@{MTMT:34750674,
	title = {Nőgyógyászati sebészet az általános sebészetben},
	url = {https://m2.mtmt.hu/api/publication/34750674},
	author = {Koppán, Miklós},
	booktitle = {Littmann Sebészeti műtéttan},
	unique-id = {34750674},
	year = {2023},
	pages = {777-807}
}

@article{MTMT:34430278,
	title = {Changes of Ex Vivo Cervical Epithelial Cells Due to Electroporation with JMY},
	url = {https://m2.mtmt.hu/api/publication/34430278},
	author = {Halász, Henriett and Szatmári, Zoltán and Kovács, Krisztina and Koppán, Miklós and Papp, Szilárd and Szabó-Meleg, Edina and Szatmári, Dávid Zoltán},
	doi = {10.3390/ijms242316863},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34430278},
	issn = {1661-6596},
	abstract = {The ionic environment within the nucleoplasm might diverge from the conditions found in the cytoplasm, potentially playing a role in the cellular stress response. As a result, it is conceivable that interactions of nuclear actin and actin-binding proteins (ABPs) with apoptosis factors may differ in the nucleoplasm and cytoplasm. The primary intracellular stress response is Ca2+ influx. The junctional mediating and regulating Y protein (JMY) is an actin-binding protein and has the capability to interact with the apoptosis factor p53 in a Ca2+-dependent manner, forming complexes that play a regulatory role in cytoskeletal remodelling and motility. JMY's presence is observed in both the cytoplasm and nucleoplasm. Here, we show that ex vivo ectocervical squamous cells subjected to electroporation with JMY protein exhibited varying morphological alterations. Specifically, the highly differentiated superficial and intermediate cells displayed reduced nuclear size. In inflamed samples, nuclear enlargement and simultaneous cytoplasmic reduction were observable and showed signs of apoptotic processes. In contrast, the less differentiated parabasal and metaplastic cells showed increased cytoplasmic activity and the formation of membrane protrusions. Surprisingly, in severe inflammation, vaginosis or ASC-US (Atypical Squamous Cells of Undetermined Significance), JMY appears to influence only the nuclear and perinuclear irregularities of differentiated cells, and cytoplasmic abnormalities still existed after the electroporation. Our observations can provide an appropriate basis for the exploration of the relationship between cytopathologically relevant morphological changes of epithelial cells and the function of ABPs. This is particularly important since ABPs are considered potential diagnostic and therapeutic biomarkers for both cancers and chronic inflammation.},
	keywords = {ACTIN; cytopathology; JMY; Actin-binding proteins; ex vivo epithelial cells},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Halász, Henriett/0009-0003-7132-634X}
}

@article{MTMT:33133019,
	title = {Female reproductive functions of the neuropeptide PACAP},
	url = {https://m2.mtmt.hu/api/publication/33133019},
	author = {Koppán, Miklós and Nagy, Zsuzsanna and Bosnyák, Inez and Reglődi, Dóra},
	doi = {10.3389/fendo.2022.982551},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {13},
	unique-id = {33133019},
	issn = {1664-2392},
	abstract = {Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a diverse spectrum of actions. Among other processes, PACAP has been shown to be involved in reproduction. In this review we summarize findings related to the entire spectrum of female reproduction. PACAP is a regulatory factor in gonadal hormone production, influences follicular development and plays a role in fertilization and embryonic/placental development. Furthermore, PACAP is involved in hormonal changes during and after birth and affects maternal behavior. Although most data come from cell cultures and animal experiments, increasing number of evidence suggests that similar effects of PACAP can be found in humans. Among other instances, PACAP levels show changes in the serum during pregnancy and birth. PACAP is also present in the human follicular and amniotic fluids and in the milk. Levels of PACAP in follicular fluid correlate with the number of retrieved oocytes in hyperstimulated women. Human milk contains very high levels of PACAP compared to plasma levels, with colostrum showing the highest concentration, remaining steady thereafter for the first 7 months of lactation. All these data imply that PACAP has important functions in reproduction both under physiological and pathological conditions.},
	keywords = {PACAP; GnRH; ovary; placenta; LH; FSH},
	year = {2022},
	eissn = {1664-2392}
}

