TY - JOUR AU - Janszky, József Vladimír AU - Bóné, Beáta AU - Karádi, Kázmér AU - Barsi, Péter AU - Juhos, Vera AU - Berta, Anikó AU - Trischlerné Gyimesi, Csilla AU - Tényi, Dalma AU - Horváth, Réka TI - Management of autoimmune temporal lobe epilepsy with GAD65 antibody: four case reports JF - NEUROLOGIA I NEUROCHIRURGIA POLSKA J2 - NEUROL NEUROCHIR POL VL - 58 PY - 2024 IS - 4 SP - 453 EP - 458 PG - 6 SN - 0028-3843 DO - 10.5603/pjnns.98738 UR - https://m2.mtmt.hu/api/publication/35172480 ID - 35172480 N1 - Short Communication AB - Aim of study. Glutamate decarboxylase (GAD) enzyme can be a target intracellular antigen in autoimmune focal epilepsy. GAD65 antibody is in found patients diagnosed with drug-refractory temporal lobe epilepsy (TLE). We explore the clinical features of the disease and therapeutic options. Material and methods. We present the cases of four TLE patients, two of them with type 1 diabetes. All of them were drug-resistant and therefore underwent presurgical evaluation, which revealed GAD65 antibody positivity. We discuss the four GAD65 antibody positive temporal lobe epilepsy patients' electroclinical data, the treatments, and their effectiveness. Results. One of them became seizure-free after right anterior temporal lobe resection, two of them did not show significant improvement with immunmodulatory agents, and the fourth patient with the shortest duration of disease had significant improvement in seizure status and normalisation of cognitive status with IVIg therapy. Conclusions and clinical implications. Our cases show that the earlier a GAD65 antibody is detected, the greater the chance of achieving seizure freedom or improvements in both seizure and cognitive status with immunomodulatory agents. However, in some cases, surgery may also bring seizure freedom, but with a risk of cognitive deterioration. LA - English DB - MTMT ER - TY - JOUR AU - Lovig, Cs. AU - Herold, Róbert AU - Pál, Endre AU - Bóné, Beáta AU - Faludi, Béla AU - Albert, Noémi AU - Dibusz, Dominik AU - Hernádi, G. AU - Péterfi, Zoltán AU - Sipos, Dávid AU - Tényi, Tamás TI - Pszichiátriai osztályon diagnosztizált, AIDS talaján kialakult progresszív multifokális leukoencephalopathia JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 33 SP - 1295 EP - 1302 PG - 8 SN - 0030-6002 DO - 10.1556/650.2024.33102 UR - https://m2.mtmt.hu/api/publication/35170581 ID - 35170581 N1 - Journal Article; Case Reports; Review LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kaufmann, Elisabeth AU - Peltola, Jukka AU - Colon, Albert J AU - Lehtimäki, Kai AU - Majtanik, Milan AU - Mai, Jürgen K AU - Bóné, Beáta AU - Bentes, Carla AU - Coenen, Volker AU - Gil-Nagel, Antonio AU - Goncalves-Ferreira, Antonio J AU - Ryvlin, Philippe AU - Taylor, Rod AU - Brionne, Thomas C AU - Gielen, Frans AU - Song, Shannon AU - Boon, Paul TI - Long-term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry. JF - EPILEPSIA J2 - EPILEPSIA VL - 65 PY - 2024 IS - 8 SP - 2438 EP - 2458 PG - 21 SN - 0013-9580 DO - 10.1111/epi.18003 UR - https://m2.mtmt.hu/api/publication/34999593 ID - 34999593 AB - Short-term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) were reported for people with drug-resistant focal epilepsy (PwE). Because long-term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT-DBS.In this multicenter registry, PwE with ANT-DBS were followed up for safety, efficacy, and battery longevity. Follow-up ended after 5 years or upon study closure. Clinical characteristics and stimulation settings were compared between PwE with no benefit, improvers, and responders, that is, PwE with average monthly seizure frequency reduction rates of ≥50%.Of 170 eligible PwE, 104, 62, and 49 completed the 3-, 4-, and 5-year follow-up, respectively. Most discontinuations (68%) were due to planned study closure as follow-up beyond 2 years was optional. The 5-year follow-up cohort had a median seizure frequency reduction from 16 per month at baseline to 7.9 per month at 5-year follow-up (p < .001), with most-pronounced effects on focal-to-bilateral tonic-clonic