TY - JOUR AU - Nagy, Rita AU - Ocskay, Klementina AU - Sipos, Zoltán AU - Szentesi, Andrea Ildikó AU - Vincze, Áron AU - Czakó, László AU - Izbéki, Ferenc AU - Shirinskaya, Natalia V AU - Poluektov, Vladimir L AU - Zolotov, Alexandr N AU - Zhu, Yin AU - Xia, Liang AU - He, Wenhua AU - Sutton, Robert AU - Szatmary, Peter AU - Mukherjee, Rajarshi AU - Burridge, Isobel Saffron AU - Wauchope, Emma AU - Francisco, Elsa AU - Aparicio, David AU - Pinto, Bruno AU - Gomes, António AU - Nunes, Vitor AU - Tantau, Vasile Marcel AU - Sagau, Emanuela Denisa AU - Tantau, Alina Ioana AU - Suceveanu, Andra Iulia AU - Tocia, Cristina AU - Dumitru, Andrei AU - Pando, Elizabeth AU - Alberti, Piero AU - Cirera, Arturo AU - Molero, Xavier AU - Lee, Hong Sik AU - Jung, Min Kyu AU - Kim, Eui Joo AU - Lee, Sanghyub AU - Rebollo, María Lourdes Ruiz AU - Nistal, Reyes Busta AU - Santervas, Sandra Izquierdo AU - Lesko, Dusan AU - Soltes, Marek AU - Radonak, Jozef AU - Zatorski, Hubert AU - Małecka-Panas, Ewa AU - Fabisiak, Adam AU - Yaroslav, M Susak AU - Mykhailo, V Maksymenko AU - Olekcandr, A Tkachenko AU - Barauskas, Giedrius AU - Simanaitis, Vytautas AU - Ignatavicius, Povilas AU - Jinga, Mariana AU - Balaban, Vasile-Daniel AU - Patoni, Cristina AU - Gong, Liang AU - Song, Kai AU - Li, Yunlong AU - Gonçalves, T Cúrdia AU - Freitas, Marta AU - Macedo, Vítor AU - Vornhuelz, Marlies AU - Klauss, Sarah AU - Beyer, Georg AU - Koksal, Aydin Seref AU - Tozlu, Mukaddes AU - Eminler, Ahmet Tarik AU - Monclús, Nuria Torres AU - Comas, Eva Pijoan AU - Oballe, Juan Armando Rodriguez AU - Nawacki, Łukasz AU - Głuszek, Stanisław AU - Rama-Fernández, Alberto AU - Galego, Marco AU - de la Iglesia, Daniel AU - Aykut, Umut Emre AU - Duman, Deniz Güney AU - Aslan, Rahmi AU - Gherbon, Adriana AU - Deng, Lihui AU - Huang, Wei AU - Xia, Qing AU - Poropat, Goran AU - Radovan, Anja AU - Vranić, Luka AU - Ricci, Claudio AU - Ingaldi, Carlo AU - Casadei, Riccardo AU - Negoi, Ionut AU - Ciubotaru, Cezar AU - Iordache, Florin Mihail AU - Constantinescu, Gabriel AU - Sandru, Vasile AU - Altintas, Engin AU - Balci, Hatice Rizaoglu AU - Constantino, Júlio AU - Aveiro, Débora AU - Pereira, Jorge AU - Gunay, Suleyman AU - Misirlioglu Sucan, Seda AU - Dronov, Oleksiy AU - Kovalska, Inna AU - Bush, Nikhil AU - Rana, Surinder Singh AU - Chooklin, Serge AU - Chuklin, Serhii AU - Saizu, Ionut Adrian AU - Gheorghe, Cristian AU - Göltl, Philipp AU - Hirth, Michael AU - Mateescu, Radu Bogdan AU - Papuc, Geanina AU - Minkov, Georgi Angelov AU - Enchev, Emil Tihomirov AU - Mastrangelo, Laura AU - Jovine, Elio AU - Chen, Weiwei AU - Zhu, Quping AU - Gąsiorowska, Anita AU - Fabisiak, Natalia AU - Bezmarevic, Mihailo AU - Litvin, Andrey AU - Mottes, Martina Cattani AU - Choi, Eun Kwang AU - Bánovčin, Peter AU - Nosáková, Lenka AU - Kovacheva-Slavova, Mila Dimitrova AU - Kchaou, Ali AU - Tlili, Ahmed AU - Marino, Marco V AU - Kusnierz, Katarzyna AU - Mickevicius, Artautas AU - Hollenbach, Marcus AU - Molcan, Pavol AU - Ioannidis, Orestis AU - Tokarev, Mark Valerievich AU - Ince, Ali Tüzün AU - Semenenko, Ivan Albertovich AU - Galeev, Shamil AU - Ramírez-Maldonado, Elena AU - Sallinen, Ville AU - Pencik, Petr AU - Bajor, Judit AU - Sarlós, Patrícia AU - Hágendorn, Roland AU - Gódi, Szilárd AU - Szabó, Imre AU - Czimmer, József AU - Pár, Gabriella AU - Illés, Anita AU - Faluhelyi, Nándor AU - Kanizsai, Péter László AU - Nagy, Tamás AU - Mikó, Alexandra AU - Németh, Balázs AU - Hamvas, József AU - Bod, Barnabás AU - Varga, Márta AU - Török, Imola AU - Novák, János AU - Patai, Árpád AU - Sümegi, János AU - Góg, Csaba AU - Papp, Mária AU - Erőss, Bálint Mihály AU - Váncsa, Szilárd AU - Teutsch, Brigitta AU - Márta, Katalin AU - Hegyi, Péter Jenő AU - Tornai, Tamás AU - Lázár, Balázs AU - Hussein, Tamás AU - Tarján, Dorottya AU - Lipp, Mónika Bernadett AU - Kovács, Beáta AU - Urbán, Orsolya AU - Fürst, Emese Rita AU - Tari, Edina AU - Kocsis, Ibolya AU - Maurovich-Horvat, Pál AU - Tihanyi, Balázs AU - Eperjesi, Orsolya AU - Kormos, Zita AU - Deák, Pál Ákos AU - Párniczky, Andrea AU - Hegyi, Péter TI - Discharge protocol in acute pancreatitis: an international survey and cohort analysis JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-023-48480-z UR - https://m2.mtmt.hu/api/publication/34434496 ID - 34434496 AB - There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care. LA - English DB - MTMT ER - TY - JOUR AU - Kui, Balázs AU - Pintér, József AU - Molontay, Roland AU - Nagy, Marcell AU - Borbásné Farkas, Kornélia AU - Gede, Noémi AU - Vincze, Áron AU - Bajor, Judit AU - Gódi, Szilárd AU - Czimmer, József AU - Szabó, Imre AU - Illés, Anita AU - Sarlós, Patrícia AU - Hágendorn, Roland AU - Pár, Gabriella AU - Papp, Mária AU - Vitális, Zsuzsanna AU - Kovács, György AU - Fehér, Eszter AU - Földi, Ildikó AU - Izbéki, Ferenc AU - Gajdán, László AU - Fejes, Roland AU - Németh, Balázs AU - Török, Imola AU - Farkas, Hunor AU - Mickevicius, Artautas AU - Sallinen, Ville AU - Galeev, Shamil AU - Ramírez-Maldonado, Elena AU - Párniczky, Andrea AU - Erőss, Bálint Mihály AU - Hegyi, Péter Jenő AU - Márta, Katalin AU - Váncsa, Szilárd AU - Sutton, Robert AU - Szatmary, Peter AU - Latawiec, Diane AU - Halloran, Chris AU - de-Madaria, Enrique AU - Pando, Elizabeth AU - Alberti, Piero AU - Gómez-Jurado, Maria José AU - Tantau, Alina AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter TI - EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis JF - CLINICAL AND TRANSLATIONAL MEDICINE J2 - CLIN TRANSL MED VL - 12 PY - 2022 IS - 6 PG - 13 SN - 2001-1326 DO - 10.1002/ctm2.842 UR - https://m2.mtmt.hu/api/publication/32865751 ID - 32865751 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office Research Fund [K131996, FK131864, K128222, FK124632]; University of Pecs Medical School Research Fund [300909] Funding text: The research was supported by National Research, Development and Innovation Office Research Fund (project grants K131996 to Peter Hegyi, FK131864 to Artautas Mickevicius, K128222 to Laszlo Gajdan, FK124632 to Balazs Csaba Nemeth), and by funding from the University of Pecs Medical School Research Fund (300909) to Andrea Szentesi. The funders had no effect on the concept, data collection, analysis and writing of the manuscript. We wish to thank all further contributing members of the Hungarian Pancreatic Study Group, full names together with affiliations are listed in the Supplementary material. AB - Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed.The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit-learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross-validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross-validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP).The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy-to-use