TY - CHAP AU - Patyi, Gábor AU - Páger, Csilla AU - Sándor, Viktor AU - Kiss, Ibolya ED - Karádi, Krisztina Anna ED - Kocsis, Marianna ED - Takács, Dóra ED - Árok, Zsófia TI - LIPOPEPTIDEK VIZSGÁLATA CE-MS MÓDSZERREL VÍZMENTES KÖZEGBEN T2 - XLIV. Kémiai Előadói Napok PB - Magyar Kémikusok Egyesülete (MKE) CY - Szeged CY - Budapest SN - 9786156018090 PY - 2021 SP - 22 UR - https://m2.mtmt.hu/api/publication/34050384 ID - 34050384 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Horváth, Ádám István AU - Botz, Bálint AU - Kiss, Tamas AU - Csekő, Kata AU - Kiss, Ibolya AU - Felinger, Attila AU - Szabados, Tamara AU - Kenyeres, Éva AU - Bencsik, Péter AU - Mócsai, Attila AU - Ferdinandy, Péter AU - Helyes, Zsuzsanna TI - Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases? JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 10 PY - 2019 PG - 15 SN - 1663-9812 DO - 10.3389/fphar.2019.00233 UR - https://m2.mtmt.hu/api/publication/30620557 ID - 30620557 N1 - Export Date: 20 September 2023 Correspondence Address: Helyes, Z.; Department of Pharmacology and Pharmacotherapy, Hungary; email: zsuzsanna.helyes@aok.pte.hu AB - Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role in this process. Numerous MMPs have been examined in humans and animals, but their functions are still not fully understood. Therefore, we investigated the role of MMPs in the K/BxN serum-transfer model of RA with the broad-spectrum MMP inhibitor subantimicrobial dose doxycycline (SDD) using complex in vivo and in vitro methodolgy. Methods: Chronic arthritis was induced by repetitive i.p. injections of K/BxN serum in C57BL/6J mice. SDD was administered daily in acidified drinking water (0.5 mg/mL, 80 mg/kg) during the 30 days experimental period. Mechanonociceptive threshold of the paw was evaluated by aesthesiometry, grasping ability by grid test, arthritis severity by scoring, neutrophil myeloperoxidase activity by luminescence, vascular hyperpermeability and MMP activity by fluorescence in vivo imaging and the latter also by gelatin zymography, bone structure by micro-computed tomography (micro-CT). Plasma concentrations of doxycycline were determined by liquid chromatography-mass spectrometry analysis. Results: K/BxN serum induced significant inflammatory signs, mechanical hyperalgesia, joint function impairment, increased myeloperoxidase activity and vascular hyperpermeability. Significant increase of MMP activity was also observed both in vivo and ex vivo with elevation of the 57-60, 75, and 92 kDa gelatinolytic isoforms in the arthritic ankle joints, but neither MMP activity nor any above described functional parameters were influenced by SDD. Most importantly, SDD significantly reduced bone mineral density in the distal tibia and enhanced the Euler number in the ankle. Arthritis-induced microarchitectural alterations demonstrating increased irregularity and cancellous bone remodeling, such as increased Euler number was significantly elevated by SDD in both regions. Conclusion: We showed increase of various MMP activities in the joints by in vivo fluorescence imaging together with ex vivo zymography, and investigated their functional significance using the broad-spectrum MMP inhibitor SDD in the translational RA model. This is the first demonstration that SDD worsens arthritis-induced bone microarchitectural alterations, but it appears to be independent of MMP inhibition. LA - English DB - MTMT ER - TY - CONF AU - Kiss, Ibolya ED - Majdik, Cornelia TI - Policiklusos aromás szénhidrogének (PAHok) meghatározása környezeti mintákból T2 - XXIII. Nemzetközi Vegyészkonferencia PB - Erdélyi Magyar Műszaki Tudományos Társaság (EMT) C1 - Kolozsvár T3 - Nemzetközi Vegyészkonferencia, ISSN 1843-6293 PY - 2017 SP - 71 EP - 71 PG - 1 UR - https://m2.mtmt.hu/api/publication/3286388 ID - 3286388 N1 - Előadás LA - Hungarian DB - MTMT ER - TY - CONF AU - Kiss, Ibolya ED - Szigyártó, Irma-Lidia ED - Szikszai, A TI - Determination of Polycyclic Aromatic Hydrocarbons from Air Contamination by Using HPLC T2 - XIII. Kárpát-medencei Környezettudományi Konferencia PB - Ábel Kiadó C1 - Kolozsvár T3 - Kárpát-Medencei Környezettudományi Konferencia, ISSN 1842-9815 PY - 2017 SP - 153 EP - 153 PG - 1 UR - https://m2.mtmt.hu/api/publication/3286384 ID - 3286384 N1 - Előadás LA - English DB - MTMT ER - TY - BOOK ED - Csicsek, Gábor ED - Kiss, Ibolya ED - Pincehelyi, Zita Éva TI - XII. Kárpát-Medencei Környezettudományi Konferencia = 12th Environmental Science Conference of the Carpathian Basin. Tanulmánykötet TS - Tanulmánykötet T3 - Kárpát-Medencei Környezettudományi Konferencia, ISSN 1842-9815 ET - 0 PB - PTE TTK Szentágothai János Protestáns Szakkollégium CY - Pécs PY - 2017 SP - 272 SN - 9789634290490 UR - https://m2.mtmt.hu/api/publication/3211830 ID - 3211830 LA - Hungarian DB - MTMT ER - TY - CONF AU - Mester, Adrienn AU - Vajda, Péter AU - Kiss, Ibolya ED - [sn], null TI - The Motions of Insulin Through a Core - Shell Adsorbent T2 - 16th CEEPUS Symposium and Summer School on Bioanalysis PB - University of Warsaw C1 - Warsaw PY - 2016 SP - 71 UR - https://m2.mtmt.hu/api/publication/3093102 ID - 3093102 LA - English DB - MTMT ER - TY - BOOK ED - Kiss, Ibolya ED - Pincehelyi, Z É TI - XII. Kárpát-medencei Könyezettudományi Konferencia = XII. Environmental Scientific Conference of the Carpathian Basin ET - 0 PB - PTE TTK Szentágothai János Protestáns Szakkollégium CY - Pécs PY - 2016 SP - 126 SN - 9789634290506 UR - https://m2.mtmt.hu/api/publication/3082056 ID - 3082056 N1 - absztrakt kötet LA - English DB - MTMT ER - TY - JOUR AU - Bartó, Endre AU - Prauda, Ibolya AU - Kilár, Ferenc AU - Kiss, Ibolya AU - Felinger, Attila TI - Investigation of retention mechanism of resorcinarene based cavitands by linear and nonlinear chromatography JF - JOURNAL OF CHROMATOGRAPHY A J2 - J CHROMATOGR A VL - 1456 PY - 2016 SP - 152 EP - 161 PG - 10 SN - 0021-9673 DO - 10.1016/j.chroma.2016.06.002 UR - https://m2.mtmt.hu/api/publication/3073566 ID - 3073566 N1 - * Megosztott szerzőség AB - Abstract LA - English DB - MTMT ER - TY - CHAP AU - Mester, Adrienn AU - Bacskay, Ivett Orsolya AU - Kilár, Ferenc AU - Kiss, Ibolya ED - Csicsek, Gábor ED - Kiss, Ibolya TI - Arzén, szelén és policiklusos aromás szénhidrogének kimutatása környezeti mintákból T2 - XI. Kárpát-medencei Környezettudományi Konferencia tanulmánykötete PB - Szentágothai János Szakkollégium CY - Pécs SN - 9789636428730 T3 - Kárpát-Medencei Környezettudományi Konferencia, ISSN 1842-9815 PY - 2015 SP - 126 EP - 132 PG - 7 UR - https://m2.mtmt.hu/api/publication/3002563 ID - 3002563 LA - Hungarian DB - MTMT ER - TY - BOOK ED - Csicsek, Gábor ED - Kiss, Ibolya TI - XI. Kárpát-medencei Környezettudományi Konferencia tanulmánykötete T3 - Kárpát-Medencei Környezettudományi Konferencia, ISSN 1842-9815 ET - 0 PB - Szentágothai János Szakkollégium CY - Pécs PY - 2015 SP - 200 SN - 9789636428730 UR - https://m2.mtmt.hu/api/publication/2995808 ID - 2995808 LA - English DB - MTMT ER -