@{MTMT:34529069, title = {Hozzáadott koleszterint tartalmazó takarmány fogyasztásának hatása a szervezet antioxidáns rendszerére NOX4 génkiütött nyulakban}, url = {https://m2.mtmt.hu/api/publication/34529069}, author = {Major, Fanni and Pintér, Tímea and Erdélyi, Márta and Balogh, Krisztián Milán and Petheő, Gábor L. and Geiszt, Miklós and Bodrogi, Lilla}, booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa}, unique-id = {34529069}, year = {2023}, pages = {42-43}, orcid-numbers = {Petheő, Gábor L./0000-0002-1773-4129; Bodrogi, Lilla/0000-0003-4696-9282} } @{MTMT:34528981, title = {Genomszerkesztéssel előállított nyúlmodellek a szabadgyökkutatásban}, url = {https://m2.mtmt.hu/api/publication/34528981}, author = {Pintér, Tímea and Major, Fanni and Urbán, Martin and Erdélyi, Márta and Balogh, Krisztián Milán and Skoda, Gabriella and Kerekes, Andrea and Lipták, Nándor and Petheő, Gábor L. and Szeles, Zsolt and Gócza, Elen and Hiripi, László and Hoffmann, Orsolya Ivett and Szőke, Zsuzsanna and Geiszt, Miklós and Bodrogi, Lilla}, booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa}, unique-id = {34528981}, year = {2023}, pages = {51-52}, orcid-numbers = {Lipták, Nándor/0000-0002-9406-1482; Petheő, Gábor L./0000-0002-1773-4129; Bodrogi, Lilla/0000-0003-4696-9282} } @article{MTMT:34213267, title = {Autotaxin–lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling}, url = {https://m2.mtmt.hu/api/publication/34213267}, author = {Janovicz, Anna and Majer, Aliz and Kosztelnik, Mónika and Geiszt, Miklós and Chun, Jerold and Ishii, Satoshi and Tigyi, Gabor and Benyó, Zoltán and Ruisanchez, Éva}, doi = {10.1177/15353702231199081}, journal-iso = {EXP BIOL MED}, journal = {EXPERIMENTAL BIOLOGY AND MEDICINE}, volume = {248}, unique-id = {34213267}, issn = {1535-3702}, abstract = {Lysophosphatidylcholine (LPC) is a bioactive lipid that has been shown to attenuate endothelium-dependent vasorelaxation contributing to endothelial dysfunction; however, the underlying mechanisms are not well understood. In this study, we investigated the molecular mechanisms involved in the development of LPC-evoked impairment of endothelium-dependent vasorelaxation. In aortic rings isolated from wild-type (WT) mice, a 20-min exposure to LPC significantly reduced the acetylcholine chloride (ACh)–induced vasorelaxation indicating the impairment of normal endothelial function. Interestingly, pharmacological inhibition of autotaxin (ATX) by GLPG1690 partially reversed the endothelial dysfunction, suggesting that lysophosphatidic acid (LPA) derived from LPC may be involved in the effect. Therefore, the effect of LPC was also tested in aortic rings isolated from different LPA receptor knock-out (KO) mice. LPC evoked a marked reduction in ACh-dependent vasorelaxation in Lpar1, Lpar2, and Lpar4 KO, but its effect was significantly attenuated in Lpar5 KO vessels. Furthermore, addition of superoxide dismutase reduced the LPC-induced endothelial dysfunction in WT but not in the Lpar5 KO mice. In addition, LPC increased H 2 O 2 release from WT vessels, which was significantly reduced in Lpar5 KO vessels. Our findings indicate that the ATX–LPA–LPA 5 receptor axis is involved in the development of LPC-induced impairment of endothelium-dependent vasorelaxation via LPA 5 receptor–mediated reactive oxygen species production. Taken together, in this study, we identified a new pathway contributing to the development of LPC-induced endothelial dysfunction.}, year = {2023}, eissn = {1535-3699}, pages = {1887-1894}, orcid-numbers = {Janovicz, Anna/0000-0003-3383-5576; Kosztelnik, Mónika/0000-0001-6735-3597; Tigyi, Gabor/0000-0001-5371-171X; Benyó, Zoltán/0000-0001-6015-0359; Ruisanchez, Éva/0000-0001-7779-226X} } @article{MTMT:34198665, title = {A novel monoclonal antibody reveals the enrichment of NADPH oxidase 5 in human splenic endothelial cells}, url = {https://m2.mtmt.hu/api/publication/34198665}, author = {Szeles, Zsolt and Petheő, Gábor L. and Szikora, Bence and Kacskovics, Imre and Geiszt, Miklós}, doi = {10.1038/s41598-023-44018-5}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34198665}, issn = {2045-2322}, abstract = {Members of the NOX/DUOX family of NADPH oxidases are responsible for regulated ROS production in diverse cells and tissues. Detection of NOX/DUOX proteins at the protein level remains an important challenge in the field. Here we report the development and characterization of a novel anti-NOX5 monoclonal antibody, which recognizes the human NOX5 protein in both Western blot, immunocytochemistry, and histochemistry applications. With the help of the antibody