web application in the Streamlit Python-based framework (http://easy-app.org/).The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model. LA - English DB - MTMT ER - TY - JOUR AU - Ocskay, Klementina AU - Vinkó, Zsófia AU - Németh, Dávid AU - Szabó, László AU - Bajor, Judit AU - Gódi, Szilárd AU - Sarlós, Patrícia AU - Czakó, László AU - Izbéki, Ferenc AU - Hamvas, József AU - Papp, Mária AU - Varga, Márta AU - Török, Imola AU - Mickevicius, Artautas AU - Sallinen, Ville AU - Maldonado, Elena Ramirez AU - Galeev, Shamil AU - Mikó, Alexandra AU - Erőss, Bálint Mihály AU - Imrei, Marcell AU - Hegyi, Péter Jenő AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Kanizsai, Péter László AU - Miseta, Attila János AU - Nagy, Tamás AU - Hágendorn, Roland AU - Márton, Zsolt AU - Szakács, Zsolt AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter AU - Párniczky, Andrea TI - Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-021-03449-8 UR - https://m2.mtmt.hu/api/publication/32546426 ID - 32546426 N1 - * Megosztott szerzőség AB - The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay. LA - English DB - MTMT ER - TY - THES AU - Gódi, Szilárd TI - EVIDENCE-BASED MANAGEMENT OF ACUTE PANCREATITIS PB - University of Pécs PY - 2021 UR - https://m2.mtmt.hu/api/publication/32017118 ID - 32017118 LA - English DB - MTMT ER - TY - JOUR AU - Pécsi, Dániel AU - Gódi, Szilárd AU - Hegyi, Péter AU - Hanák, Lilla AU - Szentesi, Andrea Ildikó AU - Altorjay, István AU - Bakucz, Tamás AU - Czakó, László AU - Kovács, György AU - Orbán-Szilágyi, Ákos AU - Pakodi, Ferenc AU - Patai, Árpád AU - Szepes, Zoltán AU - Gyökeres, Tibor Zoltán AU - Fejes, Roland AU - Dubravcsik, Zsolt AU - Vincze, Áron TI - ERCP is more challenging in cases of acute biliary pancreatitis than in acute cholangitis - Analysis of the Hungarian ERCP registry data JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 21 PY - 2021 IS - 1 SP - 59 EP - 63 PG - 5 SN - 1424-3903 DO - 10.1016/j.pan.2020.11.025 UR - https://m2.mtmt.hu/api/publication/31782996 ID - 31782996 N1 - Institute for Translational Medicine, Szentágothai Research Center, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Second Department of Medicine, University of Debrecen, Debrecen, Hungary Department of Gastroenterology, Medical Centre Hungarian Defence Forces, Budapest, Hungary First Department of Medicine, University of Szeged, Szeged, Hungary First Department of Gastroenterology and Medicine, Markusovszky University Teaching Hospital, Szombathely, Hungary First Department of Medicine, Szent György University Teaching Hospital of County Fejér, Székesfehérvár, Hungary Bács-Kiskun County University Teaching Hospital, Kecskemét, Hungary Cited By :3 Export Date: 13 October 2023 CODEN: PANCC Correspondence Address: Vincze, Á.Ifjúság u. 13., Hungary; email: vincze.aron@pte.hu Chemicals/CAS: clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8 Tradenames: SPSS, IBM, United States Manufacturers: IBM, United States AB - Endoscopic retrograde cholangiopancreatography (ERCP) is an important therapeutic modality in acute biliary pancreatitis (ABP) cases with