TY - JOUR AU - Faragó, Tünde AU - Remete, Attila Márió AU - Szatmári, István AU - Ambrus, Rita AU - Palkó, Márta TI - The synthesis of pharmacologically important oxindoles via the asymmetric aldol reaction of isatin and the investigation of the organocatalytic activity of new alicyclic β-amino acid derivatives JF - RSC ADVANCES J2 - RSC ADV VL - 13 PY - 2023 IS - 28 SP - 19356 EP - 19365 PG - 10 SN - 2046-2069 DO - 10.1039/D3RA03528J UR - https://m2.mtmt.hu/api/publication/34035454 ID - 34035454 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, Szeged, H-6720, Hungary Stereochemistry Research Group, Eötvös Loránd Research Network, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs Faculty of Pharmacy, University of Szeged, Eötvös utca 6, Szeged, H-6720, Hungary Export Date: 24 July 2023 CODEN: RSCAC Correspondence Address: Palkó, M.; Institute of Pharmaceutical Chemistry, Eötvös utca 6, Hungary; email: palko.marta@szte.hu Funding details: ÚNKP-22-3-SZTE-150 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, TKP2021-EGA-32 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The authors' thanks are due to the Hungarian Research Foundation (OTKA No. K-138871) and the Ministry of Human Capacities, Hungary grant, TKP-2021-EGA-32. T. F: was supported by the ÚNKP-22-3-SZTE-150 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. The high-resolution mass spectrometric (HRMS) analysis was performed by Robert Berkecz. Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. AB - This work involves the synthesis and subsequent development of a number of novel organocatalysts generated from β-amino acids bearing diendo and diexo norbornene skeletons to improve their catalytic characteristics. LA - English DB - MTMT ER - TY - JOUR AU - Said, Awad I. AU - Gajdács, Márió AU - Zupkó, István AU - Haukka, Matti AU - Palkó, Márta TI - Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 9 PG - 10 SN - 1420-3049 DO - 10.3390/molecules28093718 UR - https://m2.mtmt.hu/api/publication/33773728 ID - 33773728 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Chemistry Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Chemistry, University of Jyväskulä, Jyväskulä, FIN-40014, Finland Export Date: 29 May 2023 CODEN: MOLEF Correspondence Address: Said, A.I.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: awadsaid@aun.edu.eg Correspondence Address: Palkó, M.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: palko.marta@szte.hu Funding details: TKP-2021-EGA-32 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This paper is a tribute to the memory of a wonderful person and scientist, Ferenc Fülöp. His important contributions to science will be remembered by the whole scientific community. The authors’ thanks are due to the Hungarian Research Foundation (OTKA No. K-138871) and the Ministry of Human Capacities, Hungary grant, TKP-2021-EGA-32. The high-resolution mass spectrometric analysis (HRMS) was performed by Robert Berkecz. Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. AB - New 2-thioxopyrimidin-4-ones capable of participating in regioselective reactions with functionally diverse hydrazonoyl chlorides towards angular regioisomers, rather than linear ones, were designed and synthesized to form stereoisomeric cis- and trans-hexahydro [1,2,4]triazolo[4,3-a]quinazolin-9-ones to be tested as antitumor candidates. The angular regiochemistry of the products was verified through crystallographic experiments and NMR studies. In addition, the regioselectivity of the reaction was found to be independent of the stereochemistry of the used 2-thioxopyrimidin-4-one. Only compound 4c demonstrated satisfactory growth inhibition against all the cancer cells used among all the produced drugs. LA - English DB - MTMT ER - TY - CONF AU - Shahmohammadi, Sayeh AU - Faragó, Tünde AU - Palkó, Márta AU - Forró, Enikő TI - Green enzymatic