsRegarding ratio of low to high frequency component (LF/HF), no differences were found between the two populations (p = 0.227). All the further, time domain, frequency domain, and nonlinear HRV indices were significantly lower in T1DM patients (each p < 0.001). In multiple linear models, disease duration remained the only independent predictor of LF/HF ratio (p = 0.019). HbA1c was found to be significant independent predictor of all further time domain (SDNN, p < 0.001; rMSSD, p < 0.001), frequency domain (VLF, p < 0.001; LF, p = 0.002; HF, p = 0.006; Total Power, p = 0.002), and nonlinear indices (SD1, p = 0.006; SD2, p = 0.007), alone, or in combination with other factors, such as age or body mass index.</sec><sec>ConclusionAsymptomatic T1DM patients have significantly reduced overall HRV as compared with healthy subjects, indicating subclinical CAN. Quality of the glycemic control is important determinant of HRV among T1DM patients. This relationship is independent of other risk factors for CAN or cardiovascular diseases.</sec>
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kosztin, Annamária
AU  - Polgár, Balázs
AU  - Kónyi, Attila
AU  - Hejjel, László
AU  - Gellér, László Alajos
AU  - Vámos, Máté
TI  - A kardiális reszinkronizációs kezelésben részesülő betegek interdiszciplináris gondozása
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 53
PY  - 2023
IS  - 4
SP  - 365
EP  - 374
PG  - 10
SN  - 0133-5596
DO  - 10.26430/CHUNGARICA.2023.53.4.365
UR  - https://m2.mtmt.hu/api/publication/34173278
ID  - 34173278
N1  - Semmelweis Egyetem, Városmajori Szív-és Érgyógyászati Klinika, Budapest, Hungary            
            Észak-pesti Centrumkórház – Honvédkórház, Kardiológia Osztály, Budapest, Hungary            
            Pécsi Tudományegyetem, Szívgyógyászati Klinika, Pacemaker Részleg, Pécs, Hungary            
            Pécsi Tudományegyetem, Szívgyógyászati Klinika, Szívsebészeti osztály, Pécs, Hungary            
            Szegedi Tudományegyetem, Belgyógyászati Klinika, Kardiológiai Centrum, Elektrofiziológiai Részleg, Szeged, Hungary            
            Export Date: 16 April 2024            
            Correspondence Address: Máté, V.; Szegedi Tudományegyetem, Semmelweis u. 8, Hungary; email: vamos.mate@med.u-szeged.hu
AB  - Bár a kardiális reszinkronizációs kezelés (CRT) klinikai végpontokra kifejtett kedvező hatása jól ismert, sajnos nem minden beteg reagál ugyanolyan mértékben a kezelésre, a nonreszponderitás továbbra is fontos probléma. A reszponderitás arányának optimalizálása a műtét előtti betegkiválasztásnál kezdődik, jelentősége van a beültetett eszközök/ elektródák típusának és a beültetés módjának, valamint a szoros követésnek is. A CRT-re adott válasz értékelése közös feladata a beteget gondozó kardiológusnak, szívelégtelenség specialistának, az echokardiográfiás kontrollt végzőnek, a készüléket ellenőrző elektrofiziológusnak és a családorvosnak. Jelen összefoglalóban ezeket a speciális beteggondozási feladatokat, illetve optimalizációs lehetőségeket tekintjük át.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ajtay, Bella Eszter
AU  - Béres, Szabolcs
AU  - Hejjel, László
TI  - The Effect of Device-Controlled Breathing on the Pulse Arrival Time and the Heart Rate Asymmetry Parameters in Healthy Volunteers
JF  - APPLIED SCIENCES-BASEL
J2  - APPL SCI-BASEL
VL  - 13
PY  - 2023
IS  - 9
PG  - 14
SN  - 2076-3417
DO  - 10.3390/app13095642
UR  - https://m2.mtmt.hu/api/publication/33802298
ID  - 33802298
AB  - Background: The development of wearables has facilitated the monitoring of biomedical parameters in everyday life. One of the most common sensors of these gadgets is the photoplethysmograph (PPG); hence, the proper processing and interpretation of the PPG signal are essential. Besides pulse rate detection, these devices—together with an ECG—compute the pulse arrival time (PAT), from which the actual beat-to-beat blood pressure can be estimated. The heart rate shows asymmetrical accelerations and decelerations, quantified by the parameters of heart rate asymmetry (HRA). In the present study, we investigated the influences of different breathing-patterns on the PATs and HRA parameters. Methods: The authors evaluated 5 min simultaneous respiratory-, ECG- and