TY - JOUR AU - Ezer, Erzsébet AU - Schrick, Diana Zsuzsanna AU - Tőkés-Füzesi, Margit AU - Papp, István AU - Réger, Barbara AU - Molnár, Abigél AU - Ábrahám, Hajnalka AU - Koller, Ákos AU - Hársfalvi, Jolán AU - Kellermayer, Miklós AU - Molnár, Tihamér TI - Gravity sedimentation reveals functionally and morphologically different platelets in human blood JF - PLATELETS J2 - PLATELETS VL - 35 PY - 2024 IS - 1 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2023.2298341 UR - https://m2.mtmt.hu/api/publication/34493390 ID - 34493390 LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Tabák, Ádám AU - Ádány, Róza AU - Purebl, György AU - Kaposvári, Csilla AU - Fazekas-Pongor, Vince AU - Csípő, Tamás AU - Szarvas, Zsófia AU - Horváth, Krisztián AU - Mukli, Péter AU - Balog, Piroska AU - Bódizs, Róbert AU - Ujma, Przemyslaw Péter AU - Stauder, Adrienne AU - Belsky, Daniel W. AU - Kovács, Illés AU - Yabluchanskiy, Andriy AU - Maier, Andrea B. AU - Moizs, Mariann AU - Östlin, Piroska AU - Yon, Yongjie AU - Varga, Péter AU - Vokó, Zoltán AU - Papp, Magor Csongor AU - Takács, István AU - Vásárhelyi, Barna AU - Torzsa, Péter AU - Ferdinandy, Péter AU - Csiszar, Anna AU - Benyó, Zoltán AU - Szabó, Attila AU - Bednárikné Dörnyei, Gabriella AU - Kivimäki, Mika AU - Kellermayer, Miklós AU - Merkely, Béla Péter TI - The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 1 SP - 191 EP - 218 PG - 28 SN - 2509-2715 DO - 10.1007/s11357-023-01018-7 UR - https://m2.mtmt.hu/api/publication/34425939 ID - 34425939 N1 - International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary UCL Brain Sciences, University College London, London, United Kingdom Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary Robert N. Butler Columbia Aging Center, Columbia University, New York, NY, United States Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Ophthalmology, Weill Cornell Medical College, New York City, NY, United States Department of Clinical Ophthalmology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Centre for Healthy Longevity, National University Health System, Singapore, Singapore Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, Netherlands Ministry of Interior of Hungary, Budapest, Hungary WHO Regional Office for Europe, Copenhagen, Denmark Clinical Center, Semmelweis University, Budapest, Hungary Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Pediatrics and Nephrology Research Group, Semmelweis University, Budapest, Hungary Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Cited By :1 Export Date: 29 February 2024 Correspondence Address: Ungvari, Z.; International Training Program in Geroscience/Healthy Aging Program, Hungary; email: Zoltan-Ungvari@ouhsc.edu Correspondence Address: Adany, R.; International Training Program in Geroscience/Healthy Aging Program, Hungary AB - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions. LA - English DB - MTMT ER - TY - JOUR AU - Kellermayer, Dalma Lucia AU - Tordai, Hedvig AU - Kiss, Balázs AU - Török, György AU - Péter, Dániel M. AU - Sayour, Alex Ali AU - Pólos, Miklós AU - Hartyánszky, István AU - Szilveszter, Bálint AU - Labeit, Siegfried AU - Gángó, Ambrus AU - Bedics, Gábor AU - Bödör, Csaba AU - Radovits, Tamás AU - Merkely, Béla Péter AU - Kellermayer, Miklós TI - Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere JF - JOURNAL OF CLINICAL INVESTIGATION J2 - J CLIN INVEST VL - 134 PY - 2024 IS - 2 PG - 13 SN - 0021-9738 DO - 10.1172/JCI169753 UR - https://m2.mtmt.hu/api/publication/34395421 ID - 34395421 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Bálint AU - Kellermayer, Miklós TI - Packing up the genome JF - ELIFE J2 - ELIFE VL - 12 PY - 2023 PG - 3 SN - 2050-084X DO - 10.7554/eLife.94128 UR - https://m2.mtmt.hu/api/publication/34452952 ID - 34452952 AB - Nucleotide and force-dependent mechanisms control how the viral genome of lambda bacteriophage is inserted into capsids. LA - English DB - MTMT ER - TY - JOUR AU - Nonn, A. AU - Kiss, Bálint AU - Pezeshkian, W. AU - Tancogne-Dejean, T. AU - Cerrone, A. AU - Kellermayer, Miklós AU - Bai, Y. AU - Li, W. AU - Wierzbicki, T. TI - Inferring mechanical properties of the SARS-CoV-2 virus particle with nano-indentation tests and numerical simulations JF - JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS J2 - J MECH BEHAV BIOMED VL - 148 PY - 2023 PG - 15 SN - 1751-6161 DO - 10.1016/j.jmbbm.2023.106153 UR - https://m2.mtmt.hu/api/publication/34231576 ID - 34231576 LA - English DB - MTMT ER - TY - JOUR AU - Bányász, István AU - Rajta, István AU - Havránek, V. AU - Mackova, A. AU - Laki, András József AU - Kellermayer, Miklós AU - Szittner, Zoltán AU - Kurunczi, Sándor AU - Novák, Szabolcs AU - Székács, Inna AU - Horváth, Róbert AU - Fried, Miklós AU - Nagy, Gyula TI - Design, fabrication, and characterization of picowell arrays on cyclic olefin copolymer surfaces generated with a 10.5 MeV N4+ ion microbeam JF - APPLIED PHYSICS LETTERS J2 - APPL PHYS LETT VL - 123 PY - 2023 IS - 5 PG - 6 SN - 0003-6951 DO - 10.1063/5.0155681 UR - https://m2.mtmt.hu/api/publication/34086354 ID - 34086354 AB - Handling of picoliter-to-nanoliter-scale volumes and objects has increasing importance in life sciences. This is the volume scale of cell extractions and individual living cells. Here, we introduce a method of generating a picoliter-scale device by direct writing of picowell arrays on a ZEONOR™ copolymer surface with high-energy medium-mass ion microbeam. Arrays of various microstructures were written in the sample using a microbeam of 10.5 MeV N4+ ions at various implanted ion fluences. The best array was obtained by implantation of annuli of 10 and 11 μm of inner and outer diameters with a fluence of 7.8 × 1012 ions/cm2. LA - English DB - MTMT ER - TY - JOUR AU - Szebeni, János AU - Kiss, Bálint AU - Bozó, Tamás AU - Turjeman, Keren AU - Levi-Kalisman, Yael AU - Barenholz, Yechezkel AU - Kellermayer, Miklós TI - Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid Complexes JF - ACS NANO J2 - ACS NANO VL - 17 PY - 2023 IS - 14 SP - 13147 EP - 13157 PG - 11 SN - 1936-0851 DO - 10.1021/acsnano.2c11904 UR - https://m2.mtmt.hu/api/publication/34058342 ID - 34058342 N1 - Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University, Budapest, 1089, Hungary Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health Sciences, Miskolc University, Miskolc, 2880, Hungary School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, 16419, South Korea Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, 1094, Hungary Hungarian Centre of Excellence for Molecular Medicine (HCEMM), In Vivo Imaging Advanced Core Facility, Budapest, 1094, Hungary ELKH-SE Biophysical Virology Research Group, Budapest, 1094, Hungary The Laboratory of Membrane and Liposome Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, 9112102, Israel Institute of Life Sciences and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 9190401, Israel Export Date: 19 October 2023 Correspondence Address: Szebeni, J.; Nanomedicine Research and Education Center, Hungary; email: jszebeni2@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Bozó, Tamás AU - Agócs, Gergely AU - Kellermayer, Miklós AU - Antal, István TI - Determination of the Main Phase Transition Temperature of Phospholipids by Oscillatory Rheology JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 13 PG - 13 SN - 1420-3049 DO - 10.3390/molecules28135125 UR - https://m2.mtmt.hu/api/publication/34041182 ID - 34041182 AB - Knowledge of the physical and chemical properties of phospholipids, such as phase transition temperatures (Tc), is of great importance in order to reveal the functionalities of biological and artificial membranes. Our research group developed an oscillatory rheological method for the simple and rapid determination of phase transition temperatures (Tc). The phospholipids constructing the membranes undergo