TY - JOUR AU - Kovács, Mónika AU - Makszin, Lilla AU - Nyul, Zoltán AU - Ohmachtné Hollódy, Katalin TI - Has the Incidence of Febrile Convulsions in Childhood Changed During the SARS-CoV-2 Pandemic? JF - JOURNAL OF CHILD NEUROLOGY J2 - J CHILD NEUROL PY - 2024 SN - 0883-0738 DO - 10.1177/08830738241249630 UR - https://m2.mtmt.hu/api/publication/34825166 ID - 34825166 LA - English DB - MTMT ER - TY - JOUR AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Makszin, Lilla AU - Szabó, Éva AU - Tóth, Attila AU - Kocsis, Béla AU - Kovács, Krisztina AU - Hormay, Edina AU - Lénárd, László AU - Karádi, Zoltán György AU - Bufa, Anita TI - Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57046-6 UR - https://m2.mtmt.hu/api/publication/34745300 ID - 34745300 N1 - * Megosztott szerzőség AB - Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes. LA - English DB - MTMT ER - TY - JOUR AU - Szabadi, Vivien AU - Simon, Gábor AU - Makszin, Lilla AU - Sipos, Katalin AU - Poór, Viktor Soma TI - Evaluation of the effect of ozone disinfection on forensic identification of blood, saliva, and semen stains JF - SCIENCE & JUSTICE J2 - SCI JUSTICE VL - 64 PY - 2024 IS - 2 SP - 151 EP - 158 PG - 8 SN - 1355-0306 DO - 10.1016/j.scijus.2023.12.005 UR - https://m2.mtmt.hu/api/publication/34454359 ID - 34454359 N1 - Department of Forensic Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, Pécs, 7624, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary Export Date: 16 January 2024 Correspondence Address: Poor, V.S.H-7624 Pécs, Szigeti street 12, Hungary; email: viktor.s.poor@aok.pte.hu LA - English DB - MTMT ER - TY - CONF AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Makszin, Lilla AU - Szabó, Éva AU - Attila, Toth AU - Béla, Kocsis AU - Zoltan, Karadi AU - Bufa, Anita TI - Antibiotic-induced effects on the fatty acid composition of faeces in a rat model T2 - 2023 15th International ISSFAL Congress PY - 2023 SP - 269 UR - https://m2.mtmt.hu/api/publication/34797768 ID - 34797768 LA - English DB - MTMT ER - TY - GEN AU - Mocher, Judit AU - Gátos, Attila AU - Makszin, Lilla AU - Wiegand, Norbert AU - Patonai, Zoltán TI - A haemostasist befolyásoló szerek hatása a pertrochnater törést szenvedett betegek műtétre kerülési idejére és a perioperatív időszakára PY - 2023 UR - https://m2.mtmt.hu/api/publication/34249841 ID - 34249841 LA - Hungarian DB - MTMT ER - TY - CONF AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic-based protein quantification in plant- based drinks derived from nuts T2 - 13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts PY - 2023 PG - 1 UR - https://m2.mtmt.hu/api/publication/34186807 ID - 34186807 LA - English DB - MTMT ER - TY - CONF AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic analysis for determination of the protein content in legume-based plant drinks T2 - 13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts PY - 2023 UR - https://m2.mtmt.hu/api/publication/34186786 ID - 34186786 LA - English DB - MTMT ER - TY - JOUR AU - Vámos, Eszter AU - Kálmán, Nikoletta AU - Sturm, Eva Maria AU - Nayak, Barsha Baisakhi AU - Teppan, Julia AU - Bagóné Vántus, Viola AU - Kovács, Dominika AU - Makszin, Lilla AU - Lóránd, Tamás AU - Gallyas, Ferenc AU - Radnai, Balázs TI - Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 10 PG - 23 SN - 2076-3921 DO - 10.3390/antiox12101790 UR - https://m2.mtmt.hu/api/publication/34172544 ID - 34172544 N1 - Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 12 Szigeti Str, Pécs, 7624, Hungary Otto-Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, Neue Stiftingtalstraße 6, Graz, 8010, Austria Institute of Bioanalysis, Medical School, Szentágothai Research Center, University of Pécs, Pécs, 7622, Hungary Export Date: 15 November 