TY - JOUR AU - Berki, A. AU - Palotai, M. AU - Muthuraman, M. AU - Ding, H. AU - Halasz, L. AU - Eross, L. AU - Fekete, G. AU - Bognár, László AU - Pichner, E. AU - Tamas, G. TI - Quantifying the effect of subthalamic stimulation on bradykinesia using digitized spiral drawings in Parkinson's disease JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 30 PY - 2023 IS - Supplement_1 SP - 231 EP - 231 PG - 1 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/34718768 ID - 34718768 LA - English DB - MTMT ER - TY - JOUR AU - Kelemen, Andrea Judit AU - Halász, László AU - Muthuraman, Muthuraman AU - Erőss, Loránd AU - Barsi, Péter AU - Zádori, Dénes AU - Laczó, Bence AU - Kis, Dávid AU - Klivényi, Péter AU - Fekete, Gábor AU - Bognár, László AU - Bereczki, Dániel AU - Tamás, Gertrúd TI - Clinical parameters predict the effect of bilateral subthalamic stimulation on dynamic balance parameters during gait in Parkinson's disease JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 13 PY - 2022 PG - 9 SN - 1664-2295 DO - 10.3389/fneur.2022.917187 UR - https://m2.mtmt.hu/api/publication/33118864 ID - 33118864 AB - We investigated the effect of deep brain stimulation on dynamic balance during gait in Parkinson's disease with motion sensor measurements and predicted their values from disease-related factors. We recruited twenty patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least 12 months and 24 healthy controls. Six monitors with three-dimensional gyroscopes and accelerometers were placed on the chest, the lumbar region, the two wrists, and the shins. Patients performed the instrumented Timed Up and Go test in stimulation OFF, stimulation ON, and right- and left-sided stimulation ON conditions. Gait parameters and dynamic balance parameters such as double support, peak turn velocity, and the trunk's range of motion and velocity in three dimensions were analyzed. Age, disease duration, the time elapsed after implantation, the Hoehn-Yahr stage before and after the operation, the levodopa, and stimulation responsiveness were reported. We individually calculated the distance values of stimulation locations from the subthalamic motor center in three dimensions. Sway values of static balance were collected. We compared the gait parameters in the OFF and stimulation ON states and controls. With cluster analysis and a machine-learning-based multiple regression method, we explored the predictive clinical factors for each dynamic balance parameter (with age as a confounder). The arm movements improved the most among gait parameters due to stimulation and the horizontal and sagittal trunk movements. Double support did not change after switching on the stimulation on the group level and did not differ from control values. Individual changes in double support and horizontal range of trunk motion due to stimulation could be predicted from the most disease-related factors and the severity of the disease; the latter also from the stimulation-related changes in the static balance parameters. Physiotherapy should focus on double support and horizontal trunk movements when treating patients with subthalamic deep brain stimulation. LA - English DB - MTMT ER - TY - JOUR AU - Kelemen, Andrea Judit AU - Halász, László AU - Erőss, Loránd AU - Rudas, Gábor AU - Muthuraman, Muthuraman AU - Zádori, Dénes AU - Laczó, Bence AU - Kis, Dávid AU - Klivényi, Péter AU - Fekete, Gábor AU - Bognár, László AU - Bereczki, Dániel AU - Tamás, Gertrúd TI - Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 2 PG - 17 SN - 1932-6203 DO - 10.1371/journal.pone.0264114 UR - https://m2.mtmt.hu/api/publication/32704613 ID - 32704613 AB - Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least one year.We recruited 24 patients with Parkinson's disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine-learning-based multiple regression method.Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation.The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson's disease. LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Gábor AU - Tamás, Gertrúd AU - Novák, László AU - Bognár, László TI - Globus Pallidus Internus Deep Brain Stimulation For a Patient With Parkinson's Disease And Cerebral Developmental Venous Anomaly In The Region Of The Basal Ganglia JF - NEUROLOGY INDIA J2 - NEUROL INDIA VL - 70 PY - 2022 IS - 1 SP - 457 EP - 458 PG - 2 SN - 0028-3886 DO - 10.4103/0028-3886.338678 UR - https://m2.mtmt.hu/api/publication/32528263 ID - 32528263 LA - English DB - MTMT ER - TY - JOUR AU - Muthuraman, Muthuraman AU - Palotai, Marcell László AU - Jávor-Duray, Borbála AU - Kelemen, Andrea Judit AU - Koirala, Nabin AU - Halász, László AU - Erőss, Loránd AU - Fekete, Gábor AU - Bognár, László AU - Deuschl, Günther AU - Tamás, Gertrúd TI - Frequency-specific network activity predicts bradykinesia severity in Parkinson's disease JF - NEUROIMAGE-CLINICAL J2 - NEUROIMAGE-CLIN VL - 32 PY - 2021 PG - 14 SN - 2213-1582 DO - 10.1016/j.nicl.2021.102857 UR - https://m2.mtmt.hu/api/publication/32461994 ID - 32461994 N1 - Movement Disorders, Imaging and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing, Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany Department of Neurology, Semmelweis University, Budapest, Hungary Haskins Laboratories, New Haven, United States National Institute of Clinical Neurosciences, Budapest, Hungary Department of Neurosurgery, University of Debrecen, Debrecen, Hungary Department of Neurology, Christian-Albrechts University, Kiel, Germany Cited By :1 Export Date: 30 September 2022 Correspondence Address: Tamás, G.; Department of Neurology, Balassa utca 6., Hungary; email: tamas.gertrud@med.semmelweis-univ.hu AB - Bradykinesia has been associated with beta and gamma band interactions in the basal ganglia-thalamo-cortical circuit in Parkinson's disease. In this present cross-sectional study, we aimed to search for neural networks with electroencephalography whose frequency-specific actions may predict bradykinesia.Twenty Parkinsonian patients treated with bilateral subthalamic stimulation were first prescreened while we selected four levels of contralateral stimulation (0: OFF, 1-3: decreasing symptoms to ON state) individually, based on kinematics. In the screening period, we performed 64-channel electroencephalography measurements simultaneously with electromyography and motion detection during a resting state, finger tapping, hand grasping tasks, and pronation-supination of the arm, with the four levels of contralateral stimulation. We analyzed spectral power at the low (13-20 Hz) and high (21-30 Hz) beta frequency bands and low (31-60 Hz) and high (61-100 Hz) gamma frequency bands using the dynamic imaging of coherent sources. Structural equation modelling estimated causal relationships between the slope of changes in network beta and gamma activities and the slope of changes in bradykinesia measures.Activity in different subnetworks, including predominantly the primary motor and premotor cortex, the subthalamic nucleus predicted the slopes in amplitude and speed while switching between stimulation levels. These subnetwork dynamics on their preferred frequencies predicted distinct types and parameters of the movement only on the contralateral side.Concurrent subnetworks affected in bradykinesia and their activity changes in the different frequency bands are specific to the type and parameters of the movement; and the primary motor and premotor cortex are common nodes. LA - English DB - MTMT ER - TY - JOUR AU - Coulter, Ian C. AU - Kulkarni, Abhaya AU - Sgouros, Spyros AU - Constantini, Shlomi AU - Constantini, Shlomi AU - Sgouros, Spyros AU - Kulkarni, Abhaya AU - Leitner, Yael AU - Kestle, John R. W. AU - Cochrane, Douglas D. AU - Choux, Maurice AU - Gjerris, Fleming AU - Sherer, Adina AU - Akalan, Nejat AU - Bilginer, Burçak AU - Navarro, Ramon AU - Vujotic, Ljiljana AU - Haberl, Hannes AU - Thomale, Ulrich-Wilhelm AU - Zúccaro, Graciela AU - Jaimovitch, Roberto AU - Frim, David AU - Loftis, Lori AU - Swift, Dale M. AU - Robertson, Brian AU - Gargan, Lynn AU - Bognár, László AU - Cseke, Georgina AU - Cama, Armando AU - Ravegnani, Giuseppe Marcello AU - Preuß, Matthias AU - Schroeder, Henry W. AU - Fritsch, Michael AU - Baldauf, Joerg AU - Mandera, Marek AU - Luszawski, Jerzy AU - Skorupka, Patrycja AU - Mallucci, Conor AU - Williams, Dawn AU - Zakrzewski, Krzystof AU - Nowoslawska, Emilia AU - Srivastava, Chhitij AU - Mahapatra, Ashok K. AU - Kumar, Raj AU - Sahu, Rabi Narayan AU - Melikian, Armen G. AU - Korshunov, Anton AU - Galstyan, Anna AU - Suri, Ashish AU - Gupta, Deepak AU - Grotenhuis, J. André AU - Lindert, Erik J. van AU - Costa, Val José Aloysio da AU - Di, Rocco Concezio AU - Tamburrini, Gianpiero AU - Zymberg, Samuel Tau AU - Cavalheiro, Sergio AU - Jie, Ma AU - Feng, Jiang AU - Friedman, Orna AU - Rajmohamed, Naheeda AU - Roszkowski, Marcin AU - Barszcz, Slawomir AU - Jallo, George I. AU - Pincus, David W. AU - Richter, Bridget AU - Mehdorn, H. M. AU - Schultka, Susan AU - de, Ribaupierre Sandrine AU - Thompson, Dominic AU - Gatscher, Silvia AU - Wagner, Wolfgang AU - Koch, Dorothee AU - Cipri, Saverio AU - Zaccone, Claudio AU - McDonald, Patrick ED - Novák, László / Collaborator TI - Cranial and ventricular size following shunting or endoscopic third ventriculostomy (ETV) in infants with aqueductal stenosis: further insights from the International Infant Hydrocephalus Study (IIHS) JF - CHILDS NERVOUS SYSTEM J2 - CHILD NERV SYST VL - 36 PY - 2020 IS - 7 SP - 1407 EP - 1414 PG - 8 SN - 0256-7040 DO - 10.1007/s00381-020-04503-y UR - https://m2.mtmt.hu/api/publication/32015389 ID - 32015389 N1 - 304975 LA - English DB - MTMT ER - TY - JOUR AU - Chen, Carol C.L. AU - Deshmukh, Shriya AU - Jessa, Selin AU - Hadjadj, Djihad AU - Lisi, Véronique AU - Andrade, Augusto Faria AU - Faury, Damien AU - Jawhar, Wajih AU - Dali, Rola AU - Suzuki, Hiromichi AU - Pathania, Manav AU - A, Deli AU - Dubois, Frank AU - Woodward, Eleanor AU - Hébert, Steven AU - Coutelier, Marie AU - Karamchandani, Jason AU - Albrecht, Steffen AU - Brandner, Sebastian AU - De Jay, Nicolas AU - Gayden, Tenzin AU - Bajic, Andrea AU - Harutyunyan, Ashot S. AU - Marchione, Dylan M. AU - Mikael, Leonie G. AU - Juretic, Nikoleta AU - Zeinieh, Michele AU - Russo, Caterina AU - Maestro, Nicola AU - Bassenden, Angelia V. AU - Hauser, Péter AU - Virga, József AU - Bognár, László AU - Klekner, Álmos AU - Zapotocky, Michal AU - Vicha, Ales AU - Krskova, Lenka AU - Vanova, Katerina AU - Zamecnik, Josef AU - Sumerauer, David AU - Ekert, Paul G. AU - Ziegler, David S. AU - Ellezam, Benjamin AU - Filbin, Mariella G. AU - Blanchette, Mathieu AU - Hansford, Jordan R. AU - Khuong-Quang, Dong-Anh AU - Berghuis, Albert M. AU - Weil, Alexander G. AU - Garcia, Benjamin A. AU - Garzia, Livia AU - Mack, Stephen C. AU - Beroukhim, Rameen AU - Ligon, Keith L. AU - Taylor, Michael D. AU - Bandopadhayay, Pratiti AU - Kramm, Christoph AU - Pfister, Stefan M. AU - Korshunov, Andrey AU - Sturm, Dominik AU - Jones, David T.W. AU - Salomoni, Paolo AU - Kleinman, Claudia L. AU - Jabado, Nada TI - Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis JF - CELL J2 - CELL VL - 183 PY - 2020 IS - 6 SP - 1617 EP - 1633.e22 SN - 0092-8674 DO - 10.1016/j.cell.2020.11.012 UR - https://m2.mtmt.hu/api/publication/31734995 ID - 31734995 N1 - Összes idézések száma a WoS-ban: 0 LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Gábor AU - Bognár, László AU - Gutema, Emanuel AU - Novák, László TI - Intraoperative Electrophysiology in Children - Single Institute Experience of 96 Examinations JF - NEUROLOGY INDIA J2 - NEUROL INDIA VL - 68 PY - 2020 IS - 2 SP - 407 EP - 412 PG - 6 SN - 0028-3886 DO - 10.4103/0028-3886.284352 UR - https://m2.mtmt.hu/api/publication/31685444 ID - 31685444 AB - Aim: To summarize our experience gathered during the use of different intraoperative electrophysiological modalities in children.Materials and Methods: We analyzed the data collected from 96 pediatric neurosurgical interventions. During the operations. we used a combination of intraoperative electrophysiological examinations tailored to the actual pathologies. The modalities included cortical and white matter mapping, cranial nerve and cranial nerve nucleus stimulation, motor evoked potential (MEP), somatosensory evoked