TY - CHAP AU - Tóth, Miklós ED - Takács, István TI - Neuroendokrin tumorok T2 - Belgyógyászat 1 tantárgyi jegyzet PB - Semmelweis Kiadó CY - Budapest SN - 9789633316122 PY - 2024 SP - 105 EP - 116 PG - 12 UR - https://m2.mtmt.hu/api/publication/34804248 ID - 34804248 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Tóth, Miklós ED - Takács, István TI - A hypophysis és a hypothalamus megbetegedései T2 - Belgyógyászat 1 tantárgyi jegyzet PB - Semmelweis Kiadó CY - Budapest SN - 9789633316122 PY - 2024 SP - 12 EP - 45 PG - 34 UR - https://m2.mtmt.hu/api/publication/34803083 ID - 34803083 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tőke, Judit AU - Tóth, Miklós TI - Letter to the Editor From Tőke and Tóth: “Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia” JF - JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM J2 - J CLIN ENDOCR METAB VL - In press PY - 2024 SP - In press SN - 0021-972X DO - 10.1210/clinem/dgae077 UR - https://m2.mtmt.hu/api/publication/34781507 ID - 34781507 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Miklós TI - Dr. Péter Ferenc: Szerencse? Pech? Gondviselés! Számvetés 90. életévemben JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 6 SP - 240 SN - 0030-6002 DO - 10.1556/650.2024.6M UR - https://m2.mtmt.hu/api/publication/34683159 ID - 34683159 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tömböl, Zsófia AU - Tőke, Judit AU - Tóth, Géza AU - Varga, Zsolt AU - Balázs, Eszter AU - Tóth, Erika AU - Gergely, Lajos AU - Danihel, Ľudovít AU - Medvecz, Márta AU - Borka, Katalin AU - Tóth, Miklós TI - Multiple bronchial carcinoids associated with Cowden syndrome. JF - ENDOCRINE J2 - ENDOCRINE VL - In press PY - 2024 SP - In press SN - 1355-008X DO - 10.1007/s12020-024-03693-8 UR - https://m2.mtmt.hu/api/publication/34641076 ID - 34641076 AB - Cowden syndrome (CS) is a rare genetic condition due to the various germline mutations in the phosphatase and tensin homologue on chromosome ten (PTEN) tumour suppressor gene. As a result, CS is characterised by an increased risk of developing various benign and malignant tumours, such as thyroid, breast, endometrial and urogenital neoplasms, as well as gastrointestinal tract tumours. However, the neuroendocrine tumour association with CS is not elucidated yet. We present a case of a 46-year-old male patient diagnosed with testicular seminoma and follicular thyroid cancer in his medical history. Our patient met the clinical diagnostic criteria of Cowden syndrome. Genetic analysis established the clinical diagnosis; a known heterozygous PTEN mutation was detected [PTEN (LRG_311t1)c.388 C > T (p.Arg130Ter)]. Incidentally, he was also seen with multiple pulmonary lesions during his oncological follow-up. A video-assisted thoracoscopic left lingula wedge resection and later resections from the right lung were performed. Histological findings revealed typical pulmonary carcinoid tumours and smaller tumorlets. Somatostatin receptor SPECT-CT, 18F-FDG-PET-CT and 18F-FDOPA-PET-CT scans and endoscopy procedures could not identify any primary tumours in other locations. Our patient is the first published case of Cowden syndrome, associated with multifocal pulmonary carcinoids. Besides multiple endocrine neoplasia type 1, we propose Cowden syndrome as another hereditary condition predisposing to multiple pulmonary tumorlets and carcinoid tumours. LA - English DB - MTMT ER - TY - JOUR AU - Tőke, Judit AU - Tóth, Miklós TI - A mellékvesekéreg-carcinoma diagnosztikája JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 4 SP - 123 EP - 131 PG - 9 SN - 0030-6002 DO - 10.1556/650.2024.32958 UR - https://m2.mtmt.hu/api/publication/34540854 ID - 34540854 N1 - Export Date: 12 March 2024 CODEN: ORHEA AB - A mellékvesekéreg-carcinoma