@article{MTMT:34434496, title = {Discharge protocol in acute pancreatitis: an international survey and cohort analysis}, url = {https://m2.mtmt.hu/api/publication/34434496}, author = {Nagy, Rita and Ocskay, Klementina and Sipos, Zoltán and Szentesi, Andrea Ildikó and Vincze, Áron and Czakó, László and Izbéki, Ferenc and Shirinskaya, Natalia V and Poluektov, Vladimir L and Zolotov, Alexandr N and Zhu, Yin and Xia, Liang and He, Wenhua and Sutton, Robert and Szatmary, Peter and Mukherjee, Rajarshi and Burridge, Isobel Saffron and Wauchope, Emma and Francisco, Elsa and Aparicio, David and Pinto, Bruno and Gomes, António and Nunes, Vitor and Tantau, Vasile Marcel and Sagau, Emanuela Denisa and Tantau, Alina Ioana and Suceveanu, Andra Iulia and Tocia, Cristina and Dumitru, Andrei and Pando, Elizabeth and Alberti, Piero and Cirera, Arturo and Molero, Xavier and Lee, Hong Sik and Jung, Min Kyu and Kim, Eui Joo and Lee, Sanghyub and Rebollo, María Lourdes Ruiz and Nistal, Reyes Busta and Santervas, Sandra Izquierdo and Lesko, Dusan and Soltes, Marek and Radonak, Jozef and Zatorski, Hubert and Małecka-Panas, Ewa and Fabisiak, Adam and Yaroslav, M Susak and Mykhailo, V Maksymenko and Olekcandr, A Tkachenko and Barauskas, Giedrius and Simanaitis, Vytautas and Ignatavicius, Povilas and Jinga, Mariana and Balaban, Vasile-Daniel and Patoni, Cristina and Gong, Liang and Song, Kai and Li, Yunlong and Gonçalves, T Cúrdia and Freitas, Marta and Macedo, Vítor and Vornhuelz, Marlies and Klauss, Sarah and Beyer, Georg and Koksal, Aydin Seref and Tozlu, Mukaddes and Eminler, Ahmet Tarik and Monclús, Nuria Torres and Comas, Eva Pijoan and Oballe, Juan Armando Rodriguez and Nawacki, Łukasz and Głuszek, Stanisław and Rama-Fernández, Alberto and Galego, Marco and de la Iglesia, Daniel and Aykut, Umut Emre and Duman, Deniz Güney and Aslan, Rahmi and Gherbon, Adriana and Deng, Lihui and Huang, Wei and Xia, Qing and Poropat, Goran and Radovan, Anja and Vranić, Luka and Ricci, Claudio and Ingaldi, Carlo and Casadei, Riccardo and Negoi, Ionut and Ciubotaru, Cezar and Iordache, Florin Mihail and Constantinescu, Gabriel and Sandru, Vasile and Altintas, Engin and Balci, Hatice Rizaoglu and Constantino, Júlio and Aveiro, Débora and Pereira, Jorge and Gunay, Suleyman and Misirlioglu Sucan, Seda and Dronov, Oleksiy and Kovalska, Inna and Bush, Nikhil and Rana, Surinder Singh and Chooklin, Serge and Chuklin, Serhii and Saizu, Ionut Adrian and Gheorghe, Cristian and Göltl, Philipp and Hirth, Michael and Mateescu, Radu Bogdan and Papuc, Geanina and Minkov, Georgi Angelov and Enchev, Emil Tihomirov and Mastrangelo, Laura and Jovine, Elio and Chen, Weiwei and Zhu, Quping and Gąsiorowska, Anita and Fabisiak, Natalia and Bezmarevic, Mihailo and Litvin, Andrey and Mottes, Martina Cattani and Choi, Eun Kwang and Bánovčin, Peter and Nosáková, Lenka and Kovacheva-Slavova, Mila Dimitrova and Kchaou, Ali and Tlili, Ahmed and Marino, Marco V and Kusnierz, Katarzyna and Mickevicius, Artautas and Hollenbach, Marcus and Molcan, Pavol and Ioannidis, Orestis and Tokarev, Mark Valerievich and Ince, Ali Tüzün and Semenenko, Ivan Albertovich and Galeev, Shamil and Ramírez-Maldonado, Elena and Sallinen, Ville and Pencik, Petr and Bajor, Judit and Sarlós, Patrícia and Hágendorn, Roland and Gódi, Szilárd and Szabó, Imre and Czimmer, József and Pár, Gabriella and Illés, Anita and Faluhelyi, Nándor and Kanizsai, Péter László and Nagy, Tamás and Mikó, Alexandra and Németh, Balázs and Hamvas, József and Bod, Barnabás and Varga, Márta and Török, Imola and Novák, János and Patai, Árpád and Sümegi, János and Góg, Csaba and Papp, Mária and