seizures (n = 15, 77% reduction, p = .008). At last follow-up (median 3.5 years), 41% (69/170) of PwE were responders. Unifocal epilepsy (p = .035) and a negative history of epilepsy surgery (p = .002) were associated with larger average monthly seizure frequency reductions. Stimulation settings did not differ between response groups. In 179 implanted PwE, DBS-related adverse events (AEs, n = 225) and serious AEs (n = 75) included deterioration in epilepsy or seizure frequency/severity/type (33; 14 serious), memory/cognitive impairment (29; 3 serious), and depression (13; 4 serious). Five deaths occurred (none were ANT-DBS related). Most AEs (76.3%) manifested within the first 2 years after implantation. Activa PC depletion (n = 37) occurred on average after 45 months.MORE provides further evidence for the long-term application of ANT-DBS in clinical routine practice. Although clinical benefits increased over time, side effects occurred mainly during the first 2 years. Identified outcome modifiers can help inform PwE selection and management. LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Katalin Nóra AU - Bóné, Beáta AU - Karádi, Kázmér AU - Kis-Jakab, Gréta AU - Tóth, Natália AU - Halász, László AU - Erőss, Loránd AU - Balás, István AU - Faludi, Béla AU - Jordán, Zsófia AU - Zoltan, Chadaide AU - Trischlerné Gyimesi, Csilla AU - Fabó, Dániel AU - Janszky, József Vladimír TI - Effects of anterior thalamic nucleus DBS on interictal heart rate variability in patients with refractory epilepsy JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 147 PY - 2023 SP - 17 EP - 30 PG - 14 SN - 1388-2457 DO - 10.1016/j.clinph.2022.11.020 UR - https://m2.mtmt.hu/api/publication/33420086 ID - 33420086 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program [EFOP-3.6.2-16-2 017-00008]; NKFIH Funding text: This work was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002) and NKFIH EFOP-3.6.2-16-2 017-00008 government -based funds (J.J.) , and by the National Brain Research Program (2017-1.2.1-NKP-2017-00002: National Research Development and Innovation Office) (D.F.) . LA - English DB - MTMT ER - TY - JOUR AU - Kaufmann, E. AU - Peltola, J. AU - Colon, A. AU - Bóné, Beáta AU - Bentes, C. AU - Coenen, V. AU - Gil-Nagel, A. AU - Goncalves-Ferreira, A. AU - Lehtimaki, K. AU - Ryvlin, P. AU - Taylor, R. AU - Brionne, T. AU - Gielen, F. AU - Song, S. AU - Boon, P. TI - Multicenter long-term evaluation of safety and efficacy aspects of anterior thalamic deep brain stimulation JF - EPILEPSIA J2 - EPILEPSIA VL - 63 PY - 2022 SP - 225 EP - 226 PG - 2 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/33117632 ID - 33117632 LA - English DB - MTMT ER - TY - JOUR AU - Tényi, Dalma AU - Tényi, Tamás AU - Tényiné Csábi, Györgyi AU - Bóné, Beáta AU - Janszky, József Vladimír TI - Increased prevalence of minor physical anomalies in patients with epilepsy – results with the Méhes Scale JF - EPILEPSIA J2 - EPILEPSIA VL - 63 PY - 2022 IS - Suppl. 2 SP - 71 EP - 71 PG - 1 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/33106785 ID - 33106785 LA - English DB - MTMT ER - TY - JOUR AU - Tényi, Dalma AU - Tényi, Tamás AU - Tényiné Csábi, Györgyi AU - Jeges, Sára AU - Bóné, Beáta AU - Lőrincz, Katalin AU - Kovács, Norbert AU - Janszky, József Vladimír TI - Increased prevalence of minor physical anomalies in patients with epilepsy JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-022-17853-1 UR - https://m2.mtmt.hu/api/publication/33050343 ID - 33050343 N1 - Department of Neurology, University of Pécs, Rét u 2, Pécs, 7623, Hungary Department of Psychiatry and Psychotherapy, University of Pécs, Pécs, Hungary Department of Pediatrics, University of Pécs, Pécs, Hungary Institute of Nursing and Patients Care, Faculty of Health Sciences, University of Pécs, Pécs, Hungary Cited By :2 Export Date: 26 July 2024 Correspondence Address: Tényi, D.; Department of Neurology, Rét u 2, Hungary; email: tenyi.dalma@pte.hu AB - Our aim was to investigate the rate and topological profile of minor physical anomalies (MPAs) in adult patients with