TY - CONF AU - Kovács, Bettina AU - Kajos, Luca Fanni AU - Szapáry, László AU - Boncz, Imre ED - Kovács, Bettina ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám TI - Rövidtávú életminőség vizsgálat intravénás thrombolyticus és mechanikus thrombectomiás rekanalizációs beavatkozással kezelt akut ischaemiás strokeos betegek körében T2 - Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat C1 - Pécs SN - 9789636262457 PY - 2024 SP - 140 EP - 140 PG - 1 UR - https://m2.mtmt.hu/api/publication/34813541 ID - 34813541 N1 - Poszter szekció. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Bettina AU - Boncz, Imre AU - Kajos, Luca Fanni AU - Szapáry, László TI - Az intravénás thrombolyticus és mechanikus thrombectomiás rekanalizációs beavatkozással kezelt, ischaemiás stroke-on átesett betegek életminőségének vizsgálata JF - ORVOSKÉPZÉS J2 - ORVOSKÉPZÉS VL - 98 PY - 2023 IS - 2 SP - 466 EP - 466 PG - 1 SN - 0030-6037 UR - https://m2.mtmt.hu/api/publication/34400760 ID - 34400760 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Kalmár, Péter János AU - Szapáry, László ED - Kajos, Luca Fanni ED - Bali, Cintia ED - Puskás, Tamás ED - Szabó, Rebeka TI - Comparing the endovascular treatment of tandem occlusions and isolated intracranial occlusions in acute ischemic stroke T2 - XI. Interdiszciplináris Doktorandusz Konferencia 2022 Tanulmánykötet PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789636260705 PY - 2023 SP - 287 EP - 295 PG - 9 UR - https://m2.mtmt.hu/api/publication/34394178 ID - 34394178 LA - English DB - MTMT ER - TY - GEN AU - Kovács, Bettina AU - Kajos, Luca Fanni AU - Szapáry, László AU - Boncz, Imre TI - AZ INTRAVÉNÁS THROMBOLYTICUS ÉS MECHANIKUS THROMBECTOMIÁS REKANALIZÁCIÓS BEAVATKOZÁSSAL KEZELT, ISCHAEMIÁS STROKE-ON ÁTESETT BETEGEK ÉLETMINŐSÉGÉNEK VIZSGÁLATA PY - 2023 UR - https://m2.mtmt.hu/api/publication/34186882 ID - 34186882 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tornyos, Dániel AU - Komócsi, András AU - Bálint, Alexandra AU - Kupó, Péter AU - El Alaoui El Abdallaoui, Oumaima AU - Szapáry, László AU - Szapáry, László Botond TI - Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 8 PG - 13 SN - 1932-6203 DO - 10.1371/journal.pone.0273103 UR - https://m2.mtmt.hu/api/publication/33061359 ID - 33061359 N1 - * Megosztott szerzőség AB - As stroke represents one of the leading causes of mortality and disability worldwide, we aimed to determine the preventive effect of different antiplatelet therapies after an ischemic stroke or transient ischemic attack.Network meta-analysis evaluating antiplatelet regimes after an ischemic stroke or transient ischemic attack. Searches were conducted in MEDLINE, EMBASE, and Cochrane Library databases until Nov. 23, 2021, for randomized controlled trials. Direct comparisons within trials were combined with indirect evidence from other trials by using a frequentist model. An additive network meta-analysis model was used to evaluate the influence of individual components. The primary efficacy endpoint was a recurrent stroke, the main safety outcomes were the risk of major bleeding and mortality at the longest available follow-up.58 randomized controlled trials (175,730 patients) were analyzed. The analysis involved 20 antithrombotic strategies including different antiplatelet agents, combinations with aspirin, and anticoagulant therapies. Cilostazol proved to be the most efficacious in reducing stroke recurrence and the risk of bleeding (RR = 0.66, 95%CI = 0.55-0.80 and RR = 0.39, 95%CI = 0.08-2.01) compared to aspirin, respectively. Intensification with combinations of aspirin with ticagrelor or clopidogrel resulted in a lower risk of stroke recurrence (RR = 0.79, 95%CI = 0.67-0.93 and RR = 0.79, 95%CI = 0.72-0.87) but carried a higher bleeding risk (RR = 3.01, 95%CI = 1.65-5.49 and RR = 1.78 95%CI = 1.49-2.13).The prognosis of patients with an ischemic stroke or transient ischemic attack is improved with antiplatelets. Cilostazol showed the best risk-benefit characteristics without trade-off with the risk of major bleeding. Improved stroke recurrence with intensified antiplatelet regimens is counterbalanced with higher bleeding risk, and consequently, mortality remains unaffected. Treatment decisions in stroke survivals should integrate the assessment of bleeding risk for better identification of patients with the highest benefit of treatment intensification.Prospero registration number: CRD42020197143, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197143. LA - English DB - MTMT ER - TY - JOUR AU - Szapáry, László TI - Intracranialis vérzések DOAC-terápia kapcsán JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 34 EP - 34 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32894010 ID - 32894010 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kalmár, Péter János AU - Tárkányi, Gábor AU - Karadi, Zsofia Nozomi AU - Szapáry, László AU - Bosnyák, Edit TI - The Impact of Diabetes Mellitus and Admission Hyperglycemia on Clinical Outcomes after Recanalization Therapies for Acute Ischemic Stroke: STAY ALIVE National Prospective Registry JF - LIFE-BASEL J2 - LIFE-BASEL VL - 12 PY - 2022 IS - 5 PG - 10 SN - 2075-1729 DO - 10.3390/life12050632 UR - https://m2.mtmt.hu/api/publication/32797860 ID - 32797860 LA - English DB - MTMT ER - TY - JOUR AU - Tárkányi, Gábor AU - Tenyi, Akos AU - Hollós, Roland AU - Kalmár, Péter János AU - Szapáry, László TI - Optimization of Large Vessel Occlusion Detection in Acute Ischemic Stroke Using Machine Learning Methods JF - LIFE-BASEL J2 - LIFE-BASEL VL - 12 PY - 2022 IS - 2 PG - 10 SN - 2075-1729 DO - 10.3390/life12020230 UR - https://m2.mtmt.hu/api/publication/32654078 ID - 32654078 LA - English DB - MTMT ER - TY - JOUR AU - Kalmár, Péter János AU - Tárkányi, Gábor AU - Karádi, Nozomi Zsófia AU - Bosnyák, Edit AU - Nagy, Csaba Balázs AU - Csécsei, Péter AU - Lenzsér, Gábor AU - Büki, András AU - Janszky, József Vladimír AU - Szapáry, László TI - A mechanikus thrombectomiát megelőző intravénás thrombolysis szerepe az akut agyi nagyérelzáródások kezelésében JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 75 PY - 2022 IS - 1-2 SP - 23 EP - 29 PG - 7 SN - 0019-1442 DO - 10.18071/isz.75.0023 UR - https://m2.mtmt.hu/api/publication/32647101 ID - 32647101 AB - The efficacy of intravenous thrombolysis (IVT) is moderate in the proximal vascular segments of intracranial arteries, as opposed to mecha-nical thrombectomy (MT). In the management of acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), IVT prior to MT is highly recommended based on the latest guidelines, but the necessity of IVT has been questioned by the latest studies of the past years. The aim of our study was to investigate and compare the efficacy and safety of direct mechanical thrombectomy (dMT) and combined therapy (CT) for patients who suffered an AIS with LVO and were treated in our department.We investigated patients with AIS caused by LVO who were admitted up to 4.5 hours after symptom onset and underwent MT in our department between November 2017 and August 2019. Patients' data were collected in our stroke register. Patients enrolled in our study were divided into two groups depending on whether dMT or CT was used. Our primary outcome was the 30- and 90- day functional outcome measured by modified Rankin Scale (mRS). Mortality at 30- and 90- day, successful recanalization rates, and symptomatic intracranial hemorrhage were considered as secondary outcomes.A total of 142 patients (age: 68.3 ± 12.6 years, 53.5% female) were enrolled in our study, including 81 (57.0%) dMT cases, and 61 (43.0%) patients who received CT. The vascular risk factors and comorbidities were significantly higher in the dMT-treated group. At day 30, the rate of favorable functional outcomes was 34.7% in dMT vs. 43.6% among those who received CT (p = 0.307), by day 90 this ratio changed to 40.8% vs. 46.3% (p = 0.542). Mortality rates at day 30 were 22.2% and 23.6% (p = 0.851), and at day 90 33.8% and 25.9% (p = 0.343). The rate of effective recanalization was 94.2% for dMT-treated patients and 98.0% for CT-treated patients (p = 0.318). Symptomatic intracranial hemorrhage was detected in 2.5% of dMT-treated patients and 3.4% of CT-treated group (p = 0.757).Our results suggest that CT is associated with a moderately better outcome compared to dMT. IVT prior to MT did not increase the risk of symptomatic intracranial hemorrhages. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kenyeres, Péter AU - Totsimon, Kinga AU - Nagy, Alexandra AU - Sándor, Barbara AU - Biro, Katalin AU - Szapáry, László AU - Tóth, Kálmán AU - Marton, Zsolt TI - Hemorheological alterations in patients with chronic cerebrovascular disease JF - BIORHEOLOGY J2 - BIORHEOLOGY VL - 58 PY - 2021 IS - 3-4 SP - 126 EP - 127 PG - 2 SN - 0006-355X UR - https://m2.mtmt.hu/api/publication/32866517 ID - 32866517 LA - English DB - MTMT ER -