TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Pápay, Zsófia Edit AU - Szalkai, Petra AU - Niczinger, Noémi AU - Kijima, S. AU - Sugibayashi, K. AU - Antal, István AU - Kállai-Szabó, Nikolett TI - Viscoelasticity of Liposomal Dispersions JF - NANOMATERIALS J2 - NANOMATERIALS-BASEL VL - 13 PY - 2023 IS - 16 PG - 14 SN - 2079-4991 DO - 10.3390/nano13162340 UR - https://m2.mtmt.hu/api/publication/34096011 ID - 34096011 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, 1092, Hungary Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Saitama, Sakado, 350-0295, Japan Export Date: 21 November 2023 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: antal.istvan@semmelweis.hu Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Bozó, Tamás AU - Agócs, Gergely AU - Kellermayer, Miklós AU - Antal, István TI - Determination of the Main Phase Transition Temperature of Phospholipids by Oscillatory Rheology JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 13 PG - 13 SN - 1420-3049 DO - 10.3390/molecules28135125 UR - https://m2.mtmt.hu/api/publication/34041182 ID - 34041182 AB - Knowledge of the physical and chemical properties of phospholipids, such as phase transition temperatures (Tc), is of great importance in order to reveal the functionalities of biological and artificial membranes. Our research group developed an oscillatory rheological method for the simple and rapid determination of phase transition temperatures (Tc). The phospholipids constructing the membranes undergo conformational changes at their Tc, which cause alterations of viscoelastic properties of the molecules. The oscillatory technique recommended by us proved to be appropriate to reveal the altered molecular properties of phospholipids as tracking the slightest changes in the viscoelasticity. Our study demonstrates the abrupt changes in rheological properties at Tc for the following phospholipids: 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine (DMPC), 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine (DPPC), and 1,2-Distearoyl-sn-glycero-3-Phosphocholine (DSPC), proving that the applied methodology is adequate for determining the Tc of phospholipids. LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Pápay, Zsófia Edit AU - Vilimi, Zsófia AU - Antal, István TI - Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity JF - GELS (BASEL) J2 - GELS-BASEL VL - 9 PY - 2023 IS - 6 PG - 20 SN - 2310-2861 DO - 10.3390/gels9060469 UR - https://m2.mtmt.hu/api/publication/34009564 ID - 34009564 AB - Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine. LA - English DB - MTMT ER - TY - JOUR AU - Jayanna, PK AU - Budai, Lívia AU - Petrikovics, I. TI - Lipid Nano-Vehicles for Cyanide Antagonism: A Mini-Review JF - Journal of Drug Design and Discovery Research J2 - J Drug Design Discov Res VL - 2 PY - 2021 IS - 2 SP - 79 EP - 80 PG - 2 SN - 2349-9036 UR - https://m2.mtmt.hu/api/publication/34010818 ID - 34010818 LA - English DB - MTMT ER - TY - JOUR AU - Szalkai, Petra AU - Pápay, Zsófia Edit AU - Budai, Lívia AU - Sárády-Kesztyűs, Ágnes AU - Antal, István TI - Rheological Studies of Hydrogels and Liposomal Dispersions: Factors Influencing the Viscoelastic Properties JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 320 EP - 321 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/32496688 ID - 32496688 N1 - P-78 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Zoltán-István AU - Orbán, György AU - Borbás, Enikő AU - Csicsák, Dóra AU - Kádár, Szabina AU - Fiser, Béla AU - Dobó, Máté AU - Horváth, Péter AU - Kiss, Eszter AU - Budai, Lívia AU - Dobos, Judit AU - Pálla, Tamás AU - Őrfi, László AU - Völgyi, Gergely AU - Tóth, Gergő TI - Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility JF - HELIYON J2 - HELIYON VL - 7 PY - 2021 IS - 7 PG - 10 SN - 2405-8440 DO - 10.1016/j.heliyon.2021.e07581 UR - https://m2.mtmt.hu/api/publication/32107318 ID - 32107318 N1 - Funding Agency and Grant Number: European Regional Development FundEuropean Commission [GINOP2.3.415201600004]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Ministry for Innovation and Technology [UNKP-20-5-SE-14] Funding text: Dr. Be?la Fiser was supported by European Regional Development Fund (GINOP2.3.415201600004) ; This work was supported by the Ja?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (G.T.) and Bolyai thorn New National Excellence Program (UNKP-20-5-SE-14) of the Ministry for Innovation and Technology is highly appreciated (G.T.) . LA - English DB - MTMT ER - TY - CHAP AU - Budai, Marianna AU - Budai, Lívia ED - Szarvasházi, Judit: TI - A pici első hónapjai T2 - 2 x 9 hónap biztonságban. Mit szedhetek, és mit nem? Szakemberek válaszai a babavárástól a babázásig. PB - Galenus Kiadó CY - Budapest SN - 9789637157592 T3 - Patika Magazin Könyvek ; [8.]. PY - 2020 SP - 155 EP - 175 PG - 21 UR - https://m2.mtmt.hu/api/publication/31608791 ID - 31608791 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Budai, Marianna AU - Budai, Lívia ED - Szarvasházi, Judit: TI - A második 9 hónap T2 - 2 x 9 hónap biztonságban. Mit szedhetek, és mit nem? Szakemberek válaszai a babavárástól a babázásig. PB - Galenus Kiadó CY - Budapest SN - 9789637157592 T3 - Patika Magazin Könyvek ; [8.]