we could successfully detect both heterologously and endogenously expressed NOX5 in mammalian cells. Furthermore, we could also detect NOX5 protein in the human spleen, testis, and ovary. Immunohistochemical studies on human testis revealed that NOX5 localized to spermatogenic cells. This expression pattern was also supported by the result of in silico analysis of single-cell RNA sequencing data that indicated that NOX5 protein is present in developing spermatids and spermatocytes. Mature spermatozoa, however, did not contain detectable NOX5. In the human ovary, both immunostaining and single-cell RNA sequencing suggest that NOX5 is expressed in interstitial fibroblasts and theca cells. We also analyzed vascular cells for the presence of NOX5 and we found that NOX5 expression is a fairly specific feature of splenic endothelial cells.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Petheő, Gábor L./0000-0002-1773-4129; Szikora, Bence/0000-0002-0766-5684; Kacskovics, Imre/0000-0002-0402-3862} } @{MTMT:34157366, title = {NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut Microbiota}, url = {https://m2.mtmt.hu/api/publication/34157366}, author = {Leto, T.L. and Geiszt, Miklós}, booktitle = {NADPH Oxidases Revisited: From Function to Structure}, doi = {10.1007/978-3-031-23752-2_10}, unique-id = {34157366}, year = {2023}, pages = {147-163} } @CONFERENCE{MTMT:33780242, title = {Involvement of nesfatin-1/NUCB2 in glucose homeostasis in the arcuate nucleus}, url = {https://m2.mtmt.hu/api/publication/33780242}, author = {Durst, Máté and Sípos, Klaudia and Matuska, Rita and Várnai, Péter and Soltész-Katona, Eszter and Geiszt, Miklós and Tóth, Zsuzsanna}, booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)}, unique-id = {33780242}, year = {2023}, orcid-numbers = {Durst, Máté/0000-0002-6456-4740; Sípos, Klaudia/0000-0003-0534-7348; Matuska, Rita/0000-0003-2805-6957; Várnai, Péter/0000-0002-7777-806X; Soltész-Katona, Eszter/0000-0002-9054-740X; Tóth, Zsuzsanna/0000-0002-0628-1320} } @article{MTMT:33718115, title = {Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals}, url = {https://m2.mtmt.hu/api/publication/33718115}, author = {Pató, Anna Terézia and Bölcskei, Kata and Donkó, Ágnes and Kaszás, Diána Patricia and Boros, Melinda and Bodrogi, Lilla and Várady, György and Pape, Veronika and Roux, Benoit and Enyedi, Balázs and Helyes, Zsuzsanna and Watt, F.M. and Sirokmány, Gábor and Geiszt, Miklós}, doi = {10.1016/j.redox.2023.102670}, journal-iso = {REDOX BIOL}, journal = {REDOX BIOLOGY}, volume = {62}, unique-id = {33718115}, issn = {2213-2317}, year = {2023}, eissn = {2213-2317}, orcid-numbers = {Pató, Anna Terézia/0000-0003-1238-3662; Bodrogi, Lilla/0000-0003-4696-9282; Várady, György/0000-0003-2012-9680; Pape, Veronika/0000-0001-6589-6950; Enyedi, Balázs/0000-0001-5713-3785; Sirokmány, Gábor/0000-0002-9473-2434} } @article{MTMT:33666662, title = {Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation}, url = {https://m2.mtmt.hu/api/publication/33666662}, author = {Habibovic, A. and Hristova, M. and Morris, C.R. and Lin, M.-C.J. and Cruz, L.C. and Ather, J.L. and Geiszt, Miklós and Anathy, V. and Janssen-Heininger, Y.M.W. and Poynter, M.E. and Dixon, A.E. and van, der Vliet A.}, doi = {10.1152/ajplung.00331.2022}, journal-iso = {AM J PHYSIOL LUNG C}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: LUNG CELLULAR AND MOLECULAR PHYSIOLOGY}, volume = {324}, unique-id = {33666662}, issn = {1040-0605}, year = {2023}, eissn = {1522-1504}, pages = {L228-L242} } @misc{MTMT:33602930, title = {Examination of the antioxidant system in knock-out rabbits on cholesterolrich diet}, url = {https://m2.mtmt.hu/api/publication/33602930}, author = {Pintér, Tímea and Muhammad, F and Major, Fanni and Petheő, Gábor L. and Szeles, Zsolt and Skoda, Gabriella and Kerekes, Andrea and Hiripi, László and Geiszt, Miklós and Bodrogi, Lilla}, unique-id = {33602930}, year = {2022}, pages = {110}, orcid-numbers = {Petheő, Gábor L./0000-0002-1773-4129; Bodrogi, Lilla/0000-0003-4696-9282} } @{MTMT:33299292, title = {The effect of cholesterol-rich diet on the antioxidant system of NOX5-deficient rabbit}, url = {https://m2.mtmt.hu/api/publication/33299292}, author = {Pintér, Tímea and Lóki, Lilla and Petheő, Gábor L. and Szeles, Zsolt and Skoda, Gabriella and Kerekes, Andrea and Hiripi, László and Geiszt, Miklós and Bodrogi, Lilla}, booktitle = {„FIBOK 2022” : Fiatal Biotechnológusok V. Országos Konferenciája}, unique-id = {33299292}, year = {2022}, pages = {121-121}, orcid-numbers = {Petheő, Gábor L./0000-0002-1773-4129; Bodrogi, Lilla/0000-0003-4696-9282} }