2023 Correspondence Address: Radnai, B.; Department of Biochemistry and Medical Chemistry, 12 Szigeti Str, Hungary; email: balazs.radnai@aok.pte.hu AB - Macrophage polarization is highly involved in autoimmunity. M1 polarized macrophages drive inflammation and undergo metabolic reprogramming, involving downregulation of mitochondrial energy production and acceleration of glycolysis. Macrophage migration inhibitory factor (MIF), an enigmatic tautomerase (ketonase and enolase), was discovered to regulate M1 polarization. Here, we reveal that KRP-6, a potent and highly selective MIF ketonase inhibitor, reduces MIF-induced human blood eosinophil and neutrophil migration similarly to ISO-1, the most investigated tautomerase inhibitor. We equally discovered that KRP-6 prevents M1 macrophage polarization and reduces ROS production in IFN-γ-treated cells. During metabolic reprogramming, KRP-6 improved mitochondrial bioenergetics by ameliorating basal respiration, ATP production, coupling efficiency and maximal respiration in LPS+IFN-γ-treated cells. KRP-6 also reduced glycolytic flux in M1 macrophages. Moreover, the selective MIF ketonase inhibitor attenuated LPS+IFN-γ-induced downregulation of PARP-1 and PARP-2 mRNA expression. We conclude that KRP-6 represents a promising novel therapeutic compound for autoimmune diseases, which strongly involves M1 macrophage polarization. LA - English DB - MTMT ER - TY - JOUR AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Verzár, Zsófia AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic Analysis for the Determination of Protein Content in Different Types of Plant-Based Drinks JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 18 PG - 19 SN - 1420-3049 DO - 10.3390/molecules28186684 UR - https://m2.mtmt.hu/api/publication/34167332 ID - 34167332 N1 - Institute of Bioanalysis, Medical School, Szentágothai Research Center, University of Pécs, Pécs, 7622, Hungary Institute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pécs, Pécs, 7621, Hungary Export Date: 9 October 2023 CODEN: MOLEF Correspondence Address: Makszin, L.; Institute of Bioanalysis, Hungary; email: lilla.makszin@aok.pte.hu AB - The widespread consumption of plant-based drinks, driven by health and dietary reasons (including cow's milk allergy, lactose intolerance, milk protein intolerance, following a vegetarian or vegan diet) necessitates automated and accurate test methods. Our study demonstrates the simultaneous determination of protein components and total protein concentrations in plant-based milk alternatives using a rapid and reproducible microchip gel electrophoretic method. As expected, the electrophoretic profiles of each plant-based drink differed. Based on our analyses and statistical evaluation, it can be determined that the protein profiles of different plant-based beverages do not differ significantly between different manufacturers or different expiry dates. The measured total protein content was compared with the nominal values, i.e., the values stated on the beverage labels. As the number of consumers of functional and specialized plant-based milk alternatives continues to rise, it is important to prioritize methods that provide qualitative and quantitative information on protein composition and other nutrients. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Makszin, Lilla AU - Bufa, Anita AU - Sipos, Dávid AU - Kása, Péter AU - Pál, Szilárd AU - Rosenstiel, Philip AU - Sommer, Felix AU - Kocsis, Béla AU - Péterfi, Zoltán TI - Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 13 PY - 2023 PG - 15 SN - 2235-2988 DO - 10.3389/fcimb.2023.1041384 UR - https://m2.mtmt.hu/api/publication/33588242 ID - 33588242 N1 - * Megosztott szerzőség LA - English DB - MTMT ER -