strategies for the preparation of enantiomeric carbocyclic beta-amino acid derivatives T2 - GreenCat 2022 Book of Abstracts PY - 2022 PG - 1 UR - https://m2.mtmt.hu/api/publication/33672957 ID - 33672957 LA - English DB - MTMT ER - TY - JOUR AU - Shahmohammadi, Sayeh AU - Faragó, Tünde AU - Palkó, Márta AU - Forró, Enikő TI - Green Strategies for the Preparation of Enantiomeric 5–8-Membered Carbocyclic β-Amino Acid Derivatives through CALB-Catalyzed Hydrolysis JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 8 PG - 11 SN - 1420-3049 DO - 10.3390/molecules27082600 UR - https://m2.mtmt.hu/api/publication/32787510 ID - 32787510 N1 - Institute of Pharmaceutical Chemistry, Interdisciplinary Excellence Center, Faculty of Pharmacy, University of Szeged, Szeged, H-6720, Hungary MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Export Date: 4 June 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Hungary; email: forro.eniko@szte.hu Chemicals/CAS: amino acid, 65072-01-7; Amino Acids; Esters; Fungal Proteins; Solvents Funding details: 2.3.2-15-2016-00014, EFOP 3.6.3-VEKOP-16-2017-00009 Funding details: Hungarian Scientific Research Fund, OTKA, K129049, K138871 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: The authors thank the Hungarian Scientific Research Council (OTKA, K129049 and K138871) and the Ministry of National Economy, National Research, Development and Innovation Office (GINOP, 2.3.2-15-2016-00014) and (EFOP 3.6.3-VEKOP-16-2017-00009) for financial support. LA - English DB - MTMT ER - TY - JOUR AU - El Haimer, Mohamed AU - Faragó, Tünde AU - Schelz, Zsuzsanna AU - Zupkó, István AU - Palkó, Márta TI - Synthesis of Alicyclic 2-Methylenethiazolo[2,3-b]quinazolinone Derivatives via Base-Promoted Cascade Reactions JF - SYNTHESIS-STUTTGART J2 - SYNTHESIS-STUTTGART VL - 54 PY - 2022 IS - 17 SP - 3809 EP - 3816 PG - 8 SN - 0039-7881 DO - 10.1055/s-0040-1720028 UR - https://m2.mtmt.hu/api/publication/32533923 ID - 32533923 N1 - Special Issue dedicated to Prof. Ferenc Fülöp Összes idézések száma a WoS-ban: 0 LA - English DB - MTMT ER - TY - JOUR AU - Dvorácskó, Szabolcs AU - Lázár, László AU - Fülöp, Ferenc AU - Palkó, Márta AU - Zalán, Zita AU - Penke, Botond AU - Fülöp, Lívia AU - Tömböly, Csaba AU - Bogár, Ferenc TI - Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 15 PG - 17 SN - 1661-6596 DO - 10.3390/ijms22158112 UR - https://m2.mtmt.hu/api/publication/32123857 ID - 32123857 LA - English DB - MTMT ER - TY - JOUR AU - El Haimer, Mohamed AU - Palkó, Márta AU - Matti, Haukka AU - Gajdács, Márió AU - Zupkó, István AU - Fülöp, Ferenc TI - Synthesis and biological evaluation of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine and its cycloalkane and cycloalkene condensed analogues JF - RSC ADVANCES J2 - RSC ADV VL - 11 PY - 2021 IS - 12 SP - 6952 EP - 6957 PG - 6 SN - 2046-2069 DO - 10.1039/D0RA10553H UR - https://m2.mtmt.hu/api/publication/31860636 ID - 31860636 N1 - Funding Agency and Grant Number: Hungarian Research Foundation (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 115731]; Ministry of Human Capacities, Hungary grant, TKP-2020; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences [BO/00144/20/5]; New National Excellence Programme of the Ministry of Human Resources [NKP-20-5-SZTE-330]; ESCMID's "30 under 30" Award; [GINOP-2.3.2-15-2016-00038] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00038 project is acknowledged. The Ministry of Human Capacities, Hungary grant, TKP-2020 is acknowledged. M. G. was supported by the Janos Bolyai Research Scholarship (BO/00144/20/5) of the Hungarian Academy of Sciences, the New National Excellence Programme (uNKP-20-5-SZTE-330) of the Ministry of Human Resources, and ESCMID's "30 under 30" Award. Institute of Pharmaceutical Chemistry, University of Szeged, Interdisciplinary Excellence Centre, Eötvös utca 6, Szeged H, 6720, Hungary Department