Erőss, Bálint Mihály and Váncsa, Szilárd and Teutsch, Brigitta and Márta, Katalin and Hegyi, Péter Jenő and Tornai, Tamás and Lázár, Balázs and Hussein, Tamás and Tarján, Dorottya and Lipp, Mónika Bernadett and Kovács, Beáta and Urbán, Orsolya and Fürst, Emese Rita and Tari, Edina and Kocsis, Ibolya and Maurovich-Horvat, Pál and Tihanyi, Balázs and Eperjesi, Orsolya and Kormos, Zita and Deák, Pál Ákos and Párniczky, Andrea and Hegyi, Péter}, doi = {10.1038/s41598-023-48480-z}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34434496}, issn = {2045-2322}, abstract = {There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Nagy, Rita/0000-0002-2663-4912; Ocskay, Klementina/0000-0001-5848-2506; Sipos, Zoltán/0000-0001-7845-8116; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Kanizsai, Péter László/0000-0001-7896-2857; Nagy, Tamás/0000-0001-5437-1411; Németh, Balázs/0000-0001-5338-7577; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Váncsa, Szilárd/0000-0002-9347-8163; Teutsch, Brigitta/0000-0002-9530-7886; Márta, Katalin/0000-0002-2213-4865; Tari, Edina/0000-0002-8540-0614; Kocsis, Ibolya/0000-0003-3128-2832; Maurovich-Horvat, Pál/0000-0003-0885-736X; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:32865751, title = {EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis}, url = {https://m2.mtmt.hu/api/publication/32865751}, author = {Kui, Balázs and Pintér, József and Molontay, Roland and Nagy, Marcell and Borbásné Farkas, Kornélia and Gede, Noémi and Vincze, Áron and Bajor, Judit and Gódi, Szilárd and Czimmer, József and Szabó, Imre and Illés, Anita and Sarlós, Patrícia and Hágendorn, Roland and Pár, Gabriella and Papp, Mária and Vitális, Zsuzsanna and Kovács, György and Fehér, Eszter and Földi, Ildikó and Izbéki, Ferenc and Gajdán, László and Fejes, Roland and Németh, Balázs and Török, Imola and Farkas, Hunor and Mickevicius, Artautas and Sallinen, Ville and Galeev, Shamil and Ramírez-Maldonado, Elena and Párniczky, Andrea and Erőss, Bálint Mihály and Hegyi, Péter Jenő and Márta, Katalin and Váncsa, Szilárd and Sutton, Robert and Szatmary, Peter and Latawiec, Diane and Halloran, Chris and de-Madaria, Enrique and Pando, Elizabeth and Alberti, Piero and Gómez-Jurado, Maria José and Tantau, Alina and Szentesi, Andrea Ildikó and Hegyi, Péter}, doi = {10.1002/ctm2.842}, journal-iso = {CLIN TRANSL MED}, journal = {CLINICAL AND TRANSLATIONAL MEDICINE}, volume = {12}, unique-id = {32865751}, issn = {2001-1326}, abstract = {Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed.The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit-learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross-validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross-validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP).The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy-to-use web application in the Streamlit Python-based framework (http://easy-app.org/).The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model.}, keywords = {Artificial intelligence; Acute pancreatitis; severity prediction}, year = {2022}, eissn = {2001-1326}, orcid-numbers = {Molontay, Roland/0000-0002-0666-5279; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Vincze, Áron/0000-0003-2217-7686; Czimmer, József/0000-0001-7831-3523; Sarlós, Patrícia/0000-0002-5086-9455; Papp, Mária/0000-0003-3662-4010; Vitális, Zsuzsanna/0000-0001-8198-5312; Izbéki, Ferenc/0000-0001-7767-4319; Németh, Balázs/0000-0001-5338-7577; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Váncsa, Szilárd/0000-0002-9347-8163; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:32546426, title = {Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality}, url = {https://m2.mtmt.hu/api/publication/32546426}, author = {Ocskay, Klementina and Vinkó, Zsófia and Németh, Dávid and Szabó, László and Bajor, Judit and Gódi, Szilárd and Sarlós, Patrícia and Czakó, László and Izbéki, Ferenc and Hamvas, József and Papp, Mária and Varga, Márta and Török, Imola and Mickevicius, Artautas and Sallinen, Ville and Maldonado, Elena Ramirez and Galeev, Shamil and Mikó, Alexandra and Erőss, Bálint Mihály and Imrei, Marcell and Hegyi, Péter Jenő and Faluhelyi, Nándor and Farkas, Orsolya and Kanizsai, Péter László and Miseta, Attila János and Nagy, Tamás and Hágendorn, Roland and Márton, Zsolt and Szakács, Zsolt and Szentesi, Andrea Ildikó and Hegyi, Péter and Párniczky, Andrea}, doi = {10.1038/s41598-021-03449-8}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {11}, unique-id = {32546426}, issn = {2045-2322}, abstract = {The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.}, year = {2021}, eissn = {2045-2322}, orcid-numbers = {Ocskay, Klementina/0000-0001-5848-2506; Sarlós, Patrícia/0000-0002-5086-9455; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Imrei, Marcell/0000-0003-0175-7462; Kanizsai, Péter László/0000-0001-7896-2857; Miseta, Attila János/0000-0002-7984-3347; Nagy, Tamás/0000-0001-5437-1411; Szakács, Zsolt/0000-0002-7035-941X; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @mastersthesis{MTMT:32017118, title = {EVIDENCE-BASED MANAGEMENT OF ACUTE PANCREATITIS}, url = {https://m2.mtmt.hu/api/publication/32017118}, author = {Gódi, Szilárd}, publisher = {Pécsi Tudományegyetem}, unique-id = {32017118}, year = {2021} } @article{MTMT:31782996, title = {ERCP is more challenging in cases of acute biliary pancreatitis than in acute cholangitis - Analysis of the Hungarian ERCP registry data}, url = {https://m2.mtmt.hu/api/publication/31782996}, author = {Pécsi, Dániel and Gódi, Szilárd and Hegyi, Péter and Hanák, Lilla and Szentesi, Andrea Ildikó and Altorjay, István and Bakucz, Tamás and Czakó, László and Kovács, György and Orbán-Szilágyi, Ákos and Pakodi, Ferenc and Patai, Árpád and Szepes, Zoltán and Gyökeres, Tibor Zoltán and Fejes, Roland and Dubravcsik, Zsolt and Vincze, Áron}, doi = {10.1016/j.pan.2020.11.025}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {21}, unique-id = {31782996}, issn = {1424-3903}, abstract = {Endoscopic retrograde cholangiopancreatography (ERCP) is an important therapeutic modality in acute biliary pancreatitis (ABP) cases with cholangitis or ongoing common bile duct obstruction. Theoretically, inflammation of the surrounding tissues would result in a more difficult procedure. No previous studies examined this hypothesis.ABP and acute cholangitis (AC) without ABP cases were compared to assess difficulty of ERCP.The rate of successful biliary access, advanced cannulation method, adverse events, cannulation and fluoroscopy time were compared in 240 ABP cases and 250 AC cases without ABP. Previous papillotomy, altered gastroduodenal anatomy, and cases with biliary stricture were excluded.Significantly more pancreatic guidewire manipulation (adjusted odds ratio (aOR) 1.921 [1.241-2.974]) and prophylactic pancreatic stent use (aOR 4.687 [2.415-9.098]) were seen in the ABP than in AC group. Average cannulation time in the ABP patients (248 vs. 185 s; p = 0.043) were longer than in AC cases. No difference was found between biliary cannulation and adverse events rates.ERCP in ABP cases seem to be more challenging than in AC. Difficult biliary access is more frequent in the ABP cases which warrants the involvement of an experienced endoscopist.