PPG-signal recordings of 35 healthy, young volunteers specifically expressing the following breathing patterns: metronome-controlled inspiration, and both inspiration and expiration controlled at 1:1 and 1:2 ratios, respectively. The records were analyzed by HRVScan_Merge v3.2 software. The PAT values were calculated at eight different reference points. The HRA parameters and the PAT values at different breathing patterns were compared using the Friedman test and post hoc Wilcoxon paired-sample test. Results: Porta- and Guzik-indices significantly increased at 1:1 breathing compared to 1:2 and single-paced breathing. PATs increased significantly in dual-paced series compared to single-paced series at each reference point. Conclusion: Based on our results, the increased PATs at dual-paced versus single-paced breathing may indicate the involvement of cognitive functions. The symmetrical respiration ratio increases the heart rate symmetry; however, this effect is not detectable in the periphery through the PATs.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ajtay, Bella Eszter
AU  - Béres, Szabolcs
AU  - Hejjel, László
TI  - The oscillating pulse arrival time as a physiological explanation regarding the difference between ECG- and Photoplethysmogram-derived heart rate variability parameters
JF  - BIOMEDICAL SIGNAL PROCESSING AND CONTROL
J2  - BIOMED SIGNAL PROCES
VL  - 79
PY  - 2023
IS  - 1
PG  - 12
SN  - 1746-8094
DO  - 10.1016/j.bspc.2022.104033
UR  - https://m2.mtmt.hu/api/publication/33050034
ID  - 33050034
AB  - Background and Objective: ECG-based heart rate variability (HRV), and more recently, optical pulse rate variability (PRV) analysis used in wearables are non-invasive tools of neurocardiac investigation. Pulse arrival time (PAT) is derived from their simultaneous recording. We examined the beat-to-beat PAT in greater detail, while analyzed the PRV to HRV relationship. Methods: We acquired 300sec ECG, photoplethysmogram (PPG), and respiratory-signals from 35 young, healthy volunteers while in a supine position including different breathing patterns. PAT at eight reference points on the PPG-side was assessed by the mean, relative precision (RP%) and spectral analysis. PRV and HRV parameters were compared by relative accuracy error (RAE) and the Bland-Altman-Ratio (BAR). Results: PAT showed the minimum RP% at the 1/2-amplitude point whereas RP% reached the maximum at the base point; its observed fine oscillation was associated to breathing as confirmed through spectral analysis. The instantaneous slope of PPG rise is inversely proportional to the corresponding PAT. RAE and BAR showed excellent agreement in 15 of 16 analysis at time-domain, mostly excellent or moderate on frequency-domain and nonlinear analysis. The inherent difference between HRV and PRV is formally due to the difference among two consecutive PATs. Conclusion and Significance: The present study supported the interchangeability of HRV- and PRV-analysis. Our formalistic explanation linking successive PAT-pairs and the inborn difference between HRV and PRV may bear further implications in selecting the appropriate fiducial points, approximating PRV to HRV measures, and in creating innovative neurocardiac parameters or complex PPG models/simulators. © 2022
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hajdu, Máté
AU  - Garmpis, Konstandia
AU  - Vértes, Vivien
AU  - Vorobcsuk-Varga, Noémi
AU  - Hejjel, László
AU  - Molnár, Gergő Attila
AU  - Wittmann, István
AU  - Faludi, Réka
TI  - A glikémiás kontroll minősége szignifikánsan befolyásolja a szívfrekvencia variabilitást 1-es típusú diabéteszben = Quality of glycaemic control has significant impact on heart rate variability in type 1 diabetes mellitus
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 52
PY  - 2022
IS  - Suppl. C.
SP  - 335
EP  - 335
PG  - 1
SN  - 0133-5596
UR  - https://m2.mtmt.hu/api/publication/34104415
ID  - 34104415
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Molnár, B.
AU  - Micsinyei, L.
AU  - Perlaki, Gábor
AU  - Orsi, Gergely
AU  - Hejjel, László
AU  - Dóczi, Tamás Péter
AU  - Janszky, József Vladimír
AU  - Laky, N.
AU  - Tényi, Á.
ED  - Rojas, I.
ED  - Valenzuela, O.
ED  - Rojas, F.
ED  - Herrera, L.J.
ED  - Ortuno, F.
