@article{MTMT:34424560,
	title = {Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis},
	url = {https://m2.mtmt.hu/api/publication/34424560},
	author = {Gomaa, Nariman Essmat Mohamed Aldeltawab and Karádi, Dávid Árpád and Zádor, Ferenc and Király, Kornél P and Fürst, Zsuzsanna and Al-Khrasani, Mahmoud},
	doi = {10.3390/molecules28237766},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34424560},
	issn = {1420-3049},
	abstract = {Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are essential analgesic agents for acute or chronic mild to severe pain treatment. However, their use has raised concerns including, among others, intestinal dysbiosis. In addition, growing data on constipation-evoked intestinal dysbiosis have been reported. Opioid-induced constipation (OIC) creates an obstacle to continuing treatment with opioid analgesics. When non-opioid therapies fail to overcome the OIC, opioid antagonists with peripheral, fast first-pass metabolism, and gastrointestinal localized effects remain the drug of choice for OIC, which are discussed here. At first glance, their use seems to only be restricted to constipation, however, recent data on OIC-related dysbiosis and its contribution to the appearance of several opioid side effects has garnered a great of attention from researchers. Peripheral MORs have also been considered as a future target for opioid analgesics with limited central side effects. The properties of MOR antagonists counteracting OIC, and with limited influence on central and possibly peripheral MOR-mediated antinociception, will be highlighted. A new concept is also proposed for developing gut-selective MOR antagonists to treat or restore OIC while keeping peripheral antinociception unaffected. The impact of opioid antagonists on OIC in relation to changes in the gut microbiome is included.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Gomaa, Nariman Essmat Mohamed Aldeltawab/0000-0003-3440-6263; Király, Kornél P/0000-0002-7252-0422; Fürst, Zsuzsanna/0000-0002-2760-1274; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}

@article{MTMT:34090834,
	title = {Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats},
	url = {https://m2.mtmt.hu/api/publication/34090834},
	author = {Gomaa, Nariman Essmat Mohamed Aldeltawab and Galambos, Anna Rita and Lakatos, Péter Pál and Karádi, Dávid Árpád and Mohammadzadeh, Amir and Abbood, Sarah Kadhim and Geda, Orsolya and Laufer, Rudolf and Király, Kornél P and Riba, Pál and Zádori, Zoltán Sándor and Szökő, Éva and Tábi, Tamás and Al-Khrasani, Mahmoud},
	doi = {10.3390/ph16081115},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {16},
	unique-id = {34090834},
	year = {2023},
	eissn = {1424-8247},
	orcid-numbers = {Gomaa, Nariman Essmat Mohamed Aldeltawab/0000-0003-3440-6263; Lakatos, Péter Pál/0000-0001-6410-0471; Mohammadzadeh, Amir/0000-0001-6747-1913; Abbood, Sarah Kadhim/0000-0001-5305-8730; Geda, Orsolya/0000-0001-8085-816X; Király, Kornél P/0000-0002-7252-0422; Riba, Pál/0000-0002-7886-4816; Zádori, Zoltán Sándor/0000-0001-7312-618X; Szökő, Éva/0000-0003-1464-6403; Tábi, Tamás/0000-0001-5343-0205; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}

@article{MTMT:33784924,
	title = {Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats},
	url = {https://m2.mtmt.hu/api/publication/33784924},
	author = {Karádi, Dávid Árpád and Galambos, Anna Rita and Lakatos, Péter Pál and Apenberg, Joost and Abbood, Sarah Kadhim and Balogh, Mihály and Király, Kornél P and Riba, Pál and Gomaa, Nariman Essmat Mohamed Aldeltawab and Szűcs, Edina and Benyhe, Sándor and Varga, Zoltán and Szökő, Éva and Tábi, Tamás and Al-Khrasani, Mahmoud},
	doi = {10.3390/ijms24097970},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33784924},
	issn = {1661-6596},
	abstract = {Despite the large arsenal of analgesic medications, neuropathic pain (NP) management is not solved yet. Angiotensin II receptor type 1 (AT1) has been identified as a potential target in NP therapy. Here, we investigate the antiallodynic effect of AT1 blockers telmisartan and losartan, and particularly their combination with morphine on rat mononeuropathic pain following acute or chronic oral administration. The impact of telmisartan on morphine analgesic tolerance was also assessed using the rat tail-flick assay. Morphine potency and efficacy in spinal cord samples of treated neuropathic animals were assessed by [35S]GTPγS-binding assay. Finally, the glutamate content of the cerebrospinal fluid (CSF) was measured by capillary electrophoresis. Oral telmisartan or losartan in higher doses showed an acute antiallodynic effect. In the chronic treatment study, the combination of subanalgesic doses of telmisartan and morphine ameliorated allodynia and resulted in a leftward shift in the dose–response curve of morphine in the [35S]GTPγS binding assay and increased CSF glutamate content. Telmisartan delayed morphine analgesic-tolerance development. Our study has identified a promising combination therapy composed of telmisartan and morphine for NP and opioid tolerance. Since telmisartan is an inhibitor of AT1 and activator of PPAR-γ, future studies are needed to analyze the effect of each component.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Lakatos, Péter Pál/0000-0001-6410-0471; Abbood, Sarah Kadhim/0000-0001-5305-8730; Balogh, Mihály/0000-0003-3296-0316; Király, Kornél P/0000-0002-7252-0422; Riba, Pál/0000-0002-7886-4816; Gomaa, Nariman Essmat Mohamed Aldeltawab/0000-0003-3440-6263; Benyhe, Sándor/0000-0002-2235-5334; Varga, Zoltán/0000-0002-2758-0784; Szökő, Éva/0000-0003-1464-6403; Tábi, Tamás/0000-0001-5343-0205; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}

