@article{MTMT:32024936, title = {POLAR study revisited: Therapeutic hypothermia in severe brain trauma should not be abandoned}, url = {https://m2.mtmt.hu/api/publication/32024936}, author = {Pótóné Oláh, Emőke and Pótó, László and Rumbus, Zoltán and Pákai, Eszter and Romanovsky, Andrej A and Hegyi, Péter and Garami, András}, doi = {10.1089/neu.2020.7509}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {38}, unique-id = {32024936}, issn = {0897-7151}, abstract = {The benefits of therapeutic hypothermia (TH) in severe traumatic brain injury (sTBI) have been long debated. In 2018, the POLAR study, a high-quality international trial, appeared to end the debate by showing that TH did not improve mortality in sTBI. However, the POLAR-based recommendation to abandon TH was challenged by different investigators. In our recent meta-analysis, we introduced the cooling index (COIN) to assess the extent of cooling and showed that TH is beneficial in sTBI, but only when the COIN is sufficiently high. In the present study, we calculated the COIN for the POLAR study and ran a new meta-analysis, which included the POLAR data and accounted for the cooling extent. The POLAR study targeted a high cooling extent (COIN of 276 degrees C x h; calculated for 72 h), but the achieved cooling was much lower (COIN of 193 degrees C x h)-because of deviations from the protocol. When the POLAR data were included in the COIN-based meta-analysis, TH had an overall effect of reducing death (odds rate of 0.686; p = 0.007). Among the subgroups with different COIN levels, the only significantly decreased odds rate (i.e., beneficial effect of TH) was observed in the subgroup with high COIN (0.470; p = 0.013). We conclude that, because of deviations from the targeted cooling protocol, the overall cooling extent was not sufficiently high in the POLAR study, thus masking the beneficial effects of TH. The current analysis shows that TH is beneficial in sTBI, but only when the COIN is high. Abandoning the use of TH in sTBI may be premature.}, year = {2021}, eissn = {1557-9042}, pages = {2772-2776}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Garami, András/0000-0003-2493-0571} } @article{MTMT:31937878, title = {A korai posztoperatív enterális táplálás megvalósulásának gyakorlata colorectalis daganatos betegeknél}, url = {https://m2.mtmt.hu/api/publication/31937878}, author = {Vereczkei, Zsófia and Szekeresné Szabó, Szilvia and Pótó, László and Vereczkei, András}, journal-iso = {TÁPLÁLKOZÁSTUDOMÁNYI ÉS DIETETIKAI SZEMLE}, journal = {TÁPLÁLKOZÁSTUDOMÁNYI ÉS DIETETIKAI SZEMLE}, volume = {1}, unique-id = {31937878}, year = {2021}, eissn = {2732-3595}, pages = {27-34}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628} } @book{MTMT:32039615, title = {Biometria. Kísérleti tankönyv az 1. félévi Biometria gyakorlathoz}, url = {https://m2.mtmt.hu/api/publication/32039615}, author = {Pótó, László}, publisher = {PTE ÁOK}, unique-id = {32039615}, year = {2020} } @book{MTMT:32039604, title = {Biometrics. Workbook for the first course in statistics for medical students}, url = {https://m2.mtmt.hu/api/publication/32039604}, author = {Pótó, László}, publisher = {PTE ÁOK}, unique-id = {32039604}, year = {2020} } @article{MTMT:31012562, title = {Meta-Analysis of 196 Articles: Plasma Phospholipid Fatty Acid Supply of Expecting Women during Pregnancy and at Delivery}, url = {https://m2.mtmt.hu/api/publication/31012562}, author = {Szabó, Éva and Marosvölgyi, Tamás and Pótó, László and Decsi, Tamás}, journal-iso = {EUR J PEDIATR}, journal = {EUROPEAN JOURNAL OF PEDIATRICS}, volume = {178}, unique-id = {31012562}, issn = {0340-6199}, year = {2019}, eissn = {1432-1076}, pages = {1620-1620}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513} } @article{MTMT:30626388, title = {Follicular fluid progesterone concentration is associated with fertilization outcome after IVF : a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/30626388}, author = {Nagy, Bernadett and Pótó, László and Borbásné Farkas, Kornélia and Koppán, Miklós and Várnagy, Ákos and Kovács, Kálmán András and Papp, Szilárd and Bohonyi, Noémi and Bódis, József}, doi = {10.1016/j.rbmo.2018.12.045}, journal-iso = {REPROD BIOMED ONLINE}, journal = {REPRODUCTIVE BIOMEDICINE ONLINE: AN INTERNATIONAL JOURNAL DEVOTED TO BIOMEDICAL RESEARCH ON HUMAN CONCEPTION AND THE WELFARE OF THE HUMAN EMBRYO}, volume = {38}, unique-id = {30626388}, issn = {1472-6483}, abstract = {Follicular fluid is a key biochemical environment for oocyte development. The potential effect of follicular progesterone level on successful fertilization is a subject of debate, and so the aim of this study was to provide a summary of the currently available evidence on the association between follicular fluid progesterone level and fertilization outcome. To do so, a systematic review and a meta-analysis were performed, with the literature searches being conducted in three databases (PubMed, Embase and the Cochrane Library) to identify all relevant studies published up to 19 August 2017. Data were available from 13 studies (four intracytoplasmic sperm injection [ICSI] and nine conventional IVF) and 1009 individually aspirated follicular fluid samples were included in the analysis. The progesterone levels in follicular fluid were significantly higher in normal fertilization than in failed fertilization, both in conventional IVF (33% difference, P < 0.001) and ICSI (34% difference, P = 0.004). Although these data show that fertilized oocytes are derived from follicles with higher levels of progesterone, the results must be interpreted with caution, because of various progesterone measurement methods and different treatment protocols and it is too early to state that follicular fluid progesterone level could be considered as a marker for oocyte quality.}, keywords = {PROGESTERONE; IVF; follicular fluid; intracytoplasmic sperm injection; oocyte}, year = {2019}, eissn = {1472-6491}, pages = {871-882}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527} } @article{MTMT:30330535, title = {Metformin induces significant reduction of body weight, total cholesterol and LDL levels in the elderly - A meta-analysis}, url = {https://m2.mtmt.hu/api/publication/30330535}, author = {Varjú-Solymár, Margit and Ivic, Ivan and Pótó, László and Hegyi, Péter and Garami, András and Hartmann, Petra and Pétervári, Erika and Czopf, László and Alizadeh, Hussain and Gyöngyi, Zoltán and Sarlós, Patrícia and Simon, Mária and Mátrai, Péter and Bérczi, Bálint and Balaskó, Márta}, doi = {10.1371/journal.pone.0207947}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {13}, unique-id = {30330535}, issn = {1932-6203}, abstract = {Metformin is the first-choice drug for patients with Type 2 diabetes, and this therapy is characterized by being weight neutral. However, in the elderly an additional unintentional weight loss could be considered as an adverse effect of the treatment.We aimed to perform a meta-analysis of placebo-controlled studies investigating the body weight changes upon metformin treatment in participants older than 60 years.PubMed, EMBASE and the Cochrane Library were searched. We included at least 12 week-long studies with placebo control where the mean age of the metformin-treated patients was 60 years or older and the body weight changes of the patients were reported. We registered our protocol on PROSPERO (CRD42017055287).From the 971 articles identified by the search, 6 randomized placebo-controlled studies (RCTs) were included in the meta-analysis (n = 1541 participants). A raw difference of -2.23 kg (95% CI: -2.84 --1.62 kg) body weight change was detected in the metformin-treated groups as compared with that of the placebo groups (p<0.001). Both total cholesterol (-0.184 mmol/L, p<0.001) and LDL cholesterol levels (-0.182 mmol/L, p<0.001) decreased upon metformin-treatment.Our meta-analysis of RCTs showed a small reduction of body weight together with slight improvement of the blood lipid profile in patients over 60 years. With regard to the risk of unintentional weight loss, metformin seems to be a safe agent in the population of over 60 years. Our results also suggest that metformin treatment may reduce the risk of major coronary events (-4-5%) and all-cause mortality (-2%) in elderly diabetic populations.