@CONFERENCE{MTMT:34813541, title = {Rövidtávú életminőség vizsgálat intravénás thrombolyticus és mechanikus thrombectomiás rekanalizációs beavatkozással kezelt akut ischaemiás strokeos betegek körében}, url = {https://m2.mtmt.hu/api/publication/34813541}, author = {Kovács, Bettina and Kajos, Luca Fanni and Szapáry, László and Boncz, Imre}, booktitle = {Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference}, unique-id = {34813541}, year = {2024}, pages = {140-140}, orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Boncz, Imre/0000-0003-3699-6236} } @article{MTMT:34400760, title = {Az intravénás thrombolyticus és mechanikus thrombectomiás rekanalizációs beavatkozással kezelt, ischaemiás stroke-on átesett betegek életminőségének vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34400760}, author = {Kovács, Bettina and Boncz, Imre and Kajos, Luca Fanni and Szapáry, László}, journal-iso = {ORVOSKÉPZÉS}, journal = {ORVOSKÉPZÉS}, volume = {98}, unique-id = {34400760}, issn = {0030-6037}, year = {2023}, pages = {466-466}, orcid-numbers = {Boncz, Imre/0000-0003-3699-6236; Kajos, Luca Fanni/0000-0002-0574-5787} } @inbook{MTMT:34394178, title = {Comparing the endovascular treatment of tandem occlusions and isolated intracranial occlusions in acute ischemic stroke}, url = {https://m2.mtmt.hu/api/publication/34394178}, author = {Kalmár, Péter János and Szapáry, László}, booktitle = {XI. Interdiszciplináris Doktorandusz Konferencia 2022 Tanulmánykötet}, unique-id = {34394178}, year = {2023}, pages = {287-295} } @misc{MTMT:34186882, title = {AZ INTRAVÉNÁS THROMBOLYTICUS ÉS MECHANIKUS THROMBECTOMIÁS REKANALIZÁCIÓS BEAVATKOZÁSSAL KEZELT, ISCHAEMIÁS STROKE-ON ÁTESETT BETEGEK ÉLETMINŐSÉGÉNEK VIZSGÁLATA}, url = {https://m2.mtmt.hu/api/publication/34186882}, author = {Kovács, Bettina and Kajos, Luca Fanni and Szapáry, László and Boncz, Imre}, unique-id = {34186882}, year = {2023}, orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Boncz, Imre/0000-0003-3699-6236} } @article{MTMT:33061359, title = {Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials}, url = {https://m2.mtmt.hu/api/publication/33061359}, author = {Tornyos, Dániel and Komócsi, András and Bálint, Alexandra and Kupó, Péter and El Alaoui El Abdallaoui, Oumaima and Szapáry, László and Szapáry, László Botond}, doi = {10.1371/journal.pone.0273103}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {33061359}, issn = {1932-6203}, abstract = {As stroke represents one of the leading causes of mortality and disability worldwide, we aimed to determine the preventive effect of different antiplatelet therapies after an ischemic stroke or transient ischemic attack.Network meta-analysis evaluating antiplatelet regimes after an ischemic stroke or transient ischemic attack. Searches were conducted in MEDLINE, EMBASE, and Cochrane Library databases until Nov. 23, 2021, for randomized controlled trials. Direct comparisons within trials were combined with indirect evidence from other trials by using a frequentist model. An additive network meta-analysis model was used to evaluate the influence of individual components. The primary efficacy endpoint was a recurrent stroke, the main safety outcomes were the risk of major bleeding and mortality at the longest available follow-up.58 randomized controlled trials (175,730 patients) were analyzed. The analysis involved 20 antithrombotic strategies including different antiplatelet agents, combinations with aspirin, and anticoagulant therapies. Cilostazol proved to be the most efficacious in reducing stroke recurrence and the risk of bleeding (RR = 0.66, 95%CI = 0.55-0.80 and RR = 0.39, 95%CI = 0.08-2.01) compared to aspirin, respectively. Intensification with combinations of aspirin with ticagrelor or clopidogrel resulted in a lower risk of stroke recurrence (RR = 0.79, 95%CI = 0.67-0.93 and RR = 0.79, 95%CI = 0.72-0.87) but carried a higher bleeding risk (RR = 3.01, 95%CI = 1.65-5.49 and RR = 1.78 95%CI = 1.49-2.13).The prognosis of patients with an ischemic stroke or transient ischemic attack is improved with antiplatelets. Cilostazol showed the best risk-benefit characteristics without trade-off with the risk of major bleeding. Improved stroke recurrence with intensified antiplatelet regimens is counterbalanced with higher bleeding risk, and consequently, mortality remains unaffected. Treatment decisions in stroke survivals should integrate the assessment of bleeding risk for better identification of patients with the highest benefit of treatment intensification.Prospero registration number: CRD42020197143, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197143.