TI  - Data Quality Enhancement for Machine Learning on Wearable ECGs
VL  - 13346 LNBI
PB  - Springer Science+Business Media
SN  - 9783031077036
T3  - Lecture Notes in Computer Science, ISSN 0302-9743 ; 13346 LNBI.
PY  - 2022
SP  - 269
EP  - 279
PG  - 11
DO  - 10.1007/978-3-031-07704-3_22
UR  - https://m2.mtmt.hu/api/publication/32925495
ID  - 32925495
N1  - Export Date: 27 January 2024
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kreska, Zita
AU  - Mátrai, Péter
AU  - Németh, Balázs
AU  - Ajtay, Bella Eszter
AU  - Kiss, István
AU  - Hejjel, László
AU  - Ajtay, Zénó
TI  - Physical Vascular Therapy (BEMER) Affects Heart Rate Asymmetry in Patients With Coronary Heart Disease.
JF  - IN VIVO
J2  - IN VIVO
VL  - 36
PY  - 2022
IS  - 3
SP  - 1408
EP  - 1415
PG  - 8
SN  - 0258-851X
DO  - 10.21873/invivo.12845
UR  - https://m2.mtmt.hu/api/publication/32800048
ID  - 32800048
AB  - The aim of this study was to assess the acute effects of physical vascular therapy (PVT) on the autonomous nervous system by heart rate variability (HRV) and heart rate asymmetry (HRA) analysis. The low-frequency, pulsed electromagnetic field (<35 μTesla) with a patented BEMER pattern can improve vasomotion and microcirculation. A non-invasive confirmation of the instant effects of PVT may provide an opportunity to give an immediate feedback to the patient and therapist.Altogether 48 patients on inward rehabilitation with coronary heart disease (CHD) were involved, their treatment included PVT with B.Box Professional and B.Body Pro applicator (BEMER International AG, Triesen, Lichtenstein). After 15 min of postural adaptation, 6-min electrocardiograms (ECG) were taken immediately before, in the first and in the last 6 min of the 20-min PVT, and one hour after the treatment. Of the 48 patients, the last twenty patients received sham PVT with the same protocol. Off-line analysis was blinded. We used linear mixed statistical model to compare HRV and HRA parameters.The time domain parameters did not show any statistically significant differences between the changes in the real PVT and sham groups but, in the first stage of the treatment, Porta and Guzik indices significantly rose everywhere except in the sham group.PVT significantly increases the Guzik and Porta indices in chronic ischemic heart disease patients reflecting a delicate autonomic response. HRA as a measure of autonomic regulation seems to be more sensitive than time domain parameters.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Béres, Szabolcs
AU  - Hejjel, László
TI  - The minimal sampling frequency of the photoplethysmogram for accurate pulse rate variability parameters in healthy volunteers
JF  - BIOMEDICAL SIGNAL PROCESSING AND CONTROL
J2  - BIOMED SIGNAL PROCES
VL  - 68
PY  - 2021
PG  - 8
SN  - 1746-8094
DO  - 10.1016/j.bspc.2021.102589
UR  - https://m2.mtmt.hu/api/publication/31969946
ID  - 31969946
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hejjel, László
AU  - Béres, Szabolcs
TI  - Comment on 'Pulse rate variability in cardiovascular health : a review on its applications and relationship with heart rate variability'
JF  - PHYSIOLOGICAL MEASUREMENT
J2  - PHYSIOL MEAS
VL  - 42
PY  - 2021
IS  - 1
PG  - 3
SN  - 0967-3334
DO  - 10.1088/1361-6579/abd332
UR  - https://m2.mtmt.hu/api/publication/31857900
ID  - 31857900
N1  - Comment
AB  - Precise beat-to-beat fiducial point detection in the photoplethysmogram signal is essential for reliable pulse rate variability (PRV) analysis, which is considered an integral part of health monitoring devices in the evolving era of mobile health. Several studies have aimed to compare PRV to the well-investigated, gold standard heart rate variability (HRV) analysis, to see if they are interchangeable. The agreement between PRV and HRV is not unequivocal, as we learn from the commented metaanalysis. Technical factors like low sampling rate of photoplethysmography (PPG) or imprecise fiducial point detection are more important in this difference than physiological factors corresponding to pulse arrival time. Standardization of the PPG acquisition and reference point detection is necessary for comparable studies and correct measurement.
LA  - English
DB  - MTMT
ER  -