@{MTMT:34050384, title = {LIPOPEPTIDEK VIZSGÁLATA CE-MS MÓDSZERREL VÍZMENTES KÖZEGBEN}, url = {https://m2.mtmt.hu/api/publication/34050384}, author = {Patyi, Gábor and Páger, Csilla and Sándor, Viktor and Kiss, Ibolya}, booktitle = {XLIV. Kémiai Előadói Napok}, unique-id = {34050384}, year = {2021}, pages = {22}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @article{MTMT:30620557, title = {Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?}, url = {https://m2.mtmt.hu/api/publication/30620557}, author = {Horváth, Ádám István and Botz, Bálint and Kiss, Tamas and Csekő, Kata and Kiss, Ibolya and Felinger, Attila and Szabados, Tamara and Kenyeres, Éva and Bencsik, Péter and Mócsai, Attila and Ferdinandy, Péter and Helyes, Zsuzsanna}, doi = {10.3389/fphar.2019.00233}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {10}, unique-id = {30620557}, abstract = {Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role in this process. Numerous MMPs have been examined in humans and animals, but their functions are still not fully understood. Therefore, we investigated the role of MMPs in the K/BxN serum-transfer model of RA with the broad-spectrum MMP inhibitor subantimicrobial dose doxycycline (SDD) using complex in vivo and in vitro methodolgy. Methods: Chronic arthritis was induced by repetitive i.p. injections of K/BxN serum in C57BL/6J mice. SDD was administered daily in acidified drinking water (0.5 mg/mL, 80 mg/kg) during the 30 days experimental period. Mechanonociceptive threshold of the paw was evaluated by aesthesiometry, grasping ability by grid test, arthritis severity by scoring, neutrophil myeloperoxidase activity by luminescence, vascular hyperpermeability and MMP activity by fluorescence in vivo imaging and the latter also by gelatin zymography, bone structure by micro-computed tomography (micro-CT). Plasma concentrations of doxycycline were determined by liquid chromatography-mass spectrometry analysis. Results: K/BxN serum induced significant inflammatory signs, mechanical hyperalgesia, joint function impairment, increased myeloperoxidase activity and vascular hyperpermeability. Significant increase of MMP activity was also observed both in vivo and ex vivo with elevation of the 57-60, 75, and 92 kDa gelatinolytic isoforms in the arthritic ankle joints, but neither MMP activity nor any above described functional parameters were influenced by SDD. Most importantly, SDD significantly reduced bone mineral density in the distal tibia and enhanced the Euler number in the ankle. Arthritis-induced microarchitectural alterations demonstrating increased irregularity and cancellous bone remodeling, such as increased Euler number was significantly elevated by SDD in both regions. Conclusion: We showed increase of various MMP activities in the joints by in vivo fluorescence imaging together with ex vivo zymography, and investigated their functional significance using the broad-spectrum MMP inhibitor SDD in the translational RA model. This is the first demonstration that SDD worsens arthritis-induced bone microarchitectural alterations, but it appears to be independent of MMP inhibition.}, keywords = {EXPRESSION; SERUM; RHEUMATOID-ARTHRITIS; TISSUE INHIBITORS; MATRIX METALLOPROTEINASES; rheumatoid arthritis; stromelysin; Chondrocytes; SYNOVIAL FIBROBLASTS; collagenase 3; micro-CT; bone homeostasis; joint damage; K/BxN serum-transfer arthritis; subantimicrobial dose doxycycline; in vivo optical imaging}, year = {2019}, eissn = {1663-9812}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706; Szabados, Tamara/0000-0001-8920-1666; Kenyeres, Éva/0000-0002-6070-2560; Bencsik, Péter/0000-0003-1936-6232; Mócsai, Attila/0000-0002-0512-1157; Ferdinandy, Péter/0000-0002-6424-6806} } @CONFERENCE{MTMT:3286388, title = {Policiklusos aromás szénhidrogének (PAHok) meghatározása környezeti mintákból}, url = {https://m2.mtmt.hu/api/publication/3286388}, author = {Kiss, Ibolya}, booktitle = {XXIII. Nemzetközi Vegyészkonferencia}, unique-id = {3286388}, year = {2017}, pages = {71-71}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @CONFERENCE{MTMT:3286384, title = {Determination of Polycyclic Aromatic Hydrocarbons from Air Contamination by Using HPLC}, url = {https://m2.mtmt.hu/api/publication/3286384}, author = {Kiss, Ibolya}, booktitle = {XIII. Kárpát-medencei Környezettudományi Konferencia}, unique-id = {3286384}, year = {2017}, pages = {153-153}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @book{MTMT:3211830, title = {XII. Kárpát-Medencei Környezettudományi Konferencia = 12th Environmental Science Conference of the Carpathian Basin. Tanulmánykötet}, url = {https://m2.mtmt.hu/api/publication/3211830}, isbn = {9789634290490}, editor = {Csicsek, Gábor and Kiss, Ibolya and Pincehelyi, Zita Éva}, publisher = {Pécsi Tudományegyetem Természettudományi Kar Szentágothai János Protestáns Szakkollégium}, unique-id = {3211830}, year = {2017}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @CONFERENCE{MTMT:3093102, title = {The Motions of Insulin Through a Core - Shell Adsorbent}, url = {https://m2.mtmt.hu/api/publication/3093102}, author = {Mester, Adrienn and Vajda, Péter and Kiss, Ibolya}, booktitle = {16th CEEPUS Symposium and Summer School on Bioanalysis}, unique-id = {3093102}, year = {2016}, pages = {71}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @book{MTMT:3082056, title = {XII. Kárpát-medencei Könyezettudományi Konferencia = XII. Environmental Scientific Conference of the Carpathian Basin}, url = {https://m2.mtmt.hu/api/publication/3082056}, isbn = {9789634290506}, editor = {Kiss, Ibolya and Pincehelyi, Z É}, publisher = {Pécsi Tudományegyetem Természettudományi Kar Szentágothai János Protestáns Szakkollégium}, unique-id = {3082056}, year = {2016}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} } @article{MTMT:3073566, title = {Investigation of retention mechanism of resorcinarene based cavitands by linear and nonlinear chromatography}, url = {https://m2.mtmt.hu/api/publication/3073566}, author = {Bartó, Endre and Prauda, Ibolya and Kilár, Ferenc and Kiss, Ibolya and Felinger, Attila}, doi = {10.1016/j.chroma.2016.06.002}, journal-iso = {J CHROMATOGR A}, journal = {JOURNAL OF CHROMATOGRAPHY A}, volume = {1456}, unique-id = {3073566}, issn = {0021-9673}, abstract = {Abstract}, keywords = {RETENTION MECHANISM; Inverse method; Adsorption isotherm; Van't Hoff equation; Resorcinarene based cavitands}, year = {2016}, eissn = {1873-3778}, pages = {152-161}, orcid-numbers = {Kilár, Ferenc/0000-0001-5737-5514; Kiss, Ibolya/0000-0001-5447-2706} } @inproceedings{MTMT:3002563, title = {Arzén, szelén és policiklusos aromás szénhidrogének kimutatása környezeti mintákból}, url = {https://m2.mtmt.hu/api/publication/3002563}, author = {Mester, Adrienn and Bacskay, Ivett Orsolya and Kilár, Ferenc and Kiss, Ibolya}, booktitle = {XI. Kárpát-medencei Környezettudományi Konferencia tanulmánykötete}, unique-id = {3002563}, year = {2015}, pages = {126-132}, orcid-numbers = {Kilár, Ferenc/0000-0001-5737-5514; Kiss, Ibolya/0000-0001-5447-2706} } @book{MTMT:2995808, title = {XI. Kárpát-medencei Környezettudományi Konferencia tanulmánykötete}, url = {https://m2.mtmt.hu/api/publication/2995808}, isbn = {9789636428730}, editor = {Csicsek, Gábor and Kiss, Ibolya}, publisher = {Szentágothai János Szakkollégium}, unique-id = {2995808}, year = {2015}, orcid-numbers = {Kiss, Ibolya/0000-0001-5447-2706} }