potential (SSEP). peripheral nerve stimulation, bulbocavernosus reflex. and a special setup for selective dorsal rhizotomy.Results: The success ratio of the different modalities varied between 25% and 100%. All the applied methods could be used in children.Conclusion: Although the application of certain intraoperative techniques could be limited due to the ongoing developmental and maturation processes in childhood, we can not exclude the possibility of successful recording in any modality. Thus, we recommend to apply all the available methods in children bearing in mind that the success ratio might be lower than that in the adult population. LA - English DB - MTMT ER - TY - JOUR AU - Szivos, László AU - Virga, József AU - Hortobágyi, Tibor AU - Zahuczky, Gábor AU - Uray, Iván AU - Jenei, Adrienn AU - Bognár, László AU - Árkosy, Péter AU - Klekner, Álmos TI - Az inváziós spektrum prognosztikai jelentősége glioblastomában JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 73 PY - 2020 IS - 9-10 SP - 317 EP - 325 PG - 9 SN - 0019-1442 DO - 10.18071/ISZ.73.0317 UR - https://m2.mtmt.hu/api/publication/31625559 ID - 31625559 N1 - 296635 AB - A glioblastoma a leggyakoribb központi idegrendszeri rosszindulatú daganat; sebészi kezelése a da­ganatok invazív jellegénél fogva nem lehetséges, onko­te­rá­piája pedig csupán szerény eredményeket hoz – a bete­gek átlagos teljes túlélése (OS) 16–24 hónap. A betegek egy része alig reagál az alkalmazott kezelésre; a klinikumban jelenleg nincs olyan prognosztikai vagy prediktív marker, ami segítené a betegek túlélésében tapasztalható jelentős szórás érdemi feltérképezését és a kezelési algoritmus optimalizálását. Jelen kutatásban az invázióban sze­re­pet játszó extracelluláris mátrix (ECM-) molekulák expresszió­jának prognosztikai jelentőségét kívántuk meghatározni. Eltérő prognózisú betegcsoportokat létrehozva (A csoport OS < 16 hónap, B csoport OS > 16 hó­nap) vizsgáltuk meg glioblastomás betegek gyors­fa­gyasz­tott tu­mor­mintáiban a szakirodalom által jelenleg elismert mar­kerek (IDH1 mutációs és MGMT metilációs státusz) je­len­lé­tét, továbbá 46 inváziós ECM-molekula mRNS-szintjét. A DE KK Idegsebészeti Klinikán operált és az Onkológiai Klinikán utókezelt betegek klinikai adatai nem mutattak jelentős különbségeket a túlélési adatokat (progressziómentes és teljes túlélés) és a reoperációs arányt leszámítva. Minden minta IDH vad típusú volt. Je­len­tős különbség volt a jobb és a rosszabb túlélésű be­­te­gek kö­zött az MGMT promoter hipermetiláció arányá­ban (28,6% vs. 68,8%). Az inváziós ECM-molekulák expressziós mintá­zata, az inváziós spektrum szintén jelentős különbséget mutatott; szignifikáns különbség mutatkozott az integrin β2, kadhe­rin-12, FLT4/VEGFR-3, verzikán molekulák expressziójá­ban. Az inváziós spektrum megbízhatóságát statisztikai osz­tályozóval tesztelve a módszer a minták 83,3%-át sorolta a megfelelő prognosztikai csoportba (PPÉ: 0,93). A különböző túlélésű betegcsoportok összehasonlítása során a reoperációs arányban megfigyel­hető különbség az irodalmi adatokkal összevágó tény. Az MGMT promoter metiláltságának vizsgálata hazai ­ újdonság, az eredmény az eddigi ismereteket megerősítve sürgeti a vizsgálat rutinszerű bevezetését. Az inváziós spektrum vizsgálata többletinformációt ad a tumorról, prognosztikai markerként segíthet felismerni az ag­resszívabb tumorokat, továbbá felhívja a figyelmet az antiinvazív ágensek jövőbeni használatának szükségességére a GBM terápiájában. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fejes, Zsolt AU - Erdei, Judit Zsuzsa AU - Pócsi, Marianna AU - Takai, Jun AU - Jeney, Viktória AU - Nagy, Andrea AU - Varga, Aliz AU - Bácsi, Attila AU - Bognár, László AU - Novák, László AU - Kappelmayer, János AU - Nagy, Béla TI - Elevated Pro-Inflammatory Cell-Free MicroRNA Levels in Cerebrospinal Fluid of Premature Infants after Intraventricular Hemorrhage JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 18 PG - 20 SN - 1661-6596 DO - 10.3390/ijms21186870 UR - https://m2.mtmt.hu/api/publication/31615186 ID - 31615186 N1 - 296609 LA - English DB - MTMT ER -