@article{MTMT:32468138,
	title = {Női kismedencei funkciózavarok keresztmetszeti vizsgálata magyarországi populáción = Cross-sectional study of female pelvic floor dysfunction in a Hungarian population},
	url = {https://m2.mtmt.hu/api/publication/32468138},
	author = {Ambrus, Eszter Krisztina and Makai, Alexandra and Prémusz, Viktória and Boros-Balint, Luliana and Tardi, Péter and Tóvári, Anett and Csizmadiáné Nusser, Nóra and Járomi, Melinda and Ács, Pongrác and Koppán, Miklós and Bódis, József and Hock, Márta},
	doi = {10.1556/650.2021.32221},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {162},
	unique-id = {32468138},
	issn = {0030-6002},
	abstract = {Összefoglaló. Bevezetés és célkitűzés: A női kismedencei funkciózavarok változatos tünetekkel jelentkezhetnek, és jelentősen befolyásolják az érintettek életminőségét. Vizsgálatunk célja volt felmérni a medencefenék-diszfunkciós tüneteket és azok hatását az egyén életminőségére. Módszer: Vizsgálatunkba 203 nőt vontunk be. Az adatgyűjtést két kérdőív, egy általunk összeállított és az Australian Pelvic Floor Questionnaire segítségével végeztük. Az adatok statisztikai elemzéséhez SPSS 20.0 rendszert használtunk. Spearman-korrelációt, khi-négyzet-próbát, Mann-Whitney-féle U-tesztet, Kruskal-Wallis-próbát és többváltozós lineáris regressziót alkalmaztunk. A szignifikanciaszintet p≤0,05 határnál állapítottuk meg. Eredmények: A hólyagdiszfunkciók gyakorisága (56,2%) szignifikáns kapcsolatot mutatott az életkor növekedésével (p<0,001), az obesitassal (p<0,001), a szülésszámmal és -móddal (p<0,001; p<0,001), az episiotomiával (p<0,001) és a prolapsusműtétekkel (p = 0,010). A süllyedéses kismedencei kórképek gyakorisága (27,1%) szignifikáns kapcsolatot mutatott az életkor növekedésével (p = 0,002), a szülésszámmal és -móddal (p<0,001; p<0,001) és a korábbi episiotomiával (p<0,001). Az analis incontinentia gyakorisága (58,9%) a magasabb testtömegindexszel (p = 0,029) volt szignifikáns kapcsolatban. Szexuális diszfunkciót (53,2%) allergia és tüdőbetegségek (p = 0,048) jelenlétével kapcsolatban találtunk. A többes diszfunkció előfordulási gyakorisága az életkor növekedésével (p<0,001), az obesitassal (p = 0,043), a korábbi hysterectomiával (p = 0,046) és prolapsusműtétekkel (p<0,001) mutatott szignifikáns kapcsolatot. Minden diszfunkció esetén kimutatható volt az életminőség-romlás (hólyagfunkciók: p<0,001; bél- és székletürítési funkciók: p<0,001, hüvelyfali süllyedés: p<0,001, szexuális funkciók: p<0,001). Következtetés: Az általunk vizsgált női populációban nagy arányban találtunk kismedencei funkciózavarokat, melyek kedvezőtlen hatással voltak az érintettek életminőségére. Orv Hetil. 2021; 162(43): 1724-1731.Pelvic floor dysfunction (PFD) can cause several complaints in women and has an adverse effect on the quality of life (Qol). The aim of our study was to evaluate the prevalence of pelvic floor dysfunction and its effect on Qol.203 women were included. We used two questionnaires, a self-constructed and the Australian Pelvic Floor Questionnaire. Statistical analysis was performed by SPSS 20.0. Spearman's correlation, chi-square, Mann-Whitney U, Kruskal-Wallis tests and multivariate linear regression were used. Statistical significance was set at p≤0.05.There was a significant association between the prevalence of urinary incontinence (56.2%) and age (p<0.001), obesity (p<0.001), number and mode of deliveries (p<0.001; p<0.001), episiotomy (p<0.001) and pelvic organ prolapse (POP) surgery (p = 0.010); between the occurrence of POP (27.1%) and age (p = 0.002), the number and mode of deliveries (p<0.001; p<0.001) and episiotomy (p<0.001); between the prevalence of anal incontinence (58.9%) and obesity (p = 0.029); between sexual dysfunction (SD) (53.2%) and respiratory disease and allergy (p = 0.048). Multiple PFD was significantly associated with age (p<0.001), obesity (p = 0.043), hysterectomy (p = 0.046) and POP surgery (p = 0.010). There was a significant difference between women having more severe PFD than milder complaints regarding Qol (bladder p<0.001; bowel p<0.001; SD p<0.001 and POP p<0.001).Pelvic floor dysfunction was common in our study population and had a great adverse effect on Qol. Orv Hetil. 2021; 162(43): 1724-1731.},
	keywords = {Quality of Life; Urinary incontinence; életminőség; pelvic organ prolapse; Pelvic floor dysfunction; anal incontinence; analis incontinentia; medencefenék-diszfunkciók; méh- és hüvelysüllyedés; vizeletincontinentia},
	year = {2021},
	eissn = {1788-6120},
	pages = {1724-1731},
	orcid-numbers = {Ambrus, Eszter Krisztina/0000-0002-2667-3356; Makai, Alexandra/0000-0002-1907-120X; Prémusz, Viktória/0000-0002-4059-104X; Boros-Balint, Luliana/0000-0002-5717-412X; Tardi, Péter/0000-0002-5091-7373; Ács, Pongrác/0000-0002-4999-7345}
}