}, keywords = {[Meta-analysis]}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Bálint, Alexandra/0000-0002-7267-8633; Kupó, Péter/0000-0002-9422-4245; El Alaoui El Abdallaoui, Oumaima/0000-0003-1564-4506} } @article{MTMT:32894010, title = {Intracranialis vérzések DOAC-terápia kapcsán}, url = {https://m2.mtmt.hu/api/publication/32894010}, author = {Szapáry, László}, journal-iso = {IDEGGYÓGY SZEMLE PROC}, journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS}, volume = {7}, unique-id = {32894010}, issn = {2498-6240}, year = {2022}, pages = {34-34} } @article{MTMT:32797860, title = {The Impact of Diabetes Mellitus and Admission Hyperglycemia on Clinical Outcomes after Recanalization Therapies for Acute Ischemic Stroke: STAY ALIVE National Prospective Registry}, url = {https://m2.mtmt.hu/api/publication/32797860}, author = {Kalmár, Péter János and Tárkányi, Gábor and Karadi, Zsofia Nozomi and Szapáry, László and Bosnyák, Edit}, doi = {10.3390/life12050632}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {12}, unique-id = {32797860}, year = {2022}, eissn = {2075-1729} } @article{MTMT:32654078, title = {Optimization of Large Vessel Occlusion Detection in Acute Ischemic Stroke Using Machine Learning Methods}, url = {https://m2.mtmt.hu/api/publication/32654078}, author = {Tárkányi, Gábor and Tenyi, Akos and Hollós, Roland and Kalmár, Péter János and Szapáry, László}, doi = {10.3390/life12020230}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {12}, unique-id = {32654078}, year = {2022}, eissn = {2075-1729}, orcid-numbers = {Tenyi, Akos/0000-0002-4880-6594; Kalmár, Péter János/0000-0003-3243-9336} } @article{MTMT:32647101, title = {A mechanikus thrombectomiát megelőző intravénás thrombolysis szerepe az akut agyi nagyérelzáródások kezelésében}, url = {https://m2.mtmt.hu/api/publication/32647101}, author = {Kalmár, Péter János and Tárkányi, Gábor and Karádi, Nozomi Zsófia and Bosnyák, Edit and Nagy, Csaba Balázs and Csécsei, Péter and Lenzsér, Gábor and Büki, András and Janszky, József Vladimír and Szapáry, László}, doi = {10.18071/isz.75.0023}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {75}, unique-id = {32647101}, issn = {0019-1442}, abstract = {The efficacy of intravenous thrombolysis (IVT) is moderate in the proximal vascular segments of intracranial arteries, as opposed to mecha-nical thrombectomy (MT). In the management of acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), IVT prior to MT is highly recommended based on the latest guidelines, but the necessity of IVT has been questioned by the latest studies of the past years. The aim of our study was to investigate and compare the efficacy and safety of direct mechanical thrombectomy (dMT) and combined therapy (CT) for patients who suffered an AIS with LVO and were treated in our department.We investigated patients with AIS caused by LVO who were admitted up to 4.5 hours after symptom onset and underwent MT in our department between November 2017 and August 2019. Patients' data were collected in our stroke register. Patients enrolled in our study were divided into two groups depending on whether dMT or CT was used. Our primary outcome was the 30- and 90- day functional outcome measured by modified Rankin Scale (mRS). Mortality at 30- and 90- day, successful recanalization rates, and symptomatic intracranial hemorrhage were considered as secondary outcomes.A total of 142 patients (age: 68.3 ± 12.6 years, 53.5% female) were enrolled in our study, including 81 (57.0%) dMT cases, and 61 (43.0%) patients who received CT. The vascular risk factors and comorbidities were significantly higher in the dMT-treated group. At day 30, the rate of favorable functional outcomes was 34.7% in dMT vs. 43.6% among those who received CT (p = 0.307), by day 90 this ratio changed to 40.8% vs. 46.3% (p = 0.542). Mortality rates at day 30 were 22.2% and 23.6% (p = 0.851), and at day 90 33.8% and 25.9% (p = 0.343). The rate of effective recanalization was 94.2% for dMT-treated patients and 98.0% for CT-treated patients (p = 0.318). Symptomatic intracranial hemorrhage was detected in 2.5% of dMT-treated patients and 3.4% of CT-treated group (p = 0.757).Our results suggest that CT is associated with a moderately better outcome compared to dMT. IVT prior to MT did not increase the risk of symptomatic intracranial hemorrhages.}, keywords = {thrombolysis; stroke; Thrombectomy; Ischaemia}, year = {2022}, eissn = {2498-6208}, pages = {23-29}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:32866517, title = {Hemorheological alterations in patients with chronic cerebrovascular disease}, url = {https://m2.mtmt.hu/api/publication/32866517}, author = {Kenyeres, Péter and Totsimon, Kinga and Nagy, Alexandra and Sándor, Barbara and Biro, Katalin and Szapáry, László and Tóth, Kálmán and Marton, Zsolt}, journal-iso = {BIORHEOLOGY}, journal = {BIORHEOLOGY}, volume = {58}, unique-id = {32866517}, issn = {0006-355X}, keywords = {Biophysics; Engineering, Biomedical}, year = {2021}, eissn = {1878-5034}, pages = {126-127}, orcid-numbers = {Sándor, Barbara/0000-0002-7028-4227} }