@article{MTMT:34482920, title = {Studies on fluorofunctionalization of some functionalized alkene scaffolds}, url = {https://m2.mtmt.hu/api/publication/34482920}, author = {Novák, Tibor Tamás and Aradi, Klára and Gömöry, Ágnes and Nonn, Melinda and Hornyánszky, Gábor and Kiss, Loránd}, doi = {10.1016/j.rechem.2024.101309}, journal-iso = {RESULT CHEM}, journal = {RESULTS IN CHEMISTRY}, volume = {7}, unique-id = {34482920}, year = {2024}, eissn = {2211-7156}, orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135; Nonn, Melinda/0000-0002-1623-4173} } @article{MTMT:34473105, title = {Extending the substrate scope of palladium-catalyzed arylfluorination of allylic amine derivatives}, url = {https://m2.mtmt.hu/api/publication/34473105}, author = {Novák, Tibor Tamás and Nguyen, Thi Cam Tu and Gömöry, Ágnes and Hornyánszky, Gábor and Remete, Attila Márió and Kiss, Loránd}, doi = {10.1016/j.jfluchem.2023.110239}, journal-iso = {J FLUORINE CHEM}, journal = {JOURNAL OF FLUORINE CHEMISTRY}, volume = {273}, unique-id = {34473105}, issn = {0022-1139}, year = {2024}, eissn = {1873-3328}, orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135; Remete, Attila Márió/0000-0001-6388-0197} } @article{MTMT:34457260, title = {Very Low-Pressure CID Experiments: High Energy Transfer and Fragmentation Pattern at the Single Collision Regime}, url = {https://m2.mtmt.hu/api/publication/34457260}, author = {Szabó, Dániel and Gömöry, Ágnes and Ludányi, Krisztina and Vékey, Károly and Drahos, László}, doi = {10.3390/molecules29010211}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {29}, unique-id = {34457260}, issn = {1420-3049}, year = {2024}, eissn = {1420-3049}, orcid-numbers = {Szabó, Dániel/0000-0003-3375-395X; Gömöry, Ágnes/0000-0001-5216-0135; Ludányi, Krisztina/0000-0002-2380-9529; Drahos, László/0000-0001-9589-6652} } @article{MTMT:34074424, title = {Diols Speed Up Guanidine Base Catalysed Claisen‐Schmidt Condensation to Produce New 15‐Arylidene Steroids}, url = {https://m2.mtmt.hu/api/publication/34074424}, author = {Ispán, Dávid and Küzdő, Áron and Fonyó, Máté and Gömöry, Ágnes and Tumanov, Nikolay and Wouters, Johan and Mahó, Sándor and Lendvay, György and Skodáné Földes, Rita}, doi = {10.1002/ejoc.202300560}, journal-iso = {EUR J ORG CHEM}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, volume = {26}, unique-id = {34074424}, issn = {1434-193X}, abstract = {Considerable acceleration was observed in the guanidine-base catalysed Claisen-Schmidt condensation of benzaldehyde and a 17α-methyl-18-nor-5α,13α-androstan-16-one (1) in the presence of ethylene glycol. Rate-enhancement effects of various alcohols and diols were compared. In quantum chemical calculations, coordination of the carbonyl group of the substrate was found to reduce the potential barrier to the proton transfer from the α carbon and thus facilitate the formation of the anion that attacks the aldehyde. Both the experiments and the calculations showed that diols enhance the reactivity more efficiently than alcohols. Ethylene glycol/guanidine-base mixtures were found to be efficient catalysts and solvents in the synthesis of a range of new 17α-methyl-18-nor-13α-15-arylidene steroids. This solvent mixture has a further advantage: the crude products can be isolated by simple extraction after introduction of CO2. It is also shown that by the proper choice of the base, the base/diol mixture can be recycled.