@article{MTMT:32466816,
	title = {Nőgyógyászati laparoszkópia 2021},
	url = {https://m2.mtmt.hu/api/publication/32466816},
	author = {Koppán, Miklós},
	journal-iso = {MAGYAR NŐORVOSOK LAPJA},
	journal = {MAGYAR NŐORVOSOK LAPJA},
	volume = {84},
	unique-id = {32466816},
	issn = {0025-021X},
	year = {2021},
	pages = {214-222}
}

@{MTMT:32053539,
	title = {The impact of prenatal dance on neurodevelopment in infants and toddlers},
	url = {https://m2.mtmt.hu/api/publication/32053539},
	author = {Bánkyné Perjés, Beatrix and Mátrai, Gábor and Nagy, Bernadett and Erdei, D and Makai, Alexandra and Prémusz, Viktória and Koppán, Miklós and Bódis, József},
	booktitle = {Lifelong Health and Wellbeing: Seminar Programme and Abstract Book - EDUC WP9},
	unique-id = {32053539},
	year = {2021},
	pages = {13-14},
	orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X; Prémusz, Viktória/0000-0002-4059-104X}
}

@misc{MTMT:32040270,
	title = {The impact of prenatal dance on neurodevelopment in infants and toddlers},
	url = {https://m2.mtmt.hu/api/publication/32040270},
	author = {Bánkyné Perjés, Beatrix and Mátrai, Gábor and Nagy, Bernadett and Erdei, Daniella and Makai, Alexandra and Prémusz, Viktória and Koppán, Miklós and Bódis, József},
	unique-id = {32040270},
	year = {2021},
	orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X; Prémusz, Viktória/0000-0002-4059-104X}
}