@article{MTMT:33560486,
	title = {Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)},
	url = {https://m2.mtmt.hu/api/publication/33560486},
	author = {Kozsurek, Márk and Király, Kornél P and Gyimesi, Klára and Lukácsi, Erika and Fekete, Csaba and Gereben, Balázs and Mohácsik, Petra and Helyes, Zsuzsanna and Bölcskei, Kata and Tékus, Valéria and Pap, Károly and Szűcs, Edina and Benyhe, Sándor and Imre, Timea and Szabó, Pál Tamás and Gajtkó, Andrea and Szentesiné Holló, Krisztina and Puskár, Zita},
	doi = {10.3390/ijms24020918},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33560486},
	issn = {1661-6596},
	abstract = {Cocaine- and amphetamine-regulated transcript (CART) peptides are involved in several physiological and pathological processes, but their mechanism of action is unrevealed due to the lack of identified receptor(s). We provided evidence for the antihyperalgesic effect of CART(55-102) by inhibiting dipeptidyl-peptidase 4 (DPP4) in astrocytes and consequently reducing neuroinflammation in the rat spinal dorsal horn in a carrageenan-evoked inflammation model. Both naturally occurring CART(55-102) and CART(62-102) peptides are present in the spinal cord. CART(55-102) is not involved in acute nociception but regulates spinal pain transmission during peripheral inflammation. While the full-length peptide with a globular motif contributes to hyperalgesia, its N-terminal inhibits this process. Although the anti-hyperalgesic effects of CART(55-102), CART(55-76), and CART(62-76) are blocked by opioid receptor antagonists in our inflammatory models, but not in neuropathic Seltzer model, none of them bind to any opioid or G-protein coupled receptors. DPP4 interacts with Toll-like receptor 4 (TLR4) signalling in spinal astrocytes and enhances the TLR4-induced expression of interleukin-6 and tumour necrosis factor alpha contributing to inflammatory pain. Depending on the state of inflammation, CART(55-102) is processed in the spinal cord, resulting in the generation of biologically active isoleucine-proline-isoleucine (IPI) tripeptide, which inhibits DPP4, leading to significantly decreased glia-derived cytokine production and hyperalgesia.},
	keywords = {HYPERALGESIA; chronic pain; spinal cord; Allodynia; cocaine- and amphetamine-regulated transcript (CART) peptide; dipeptidyl-peptidase-4 (DPP4)},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Kozsurek, Márk/0000-0001-5465-2803; Király, Kornél P/0000-0002-7252-0422; Szabó, Pál Tamás/0000-0003-2260-4641}
}

@article{MTMT:33298915,
	title = {Interactions between NSAIDs, opioids and the gut microbiota - Future perspectives in the management of inflammation and pain},
	url = {https://m2.mtmt.hu/api/publication/33298915},
	author = {Zádori, Zoltán Sándor and Király, Kornél P and Al-Khrasani, Mahmoud and Gyires, Klára},
	doi = {10.1016/j.pharmthera.2022.108327},
	journal-iso = {PHARMACOL THERAPEUT},
	journal = {PHARMACOLOGY & THERAPEUTICS},
	volume = {241},
	unique-id = {33298915},
	issn = {0163-7258},
	year = {2023},
	eissn = {1879-016X},
	orcid-numbers = {Zádori, Zoltán Sándor/0000-0001-7312-618X; Király, Kornél P/0000-0002-7252-0422; Al-Khrasani, Mahmoud/0000-0001-8488-3266; Gyires, Klára/0000-0002-4718-2345}
}

