@article{MTMT:34825166, title = {Has the Incidence of Febrile Convulsions in Childhood Changed During the SARS-CoV-2 Pandemic?}, url = {https://m2.mtmt.hu/api/publication/34825166}, author = {Kovács, Mónika and Makszin, Lilla and Nyul, Zoltán and Ohmachtné Hollódy, Katalin}, doi = {10.1177/08830738241249630}, journal-iso = {J CHILD NEUROL}, journal = {JOURNAL OF CHILD NEUROLOGY}, unique-id = {34825166}, issn = {0883-0738}, year = {2024}, eissn = {1708-8283}, orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763} } @article{MTMT:34745300, title = {Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model}, url = {https://m2.mtmt.hu/api/publication/34745300}, author = {Marosvölgyi, Tamás and Mintál, Kitti and Borbásné Farkas, Kornélia and Sipos, Zoltán and Makszin, Lilla and Szabó, Éva and Tóth, Attila and Kocsis, Béla and Kovács, Krisztina and Hormay, Edina and Lénárd, László and Karádi, Zoltán György and Bufa, Anita}, doi = {10.1038/s41598-024-57046-6}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34745300}, issn = {2045-2322}, abstract = {Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Mintál, Kitti/0009-0003-4739-2902; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Makszin, Lilla/0000-0002-9764-4763; Hormay, Edina/0009-0004-0598-5061} } @article{MTMT:34454359, title = {Evaluation of the effect of ozone disinfection on forensic identification of blood, saliva, and semen stains}, url = {https://m2.mtmt.hu/api/publication/34454359}, author = {Szabadi, Vivien and Simon, Gábor and Makszin, Lilla and Sipos, Katalin and Poór, Viktor Soma}, doi = {10.1016/j.scijus.2023.12.005}, journal-iso = {SCI JUSTICE}, journal = {SCIENCE & JUSTICE}, volume = {64}, unique-id = {34454359}, issn = {1355-0306}, year = {2024}, eissn = {1876-4452}, pages = {151-158}, orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763; Sipos, Katalin/0000-0002-6706-2682; Poór, Viktor Soma/0000-0002-0269-0645} } @CONFERENCE{MTMT:34797768, title = {Antibiotic-induced effects on the fatty acid composition of faeces in a rat model}, url = {https://m2.mtmt.hu/api/publication/34797768}, author = {Marosvölgyi, Tamás and Mintál, Kitti and Borbásné Farkas, Kornélia and Makszin, Lilla and Szabó, Éva and Attila, Toth and Béla, Kocsis and Zoltan, Karadi and Bufa, Anita}, booktitle = {2023 15th International ISSFAL Congress}, unique-id = {34797768}, year = {2023}, pages = {269}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Mintál, Kitti/0009-0003-4739-2902; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Makszin, Lilla/0000-0002-9764-4763} } @misc{MTMT:34249841, title = {A haemostasist befolyásoló szerek hatása a pertrochnater törést szenvedett betegek műtétre kerülési idejére és a perioperatív időszakára}, url = {https://m2.mtmt.hu/api/publication/34249841}, author = {Mocher, Judit and Gátos, Attila and Makszin, Lilla and Wiegand, Norbert and Patonai, Zoltán}, unique-id = {34249841}, year = {2023}, orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763} } @CONFERENCE{MTMT:34186807, title = {Microfluidic-based protein quantification in plant- based drinks derived from nuts}, url = {https://m2.mtmt.hu/api/publication/34186807}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Marosvölgyi, Tamás and Makszin, Lilla}, booktitle = {13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts}, unique-id = {34186807}, year = {2023}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @CONFERENCE{MTMT:34186786, title = {Microfluidic analysis for determination of the protein content in legume-based plant drinks}, url = {https://m2.mtmt.hu/api/publication/34186786}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Marosvölgyi, Tamás and Makszin, Lilla}, booktitle = {13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts}, unique-id = {34186786}, year = {2023}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @article{MTMT:34172544, title = {Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming}, url = {https://m2.mtmt.hu/api/publication/34172544}, author = {Vámos, Eszter and Kálmán, Nikoletta and Sturm, Eva Maria and Nayak, Barsha Baisakhi and Teppan, Julia