@article{MTMT:31940140,
	title = {A tüszőfolyadék biomarkereinek vizsgálata in vitro fertilizációs kezelésben részesült betegekben},
	url = {https://m2.mtmt.hu/api/publication/31940140},
	author = {Bódis, József and Sulyok, Endre and Várnagy, Ákos and Koppán, Miklós and Kovács, L. Gábor},
	doi = {10.1556/650.2021.32067},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {162},
	unique-id = {31940140},
	issn = {0030-6002},
	abstract = {Összefoglaló. A szerzők ismertetik vizsgálataik eredményeit, melyeket a közelmúltban az in vitro fertilizációs kezelésben részesülő betegeikben a tüszőfolyadék biomarkereinek analízisével értek el. A vizsgálatok célja annak feltárása volt, hogy az in vitro fertilizációs eljárás során a petesejtek aspirációjakor nyert tüszőfolyadék-biomarkerek lokális/ovarialis vagy szisztémás eredetűek, és milyen összefüggést mutatnak az in vitro fertilizáció eredményességét jelző paraméterekkel. Megerősítettük, hogy az autokrin/parakrin szerotoninrendszer már a fejlődés legkorábbi időszakában is működőképes, és mind az anyai szérum, mind a tüszőfolyadék szerotoninszintje szignifikáns pozitív összefüggést mutatott az érett petesejtek számával és a klinikai terhességgel (β = 0,447, p = 0,015, illetve β = 0,443, p = 0,016). Az agyi eredetű neurotrofikus faktor (BDNF) esetében ilyen kapcsolat nem volt igazolható, de a tüszőfolyadék BDNF- és szerotoninszintjei közötti pozitív korreláció (r = 0,377, p = 0,040) azt mutatja, hogy a két neurohormon 'feed-forward' (előrecsatoló ) szabályozása ovarialis szinten is működik. A hypothalamicus kisspeptin esetében csupán a posztstimulációs anyai szérumhormonszint befolyásolta az érett petesejtek számát (β = 0,398, p = 0,029). A triptofán-kinurenin-szerotonin rendszer elemzése azt mutatta, hogy kedvezőbb in vitro fertilizációs kimenetel várható, ha a szerotonin-kinurenin egyensúly a szerotonin javára tolódik el. Az oxidatívstressz-markerek közül vizsgálták a DNS-károsodás biomarkerét, a 8-hidroxi-2'-deoxiguanozin és a totális antioxidáns-kapacitás szérum- és tüszőfolyadékszintjeit, és megállapították, hogy mindkét marker kedvezőtlenül befolyásolja az életképes embriók számát (r = 0,302, p = 0,027 és r = 0,268, p = 0,039). A protektív hatású szirtuinok - nikotinamid-adenin-dinukleotid-függő hiszton-deacetiláz fehérjék - közül a vizsgált szirtuin-1 és szirtuin-6 a szérumszintektől függetlenül kimutatható a tüszőfolyadékban. Szignifikáns pozitív korreláció van a tüszőfolyadék-szirtuin-6 és az érettpetesejt-szám (F = 6,609, p = 0,016), valamint a szérum-szirtuin-1 (F = 10,008, p = 0,005) és a szérum-szirtuin-6 (F = 5,268, p = 0,031) és a klinikai terhesség gyakorisága között. Eredményeink alapján megállapítható, hogy a tüszőfolyadék biomarkereinek vizsgálata javíthatja az in vitro fertilizáció kimenetelének megítélését. Orv Hetil. 2021; 162(14): 523-529. Summary. This article outlines the result of recent studies on several follicular fluid biomarkers in patients undergoing in vitro fertilization. The aim of these studies was to investigate whether 1) the follicular fluid biomarkers in question are produced locally by the ovaries or they originate from the circulating plasma, 2) and to establish their association with parameters of in vitro fertilization outcome. It was confirmed that the autocrine/paracrine serotonin system is functional already at the earliest stage of development and both maternal serum and follicular fluid serotonin levels were positively related to the number of mature oocytes (β = 0.447, p = 0.015 and β = 0.443, p = 0.016, respectively) and clinical pregnancy (β = 1.028, p = 0.047). Such associations for brain-derived neurotrophic factor (BDNF) could not be found, but BDNF and serotonin in the follicular fluid were closely related (r = 0.377, p<0.040) suggesting that the feed-forward regulation of these neurohormones is activated at ovarian level. The hypothalamic kisspeptin in the post-stimulation maternal serum also increased the number of mature oocytes (β = 0.398, p = 0.029). Analysis of the tryptophan-kynurenine-serotonin system showed a more favourable in vitro fertilization outcome when the serotonin-kynurenine balance was shifted and serotonin predominated over kynurenine. The oxidative stress markers, 8-hydroxy-2'-deoxyguanosine, an indicator of DNA damage and the total antioxidant capacity in follicular fluid and maternal serum had negative impact on the number of viable embryos (r = 0.302, p = 0.027 and r = 0.268, p = 0.039), respectively. The protective sirtuins - the nicotinamide adenine dinucleotide-dependent histone deacetylase proteins - could be detected in follicular fluid irrespective of their maternal serum levels. Significant positive relationship was demonstrated between follicular fluid sirtuin 6 and mature oocytes (F = 6.609, p = 0.016) as well as between serum sirtuin 1 (F = 10.008, p = 0.005) and serum sirtuin 6 (F = 5.268, p = 0.031) and the rate of clinical pregnancy, respectively. On the basis of these results, it can be concluded that measuring several follicular fluid biomarkers may improve the prediction of the outcome of in vitro fertilization. Orv Hetil. 2021; 162(14): 523-529.},
	keywords = {Biomarkers; follicular fluid; In vitro fertilization; biomarkerek; in vitro fertilizáció; tüszőfolyadék},
	year = {2021},
	eissn = {1788-6120},
	pages = {523-529},
	orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401}
}

