@article{MTMT:34493390, title = {Gravity sedimentation reveals functionally and morphologically different platelets in human blood}, url = {https://m2.mtmt.hu/api/publication/34493390}, author = {Ezer, Erzsébet and Schrick, Diana Zsuzsanna and Tőkés-Füzesi, Margit and Papp, István and Réger, Barbara and Molnár, Abigél and Ábrahám, Hajnalka and Koller, Ákos and Hársfalvi, Jolán and Kellermayer, Miklós and Molnár, Tihamér}, doi = {10.1080/09537104.2023.2298341}, journal-iso = {PLATELETS}, journal = {PLATELETS}, volume = {35}, unique-id = {34493390}, issn = {0953-7104}, year = {2024}, eissn = {1369-1635}, orcid-numbers = {Koller, Ákos/0000-0003-3256-8701; Hársfalvi, Jolán/0000-0001-9940-4846; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34425939, title = {The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging}, url = {https://m2.mtmt.hu/api/publication/34425939}, author = {Ungvári, Zoltán István and Tabák, Ádám and Ádány, Róza and Purebl, György and Kaposvári, Csilla and Fazekas-Pongor, Vince and Csípő, Tamás and Szarvas, Zsófia and Horváth, Krisztián and Mukli, Péter and Balog, Piroska and Bódizs, Róbert and Ujma, Przemyslaw Péter and Stauder, Adrienne and Belsky, Daniel W. and Kovács, Illés and Yabluchanskiy, Andriy and Maier, Andrea B. and Moizs, Mariann and Östlin, Piroska and Yon, Yongjie and Varga, Péter and Vokó, Zoltán and Papp, Magor Csongor and Takács, István and Vásárhelyi, Barna and Torzsa, Péter and Ferdinandy, Péter and Csiszar, Anna and Benyó, Zoltán and Szabó, Attila and Bednárikné Dörnyei, Gabriella and Kivimäki, Mika and Kellermayer, Miklós and Merkely, Béla Péter}, doi = {10.1007/s11357-023-01018-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34425939}, issn = {2509-2715}, abstract = {The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.}, year = {2024}, eissn = {2509-2723}, pages = {191-218}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tabák, Ádám/0000-0002-6234-3936; Purebl, György/0000-0002-9750-2001; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Mukli, Péter/0000-0003-4355-8103; Balog, Piroska/0000-0001-5025-8649; Bódizs, Róbert/0000-0001-5341-060X; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Stauder, Adrienne/0000-0002-0358-3657; Kovács, Illés/0000-0001-5763-0482; Vokó, Zoltán/0000-0002-1004-1848; Takács, István/0000-0002-7810-4833; Vásárhelyi, Barna/0000-0003-0055-7346; Torzsa, Péter/0000-0002-8148-4961; Ferdinandy, Péter/0000-0002-6424-6806; Benyó, Zoltán/0000-0001-6015-0359; Szabó, Attila/0000-0001-7321-9861; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Kellermayer, Miklós/0000-0002-5553-6553; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:34395421, title = {Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere}, url = {https://m2.mtmt.hu/api/publication/34395421}, author = {Kellermayer, Dalma Lucia and Tordai, Hedvig and Kiss, Balázs and Török, György and Péter, Dániel M. and Sayour, Alex Ali and Pólos, Miklós and Hartyánszky, István and Szilveszter, Bálint and Labeit, Siegfried and Gángó, Ambrus and Bedics, Gábor and Bödör, Csaba and Radovits, Tamás and Merkely, Béla Péter and Kellermayer, Miklós}, doi = {10.1172/JCI169753}, journal-iso = {J CLIN INVEST}, journal = {JOURNAL OF CLINICAL INVESTIGATION}, volume = {134}, unique-id = {34395421}, issn = {0021-9738}, year = {2024}, eissn = {1558-8238}, orcid-numbers = {Kellermayer, Dalma Lucia/0000-0003-0398-0801; Tordai, Hedvig/0000-0002-0875-5569; Kiss, Balázs/0000-0002-2347-5928; Török, György/0000-0001-7616-5782; Sayour, Alex Ali/0000-0001-7728-4775; Hartyánszky, István/0000-0003-1909-6500; Szilveszter, Bálint/0000-0003-1530-4288; Labeit, Siegfried/0000-0002-9009-210X; Gángó, Ambrus/0000-0001-9127-5015; Bedics, Gábor/0000-0003-4628-2384; Bödör, Csaba/0000-0002-0729-692X; Merkely, Béla Péter/0000-0001-6514-0723; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34452952, title = {Packing up the genome}, url = {https://m2.mtmt.hu/api/publication/34452952}, author = {Kiss, Bálint and Kellermayer, Miklós}, doi = {10.7554/eLife.94128}, journal-iso = {ELIFE}, journal = {ELIFE}, volume = {12}, unique-id = {34452952}, issn = {2050-084X}, abstract = {Nucleotide and force-dependent mechanisms control how the viral genome of lambda bacteriophage is inserted into capsids.