. PY - 2020 SP - 107 EP - 139 PG - 33 UR - https://m2.mtmt.hu/api/publication/31608788 ID - 31608788 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Budai, Marianna AU - Budai, Lívia ED - Szarvasházi, Judit: TI - Az első 9 hónap T2 - 2 x 9 hónap biztonságban. Mit szedhetek, és mit nem? Szakemberek válaszai a babavárástól a babázásig. PB - Galenus Kiadó CY - Budapest SN - 9789637157592 T3 - Patika Magazin Könyvek ; [8.]. PY - 2020 SP - 11 EP - 77 PG - 67 UR - https://m2.mtmt.hu/api/publication/31608783 ID - 31608783 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kapros, Anita AU - Balázs, Attila AU - Harmat, Veronika AU - Halo, Adrienn AU - Budai, Lívia AU - Pintér, István AU - Karancsiné Menyhárd, Dóra AU - Perczel, András TI - Configuration-Controlled Crystal and/or Gel Formation of Protectedd-Glucosamines Supported by Promiscuous Interaction Surfaces and a Conformationally Heterogeneous Solution State JF - CHEMISTRY-A EUROPEAN JOURNAL J2 - CHEM-EUR J VL - 26 PY - 2020 IS - 50 SP - 11643 EP - 11655 PG - 13 SN - 0947-6539 DO - 10.1002/chem.202000882 UR - https://m2.mtmt.hu/api/publication/31409208 ID - 31409208 N1 - Funding Agency and Grant Number: OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K116305]; National Research Development and Innovation Fund of Hungary [2018-1.2.1-NKP-2018-00005]; European UnionEuropean Union (EU) [VEKOP-2.3.2-16-2017-00014, VEKOP-2.3.3-15-2017-00018]; State of Hungary; European Regional Development FundEuropean Union (EU); Hungarian Academy of SciencesHungarian Academy of Sciences; National Research, Development and Innovation Office under project "Synth+: Synthetic Chemistry and Biochemistry" Funding text: This work was supported by an OTKA (K116305) and project no. 2018-1.2.1-NKP-2018-00005 of the National Research Development and Innovation Fund of Hungary, No. VEKOP-2.3.2-16-2017-00014 and VEKOP-2.3.3-15-2017-00018 of the European Union and the State of Hungary, co-financed by the European Regional Development Fund, by MedInProt Grant Facilitating Access to Instruments from the Hungarian Academy of Sciences, and within the framework of the Thematic Excellence Program 2019 by the National Research, Development and Innovation Office under project "Synth+: Synthetic Chemistry and Biochemistry". The Biostruct Lab at the Budapest University of Technology and Economics, Department of Applied Biotechnology and Food Science is gratefully acknowledged for providing X-ray diffraction data collection opportunities and Ibolya Leveles for her assistance in data collection, Erika Dudas for T2 NMR measurements, Nora Taricska for ECD measurements, Gabor Varga and Zoltan Dankhazi for the SEM data. Funding Agency and Grant Number: OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K116305]; National Research Development and Innovation Fund of Hungary [2018-1.2.1-NKP-2018-00005]; European UnionEuropean Commission [VEKOP-2.3.2-16-2017-00014, VEKOP-2.3.3-15-2017-00018]; State of Hungary; European Regional Development FundEuropean Commission; Hungarian Academy of SciencesHungarian Academy of Sciences; National Research, Development and Innovation Office under project "Synth+: Synthetic Chemistry and Biochemistry" Funding text: This work was supported by an OTKA (K116305) and project no. 2018-1.2.1-NKP-2018-00005 of the National Research Development and Innovation Fund of Hungary, No. VEKOP-2.3.2-16-2017-00014 and VEKOP-2.3.3-15-2017-00018 of the European Union and the State of Hungary, co-financed by the European Regional Development Fund, by MedInProt Grant Facilitating Access to Instruments from the Hungarian Academy of Sciences, and within the framework of the Thematic Excellence Program 2019 by the National Research, Development and Innovation Office under project "Synth+: Synthetic Chemistry and Biochemistry". The Biostruct Lab at the Budapest University of Technology and Economics, Department of Applied Biotechnology and Food Science is gratefully acknowledged for providing X-ray diffraction data collection opportunities and Ibolya Leveles for her assistance in data collection, Erika Dudas for T2 NMR measurements, Nora Taricska for ECD measurements, Gabor Varga and Zoltan Dankhazi for the SEM data. AB - The configuration-dependent self-association mode of the two anomers ofO-Ac,N-Fmoc-d-glucosamine, a foldamer building block, leading to gel and/or single crystal formation is described. The beta-anomer of the sugar amino acid (2) forms a gel from various solvents (confirmed by SEM, rheology measurements, NMR, and ECD spectroscopy), whereas the alpha-anomer (1) does not form a gel with any solvent tested. Transition from the solution state to a gel is coupled to a concurrent shift of the Fmoc-groups: from a freely rotating (almost symmetrical) to a specific, asymmetric orientation. Whereas the crystal structure of the alpha-anomer is built as an evenly packed 3D system, the beta-anomer forms a looser superstructure of well-packed 2D layers. Modeling indicates that in the lowest energy, but scarcely sampled conformer of the beta-anomer, the Fmoc-group bends above the sugar moiety, stabilized by intramolecular CH <->pi interactions between the aromatic rings. It is concluded that possessing an extended and promiscuous interaction surface and a conformationally heterogeneous solution state are among the basic requirements of gel formation for a candidate molecule. LA - English DB - MTMT ER -