TY - GEN AU - Kupai, Krisztina AU - Németh, T AU - Hausinger, Péter AU - Pósa, Anikó AU - Barzó, P AU - Valkusz, Zsuzsanna TI - Dezmopresszin szerepe sinus petrosus inferiorok szelektív katéterezése Cushing kórban: endokrinológiai és idegsebészeti kooperáció PY - 2023 UR - https://m2.mtmt.hu/api/publication/34132116 ID - 34132116 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Várkonyi, Tamás AU - Pósa, Anikó AU - Pávó, Noémi AU - Pavo, Imre TI - Perspectives on weight control in diabetes – Tirzepatide JF - DIABETES RESEARCH AND CLINICAL PRACTICE J2 - DIABETES RES CLIN PR VL - 202 PY - 2023 PG - 10 SN - 0168-8227 DO - 10.1016/j.diabres.2023.110770 UR - https://m2.mtmt.hu/api/publication/34012313 ID - 34012313 LA - English DB - MTMT ER - TY - JOUR AU - Jókai, Mátyás AU - Torma, Ferenc Gergely AU - McGreevy, Kristen M. AU - Koltai, Erika AU - Bori, Zoltán AU - Bábszky, Gergely AU - Bakonyi, Péter AU - Gombos, Zoltán AU - György, Bernadett AU - Aczél, Dóra Tímea AU - Tóth, László AU - Osváth, Péter AU - Fridvalszki, Marcell Norbert AU - Téglás, Tímea AU - Pósa, Anikó AU - Kujach, Sylwester AU - Olek, Robert AU - Kawamura, Takuji AU - Seki, Yasuhiro AU - Suzuki, Katsuhiko AU - Tanisawa, Kumpei AU - Goto, Sataro AU - Kerepesi, Csaba AU - Boldogh, Istvan AU - Ba, Xueqing AU - Davies, Kelvin J. A. AU - Horvath, Steve AU - Radák, Zsolt TI - DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 5 SP - 2805 EP - 2817 PG - 13 SN - 2509-2715 DO - 10.1007/s11357-023-00826-1 UR - https://m2.mtmt.hu/api/publication/33866054 ID - 33866054 AB - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life. LA - English DB - MTMT ER - TY - JOUR AU - Matusovits, Danica AU - Murlasits, Zsolt AU - Kupai, Krisztina AU - Baráth, Zoltán Lajos AU - Hsu, Linkang AU - Osváth, Péter AU - Szűcs, Miklós AU - Priksz, Dániel AU - Juhász, Béla AU - Radák, Zsolt AU - Várkonyi, Tamás AU - Pávó, Imre AU - Pósa, Anikó TI - Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium: Its Heme-Oxygenase Mediated Role in Cardiovascular Research JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 5 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12051129 UR - https://m2.mtmt.hu/api/publication/33856409 ID - 33856409 N1 - Megosztott első szerzőség AB - (1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-κB, TNF-α and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-κB concentration and TNF-α protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-α, MPO and NF-κB, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1. LA - English DB - MTMT ER - TY - CHAP AU - Pósa, Anikó AU - Szabó, Renáta AU - Börzsei, Denise AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Varga, Csaba ED - Dela, F. ED - Piacentini, M.F. ED - Helge, J.W. ED - Calvo Lluch, Á. ED - Sáez, E. ED - Pareja Blanco, F. ED - Tsolakidis, E. TI - Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat testis T2 - 27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE PB - European College of Sport Science CY - Köln SN - 9783981841459 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33569027 ID - 33569027 LA - English DB - MTMT ER - TY - CHAP AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Gesztelyi, Rudolf AU - Imre, Gálóczi AU - Patrícia, Pálszabó AU - Varga, Csaba AU - Pósa, Anikó ED - Dela, F. ED - Piacentini, M.F. ED - Helge, J.W. ED - Calvo Lluch, Á. ED - Sáez, E. ED - Pareja Blanco, F. ED - Tsolakidis, E. TI - The cardiac effects of nutrition and voluntary physical exercise on the raas and oxidative/inflammatory parameters in spontaneously hypertensive stroke prone rats T2 - 27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE PB - European College of Sport Science CY - Köln SN - 9783981841459 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33569018 ID - 33569018 LA - English DB - MTMT ER - TY - CHAP AU - Börzsei, Denise AU - Szabó, Renáta AU - Pálszabó, Andrea AU - Priksz, Dániel AU - Varga, Csaba AU - Pósa, Anikó ED - Dela, F. ED - Piacentini, M.F. ED - Helge, J.W. ED - Calvo Lluch, Á. ED - Sáez, E. ED - Pareja Blanco, F. ED - Tsolakidis, E. TI - Exercise-mitigated, gender-based differences in aging rat heart T2 - 27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE PB - European College of Sport Science CY - Köln SN - 9783981841459 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568999 ID - 33568999 LA - English DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Börzsei, Denise AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Nadin, Zelma Lesi AU - Szász, András AU - Varga, Csaba AU - Pósa, Anikó TI - The cardiac effects of nutrition and voluntary physical exercise on the raas and oxidative/inflammatory parameters in spontaneously hypertensive stroke prone rats PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568976 ID - 33568976 LA - English DB - MTMT ER - TY - GEN AU - Pósa, Anikó AU - Szabó, Renáta AU - Börzsei, Denise AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Nadin, Zelma Lesi AU - Szász, András AU - Varga, Csaba TI - Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat model PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568963 ID - 33568963 LA - English DB - MTMT ER - TY - GEN AU - Börzsei, Denise AU - Szabó, Renáta AU - Andrea, Pálszabó AU - Patrícia, Pálszabó AU - Nadin, Zelma Lesi AU - Szász, András AU - Varga, Csaba AU - Pósa, Anikó TI - Cardiometabolic effects mediated by endocannabinoids in estrogen-depleted rat model PY - 2022 UR - https://m2.mtmt.hu/api/publication/33568950 ID - 33568950 LA - English DB - MTMT ER -