and Bagóné Vántus, Viola and Kovács, Dominika and Makszin, Lilla and Lóránd, Tamás and Gallyas, Ferenc and Radnai, Balázs}, doi = {10.3390/antiox12101790}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {12}, unique-id = {34172544}, abstract = {Macrophage polarization is highly involved in autoimmunity. M1 polarized macrophages drive inflammation and undergo metabolic reprogramming, involving downregulation of mitochondrial energy production and acceleration of glycolysis. Macrophage migration inhibitory factor (MIF), an enigmatic tautomerase (ketonase and enolase), was discovered to regulate M1 polarization. Here, we reveal that KRP-6, a potent and highly selective MIF ketonase inhibitor, reduces MIF-induced human blood eosinophil and neutrophil migration similarly to ISO-1, the most investigated tautomerase inhibitor. We equally discovered that KRP-6 prevents M1 macrophage polarization and reduces ROS production in IFN-γ-treated cells. During metabolic reprogramming, KRP-6 improved mitochondrial bioenergetics by ameliorating basal respiration, ATP production, coupling efficiency and maximal respiration in LPS+IFN-γ-treated cells. KRP-6 also reduced glycolytic flux in M1 macrophages. Moreover, the selective MIF ketonase inhibitor attenuated LPS+IFN-γ-induced downregulation of PARP-1 and PARP-2 mRNA expression. We conclude that KRP-6 represents a promising novel therapeutic compound for autoimmune diseases, which strongly involves M1 macrophage polarization.}, year = {2023}, eissn = {2076-3921}, orcid-numbers = {Vámos, Eszter/0000-0003-0622-442X; Makszin, Lilla/0000-0002-9764-4763; Gallyas, Ferenc/0000-0002-1906-4333} } @article{MTMT:34167332, title = {Microfluidic Analysis for the Determination of Protein Content in Different Types of Plant-Based Drinks}, url = {https://m2.mtmt.hu/api/publication/34167332}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Verzár, Zsófia and Marosvölgyi, Tamás and Makszin, Lilla}, doi = {10.3390/molecules28186684}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34167332}, issn = {1420-3049}, abstract = {The widespread consumption of plant-based drinks, driven by health and dietary reasons (including cow's milk allergy, lactose intolerance, milk protein intolerance, following a vegetarian or vegan diet) necessitates automated and accurate test methods. Our study demonstrates the simultaneous determination of protein components and total protein concentrations in plant-based milk alternatives using a rapid and reproducible microchip gel electrophoretic method. As expected, the electrophoretic profiles of each plant-based drink differed. Based on our analyses and statistical evaluation, it can be determined that the protein profiles of different plant-based beverages do not differ significantly between different manufacturers or different expiry dates. The measured total protein content was compared with the nominal values, i.e., the values stated on the beverage labels. As the number of consumers of functional and specialized plant-based milk alternatives continues to rise, it is important to prioritize methods that provide qualitative and quantitative information on protein composition and other nutrients.}, keywords = {food allergy; Protein profile; Total protein content; Plant-based milk alternatives; microchip gel electrophoretic method}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Verzár, Zsófia/0000-0001-5323-0748; Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @article{MTMT:33588242, title = {Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer}, url = {https://m2.mtmt.hu/api/publication/33588242}, author = {Varga, Adorján and Makszin, Lilla and Bufa, Anita and Sipos, Dávid and Kása, Péter and Pál, Szilárd and Rosenstiel, Philip and Sommer, Felix and Kocsis, Béla and Péterfi, Zoltán}, doi = {10.3389/fcimb.2023.1041384}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {13}, unique-id = {33588242}, issn = {2235-2988}, year = {2023}, eissn = {2235-2988}, orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763; Kása, Péter/0000-0002-6134-0928; Péterfi, Zoltán/0000-0001-9658-153X} }