}, year = {2023}, eissn = {1099-0690}, orcid-numbers = {Ispán, Dávid/0000-0002-6698-0078; Gömöry, Ágnes/0000-0001-5216-0135; Lendvay, György/0000-0002-2150-0376; Skodáné Földes, Rita/0000-0002-9810-1509} } @article{MTMT:33271926, title = {Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium- and Copper-Catalyzed Reactions}, url = {https://m2.mtmt.hu/api/publication/33271926}, author = {Nagy, Enikő and Váradi, Márk and Nagymihaly, Zoltan and Kollár, László and Kovács, Krisztina and Andreidesz, Kitti and Gömöry, Ágnes and Tumanov, Nikolay and Wouters, Johan and Skodáné Földes, Rita}, doi = {10.3390/inorganics10110205}, journal-iso = {INORGANICS}, journal = {INORGANICS}, volume = {10}, unique-id = {33271926}, abstract = {The combination of the ferrocene skeleton with pharmacophores often leads to molecules with interesting biological properties. Five ferrocene-benzofuran hybrids of different structures were synthesized by transition metal catalyzed reactions. The efficiency of both homogeneous and heterogeneous catalytic methods was tested. The products were characterized using 1H, 13C NMR and FTIR spectroscopy, HRMS and cyclic voltammetry. The structure of one of the new compounds was also proved with X-ray crystallography. The new hybrids showed moderate cytotoxicity on MCF-7 and MDA-MB-231 cell lines. It is remarkable that the less curable MDA-MB-231 cell line was more sensitive to treatment with three ferrocene derivatives.}, year = {2022}, eissn = {2304-6740}, orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135; Tumanov, Nikolay/0000-0001-6898-9036; Wouters, Johan/0000-0002-4920-6857; Skodáné Földes, Rita/0000-0002-9810-1509} } @article{MTMT:33049993, title = {Synthesis of Steroidal Thioethers via [HDBU][OAc]-Mediated Michael Addition of Thiols to 16-Dehydropregnenolone}, url = {https://m2.mtmt.hu/api/publication/33049993}, author = {Maksó, Lilla and Kovács, Krisztina and Andreidesz, Kitti and Gömöry, Ágnes and Mahó, Sándor and Skodáné Földes, Rita}, doi = {10.1002/slct.202200967}, journal-iso = {CHEMISTRYSELECT}, journal = {CHEMISTRYSELECT}, volume = {7}, unique-id = {33049993}, issn = {2365-6549}, year = {2022}, eissn = {2365-6549}, orcid-numbers = {Maksó, Lilla/0000-0002-2023-8222; Gömöry, Ágnes/0000-0001-5216-0135; Skodáné Földes, Rita/0000-0002-9810-1509} } @article{MTMT:32544488, title = {Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads}, url = {https://m2.mtmt.hu/api/publication/32544488}, author = {Kollár, Levente and Gobec, Martina and Proj, Matic and Smrdel, Lara and Knez, Damijan and Imre, Timea and Gömöry, Ágnes and Petri, László and Ábrányi-Balogh, Péter and Csányi, Dorottya and Ferenczy, György and Gobec, Stanislav and Sosič, Izidor and Keserű, György Miklós}, doi = {10.3390/cells10123431}, journal-iso = {CELLS-BASEL}, journal = {CELLS}, volume = {10}, unique-id = {32544488}, year = {2021}, eissn = {2073-4409}, orcid-numbers = {Kollár, Levente/0000-0001-9679-3735; Proj, Matic/0000-0003-4043-9686; Knez, Damijan/0000-0001-9917-1384; Gömöry, Ágnes/0000-0001-5216-0135; Ferenczy, György/0000-0002-5771-4616; Gobec, Stanislav/0000-0002-9678-3083; Sosič, Izidor/0000-0002-3370-4587} } @article{MTMT:32449040, title = {What are molecular effects of co-administering vitamin C with artemisinin-type antimalarials? A model mass spectrometry and quantum chemical study}, url = {https://m2.mtmt.hu/api/publication/32449040}, author = {Pashynska, Vlada and Stepanian, Stepan and Gömöry, Ágnes and Adamowicz, Ludwik}, doi = {10.1016/j.molstruc.2021.130039}, journal-iso = {J MOL STRUCT}, journal = {JOURNAL OF MOLECULAR STRUCTURE}, volume = {1232}, unique-id = {32449040}, issn = {0022-2860}, abstract = {In this study the electrospray ionization mass spectrometry (ESI MS) and quantum chemical modeling methods are employed to examine the interactions of molecules of artemisinin-type drugs and of ascorbic acid (ASC). These biologically