cholangitis or ongoing common bile duct obstruction. Theoretically, inflammation of the surrounding tissues would result in a more difficult procedure. No previous studies examined this hypothesis.ABP and acute cholangitis (AC) without ABP cases were compared to assess difficulty of ERCP.The rate of successful biliary access, advanced cannulation method, adverse events, cannulation and fluoroscopy time were compared in 240 ABP cases and 250 AC cases without ABP. Previous papillotomy, altered gastroduodenal anatomy, and cases with biliary stricture were excluded.Significantly more pancreatic guidewire manipulation (adjusted odds ratio (aOR) 1.921 [1.241-2.974]) and prophylactic pancreatic stent use (aOR 4.687 [2.415-9.098]) were seen in the ABP than in AC group. Average cannulation time in the ABP patients (248 vs. 185 s; p = 0.043) were longer than in AC cases. No difference was found between biliary cannulation and adverse events rates.ERCP in ABP cases seem to be more challenging than in AC. Difficult biliary access is more frequent in the ABP cases which warrants the involvement of an experienced endoscopist. LA - English DB - MTMT ER - TY - JOUR AU - Hágendorn, Roland AU - Vincze, Áron AU - Izbéki, Ferenc AU - Gajdán, László AU - Gódi, Szilárd AU - Illés, Anita AU - Sarlós, Patrícia AU - Borbásné Farkas, Kornélia AU - Erőss, Bálint Mihály AU - Lillik, Veronika AU - Illés, Dóra AU - Varjú, Péter AU - Márta, Katalin AU - Török, Imola AU - Papp, Mária AU - Vitális, Zsuzsanna AU - Bod, Barnabás AU - Hamvas, József AU - Szepes, Zoltán AU - Takács, Tamás AU - Czakó, László AU - Márton, Zsolt AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Hegyi, Péter AU - Mikó, Alexandra TI - Development of disturbance of consciousness is associated with increased severity in acute pancreatitis JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 5 SP - 806 EP - 812 PG - 7 SN - 1424-3903 DO - 10.1016/j.pan.2020.05.009 UR - https://m2.mtmt.hu/api/publication/31333638 ID - 31333638 N1 - Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary School of Clinical Medicine, University of Szeged, Szeged, Hungary Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary 1st Department of Medicine, University of Szeged, Szeged, Hungary County Emergency Clinical Hospital Târgu Mures, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Romania Department of Internal Medicine, Division of Gastroenterology, University of Debrecen, Debrecen, Hungary Bugyi István Hospital, Szentes, Hungary Bajcsy-Zsilinszky Hospital, Budapest, Hungary Intensive Care Unit, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Heim Pál National Institute for Pediatrics, Budapest, Hungary Division of Translational Medicine, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Hungarian Academy of Sciences, University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary Cited By :3 Export Date: 24 January 2024 CODEN: PANCC Correspondence Address: Mikó, A.; Institute for Translational Medicine, Szigeti Street 12., II. floor, Hungary; email: miko.szandi@gmail.com AB - Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality. LA - English DB - MTMT ER - TY - JOUR AU - Mosztbacher, Dóra AU - Hanák, Lilla AU - Borbásné Farkas, Kornélia AU - Szentesi, Andrea Ildikó AU - Mikó, Alexandra AU - Bajor, Judit AU - Sarlós, Patrícia AU - Czimmer, József AU - Vincze, Áron AU - Hegyi, Péter Jenő AU - Erőss, Bálint Mihály AU - Takács, Tamás AU - Czakó, László AU - Németh, Balázs AU - Izbéki, Ferenc AU - Szabó-Halász, Adrienn AU - Gajdán, László AU - Hamvas, József AU - Papp, Mária AU - Földi, Ildikó AU - Fehér, Krisztina Eszter AU - Varga, Márta AU - Csefkó, Klára AU - Török, Imola AU - Farkas, Hunor Pál AU - Mickevicius, Artautas AU - Maldonado, Elena Ramirez AU - Sallinen, Ville AU - Novák, János AU - Ince, Ali Tüzün AU - Galeev, Shamil AU - Bod, Barnabás AU - Sümegi, János AU - Pencik, Petr AU - Dubravcsik, Zsolt AU - Illés, Dóra AU - Gódi, Szilárd AU - Kui, Balázs AU - Márta, Katalin AU - Pécsi, Dániel AU - Varjú, Péter AU - Szakács, Zsolt AU - Darvasi, Erika AU - Párniczky, Andrea AU - Hegyi, Péter TI - Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 4 SP - 608 EP - 616 PG - 9 SN - 1424-3903 DO - 10.1016/j.pan.2020.03.018 UR - https://m2.mtmt.hu/api/publication/31280739 ID - 31280739 N1 - * Megosztott szerzőség AB - Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (≥11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Balázs AU - Madarasz, R. AU - Nagy, A. AU - Sandor, M. AU - Takács, Tamás AU - Farkas, G. Jr. AU - Izbéki, Ferenc AU - Czakó, László AU - Szmola, Richárd AU - Gervain, Judit AU - Gódi, Szilárd AU - Szentesi, Andrea Ildikó AU - Szucs, A. AU - Sahin-Toth, M. AU - Hegyi, Péter TI - Mutations in the 5 ' Upstream Region of Chymotrypsinogen C Gene Are Not Associated With Chronic Pancreatitis JF - PANCREAS J2 - PANCREAS VL - 48 PY - 2019 IS - 10 SP - 1497 EP - 1497 PG - 1 SN - 0885-3177 UR - https://m2.mtmt.hu/api/publication/31133236 ID - 31133236 LA - English DB - MTMT ER - TY - JOUR AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Vincze, Áron AU - Bajor, Judit AU - Gódi, Szilárd AU - Sarlós, Patrícia AU - Gede, Noémi AU - Izbéki, Ferenc AU - Szabó-Halász, Adrienn AU - Márta, Katalin AU - Dobszai, Dalma AU - Torok, Imola AU - Farkas, Hunor AU - Papp, Mária AU - Varga, Marta AU - Hamvas, Jozsef AU - Novak, Janos AU - Mickevicius, Artautas AU - Ramirez, Maldonado Elena AU - Sallinen, Ville AU - Illés, Dóra AU - Kui, Balázs AU - Erőss, Bálint Mihály AU - Czakó, László AU - Takács, Tamás AU - Hegyi, Péter TI - Multiple hits in acute pancreatitis: components of metabolic syndrome synergize each other’s deteriorating effects JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 10 PY - 2019 PG - 13 SN - 1664-042X DO - 10.3389/fphys.2019.01202 UR - https://m2.mtmt.hu/api/publication/30829571 ID - 30829571 N1 - Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary First Department of Medicine, University of Szeged, Szeged, Hungary Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary Heim Pál National Institute of Pediatrics, Budapest, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Division of Translational Medicine, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Szent György Teaching Hospital of Fejér County, Székesfehérvár, Hungary County Emergency Clinical Hospital – Gastroenterology, University of Medicine, Pharmacy, Sciences and Technology, Târgu Mureş, Romania Division of Gastroenterology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary Dr. Réthy Pál Hospital of Békés County, Békéscsaba, Hungary Bajcsy-Zsilinszky Hospital, Budapest, Hungary