}, keywords = {VIRUSES; bacteriophage; Structural biology; genome packaging; packaging motor}, year = {2023}, eissn = {2050-084X}, orcid-numbers = {Kiss, Bálint/0000-0002-1595-0426; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34231576, title = {Inferring mechanical properties of the SARS-CoV-2 virus particle with nano-indentation tests and numerical simulations}, url = {https://m2.mtmt.hu/api/publication/34231576}, author = {Nonn, A. and Kiss, Bálint and Pezeshkian, W. and Tancogne-Dejean, T. and Cerrone, A. and Kellermayer, Miklós and Bai, Y. and Li, W. and Wierzbicki, T.}, doi = {10.1016/j.jmbbm.2023.106153}, journal-iso = {J MECH BEHAV BIOMED}, journal = {JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS}, volume = {148}, unique-id = {34231576}, issn = {1751-6161}, year = {2023}, eissn = {1878-0180}, orcid-numbers = {Kiss, Bálint/0000-0002-1595-0426; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34086354, title = {Design, fabrication, and characterization of picowell arrays on cyclic olefin copolymer surfaces generated with a 10.5 MeV N4+ ion microbeam}, url = {https://m2.mtmt.hu/api/publication/34086354}, author = {Bányász, István and Rajta, István and Havránek, V. and Mackova, A. and Laki, András József and Kellermayer, Miklós and Szittner, Zoltán and Kurunczi, Sándor and Novák, Szabolcs and Székács, Inna and Horváth, Róbert and Fried, Miklós and Nagy, Gyula}, doi = {10.1063/5.0155681}, journal-iso = {APPL PHYS LETT}, journal = {APPLIED PHYSICS LETTERS}, volume = {123}, unique-id = {34086354}, issn = {0003-6951}, abstract = {Handling of picoliter-to-nanoliter-scale volumes and objects has increasing importance in life sciences. This is the volume scale of cell extractions and individual living cells. Here, we introduce a method of generating a picoliter-scale device by direct writing of picowell arrays on a ZEONOR™ copolymer surface with high-energy medium-mass ion microbeam. Arrays of various microstructures were written in the sample using a microbeam of 10.5 MeV N4+ ions at various implanted ion fluences. The best array was obtained by implantation of annuli of 10 and 11 μm of inner and outer diameters with a fluence of 7.8 × 1012 ions/cm2.}, year = {2023}, eissn = {1077-3118}, orcid-numbers = {Havránek, V./0009-0002-8434-5577; Mackova, A./0000-0003-3008-2935; Kellermayer, Miklós/0000-0002-5553-6553; Kurunczi, Sándor/0000-0002-6567-5231; Novák, Szabolcs/0000-0003-3502-0522; Horváth, Róbert/0000-0001-8617-2302; Fried, Miklós/0000-0002-9194-735X; Nagy, Gyula/0000-0003-3172-5736} } @article{MTMT:34058342, title = {Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid Complexes}, url = {https://m2.mtmt.hu/api/publication/34058342}, author = {Szebeni, János and Kiss, Bálint and Bozó, Tamás and Turjeman, Keren and Levi-Kalisman, Yael and Barenholz, Yechezkel and Kellermayer, Miklós}, doi = {10.1021/acsnano.2c11904}, journal-iso = {ACS NANO}, journal = {ACS NANO}, volume = {17}, unique-id = {34058342}, issn = {1936-0851}, year = {2023}, eissn = {1936-086X}, pages = {13147-13157}, orcid-numbers = {Kiss, Bálint/0000-0002-1595-0426; Bozó, Tamás/0000-0002-2643-0661; Levi-Kalisman, Yael/0000-0002-2764-2738; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34041182, title = {Determination of the Main Phase Transition Temperature of Phospholipids by Oscillatory Rheology}, url = {https://m2.mtmt.hu/api/publication/34041182}, author = {Budai, Lívia and Budai, Marianna and Bozó, Tamás and Agócs, Gergely and Kellermayer, Miklós and Antal, István}, doi = {10.3390/molecules28135125}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34041182}, issn = {1420-3049}, abstract = {Knowledge of the physical and chemical properties of phospholipids, such as phase transition temperatures (Tc), is of great importance in order to reveal the functionalities of biological and artificial membranes. Our research group developed an oscillatory rheological method for the simple and rapid determination of phase transition temperatures (Tc). The phospholipids constructing the membranes undergo conformational changes at their