epilepsy with the use of the Méhes Scale, a comprehensive modern scale of dysmorphology. Consecutive epilepsy patients admitted for outpatient evaluation were included. Patients with comorbidities of neurodevelopmental origin (such as autism, severe intellectual disability, attention deficit hyperactivity disorder, schizophrenia, tic disorder, Tourette syndrome, bipolar disorder, specific learning disorder and specific language impairment) were excluded. All participants underwent physical examination with the use of the Méhes Scale for evaluation of MPAs, including 57 minor signs. The frequency and topological profile of MPAs were correlated to clinical patient data using Kruskal–Wallis, chi2 tests and logistic regression model. 235 patients were included, according to the following subgroups: acquired epilepsy (non-genetic, non-developmental etiology) [N = 63], temporal lobe epilepsy with hippocampal sclerosis (TLE with HS) [N = 27], epilepsy with cortical dysgenesis etiology [N = 29], cryptogenic epilepsy [N = 69] and idiopathic generalized epilepsy (IGE) [N = 47]. As controls, 30 healthy adults were recruited. The frequency of MPAs were significantly affected by the type of epilepsy [H(6) = 90.17; p < 0.001]. Pairwise comparisons showed that all patient groups except for acquired epilepsy were associated with increased frequency of MPAs (p < 0.001 in all cases). Furrowed tongue and high arched palate were more common compared to controls in all epilepsy subgroup except for TLE (p < 0.001 or p = 0.001 in all cases). A positive association was detected between the occurrence of MPAs and antiepileptic drug therapy resistance [Exp(B) = 4.19; CI 95% 1.37–12.80; p = 0.012]. MPAs are more common in patients with epilepsy, which corroborates the emerging concept of epilepsy as a neurodevelopmental disorder. Assessment of these signs may contribute to the clarification of the underlying etiology. Moreover, as increased frequency of MPAs may indicate pharmacoresistance, the identification of patients with high number of MPAs could allow evaluation for non-pharmacological treatment in time. LA - English DB - MTMT ER - TY - JOUR AU - Kaufmann, E. AU - Peltola, J. AU - Colon, A. AU - Bóné, Beáta AU - Bentes, C. AU - Coenen, V. AU - Gil-Nagel, A. AU - Goncalves-Ferreira, A. AU - Lehtimaki, K. AU - Ryvlin, P. AU - Taylor, R. AU - Brionne, T. AU - Gielen, F. AU - Song, S. AU - Boon, P. TI - Insights from long-term clinical routine use of thalamic deep brain stimulation for epilepsy (MORE) JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 29 PY - 2022 SP - 264 EP - 265 PG - 2 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/33030727 ID - 33030727 LA - English DB - MTMT ER - TY - JOUR AU - Trischlerné Gyimesi, Csilla AU - Barsi, Péter AU - Bóné, Beáta AU - Dóczi, Tamás Péter AU - Horváth, Réka AU - Horváth, Zsolt AU - Komoly, Sámuel AU - Lőrincz, Katalin Nóra AU - Tóth, Márton AU - Janszky, József Vladimír TI - Epilepsziasebészet a pécsi epilepsziacentrumban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 17 EP - 17 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893951 ID - 32893951 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Barsi, Péter AU - Tóth, Zoltán AU - Borbély, Katalin AU - Lückl, János AU - Emri, Miklós AU - Repa, Imre AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Halász, Péter AU - Juhos, Vera AU - Trischlerné Gyimesi, Csilla AU - Bóné, Beáta AU - Kuperczkó, Diána AU - Horváth, Réka AU - Nagy, Ferenc AU - Kelemen, Anna AU - Jordán, Zsófia AU - Ujvári, Ákos AU - Hagiwara, Koichi AU - Isnard, Jean AU - Pál, Endre AU - Fekésházy, Attila AU - Fabó, Dániel AU - Vajda, Zsolt TI - The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy JF - BMC NEUROLOGY J2 - BMC NEUROL VL - 21 PY - 2021 IS - 1 PG - 20 SN - 1471-2377 DO - 10.1186/s12883-021-02352-z UR - https://m2.mtmt.hu/api/publication/32219141 ID - 32219141 N1 - * Megosztott szerzőség AB - When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary.008899/2016/OTIG . Date of registration: 08 February 2016. LA - English DB - MTMT ER -