ritka, rossz prognózisú megbetegedés. Az érintett betegek kórjóslatát döntően meghatározza, hogy a betegség korán, még lokoregionális stádiumban kerüljön felismerésre, amikor a sebészi tumoreltávolítással jelentősen növelhető a gyógyulás esélye. A mellékvese-daganatok dignitásának meghatározása gyakran jelent kihívást a preoperatív kivizsgálás során, a diagnózisalkotást hagyományos radiológiai és laboratóriumi vizsgálatok segítik. Újabban igen jó diagnosztikai pontosságot mutató biomarkerek is megismerésre kerültek, klinikai használatuk a közeljövőben várható. Közülük is kiemelkednek a gáz-, illetve folyadékkromatográfián alapuló szteroidmetabolomikai vizsgálatok, valamint a miRNS-ek vizsgálata. Ebben az összefoglalóban bemutatjuk a mellékvesekéreg-carcinoma azonosítását segítő preoperatív klinikai és posztoperatív patológiai vizsgálómódszereket. Orv Hetil. 2024; 165(4): 123–131. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Isand, Kristina AU - Feelders, Richard AU - Brue, Thierry AU - Tóth, Miklós AU - Deutschbein, Timo AU - Reincke, Martin AU - Krsek, Michal AU - Santos, Alicia AU - Demtröder, Frank AU - Chabre, Olivier AU - Strasburger, Christian J AU - Aulinas Maso, Anna AU - Volke, Vallo AU - Pereira, Alberto M AU - Lohmann, Rüdiger AU - Gich Saladich, Ignasi AU - Webb, Susan M AU - Wass, John AU - Valassi, Elena ED - Amaral, C / Collaborator ED - Ambrogio, A / Collaborator ED - Aranda, G / Collaborator ED - Arosio, M / Collaborator ED - Balomenaki, M / Collaborator ED - Beck-Peccoz, P / Collaborator ED - Berr-Kirmair, C / Collaborator ED - Bertherat, J / Collaborator ED - Bolanowski, M / Collaborator ED - Bollerslev, J / Collaborator ED - Thierry, Brue / Collaborator ED - Cardoso, H / Collaborator ED - Carvalho, D / Collaborator ED - Cavagnini, F / Collaborator ED - Ceccato, P / Collaborator ED - Chabre, O / Collaborator ED - Chanson, P / Collaborator ED - Christ, E / Collaborator ED - Demtröder Zentrum Fur Endokrinologie, F / Collaborator ED - Denes, J / Collaborator ED - Deutschbein, T / Collaborator ED - Dimopoulou, C / Collaborator ED - Dreval, A / Collaborator ED - Droste, M / Collaborator ED - Duarte, J S / Collaborator ED - Dusek, T / Collaborator ED - Ertürk, E / Collaborator ED - Evang, J A / Collaborator ED - Fajardo, C / Collaborator ED - Fazel, J / Collaborator ED - Feelders, R A / Collaborator ED - Fica, S / Collaborator ED - García-Centeno, R / Collaborator ED - Ghigo, E / Collaborator ED - Goth, M / Collaborator ED - Greenman, Y / Collaborator ED - Halperin, I / Collaborator ED - Hanzu, F A / Collaborator ED - Hermus, A / Collaborator ED - Johannsson, G / Collaborator ED - Hubina, E / Collaborator ED - Kamenicky, P / Collaborator ED - Kasperlik-Zaluska, A / Collaborator ED - Kirchner, J / Collaborator ED - Kastelan, D / Collaborator ED - Komerdus, I / Collaborator ED - Kraljevic, I / Collaborator ED - Krsek, M / Collaborator ED - Kruszynska, A / Collaborator ED - Lamas, C / Collaborator ED - Lambrescu, I / Collaborator ED - Lang, S / Collaborator ED - Luger, A / Collaborator ED - Maiter, D / Collaborator ED - Marpole, N / Collaborator ED - Martin, S / Collaborator ED - Martinie, M / Collaborator ED - Martins Oliveira, M J / Collaborator ED - Moros, O / Collaborator ED - Netea-Maier, R / Collaborator ED - Newell-Price, J / Collaborator ED - Orbetzova, M / Collaborator ED - Paiva, I / Collaborator ED - Pecori Giraldi, F / Collaborator ED - Percovich, J C / Collaborator ED - Pereira, A M / Collaborator ED - Pfeiffer, M / Collaborator ED - Pickel, J / Collaborator ED - Pirags, V / Collaborator ED - Ragnarsson, O / Collaborator ED - Reghina, A D / Collaborator ED - Reincke, M / Collaborator ED - Riesgo, P / Collaborator ED - Roberts, M / Collaborator ED - Roerink, S / Collaborator ED - Rowan, C / Collaborator ED - Rudenko, P / Collaborator ED - Sahnoun, M A / Collaborator ED - Salvador, J / Collaborator ED - Santos, A / Collaborator ED - Scaroni, C / Collaborator ED - Sigurjonsdottir, H A / Collaborator ED - Skoric Polovina, T / Collaborator ED - Smith, R / Collaborator ED - Stachowska, B / Collaborator ED - Stalla, G / Collaborator ED - Strasburger, C / Collaborator ED - Tabarin, A / Collaborator ED - Terzolo, M / Collaborator ED - Tőke, Judit / Collaborator ED - Tóth, Miklós / Collaborator ED - Touraine, P / Collaborator ED - Trainer, P J / Collaborator ED - Tsagarakis, S / Collaborator ED - Valassi, E / Collaborator ED - Vila, G / Collaborator ED - Vinay, S / Collaborator ED - Wagenmakers, M / Collaborator ED - Webb, S / Collaborator ED - Werner, S / Collaborator ED - Young, J / Collaborator ED - Zdunowski, P / Collaborator ED - Zacharieva, S / Collaborator ED - Zopf, K / Collaborator ED - Zopp, S / Collaborator ED - Zosin, I / Collaborator TI - High prevalence of venous thrombotic events in Cushing's syndrome. data from ERCUSYN and details in relation to surgery. TS - data from ERCUSYN and details in relation to surgery. JF - EUROPEAN JOURNAL OF ENDOCRINOLOGY J2 - EUR J ENDOCRINOL VL - 190 PY - 2024 IS - 1 SP - 75 EP - 85 PG - 11 SN - 0804-4643 DO - 10.1093/ejendo/lvad176 UR - https://m2.mtmt.hu/api/publication/34452033 ID - 34452033 N1 - Institute of Biomedicine and Translational Medicine, University of Tartu, Ülikooli 18, Tartu, 50090, Estonia Department of Internal Medicine, Section of Endocrinology, ENETS Center of Excellence, Erasmus MC and Erasmus Cancer Institute, Rotterdam, 3015, Netherlands Aix Marseille Univ, APHM, INSERM, MMG, Department of Endocrinology Hospital La Conception, MarMaRa Institute, Marseille, 13305, France Department of Internal Medicine and Oncology, Semmelweis University, Budapest, 1083, Hungary Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, 97080, Germany Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, 80336, Germany Third Department of Internal Medicine, First Faculty of Medicine, Charles University, General University Hospital, Prague, 12808, Czech Republic IIB-Sant Pau, Department of Endocrinology, Hospital Sant Pau, Dept Medicine, UAB, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Barcelona, 08025, Spain Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), Barcelona, Spain Zentrum fur Endokrinologie, Diabetologie, Rheumatologie, Dr Demtröder & Kollegen im MVZ Dr. Eberhard & Partner und Klinikum Dortmund, Dortmund, 44137, Germany University Grenoble Alpes, UMR 1292 INSERM-CEA-UGA, Endocrinologie CHU Grenoble Alpes, Grenoble, F-38000, France Clinical Endocrinology, Charite-Universitätsmedizin, Campus Mitte, Berlin, 10117, Germany Department of Endocrinology & Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, 1081, Netherlands Health Care Consulting GmbH, Lohmann & Birkner Health Care Consulting GmbH, Berlin, 13407, Germany Department of Clinical Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, 08025, Spain Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals, Oxford, OX37LE, United Kingdom Endocrinology and Nutrition Department, Germans Trias i Pujol Hospital and Research Institute, Badalona, 08916, Spain Centro Hospitalar do Porto-Hospital Santo António, Portugal Istituto Auxologico Italiano IRCCS, University of Milan, Milan, Italy Department of Endocrinology, Hospital Clinic Barcelona, IDIBAPS, UB, Barcelona, Spain Unit of Endocrine Diseases & Diabetology, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy Evangelismos Hospital, Athens, Greece Endocrinology and Diabetology Unit, Fondazione IRCCS Ca” Granda—Ospedale Maggiore Policlinico, University of Milan, Milan, Italy Hôpital Cochin, France