Tc, which cause alterations of viscoelastic properties of the molecules. The oscillatory technique recommended by us proved to be appropriate to reveal the altered molecular properties of phospholipids as tracking the slightest changes in the viscoelasticity. Our study demonstrates the abrupt changes in rheological properties at Tc for the following phospholipids: 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine (DMPC), 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine (DPPC), and 1,2-Distearoyl-sn-glycero-3-Phosphocholine (DSPC), proving that the applied methodology is adequate for determining the Tc of phospholipids.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Budai, Lívia/0000-0002-6720-5989; Budai, Marianna/0000-0003-4947-9924; Bozó, Tamás/0000-0002-2643-0661; Agócs, Gergely/0000-0003-2489-3790; Kellermayer, Miklós/0000-0002-5553-6553; Antal, István/0000-0002-5434-201X} } @CONFERENCE{MTMT:33871356, title = {Cellular basis of the dominant inheritance in NPHS2- associated glomerulopathy}, url = {https://m2.mtmt.hu/api/publication/33871356}, author = {Seidl, Dániel and Antal, Violetta and Schay, Gusztáv and Aurélia, Bertholet-Thomas and Török, György and Geraldine, Mollet and Kellermayer, Miklós and Corinne, Antignac and Tory, Kálmán}, booktitle = {31st Meeting of the European Society of Paediatric Clinical Research (ESPCR 2023)}, unique-id = {33871356}, year = {2023}, pages = {34-34}, orcid-numbers = {Seidl, Dániel/0000-0002-3974-159X; Antal, Violetta/0000-0001-8658-6329; Schay, Gusztáv/0000-0001-9512-3203; Török, György/0000-0001-7616-5782; Kellermayer, Miklós/0000-0002-5553-6553; Tory, Kálmán/0000-0002-0316-6212} } @article{MTMT:33771404, title = {Nanoscale Structural Comparison of Fibrillin-1 Microfibrils Isolated from Marfan and Non-Marfan Syndrome Human Aorta}, url = {https://m2.mtmt.hu/api/publication/33771404}, author = {Sulea, Cristina Maria and Mártonfalvi, Zsolt and Csányi, Mária Csilla and Haluszka, Dóra and Pólos, Miklós and Ágg, Bence and Stengl, Roland and Benke, Kálmán and Szabolcs, Zoltán and Kellermayer, Miklós}, doi = {10.3390/ijms24087561}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33771404}, issn = {1661-6596}, abstract = {Fibrillin-1 microfibrils are essential elements of the extracellular matrix serving as a scaffold for the deposition of elastin and endowing connective tissues with tensile strength and elasticity. Mutations in the fibrillin-1 gene (FBN1) are linked to Marfan syndrome (MFS), a systemic connective tissue disorder that, besides other heterogeneous symptoms, usually manifests in life-threatening aortic complications. The aortic involvement may be explained by a dysregulation of microfibrillar function and, conceivably, alterations in the microfibrils’ supramolecular structure. Here, we present a nanoscale structural characterization of fibrillin-1 microfibrils isolated from two human aortic samples with different FBN1 gene mutations by using atomic force microscopy, and their comparison with microfibrillar assemblies purified from four non-MFS human aortic samples. Fibrillin-1 microfibrils displayed a characteristic “beads-on-a-string” appearance. The microfibrillar assemblies were investigated for bead geometry (height, length, and width), interbead region height, and periodicity. MFS fibrillin-1 microfibrils had a slightly higher mean bead height, but the bead length and width, as well as the interbead height, were significantly smaller in the MFS group. The mean periodicity varied around 50–52 nm among samples. The data suggest an overall thinner and presumably more frail structure for the MFS fibrillin-1 microfibrils, which may play a role in the development of MFS-related aortic symptomatology.}, keywords = {human; Aorta; atomic force microscopy; Marfan syndrome; Fibrillin microfibrils}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Sulea, Cristina Maria/0000-0001-5622-9136; Mártonfalvi, Zsolt/0000-0001-7820-8109; Csányi, Mária Csilla/0000-0002-7777-4229; Haluszka, Dóra/0000-0003-3760-2016; Ágg, Bence/0000-0002-6492-0426; Stengl, Roland/0000-0002-6695-9877; Benke, Kálmán/0000-0001-7885-2543; Kellermayer, Miklós/0000-0002-5553-6553} }