@article{MTMT:31603729,
	title = {Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy – with special regard to self-reported and objective measures of pre-treatment habitual physical activity},
	url = {https://m2.mtmt.hu/api/publication/31603729},
	author = {Prémusz, Viktória and Makai, Alexandra and Bánkyné Perjés, Beatrix and Máté, Orsolya and Hock, Márta and Ács, Pongrác and Koppán, Miklós and Bódis, József and Várnagy, Ákos and Lampek, Kinga},
	doi = {10.1186/s12889-020-09522-7},
	journal-iso = {BMC PUBLIC HEALTH},
	journal = {BMC PUBLIC HEALTH},
	volume = {21},
	unique-id = {31603729},
	issn = {1471-2458},
	year = {2021},
	eissn = {1471-2458},
	orcid-numbers = {Prémusz, Viktória/0000-0002-4059-104X; Makai, Alexandra/0000-0002-1907-120X; Máté, Orsolya/0000-0003-4778-3519; Ács, Pongrác/0000-0002-4999-7345}
}

@article{MTMT:31677101,
	title = {How to reduce the potential harmful effects of light on blastocyst development during IVF},
	url = {https://m2.mtmt.hu/api/publication/31677101},
	author = {Bódis, József and Gödöny, Krisztina and Várnagy, Ákos and Kovács, Kálmán András and Koppán, Miklós and Nagy, Bernadett and Erostyák, János and Herczeg, Róbert and Szekeres, Júlia and Gyenesei, Attila and Kovács, L. Gábor},
	doi = {10.1159/000509016},
	journal-iso = {MED PRIN PRACT},
	journal = {MEDICAL PRINCIPLES AND PRACTICE},
	volume = {29},
	unique-id = {31677101},
	issn = {1011-7571},
	abstract = {Earlier findings revealed the damaging effect of visible light on zygotes and gametes. The aim of our study is to eliminate or significantly reduce the potential harmful effect of light exposure during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to investigate the effect of light protection on embryo development and implantation.To protect sperm cells, oocytes and embryos from the potential harmful effects of light exposure during laboratory procedures, we created a dark environment for the cells and applied red filters on laboratory lamps and UV or infrared filters in the microscopes - to eliminate white light exposure of the cells throughout all work stages.The fertilization rate was significantly (p = 0.011) higher in light protected ICSI cycles. Blastocyst development rates (blastocyst/embryo) were significantly (p<0.001) higher in light protected embryos than in those manipulated in conventional light conditions both in IVF (20.9% difference) and ICSI (38.6% difference). Number of clinical pregnancies/transfers of ICSI fertilized day 5 blastocysts were significantly (p=0.040) higher in light protected conditions.This data show that light protection has a positive effect on fertilization rate and increases the blastocyst development as well as number of clinical pregnancies/transfers. Implementation of this light protection method in IVF centers may improve the success rate while maintaining maximal embryo safety.},
	year = {2020},
	eissn = {1423-0151},
	pages = {558-564},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082; Kovács, L. Gábor/0000-0001-5298-5401}
}