}, keywords = {DISEASE; GLUCAGON-LIKE PEPTIDE-1; INSULIN SENSITIVITY; leptin; DOUBLE-BLIND; TYPE-2; LIPOPROTEIN CHOLESTEROL}, year = {2018}, eissn = {1932-6203}, orcid-numbers = {Varjú-Solymár, Margit/0000-0001-6667-6263; Hegyi, Péter/0000-0003-0399-7259; Garami, András/0000-0003-2493-0571; Hartmann, Petra/0000-0002-4746-9792; Pétervári, Erika/0000-0002-3673-8491; Czopf, László/0000-0001-9565-0732; Gyöngyi, Zoltán/0000-0001-9330-9119; Sarlós, Patrícia/0000-0002-5086-9455} } @article{MTMT:30306914, title = {Bidirectional Relationship Between Reduced Blood pH and Acute Pancreatitis: A Translational Study of Their Noxious Combination}, url = {https://m2.mtmt.hu/api/publication/30306914}, author = {Rumbus, Zoltán and Tóth, Emese and Pótó, László and Vincze, Áron and Veres, Gábor and Czakó, László and Pótóné Oláh, Emőke and Márta, Katalin and Mikó, Alexandra and Rakonczay, Zoltán and Balla, Zsolt and Kaszaki, József and Földesi, Imre and Maléth, József and Hegyi, Péter and Garami, András}, doi = {10.3389/fphys.2018.01360}, journal-iso = {FRONT PHYSIOL}, journal = {FRONTIERS IN PHYSIOLOGY}, volume = {9}, unique-id = {30306914}, abstract = {Acute pancreatitis (AP) is often accompanied by alterations in the acid-base balance, but how blood pH influences the outcome of AP is largely unknown. We studied the association between blood pH and the outcome of AP with meta-analysis of clinical trials, and aimed to discover the causative relationship between blood pH and AP in animal models. PubMed, EMBASE, and Cochrane Controlled Trials Registry databases were searched from inception to January 2017. Human studies reporting systemic pH status and outcomes (mortality rate, severity scores, and length of hospital stay) of patient groups with AP were included in the analyses. We developed a new mouse model of chronic metabolic acidosis (MA) and induced mild or severe AP in the mice. Besides laboratory blood testing, the extent of pancreatic edema, necrosis, and leukocyte infiltration were assessed in tissue sections of the mice. Thirteen studies reported sufficient data in patient groups with AP (n = 2,311). Meta-analysis revealed markedly higher mortality, elevated severity scores, and longer hospital stay in AP patients with lower blood pH or base excess (P < 0.001 for all studied outcomes). Meta-regression analysis showed significant negative correlation between blood pH and mortality in severe AP. In our mouse model, pre-existing MA deteriorated the pancreatic damage in mild and severe AP and, vice versa, severe AP further decreased the blood pH of mice with MA. In conclusion, MA worsens the outcome of AP, while severe AP augments the decrease of blood pH. The discovery of this vicious metabolic cycle opens up new therapeutic possibilities in AP.}, keywords = {C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; CYTOKINE PRODUCTION; Meta-analysis; ACIDOSIS; FACTOR-KAPPA-B; inflammatory mediators; Acid-base balance; experimental pancreatitis; LACTATED RINGERS SOLUTION; ACINAR-CELL; DIABETIC-KETOACIDOSIS; EXTRACELLULAR ACIDOSIS}, year = {2018}, eissn = {1664-042X}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Veres, Gábor/0000-0002-0911-1941; Czakó, László/0000-0002-6331-0802; Márta, Katalin/0000-0002-2213-4865; Rakonczay, Zoltán/0000-0002-1499-3416; Kaszaki, József/0000-0002-0750-7731; Földesi, Imre/0000-0002-3329-8136; Maléth, József/0000-0001-5768-3090; Hegyi, Péter/0000-0003-0399-7259; Garami, András/0000-0003-2493-0571} } @article{MTMT:3376664, title = {Detection of high-risk thrombophilia with an automated, global test: the Coagulation Inhibitor Potential assay}, url = {https://m2.mtmt.hu/api/publication/3376664}, author = {Réger, Barbara and Losonczy, Hajna and Nagy, Ágnes and Péterfalvi, Ágnes and Mózes, Réka and Pótó, László and Borbásné Farkas, Kornélia and Kovács, L. Gábor and Miseta, Attila János and Alizadeh, Hussain and Tóth, Orsolya}, doi = {10.1097/MBC.0000000000000738}, journal-iso = {BLOOD COAGUL FIBRIN}, journal = {BLOOD COAGULATION & FIBRINOLYSIS}, volume = {29}, unique-id = {3376664}, issn = {0957-5235}, abstract = {: The diagnosis of thrombophilia is a cost-consuming and time-consuming process, as each defect should be separately investigated. The Coagulation Inhibitor Potential (CIP) assay is a promising new global test, sensitive for most of the hereditary thrombophilias, developed for manual methodology. We adapt the original method to an optical coagulation analyser. By this automation, the test will be easier, faster and more precise, and it also allows carrying out 18 measurements simultaneously. The CIP assay was performed in 126 healthy subjects and 193 patients with different types of hereditary thrombophilia conditions. Detected with conventional laboratory tests high-risk thrombophilia was present in 70 patients: deficiencies of antithrombin (AT) (n = 12), protein C (PC) (n = 14), protein S (PS) (n = 6), homozygous factor V Leiden (FVL) mutation (n = 9) and combined types (n = 29). Low-risk thrombophilia was present in 123 patients: heterozygous FVL (n = 115) and FII G2010A mutation (n = 8). Significantly lower median CIP values were found for AT-,PC-, PS deficiencies, homozygous and heterozygous FVL mutations and combined thrombophilias (P < 0.01) as compared with healthy controls. There was no significant difference between the heterozygous FIIG20210A (P = 0.669) thrombophilia group and the healthy controls. The best performance of the test was achieved at the cut-off value of 90.0 U (area: 0.981) with 96% sensitivity and 92% specificity in the high-risk thrombophilia group estimated by receiver operating characteristic analysis. The new method seems to be appropriate and reliable for the detection of AT-, PC- and PS deficiencies, homozygous FVL mutation and also for combined deficiencies. The automated CIP test is insensitive to FII G2010A mutation.}, year = {2018}, eissn = {1473-5733}, pages = {435-441}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Kovács, L. Gábor/0000-0001-5298-5401; Miseta, Attila János/0000-0002-7984-3347} } @article{MTMT:3371683, title = {Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/3371683}, author = {Mikó, Alexandra and Pótó, László and Mátrai, Péter and Hegyi, Péter and Füredi, Nóra and Garami, András and Illés, Anita and Varjú-Solymár, Margit and Vincze, Áron and Balaskó, Márta and Pár, Gabriella and Sarlós, Patrícia and Bajor, Judit and Tenk, Judit and Rostás, Ildikó and Pétervári, Erika}, doi = {10.1186/s12877-018-0798-z}, journal-iso = {BMC GERIATR}, journal = {BMC GERIATRICS}, volume = {18}, unique-id = {3371683}, issn = {1471-2318}, abstract = {BACKGROUND: Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia. The present meta-analysis was designed to assess: (1) whether plasma IL-6 in aged populations in fact correlates negatively to muscle strength; (2) whether such a correlation exists both in men and in women; and (3) whether plasma IL-6 shows a gender difference in old age. METHODS: We applied the preferred reporting items for systematic review and meta-analysis protocols (PRISMA). We searched PubMed and Embase for papers that reported data on individuals over 65 without inflammatory diseases. We extracted either separate male and female data on plasma IL-6 along with at least one muscle parameter or correlation coefficient between plasma IL-6 and these parameters. Random effect models calculated with DerSimonian and Laird weighting methods were applied to analyze correlation coefficients and gender difference in plasma IL-6. Egger's test was used to assess the small study effect. RESULTS: Twenty articles out of 468 records identified were suitable for analyses. Plasma IL-6 correlates negatively with grip strength in mixed populations and also separately in men [- 0.25 with 95% confidence interval (CI): - 0.48, - 0.02] and in women (- 0.14 with 95% CI: - 0.24, - 0.03). However, contrary to expectations, men with better muscle condition have higher plasma IL-6 than women of similar age with worse muscle condition (plasma IL-6 male-female difference: 0.25 pg/mL with 95% CI: 0.15, 0.35). CONCLUSION: This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women.}, year = {2018}, eissn = {1471-2318}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Garami, András/0000-0003-2493-0571; Varjú-Solymár, Margit/0000-0001-6667-6263; Vincze, Áron/0000-0003-2217-7686; Sarlós, Patrícia/0000-0002-5086-9455; Pétervári, Erika/0000-0002-3673-8491} }