of Chemistry, University of Jyväskylä, FIN-40014 Turku, Finland Pharmacodynamics and Biopharmacy, University of Szeged, Interdisciplinary Excellence Centre, Eötvös utca 6, Szeged H, 6720, Hungary MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Eötvös utca 6, Szeged H, 6720, Hungary Export Date: 11 July 2021 CODEN: RSCAC Correspondence Address: Palkó, M.; Institute of Pharmaceutical Chemistry, Eötvös utca 6, Hungary; email: palko.marta@szte.hu LA - English DB - MTMT ER - TY - JOUR AU - Said, Awad I. AU - Palkó, Márta AU - Haukka, Matti AU - Fülöp, Ferenc TI - Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides: Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones JF - MOLECULES J2 - MOLECULES VL - 25 PY - 2020 IS - 23 PG - 8 SN - 1420-3049 DO - 10.3390/molecules25235673 UR - https://m2.mtmt.hu/api/publication/31817950 ID - 31817950 N1 - Cited By :1 Export Date: 22 March 2023 CODEN: MOLEF Correspondence Address: Palkó, M.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: palko.marta@szte.hu Chemicals/CAS: chloride, 16887-00-6; Chlorides; Pyrimidines; Quinazolines; Triazoles Funding details: Hungarian Scientific Research Fund, OTKA, GINOP-2.3.2-15-2016-00014, K 115731 Funding details: Emberi Eroforrások Minisztériuma, EMMI, TUDFO/47138-1/2019 Funding text 1: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 project is acknowledged. The Ministry of Human Capacities, Hungary, grant TUDFO/47138-1/2019, is acknowledged. Funding text 2: Funding: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 project is acknowledged. The Ministry of Human Capacities, Hungary, grant TUDFO/47138-1/2019, is acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Said, Awad I. AU - Palkó, Márta AU - Haukka, Matti AU - Fülöp, Ferenc TI - Retro Diels Alder protocol for regioselective synthesis of novel [1,2,4]triazolo[4,3- a ]pyrimidin-7(1 H )-ones JF - RSC ADVANCES J2 - RSC ADV VL - 10 PY - 2020 IS - 56 SP - 33937 EP - 33943 PG - 7 SN - 2046-2069 DO - 10.1039/d0ra04345a UR - https://m2.mtmt.hu/api/publication/31648757 ID - 31648757 LA - English DB - MTMT ER - TY - JOUR AU - Palkó, Márta AU - El Haimer, Mohamed AU - Kormanyos, Zsanett AU - Fülöp, Ferenc TI - Synthesis of Novel N-Heterocyclic Compounds Containing 1,2,3-Triazole Ring System via Domino, "Click" and RDA Reactions JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 4 PG - 11 SN - 1420-3049 DO - 10.3390/molecules24040772 UR - https://m2.mtmt.hu/api/publication/30638151 ID - 30638151 N1 - Funding Agency and Grant Number: Hungarian Research Foundation (OTKA) [K 115731]; Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; [GINOP-2.3.2-15-2016-00038] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00038 project is acknowledged. Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Funding Agency and Grant Number: Hungarian Research Foundation (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 115731]; Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; [GINOP-2.3.2-15-2016-00038] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00038 project is acknowledged. Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. AB - An uncomplicated, high-yielding synthetic route has been developed to constitute complicated heterocycles, applying domino, click and retro-Diels-Alder (RDA) reaction sequences. Starting from 2-aminocarboxamides, a new set of isoindolo[2,1-a]quinazolinones was synthesized with domino ring closure. A click reaction was performed to create the 1,2,3-triazole heterocyclic ring, followed by an RDA reaction resulting in dihydropyrimido[2,1-a]isoindole-2,6-diones. The absolute configuration, concluded by the norbornene structure that served as a chiral source, remained constant throughout the transformations. The structure of the synthesized compounds was examined by H-1 and C-13 Nuclear Magnetic Resonance (NMR) methods. LA - English DB - MTMT ER -