@article{MTMT:33063137,
	title = {The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action},
	url = {https://m2.mtmt.hu/api/publication/33063137},
	author = {Lakatos, Péter Pál and Karádi, Dávid Árpád and Galambos, Anna Rita and Gomaa, Nariman Essmat Mohamed Aldeltawab and Király, Kornél P and Laufer, Rudolf and Geda, Orsolya and Zádori, Zoltán Sándor and Tábi, Tamás and Al-Khrasani, Mahmoud and Szökő, Éva},
	doi = {10.3390/ijms23179564},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33063137},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Lakatos, Péter Pál/0000-0001-6410-0471; Gomaa, Nariman Essmat Mohamed Aldeltawab/0000-0003-3440-6263; Király, Kornél P/0000-0002-7252-0422; Geda, Orsolya/0000-0001-8085-816X; Zádori, Zoltán Sándor/0000-0001-7312-618X; Tábi, Tamás/0000-0001-5343-0205; Al-Khrasani, Mahmoud/0000-0001-8488-3266; Szökő, Éva/0000-0003-1464-6403}
}

@article{MTMT:33013078,
	title = {Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor},
	url = {https://m2.mtmt.hu/api/publication/33013078},
	author = {Zádor, Ferenc and Király, Kornél P and Gomaa, Nariman Essmat Mohamed Aldeltawab and Al-Khrasani, Mahmoud},
	doi = {10.3389/fmolb.2022.900547},
	journal-iso = {FRONT MOL BIOSCI},
	journal = {FRONTIERS IN MOLECULAR BIOSCIENCES},
	volume = {9},
	unique-id = {33013078},
	year = {2022},
	eissn = {2296-889X},
	orcid-numbers = {Király, Kornél P/0000-0002-7252-0422; Gomaa, Nariman Essmat Mohamed Aldeltawab/0000-0003-3440-6263; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}

@article{MTMT:34139029,
	title = {Digitális távoktatás a COVID-19-járvány árnyékában – összhangban az orvosképzés megújulásával és modernizálásával a Semmelweis Egyetem Farmakológiai és Farmakoterápiás Intézetében},
	url = {https://m2.mtmt.hu/api/publication/34139029},
	author = {Köles, László and Riba, Pál and Al-Khrasani, Mahmoud and Brenner, Gábor and Giricz, Zoltán and Görbe, Anikó and Kató, Erzsébet and Király, Kornél P and Miklya, Ildikó and Varga, Zoltán and Zádori, Zoltán Sándor and Ferdinandy, Péter},
	journal-iso = {ORVOSKÉPZÉS},
	journal = {ORVOSKÉPZÉS},
	volume = {96},
	unique-id = {34139029},
	issn = {0030-6037},
	year = {2021},
	pages = {261-264},
	orcid-numbers = {Köles, László/0000-0001-6708-0269; Riba, Pál/0000-0002-7886-4816; Al-Khrasani, Mahmoud/0000-0001-8488-3266; Brenner, Gábor/0000-0001-7886-2960; Giricz, Zoltán/0000-0003-2036-8665; Görbe, Anikó/0000-0003-4908-1094; Kató, Erzsébet/0000-0001-5786-0405; Király, Kornél P/0000-0002-7252-0422; Miklya, Ildikó/0000-0003-0071-9026; Varga, Zoltán/0000-0002-2758-0784; Zádori, Zoltán Sándor/0000-0001-7312-618X; Ferdinandy, Péter/0000-0002-6424-6806}
}