significant interactions are relevant to antimalarial therapy, in particular, when artemisinin agents are co-administrated with supporting vitamin/antioxidant preparations or could be affiliated with the patient's food. The formation of stable noncovalent complexes of the artemisinin-type drugs (artemisinin, dihydroartemisinin, alpha-artemether, and beta-arteether) with ascorbic acid molecules in a polar solvent, such as methanol, is revealed by the ESI MS probing of binary systems containing an antimalarial drug and ASC in the 1:1 molar ratio. Also, a peak corresponding to noncovalent [ASC center dot DPPC center dot Na]+ cationized complexes is identified in the spectrum of the mixture of ASC and dipalmitoylphosphatidylcholine (DPPC, membrane phospholipid) with the 1:5 molar ratio. Next, the ternary system containing dihydroartemisinin (DHAn; the assumed active metabolite of the artemisinintype drugs in the human organism), ASC, and DPPC in the 1:1:5 molar ratio is examined. The study reveals a competition between the antimalarial agent and ASC for binding with the DPPC molecules. The existence of the competition is supported by the observation of peaks with similar intensities corresponding to the noncovalent DHAn center dot DPPC and ASC center dot DPPC complexes in the mass spectra. An evidence for the complexation between the antimalarial drug and ASC is also found in the spectra of triple model systems studied. To elucidate the structural and energetic characteristics of the noncovalent complexes observed in the ESI MS experiments, model ab initio calculations of DHAn and ASC complexes and clusters of the drug molecules with the polar phosphatidylcholine head of DPPC are performed using the DFT/B3LYP/aug-cc-pVDZ approach. The results of the model study show the possibility of the noncovalent complexation and of the modulation of the biological activity of artemisin-type agents and of the ascorbic acid when they are co-administered in the therapy. (C) 2021 Elsevier B.V. All rights reserved.}, keywords = {ascorbic acid; dipalmitoylphosphatidylcholine; Electrospray ionization mass spectrometry; Competitive binding; Artemisinin-type agents; DFT/B3LYP/aug-cc-pVDZ calculations}, year = {2021}, eissn = {1872-8014}, orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135} } @article{MTMT:32078602, title = {Claisen‐Schmidt Condensation and Domino Claisen‐Schmidt Condensation ‐ Michael Addition of 16‐Formyl Steroids in the Presence of Switchable Polarity Solvents}, url = {https://m2.mtmt.hu/api/publication/32078602}, author = {Ispán, Dávid and Varga, Bence and Balogh, Szabolcs and Zsirka, Balázs and Gömöry, Ágnes and Skodáné Földes, Rita}, doi = {10.1002/slct.202100886}, journal-iso = {CHEMISTRYSELECT}, journal = {CHEMISTRYSELECT}, volume = {6}, unique-id = {32078602}, issn = {2365-6549}, year = {2021}, eissn = {2365-6549}, pages = {5705-5710}, orcid-numbers = {Ispán, Dávid/0000-0002-6698-0078; Zsirka, Balázs/0000-0001-9788-484X; Gömöry, Ágnes/0000-0001-5216-0135; Skodáné Földes, Rita/0000-0002-9810-1509} } @article{MTMT:31294506, title = {Cysteine specific bioconjugation with benzyl isothiocyanates}, url = {https://m2.mtmt.hu/api/publication/31294506}, author = {Petri, László and Szijj, Péter A. and Kelemen, Ádám and Imre, Timea and Gömöry, Ágnes and Lee, Maximillian T. W. and Hegedűs, Krisztina and Ábrányi-Balogh, Péter and Chudasama, Vijay and Keserű, György Miklós}, doi = {10.1039/D0RA02934C}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {10}, unique-id = {31294506}, issn = {2046-2069}, year = {2020}, eissn = {2046-2069}, pages = {14928-14936}, orcid-numbers = {Gömöry, Ágnes/0000-0001-5216-0135} }