Wroclaw Medical University, Wroclaw, Poland Section of Specialized Endocrinology, Oslo University Hospital, Faculty of Medicine, University in Oslo, Oslo, Norway Association pour le Devéloppement des Recherches Biologiques et Médicales, France Hospital de San Joao, Porto, Portugal Endocrinology Unit, University-Hospital of Padova, Italy Hospitalier Universitaire, Grenoble, France Univ Paris-Sud, Université Paris-Saclay UMR-S1185, Le Kremlin Bicêtre, Paris, F-94276, France Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service de Endocrinologie et des Maladies de la Reproduction, Le Kremlin Bicêtre, Paris, F-94275, France University Hospital of Bern, Inelspital, Division of Endocrinology, Diabetology and Clinical Nutrition, Bern, Switzerland Division of Endocrinology, 2nd Department of Medicine, State Health Center, Budapest, Hungary Medicover Oldenburg MVZ, Germany Max-Planck-Gessellschaft zur Forderung der Wissenschaften e.V., Munich, Germany Moscow Regional Research Clinical Institute n.a. Vladimirsky, Moscow, Russian Federation Praxis für Endokrinologie Droste, Oldenburg, Germany Serviço Endocrinologia CHLO, Hospital Egas Moniz, Portugal Department of Endocrinology, University Hospital Zagreb, School of Medicine University of Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia Uludag University School of Medicine, Bursa, Turkey Hospital Universitario de la Ribera, Alzira, Spain Erasmus University Medical Centre, Rotterdam, Netherlands Elias Hospital, Bucharest, Romania Hospital General Universitario Gregorio Marañon, Spain Molinette Hospital, Department of Internal Medicine, Turin, Italy Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv, Israel Radboud University Medical Center, Nijmegen, Netherlands Goteborg University, Goteborg, Sweden Institut National de la Santé et de la Recherche Médicale U1185, Le Kremlin Bicêtre, Paris, F-94276, France Centre for Postgraduate Medical Education, Warsaw, Poland Division of Clinical Endocrinology, Department of Medicine CCM, Charité-Universitätsmedizin, Berlin, Germany Department of Endocrinology, University Hospital Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia 2nd Department of Medicine, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, Prague, Czech Republic Endocrinology and Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain Medizinische Universitat Wien, Wien, Austria UCL Cliniques Universitaires St Luc, Brussels, Belgium Christie Hospital, NHS Trust, Manchester, United Kingdom Service d'Endocrinologie-Diabétologie Nutrition, Grenoble, Cedex, France Centro Hospitalar Vila Nova Gaia/Espinho, Portugal Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands The University of Sheffield, Sheffield, United Kingdom Clinic of Endocrinology and Metabolic Diseases, “Sv. Georgy” University Hospital, Medical University, Plovdiv, Bulgaria Hospitais da Universidade de Coimbra, Portugal Leiden University Medical Center, Leiden, Netherlands Klinicni Center, Ljubljana, Slovenia Pauls Stradiņ š Clinical University Hospital, University of Latvia, Riga, Latvia Neurosurgery Department, Hospital Universitario de la Ribera, Alzira, Spain Estonian Endocrine Society, Tallinn, Estonia Aix-Marseille Université, CNRS, CRN2M UMR 7286, cedex 15, Marseille, 13344, France APHM, Hôpital Conception, Marseille, France University of Navarra, Pamplona, Spain IIB-Sant Pau, Department of Endocrinology/Medicine, Hospital Sant Pau, UAB, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Barcelona, Spain Landspitali University Hospital, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom Department of Endocrinology, Diabetology and Isotope Therapy Wroclaw Medical University, Wroclaw, Poland Department of Endocrinology, Diabetes and Nutrition, University