@article{MTMT:32593852,
	title = {A vallásosság szerepe az intenzív osztályon dolgozó orvosok és ápolók véleményének kialakításában az életvégi döntések meghozatalakor},
	url = {https://m2.mtmt.hu/api/publication/32593852},
	author = {Szűcs, Orsolya and Szabó, Léna and Élő, Gábor and Király, Kornél P and Darvas, Katalin and Szijártó, Attila and Gál, János and Zubek, László},
	doi = {10.1556/650.2021.32310},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {162},
	unique-id = {32593852},
	issn = {0030-6002},
	abstract = {Összefoglaló. Bevezetés: A haldoklást minden korban kulturális és vallási szabályok vették körül, melyek a mai napig hatnak a társadalomban. A 21. században számos beteg a kórházban, az intenzív osztályon fejezi be életét, ahol nem ritkán kerülhet sor életvégi döntés meghozatalára. Célkitűzés: Vizsgálatunk célja annak feltárása volt, milyen hatással van az orvosok és ápolók vallásossága a kezeléskorlátozással kapcsolatos döntésekre az intenzív osztályon. Módszer: Magyarországi intenzív osztályokon dolgozó orvosok és szakdolgozók körében végeztünk kérdőíves felmérést a vallás életvégi döntésekre gyakorolt hatásáról. 189 orvos és 105 ápoló által anonim módon kitöltött kérdőívet elemeztünk. Eredmények: Az intenzív osztályra történő betegfelvételre nem volt hatással a vallásosság, azonban a szabad ágyak száma a vallásos orvosokat erősebben befolyásolta, mint az ateista és választ nem adó orvosokat (<0,0001). A vallásukat gyakorló orvosok szignifikánsan jobban figyelembe vették a hozzátartozó kérését, mint az ateisták (p = 0,0002). A vallásos ápolók gyakrabban folytatnák a beteg kezelését a hozzátartozó kérése ellenére is, ha még látnának esélyt a gyógyulásra, mint a nem vallásosak. Következtetés: Vizsgálatunk alátámasztotta, hogy a világnézet befolyásolja az orvosokat és ápolókat az élet végéről hozott döntésekben. A kezeléskorlátozásról hozott döntés összetett, elengedhetetlen megismerni hozzá a beteg és családjának haldoklással kapcsolatos vallási szokásait, mivel jó életvégi döntés a világnézeti szempontok figyelembevétele nélkül nem hozható. Orv Hetil. 2021; 162(51): 2047-2054.Death has always been surrounded by habits in all ages, influenced by cultural and religious differences. Many patients finish their lives at intensive care units where end-of-life decisions are the part of everyday practice in the 21th century.The goal of our study was to assess how the religious beliefs of physicians and nurses affect their decision on therapy restriction.We have performed questionnaire-based enquiries among physicians and nurses working at intensive care units on how religion affects end-of-life decisions. We have analyzed the anonymous questionnaires filled out by 189 physicians and 105 nurses.Our results have confirmed the hypothesis that religion affects decision making about therapy restriction. Patients' admissions were not affected by religious beliefs, but the number of available patient beds influenced the religious physicians more than the atheists ones or the non-responders (<0.0001). Actively religious physicians complied significantly better with the relatives than atheists (p = 0.0002). Religious nurses would continue patient treatment even against the will of relatives more often than atheists if they see a chance for recovery.The study supports that religion influences physicians and nurses in their end-of-life decisions. Decisions on therapy restriction are complex; it is important to find out religious beliefs and perception of death among patients and families because good end-of-life decision cannot be made disregarding religious considerations. Orv Hetil. 2021; 162(51): 2047-2054.},
	keywords = {intensive care; vallás; religiosity; end-of-life decision; intenzív osztály; életvégi döntés},
	year = {2021},
	eissn = {1788-6120},
	pages = {2047-2054},
	orcid-numbers = {Szabó, Léna/0000-0003-2621-1378; Élő, Gábor/0000-0001-6425-7620; Király, Kornél P/0000-0002-7252-0422; Darvas, Katalin/0000-0003-4322-7523; Gál, János/0000-0001-9160-6478; Zubek, László/0000-0003-0583-3290}
}

@article{MTMT:32447371,
	title = {Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain},
	url = {https://m2.mtmt.hu/api/publication/32447371},
	author = {Király, Kornél P and Karádi, Dávid Árpád and Zádor, Ferenc and Mohammadzadeh, Amir and Galambos, Anna Rita and Balogh, Mihály and Riba, Pál and Tábi, Tamás and Zádori, Zoltán Sándor and Szökő, Éva and Fürst, Zsuzsanna and Al-Khrasani, Mahmoud},
	doi = {10.3390/molecules26206168},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {26},
	unique-id = {32447371},
	issn = {1420-3049},
	year = {2021},
	eissn = {1420-3049},
	orcid-numbers = {Király, Kornél P/0000-0002-7252-0422; Mohammadzadeh, Amir/0000-0001-6747-1913; Balogh, Mihály/0000-0003-3296-0316; Riba, Pál/0000-0002-7886-4816; Tábi, Tamás/0000-0001-5343-0205; Zádori, Zoltán Sándor/0000-0001-7312-618X; Szökő, Éva/0000-0003-1464-6403; Fürst, Zsuzsanna/0000-0002-2760-1274; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}