Department of Gastroenterology, Pándy Kálmán Hospital of Békés County, Gyula, Hungary Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania Clinics of Abdominal Surgery, Nephrourology and Gastroenterology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania Consorci Sanitari del Garraf, Sant Pere de Ribes, Barcelona, Spain Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland Hungarian Academy of Sciences – University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary Cited By :45 Export Date: 11 September 2023 Correspondence Address: Hegyi, P.; Institute for Translational Medicine, Hungary; email: hegyi2009@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Borbásné Farkas, Kornélia AU - Hanák, Lilla AU - Mikó, Alexandra AU - Bajor, Judit AU - Sarlós, Patrícia AU - Czimmer, József AU - Vincze, Áron AU - Gódi, Szilárd AU - Pécsi, Dániel AU - Varjú, Péter AU - Márta, Katalin AU - Hegyi, Péter Jenő AU - Erőss, Bálint Mihály AU - Szakács, Zsolt AU - Takács, Tamás AU - Czakó, László AU - Németh, Balázs AU - Illés, Dóra AU - Kui, Balázs AU - Darvasi, Erika AU - Izbéki, Ferenc AU - Szabó-Halász, Adrienn AU - Dunás-Varga, Veronika AU - Gajdán, László AU - Hamvas, József AU - Papp, Mária AU - Földi, Ildikó AU - Fehér, Krisztina Eszter AU - Varga, Márta AU - Csefkó, Klára AU - Török, Imola AU - Hunor-Pál, Farkas AU - Mickevicius, Artautas AU - Maldonado, Elena Ramirez AU - Sallinen, Ville AU - Novák, János AU - Ince, Ali Tüzün AU - Galeev, Shamil AU - Bod, Barnabás AU - Sümegi, János AU - Pencik, Petr AU - Szepes, Attila AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Hegyi, Péter TI - A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 10 PY - 2019 PG - 12 SN - 1664-042X DO - 10.3389/fphys.2019.01092 UR - https://m2.mtmt.hu/api/publication/30788843 ID - 30788843 N1 - Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary First Department of Medicine, University of Szeged, Szeged, Hungary Szent György University Teaching Hospital, Fejér County, Székesfehérvár, Hungary Bajcsy-Zsilinszky Hospital, Budapest, Hungary Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Dr. Réthy Pál Hospital, Békéscsaba, Hungary County Emergency Clinical Hospital, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Consorci Sanitari del Garraf, Barcelona, Spain Department of Transplantation and Liver Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland Pándy Kálmán Hospital of County Békés, Gyula, Hungary School of Medicine, Hospital of Bezmialem Vakif University, Istanbul, Turkey Saint Luke’s Clinical Hospital, St. Petersburg, Russian Federation Dr. Bugyi István Hospital, Szentes, Hungary Borsod-Abaúj-Zemplén County Hospital, University Teaching Hospital, Miskolc, Hungary Centrum Péče o Zažívací Trakt, Vítkovická Nemocnice a.s., Ostrava, Czech Republic Department of Gastroenterology, Bács-Kiskun County Hospital, Kecskemét, Hungary Heim Pál National Institute of Pediatrics, Budapest, Hungary Clinical Medicine Doctoral School, University of Szeged, Szeged, Hungary Momentum Gastroenterology Multidisciplinary Research Group, Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary Cited By :20 Export Date: 26 January 2024 Correspondence Address: Hegyi, P.; Institute for Translational Medicine, Hungary; email: hegyi2009@gmail.com LA - English DB - MTMT ER -