conformational changes at their Tc, which cause alterations of viscoelastic properties of the molecules. The oscillatory technique recommended by us proved to be appropriate to reveal the altered molecular properties of phospholipids as tracking the slightest changes in the viscoelasticity. Our study demonstrates the abrupt changes in rheological properties at Tc for the following phospholipids: 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine (DMPC), 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine (DPPC), and 1,2-Distearoyl-sn-glycero-3-Phosphocholine (DSPC), proving that the applied methodology is adequate for determining the Tc of phospholipids. LA - English DB - MTMT ER - TY - CONF AU - Seidl, Dániel AU - Antal, Violetta AU - Schay, Gusztáv AU - Aurélia, Bertholet-Thomas AU - Török, György AU - Geraldine, Mollet AU - Kellermayer, Miklós AU - Corinne, Antignac AU - Tory, Kálmán TI - Cellular basis of the dominant inheritance in NPHS2- associated glomerulopathy T2 - 31st Meeting of the European Society of Paediatric Clinical Research (ESPCR 2023) PY - 2023 SP - 34 EP - 34 PG - 1 UR - https://m2.mtmt.hu/api/publication/33871356 ID - 33871356 LA - English DB - MTMT ER - TY - JOUR AU - Sulea, Cristina Maria AU - Mártonfalvi, Zsolt AU - Csányi, Mária Csilla AU - Haluszka, Dóra AU - Pólos, Miklós AU - Ágg, Bence AU - Stengl, Roland AU - Benke, Kálmán AU - Szabolcs, Zoltán AU - Kellermayer, Miklós TI - Nanoscale Structural Comparison of Fibrillin-1 Microfibrils Isolated from Marfan and Non-Marfan Syndrome Human Aorta JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 8 PG - 13 SN - 1661-6596 DO - 10.3390/ijms24087561 UR - https://m2.mtmt.hu/api/publication/33771404 ID - 33771404 N1 - Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [K135360, TKP2021-EGA-23]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development, and Innovation Fund [UNKP-22-3-I-SE-49]; European Union [RRF-2.3.1-21-2022-00003] Funding text: This research was supported by grants from the Hungarian National Research, Development and Innovation Office (K135360 to M.S.Z.K. and project TKP2021-EGA-23) and the New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development, and Innovation Fund (UNKP-22-3-I-SE-49 to C.M.?.). Project no. RRF-2.3.1-21-2022-00003 (National Cardiovascular Laboratory) has been implemented with the support provided by the European Union. AB - Fibrillin-1 microfibrils are essential elements of the extracellular matrix serving as a scaffold for the deposition of elastin and endowing connective tissues with tensile strength and elasticity. Mutations in the fibrillin-1 gene (FBN1) are linked to Marfan syndrome (MFS), a systemic connective tissue disorder that, besides other heterogeneous symptoms, usually manifests in life-threatening aortic complications. The aortic involvement may be explained by a dysregulation of microfibrillar function and, conceivably, alterations in the microfibrils’ supramolecular structure. Here, we present a nanoscale structural characterization of fibrillin-1 microfibrils isolated from two human aortic samples with different FBN1 gene mutations by using atomic force microscopy, and their comparison with microfibrillar assemblies purified from four non-MFS human aortic samples. Fibrillin-1 microfibrils displayed a characteristic “beads-on-a-string” appearance. The microfibrillar assemblies were investigated for bead geometry (height, length, and width), interbead region height, and periodicity. MFS fibrillin-1 microfibrils had a slightly higher mean bead height, but the bead length and width, as well as the interbead height, were significantly smaller in the MFS group. The mean periodicity varied around 50–52 nm among samples. The data suggest an overall thinner and presumably more frail structure for the MFS fibrillin-1 microfibrils, which may play a role in the development of MFS-related aortic symptomatology. LA - English DB - MTMT ER -