TY - GEN AU - Tran, Ngoc Minh AU - Takácsi-Nagy, Anna Erzsébet AU - Medveczki, Tímea AU - Csősz, Éva AU - Kovács, Illés AU - Clyne, Megan AU - Szabó, Attila AU - Fekete, Andrea AU - Hodrea, Judit TI - Assessment of eye irritation as the first step of an intraocular pressure-lowering eye drop formulation PY - 2022 UR - https://m2.mtmt.hu/api/publication/33685814 ID - 33685814 N1 - {poszter} LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Andrea AU - Tran, Ngoc Minh AU - Besztercei, Balázs AU - Török, György AU - Medveczki, Tímea AU - Takácsi-Nagy, Anna Erzsébet AU - Gasull, Xavier AU - Szabó, Attila AU - Kovács, Illés AU - Hodrea, Judit TI - Sigma−1 receptor activation as a new option for the treatment of glaucoma in preclinical models JF - ACTA OPHTHALMOLOGICA J2 - ACTA OPHTHALMOL VL - 100 PY - 2022 SN - 1755-375X DO - 10.1111/j.1755-3768.2022.15344 UR - https://m2.mtmt.hu/api/publication/33563214 ID - 33563214 N1 - WoS:hiba:000946564000463 2023-12-31 14:43 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Papp, Nóra AU - Purger, Dragica AU - Czigle, Szilvia AU - Czégényi, Dóra Andrea AU - Stranczinger, Szilvia AU - Tóth, Mónika Margit AU - Dénes, Tünde AU - Kocsis, Marianna AU - Takácsi-Nagy, Anna Erzsébet AU - Filep, Rita TI - The Importance of Pine Species in the Ethnomedicine of Transylvania (Romania) JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 18 PG - 22 SN - 2223-7747 DO - 10.3390/plants11182331 UR - https://m2.mtmt.hu/api/publication/33082969 ID - 33082969 N1 - Funding Agency and Grant Number: OTKA (Hungarian Scientific Research Fund) [K 127944]; Ministry of Education, Science, Research and Sport of the Slovak Republic [VEGA 1/0226/22] Funding text: This research was funded by OTKA (Hungarian Scientific Research Fund, K 127944) (N.P.) and the Ministry of Education, Science, Research and Sport of the Slovak Republic grants (VEGA 1/0226/22) (S.C.). LA - English DB - MTMT ER - TY - JOUR AU - Hodrea, Judit AU - Tran, Ngoc Minh AU - Besztercei, Balazs AU - Török, György AU - Medveczki, Tímea AU - Takácsi-Nagy, Anna Erzsébet AU - Xavier, Gasull AU - Szabó, Attila AU - Kovács, Illés AU - Fekete, Andrea TI - Sigma-1 receptor aktiváció, mint a glaukóma kezelésének új lehetősége preklinikai modellekben JF - SZEMÉSZET J2 - SZEMÉSZET VL - 159 PY - 2022 IS - Suppl. 1 SP - 46 EP - 47 PG - 2 SN - 0039-8101 UR - https://m2.mtmt.hu/api/publication/32909641 ID - 32909641 LA - English DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Kilár, Ferenc AU - Thormann, Wolfgang TI - The effect of pH adjusted electrolytes on capillary isoelectric focusing assessed by high-resolution dynamic computer simulation. JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 43 PY - 2022 IS - 5-6 SP - 669 EP - 678 PG - 10 SN - 0173-0835 DO - 10.1002/elps.202100367 UR - https://m2.mtmt.hu/api/publication/32534460 ID - 32534460 N1 - Funding Agency and Grant Number: Swiss NSF [TaMOP-4.2.2, D-15/1/KONV-2015-0015, NKFIH K-125275] Funding text: This work was supported by TaMOP-4.2.2.D-15/1/KONV-2015-0015, NKFIH K-125275, and the Swiss NSF. AB - The effect of the composition of electrolytes on capillary IEF is assessed for systems with carrier ampholytes covering 2 pH units and with catholytes of decreased pH, anolytes of increased pH and both electrode solutions with adjusted pH values. For electrolytes composed of formic acid as anolyte and ammonium hydroxide as catholyte, simulation is demonstrated to provide the expected IEF system in which analytes with pI values within the formed pH gradient are focused and become immobile. Addition of formic acid to the catholyte results in the formation of an isotachophoretic zone structure that migrates towards the cathode. With ammonium hydroxide added to the anolyte migration occurs towards the anode. In the two cases, all carrier components and amphoteric analytes migrate isotachophoretically as cations or anions, respectively. The data reveal that mM amounts of a counter ion are sufficient to convert an IEF pattern into an ITP system. With increased amounts of the added counter ion, the overall length of the migrating zone structure shrinks, the range of the pH gradient changes, and the migration rate increases. The studied examples indicate that systems of this type reported in the literature should be classified as ITP and not IEF. When both electrolytes are titrated, a non-uniform background electrolyte composed of formic acid and ammonium hydroxide is established in which analytes migrate according to local pH and conductivity without forming IEF or ITP zone structures. Simulation data are in qualitative agreement with previously published experimental data. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Salem, Ala' AU - Takácsi-Nagy, Anna Erzsébet AU - Nagy, Sándor AU - Hagymási, Alexandra AU - Gősi, Fruzsina AU - Vörös-Horváth, Barbara AU - Balić, Tomislav AU - Pál, Szilárd AU - Széchenyi, Aleksandar TI - Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 13 PY - 2021 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics13020277 UR - https://m2.mtmt.hu/api/publication/31905073 ID - 31905073 AB - Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Balázs AU - Láng, Boglárka AU - Takácsi-Nagy, Anna Erzsébet AU - Horváth, Györgyi AU - Czakó, Cecilia Nóra AU - Csorba, Anita AU - Kiss, Huba AU - Szalai, Irén AU - Nagy, Zoltán Zsolt AU - Kovács, Illés TI - Meibom-mirigy-diszfunkció és a száraz szem = [Meibomian gland dysfunction and dry eye: Diagnosis and treatment]. Diagnosztikai és kezelési lehetőségek TS - Diagnosztikai és kezelési lehetőségek JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 2 SP - 43 EP - 51 PG - 9 SN - 0030-6002 DO - 10.1556/650.2021.31958 UR - https://m2.mtmt.hu/api/publication/31805804 ID - 31805804 AB - Összefoglaló. A szárazszem-panaszok hátterében gyakran áll Meibom-mirigy-diszfunkció, melynek felismerése kiemelten fontos a hatékony kezelés érdekében. A Meibom-mirigyek kóros működése miatt a termelt lipid nem oszlik el megfelelően a szemfelszínen, így a könnyfilm párolgása fokozódik. A könnytermelési zavar következtében szárazszem-panaszok alakulnak ki, melyek a hagyományos könnypótló kezelésre rendszerint csak átmenetileg javulnak. A Meibom-mirigy-diszfunkciót gyakran kíséri a szemhéjszél Demodex-atka-fertőzése - az atka eradikálása szükséges a mirigyek működésének helyreállításához és ezáltal a panaszok megszüntetéséhez. A Meibom-mirigy-diszfunkció a leggyakrabban enyhe formában jelentkezik; a terápia ilyenkor a beteg által is elvégezhető szemhéjtisztításból áll, míg a gyógyszeres kezelés csak az előrehaladottabb, kifejezett gyulladással járó formákban szükséges. Az összefoglaló áttekinti a Meibom-mirigy-diszfunkció klinikai jeleivel és kezelésével kapcsolatos legfontosabb tudnivalókat, különös tekintettel a Demodex-fertőzés felismerésére és kezelésére vonatkozóan. Orv Hetil. 2021; 162(2): 43-51. Summary. The onset of dry eye complaints is often a result of Meibomian gland dysfunction and its diagnosis is essential for effective treatment. In the case of Meibomian gland dysfunction, there is an increased evaporation of the tear film due to the abnormal secretion of lipids that cannot spread on the ocular surface. The treatment of dry eye complaints associated with Meibomian gland dysfunction with tear supplementation is usually ineffective and only results in an intermittent relief of complaints. Meibomian gland dysfunction is often associated with Demodex infestation of the eyelids, and eradicating the mites is essential to re-establish normal meibum production and thus, decreasing ocular complaints. In most cases, Meibomian gland dysfunction is mild, and the treatment of these forms is based on ocular hygiene performed by the patient, while only more advanced forms with inflammatory processes require pharmacologic treatment. This review summarizes the most important knowledge on the clinical signs and treatment of Meibomian gland dysfunction with particular attention to the diagnosis and treatment of ocular Demodex infection. Orv Hetil. 2021; 162(2): 43-51. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Székely, Adrienn AU - Takácsi-Nagy, Anna Erzsébet TI - Kakaóvaj tartalmú, egyedi előiratú kenőcs eltérő formulálási technikáinak hatása a készítmény stabilitására JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 64 PY - 2020 IS - 6 SP - 344 EP - 348 PG - 5 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/33603593 ID - 33603593 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Takácsi-Nagy, Anna Erzsébet AU - Székely, A. AU - Pál, Szilárd TI - The development of a semi-solid formulation containing cinnamon essential oil as a handsanitizer preparation JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 90 PY - 2020 IS - 2-3 SP - 144 EP - 144 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31613591 ID - 31613591 LA - English DB - MTMT ER - TY - JOUR AU - Lendvai, B. AU - Nmar, F. AU - Kocsis, Béla AU - Horváth, Györgyi AU - Pál, Szilárd AU - Takácsi-Nagy, Anna Erzsébet TI - The development of a semi-solid formulation containing natural extracts as a hand-sanitizer preparation JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 90 PY - 2020 IS - 2-3 SP - 127 EP - 128 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31613499 ID - 31613499 LA - English DB - MTMT ER -