of Bordeaux, Bordeaux, France Internal Medicine—Endocrinology, San Luigi Hospital, Italy 2nd Departement of Medicine, Semmelweis University, Budapest, Hungary GH Pitie Salpetriere, Dep. of Endocrinology and Repr. Med., France Department of Endocrinology, Christie Hospital, Manchester, United Kingdom Athens Polyclinic General Hospital, Evangelismos Hospital, Athens, Greece Department of Endocrinology, Hospital Germans Trias i Pujol, Badalona, Spain CIBERER Unit 747, ISCIII, Madrid, Spain Medical University of Sofia, Sofia, Bulgaria Romanian Society for Endocrinology, Timisoara, Romania Export Date: 30 January 2024 CODEN: EJOEE Correspondence Address: Isand, K.; Institute of Biomedicine and Translational Medicine, Ülikooli 18, Estonia; email: Kristina.iand@gmail.com Chemicals/CAS: hydrocortisone, 50-23-7; Hydrocortisone AB - The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE.A retrospective observational cohort study.Data extraction from the registry was taken on the 07.02.2022. At the time there were 2174 patients diagnosed with Cushing's syndrome (CS) and 95 VTE's reported in the database.Of 95 VTE events 70 (74%) were in pituitary-dependent CS patients, 12 (12.5%) in adrenal-dependant CS, 10 (10.5%) in ectopic CS and 3 (3%) in CS due to other causes.Sex, UFC value at diagnosis, as well as the number of operations remained statistically significant predictors of VTE.Of patients who were treated with at least one surgery, 12 (13%) VTE occured before and 80 (87%) after the surgery. Nearly half of these VTE's occurred within six months since the operation (36; 45%).Over half the centres who reported VTE did not routinely anticoagulate CS patients. Anticoagulation schemes varied widely.Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS. LA - English DB - MTMT ER - TY - JOUR AU - Ledó, Nóra AU - Németh, T AU - Szücs, Nikolette AU - Tóth, Miklós TI - KRÓNIKUS HYPOKALAEMIA KIVIZSGÁLÁSA ÉS ELLÁTÁSA – ESETBEMUTATÁSOK JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 320 EP - 321 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34565245 ID - 34565245 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bényei, E AU - Welsch, L AU - Tőke, Judit AU - Tóth, Miklós TI - A MELLÉKVESEKÉREG-CARCINOMA KOMPLEX PROGNOSZTIKÁJA: A GRAS ÉS S-GRAS PONTRENDSZEREK VIZSGÁLATA JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 301 EP - 301 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34559054 ID - 34559054 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hella, Zoltán AU - Tőke, Judit AU - Patócs, Attila Balázs AU - Varga, Zsolt AU - Dabasi, Gabriella AU - Kovács, Gábor László AU - Tóth, Miklós TI - Cushing-szindrómát okozó macronodularis mellékvese-hyperplasia ARMC5-génmutáció következtében. Az első hazai eset TS - Az első hazai eset JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 32 SP - 1271 EP - 1277 PG - 7 SN - 0030-6002 DO - 10.1556/650.2023.32817 UR - https://m2.mtmt.hu/api/publication/34090138 ID - 34090138 N1 - Misszió Egészségügyi Központ, Endokrinológia szakrendelés, Veresegyház, Hungary Semmelweis Egyetem, Belgyógyászati és Onkológiai Klinika, Endo-ERN Központ, Budapest, Hungary Semmelweis Egyetem, Laboratóriumi Medicina Intézet és MTA Örökletes Daganatok Kutatócsoport, Budapest, Hungary Semmelweis Egyetem, Orvosi Képalkotó Klinika, Nukleáris Medicina Tanszék, Budapest, Hungary Kistarcsai Flór Ferenc Kórház, I. Belgyógyászati Osztály, Kistarcsa, Hungary Export Date: 10 October 2023 CODEN: ORHEA Chemicals/CAS: corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; hydrocortisone, 50-23-7; Adrenocorticotropic Hormone; Armadillo Domain Proteins; ARMC5 protein, human; Hydrocortisone; Iodine Radioisotopes; Iodine-131; Tumor Suppressor Proteins LA - English DB - MTMT ER -