@misc{MTMT:34132116, title = {Dezmopresszin szerepe sinus petrosus inferiorok szelektív katéterezése Cushing kórban: endokrinológiai és idegsebészeti kooperáció}, url = {https://m2.mtmt.hu/api/publication/34132116}, author = {Kupai, Krisztina and Németh, T and Hausinger, Péter and Pósa, Anikó and Barzó, P and Valkusz, Zsuzsanna}, unique-id = {34132116}, year = {2023}, orcid-numbers = {Kupai, Krisztina/0000-0002-0644-1718; Pósa, Anikó/0000-0003-2167-2888; Valkusz, Zsuzsanna/0000-0003-1928-6160} } @article{MTMT:34012313, title = {Perspectives on weight control in diabetes – Tirzepatide}, url = {https://m2.mtmt.hu/api/publication/34012313}, author = {Várkonyi, Tamás and Pósa, Anikó and Pávó, Noémi and Pavo, Imre}, doi = {10.1016/j.diabres.2023.110770}, journal-iso = {DIABETES RES CLIN PR}, journal = {DIABETES RESEARCH AND CLINICAL PRACTICE}, volume = {202}, unique-id = {34012313}, issn = {0168-8227}, year = {2023}, eissn = {1872-8227}, orcid-numbers = {Várkonyi, Tamás/0000-0001-6833-3563; Pósa, Anikó/0000-0003-2167-2888} } @article{MTMT:33866054, title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation}, url = {https://m2.mtmt.hu/api/publication/33866054}, author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt}, doi = {10.1007/s11357-023-00826-1}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {45}, unique-id = {33866054}, issn = {2509-2715}, abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.}, year = {2023}, eissn = {2509-2723}, pages = {2805-2817}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:33856409, title = {Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium: Its Heme-Oxygenase Mediated Role in Cardiovascular Research}, url = {https://m2.mtmt.hu/api/publication/33856409}, author = {Matusovits, Danica and Murlasits, Zsolt and Kupai, Krisztina and Baráth, Zoltán Lajos and Hsu, Linkang and Osváth, Péter and Szűcs, Miklós and Priksz, Dániel and Juhász, Béla and Radák, Zsolt and Várkonyi, Tamás and Pávó, Imre and Pósa, Anikó}, doi = {10.3390/antiox12051129}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {12}, unique-id = {33856409}, abstract = {(1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-κB, TNF-α and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-κB concentration and TNF-α protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-α, MPO and NF-κB, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1.}, year = {2023}, eissn = {2076-3921}, orcid-numbers = {Murlasits, Zsolt/0000-0003-4101-3417; Kupai, Krisztina/0000-0002-0644-1718; Baráth, Zoltán Lajos/0000-0003-0636-6313; Hsu, Linkang/0009-0001-2220-1562; Szűcs, Miklós/0000-0002-8606-996X; Radák, Zsolt/0000-0003-1297-6804; Várkonyi, Tamás/0000-0001-6833-3563; Pósa, Anikó/0000-0003-2167-2888} } @{MTMT:33569027, title = {Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat testis}, url = {https://m2.mtmt.hu/api/publication/33569027}, author = {Pósa, Anikó and Szabó, Renáta and Börzsei, Denise and Andrea, Pálszabó and Patrícia, Pálszabó and Varga, Csaba}, booktitle = {27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE}, unique-id = {33569027}, year = {2022}, orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X} } @{MTMT:33569018, title = {The cardiac effects of nutrition and voluntary physical exercise on the raas and oxidative/inflammatory parameters in spontaneously hypertensive stroke prone rats}, url = {https://m2.mtmt.hu/api/publication/33569018}, author = {Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Gesztelyi, Rudolf and Imre, Gálóczi and Patrícia, Pálszabó and Varga, Csaba and Pósa, Anikó}, booktitle = {27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE}, unique-id = {33569018}, year = {2022}, orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X; Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888} } @{MTMT:33568999, title = {Exercise-mitigated, gender-based differences in aging rat heart}, url = {https://m2.mtmt.hu/api/publication/33568999}, author = {Börzsei, Denise and Szabó, Renáta and Pálszabó, Andrea and Priksz, Dániel and Varga, Csaba and Pósa, Anikó}, booktitle = {27th Annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE}, unique-id = {33568999}, year = {2022}, orcid-numbers = {Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888} } @misc{MTMT:33568976, title = {The cardiac effects of nutrition and voluntary physical exercise on the raas and oxidative/inflammatory parameters in spontaneously hypertensive stroke prone rats}, url = {https://m2.mtmt.hu/api/publication/33568976}, author = {Szabó, Renáta and Börzsei, Denise and Andrea, Pálszabó and Patrícia, Pálszabó and Nadin, Zelma Lesi and Szász, András and Varga, Csaba and Pósa, Anikó}, unique-id = {33568976}, year = {2022}, orcid-numbers = {Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888} } @misc{MTMT:33568963, title = {Andrological effects of sport: moderate-intensity swimming protects against isoproterenol-induced oxidative stress in a rat model}, url = {https://m2.mtmt.hu/api/publication/33568963}, author = {Pósa, Anikó and Szabó, Renáta and Börzsei, Denise and Andrea, Pálszabó and Patrícia, Pálszabó and Nadin, Zelma Lesi and Szász, András and Varga, Csaba}, unique-id = {33568963}, year = {2022}, orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X} } @misc{MTMT:33568950, title = {Cardiometabolic effects mediated by endocannabinoids in estrogen-depleted rat model}, url = {https://m2.mtmt.hu/api/publication/33568950}, author = {Börzsei, Denise and Szabó, Renáta and Andrea, Pálszabó and Patrícia, Pálszabó and Nadin, Zelma Lesi and Szász, András and Varga, Csaba and Pósa, Anikó}, unique-id = {33568950}, year = {2022}, orcid-numbers = {Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888} }