}, keywords = {endoscopic retrograde cholangiopancreatography; acute biliary pancreatitis; DIFFICULTY; acute cholangitis; Advanced cannulation}, year = {2021}, eissn = {1424-3911}, pages = {59-63}, orcid-numbers = {Pécsi, Dániel/0000-0003-0499-6004; Hegyi, Péter/0000-0003-0399-7259; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Czakó, László/0000-0002-6331-0802; Szepes, Zoltán/0000-0002-9466-8719; Dubravcsik, Zsolt/0000-0002-7231-3300; Vincze, Áron/0000-0003-2217-7686} } @article{MTMT:31333638, title = {Development of disturbance of consciousness is associated with increased severity in acute pancreatitis}, url = {https://m2.mtmt.hu/api/publication/31333638}, author = {Hágendorn, Roland and Vincze, Áron and Izbéki, Ferenc and Gajdán, László and Gódi, Szilárd and Illés, Anita and Sarlós, Patrícia and Borbásné Farkas, Kornélia and Erőss, Bálint Mihály and Lillik, Veronika and Illés, Dóra and Varjú, Péter and Márta, Katalin and Török, Imola and Papp, Mária and Vitális, Zsuzsanna and Bod, Barnabás and Hamvas, József and Szepes, Zoltán and Takács, Tamás and Czakó, László and Márton, Zsolt and Szentesi, Andrea Ildikó and Párniczky, Andrea and Hegyi, Péter and Mikó, Alexandra}, doi = {10.1016/j.pan.2020.05.009}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {20}, unique-id = {31333638}, issn = {1424-3903}, abstract = {Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.}, keywords = {ALCOHOL; MORTALITY; Acute pancreatitis; delirium; disturbance of consciousness}, year = {2020}, eissn = {1424-3911}, pages = {806-812}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Sarlós, Patrícia/0000-0002-5086-9455; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Papp, Mária/0000-0003-3662-4010; Vitális, Zsuzsanna/0000-0001-8198-5312; Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31280739, title = {Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases}, url = {https://m2.mtmt.hu/api/publication/31280739}, author = {Mosztbacher, Dóra and Hanák, Lilla and Borbásné Farkas, Kornélia and Szentesi, Andrea Ildikó and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Czimmer, József and Vincze, Áron and Hegyi, Péter Jenő and Erőss, Bálint Mihály and Takács, Tamás and Czakó, László and Németh, Balázs and Izbéki, Ferenc and Szabó-Halász, Adrienn and Gajdán, László and Hamvas, József and Papp, Mária and Földi, Ildikó and Fehér, Krisztina Eszter and Varga, Márta and Csefkó, Klára and Török, Imola and Farkas, Hunor Pál and Mickevicius, Artautas and Maldonado, Elena Ramirez and Sallinen, Ville and Novák, János and Ince, Ali Tüzün and Galeev, Shamil and Bod, Barnabás and Sümegi, János and Pencik, Petr and Dubravcsik, Zsolt and Illés, Dóra and Gódi, Szilárd and Kui, Balázs and Márta, Katalin and Pécsi, Dániel and Varjú, Péter and Szakács, Zsolt and Darvasi, Erika and Párniczky, Andrea and Hegyi, Péter}, doi = {10.1016/j.pan.2020.03.018}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {20}, unique-id = {31280739}, issn = {1424-3903}, abstract = {Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (≥11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP.}, keywords = {ETIOLOGY; HYPERTRIGLYCERIDEMIA; COHORT; SEVERITY; Acute pancreatitis}, year = {2020}, eissn = {1424-3911}, pages = {608-616}, orcid-numbers = {Mosztbacher, Dóra/0000-0002-2446-9247; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Vincze, Áron/0000-0003-2217-7686; Erőss, Bálint Mihály/0000-0003-3658-8427; Czakó, László/0000-0002-6331-0802; Németh, Balázs/0000-0001-5338-7577; Papp, Mária/0000-0003-3662-4010; Dubravcsik, Zsolt/0000-0002-7231-3300; Márta, Katalin/0000-0002-2213-4865; Pécsi, Dániel/0000-0003-0499-6004; Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31133236, title = {Mutations in the 5 ' Upstream Region of Chymotrypsinogen C Gene Are Not Associated With Chronic Pancreatitis}, url = {https://m2.mtmt.hu/api/publication/31133236}, author = {Németh, Balázs and Madarasz, R. and Nagy, A. and Sandor, M. and Takács, Tamás and Farkas, G. Jr. and Izbéki, Ferenc and Czakó, László and Szmola, Richárd and Gervain, Judit and Gódi, Szilárd and Szentesi, Andrea Ildikó and Szucs, A. and Sahin-Toth, M. and Hegyi, Péter}, journal-iso = {PANCREAS}, journal = {PANCREAS}, volume = {48}, unique-id = {31133236}, issn = {0885-3177}, year = {2019}, eissn = {1536-4828}, pages = {1497-1497}, orcid-numbers = {Németh, Balázs/0000-0001-5338-7577; Izbéki, Ferenc/0000-0001-7767-4319; Czakó, László/0000-0002-6331-0802; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:30829571, title = {Multiple hits in acute pancreatitis: components of metabolic syndrome synergize each other’s deteriorating effects}, url = {https://m2.mtmt.hu/api/publication/30829571}, author = {Szentesi, Andrea Ildikó and Párniczky, Andrea and Vincze, Áron and Bajor, Judit and Gódi, Szilárd and Sarlós, Patrícia and Gede, Noémi and Izbéki, Ferenc and Szabó-Halász, Adrienn and Márta, Katalin and Dobszai, Dalma and Torok, Imola and Farkas, Hunor and Papp, Mária and Varga, Marta and Hamvas, Jozsef and Novak, Janos and Mickevicius, Artautas and Ramirez, Maldonado Elena and Sallinen, Ville and Illés, Dóra and Kui, Balázs and Erőss, Bálint Mihály and Czakó, László and Takács, Tamás and Hegyi, Péter}, doi = {10.3389/fphys.2019.01202}, journal-iso = {FRONT PHYSIOL}, journal = {FRONTIERS IN PHYSIOLOGY}, volume = {10}, unique-id = {30829571}, year = {2019}, eissn = {1664-042X}, orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Vincze, Áron/0000-0003-2217-7686; Sarlós, Patrícia/0000-0002-5086-9455; Izbéki, Ferenc/0000-0001-7767-4319; Márta, Katalin/0000-0002-2213-4865; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Czakó, László/0000-0002-6331-0802; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:30788843, title = {A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis}, url = {https://m2.mtmt.hu/api/publication/30788843}, author = {Borbásné Farkas, Kornélia and Hanák, Lilla and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Czimmer, József and Vincze, Áron and Gódi, Szilárd and Pécsi, Dániel and Varjú, Péter and Márta, Katalin and Hegyi, Péter Jenő and Erőss, Bálint Mihály and Szakács, Zsolt and Takács, Tamás and Czakó, László and Németh, Balázs and Illés, Dóra and Kui, Balázs and Darvasi, Erika and Izbéki, Ferenc and Szabó-Halász, Adrienn and Dunás-Varga, Veronika and Gajdán, László and Hamvas, József and Papp, Mária and Földi, Ildikó and Fehér, Krisztina Eszter and Varga, Márta and Csefkó, Klára and Török, Imola and Hunor-Pál, Farkas and Mickevicius, Artautas and Maldonado, Elena Ramirez and Sallinen, Ville and Novák, János and Ince, Ali Tüzün and Galeev, Shamil and Bod, Barnabás and Sümegi, János and Pencik, Petr and Szepes, Attila and Szentesi, Andrea Ildikó and Párniczky, Andrea and Hegyi, Péter}, doi = {10.3389/fphys.2019.01092}, journal-iso = {FRONT PHYSIOL}, journal = {FRONTIERS IN PHYSIOLOGY}, volume = {10}, unique-id = {30788843}, year = {2019}, eissn = {1664-042X}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Vincze, Áron/0000-0003-2217-7686; Pécsi, Dániel/0000-0003-0499-6004; Márta, Katalin/0000-0002-2213-4865; Erőss, Bálint Mihály/0000-0003-3658-8427; Szakács, Zsolt/0000-0002-7035-941X; Czakó, László/0000-0002-6331-0802; Németh, Balázs/0000-0001-5338-7577; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} }